臨床研究　心不全

研究テーマ

　1. 心不全の病態評価、バイオマーカーに関する検討
　2. 心不全におけるエコーなどを用いた非侵襲的な血行動態評価
　3. 心不全に対する薬物療法・非薬物療法の効果に関する検討
　4. 心不全における併存疾患の影響および管理に関する検討

薬物療法や非薬物療法の進歩により、心不全診療は近年大きく変貌を遂げています。薬物療法ではARNI、SGLT2阻害薬、イバブラジン、ベルイシグアトなどは既にガイドラインに記載され広く臨床使用されていますが、近年は肥大型心筋症やアミロイドーシスなど心不全の各種原疾患に対する特異的治療薬も次々と登場しています。非薬物療法としては従来からの虚血性心疾患や不整脈だけでなく、弁膜症や先天性心疾患といった構造的心疾患もカテーテルを用いて治療ができるようになりました。重症心不全に対しては心臓移植や補助人工心臓植込みも行われています。しかし心不全診療が進歩することで、病態の評価や治療法の選択はますます複雑で高度となりました。さらに心不全患者には高齢、フレイル、悪性腫瘍などさまざまな併存症・合併症もあり、依然として心不全診療には未解決の重要な課題が数多くあります。我々は心臓の病態に関する検討に加え、心不全を全身性疾患としてとらえ、併存疾患も加味した多面的な臨床研究を行っております。日々の臨床から生じるクリニカルクエスチョンに対して、心不全の臨床研究を行い、新たな知見を見出して診療へと還元しています。複数の診療科にまたがる共同研究や多施設共同研究も積極的に行い、幅広い視点から質の高いエビデンスを提供できるよう日々活動しております。これまでに複数の論文が欧州や日本の心不全ガイドラインに引用（J Card Fail 2019: 195-203; J Cardiol 2019: 459-465; J Atheroscler Thromb 2019; 315-327; ESC Heart Fail 2018; 284-291; Eur J Prev Cardiol 2017: 1979-1987; Eur J Heart Fail 2013; 543-550 etc）され、国内外の心不全診療に影響を与えてきました。以下に近年の研究結果の一部を紹介いたします。

心不全患者のバイオマーカー

心不全患者では高カリウム血症や低カリウム血症を避けて血清カリウム値を適切な範囲に保つことが生命予後改善の観点から重要です。しかし、適正な範囲内での血清カリウム値の変動が予後に影響を与えるのかは不明でした。そこで入退院時に血清カリウム値が正常範囲であった心不全患者を入院中の血清カリウム値の変動の大きさにより分類（下図Q1～Q4）したところ、変動が大きかった患者（下図Q4）は退院後の心イベントが高率で生命予後も不良でした。そのため血清カリウム値は絶対値だけでなく変動にも注意して管理する必要があることが示唆されました。（Eur J Intern Med 2025: 106408）


（データセットより作図）

血中の重炭酸塩は酸塩基平衡を保つために重要です。心不全が増悪し神経体液性因子が活性化すると腎臓の近位尿細管で重炭酸塩の再吸収が増加します。そこで動脈血ガスのpHが正常範囲内にある心不全患者を血中重炭酸塩濃度に基づいて分類したところ、高重炭酸塩血症を示した患者群にてその後の心臓死や心不全入院が高率でした。高重炭酸塩血症を示す患者のうっ血改善にはアセタゾラミドが有用であるとの報告もあり、心不全患者における血中重炭酸塩濃度測定の有用性が示唆されました。（ESC Heart Fail 2024: 4420-4426）


（データセットより作図）

心不全患者の約半数に栄養障害を合併しているとの報告があり、栄養障害は慢性炎症を介して動脈硬化を促進します。心不全患者の栄養状態をGNRIを用いて評価しその後の出血イベント（出血性脳卒中または消化管出血）との関連を調べたところ、GNRI 106.2未満で有意に出血イベントが増加することがわかり、血圧や心不全の重症度で調整しても低GNRIを示す心不全患者は約2倍の出血リスクがあることがわかりました。高GNRI患者と低GNRI患者の抗血栓療法の使用率に差はなく、心不全患者の栄養サポートを含めた多面的な出血予防策の必要性が示唆されました。（ESC Heart Fail 2024: 702-708）


（データセットより作図）

拡張型心筋症の病因において細胞外マトリックスは重要な役割を果たします。拡張型心筋症患者と年齢性別をマッチさせた心疾患のない対照群の細胞外マトリックスタンパクのLTBP-2の血漿濃度を測定したところ、拡張型心筋症患者にて有意に高値でした。拡張型心筋症患者の血漿LTBP-2濃度は心筋生検検体内のLTBP-2と相関していました。血漿および心筋内LTBP-2は心臓死や植込型補助人工心臓移植術の予測因子でした。（Can J Cardiol 2023: 1436-1445）

心不全と腎臓との関係

古典的には心臓の血行動態はカテーテルを用いて侵襲的に評価されていました。我々はエコーを用いることで心臓と他臓器の血行動態のダイナミックな連関を評価できることを報告してきました。例えば心拍出量の指標として、腎臓の葉間腎動脈血流量（VTI）の評価が有用であり、また腎静脈の血流波形パターン（連続性・二峰性・単峰性や血流停滞時間）によりうっ血の半定量的評価が可能であることを報告しました。（Sci Rep 2020: 22257; Front Cardiovasc Med 2022: 772466）


（データセットより作成）

心不全と肝臓との関係

安静時、心臓から拍出された血液の約4分の1は肝臓へ流れます。また下大静脈は全身から心臓へ戻る血流が流れていますが、その最も心臓に近い部分に肝静脈が合流します。そのため肝臓は心不全の血行動態の影響を強く受ける臓器の一つです。我々は肝臓へと血液を送る腹腔動脈をエコーにて観察することで肝臓の低灌流を検出できることを報告しました。（J Am Heart Assoc. 2020: e016689）また肝臓の硬さや肝静脈の血流波形をエコーにて可視化することにより、右心系うっ血を評価でき、予後予測にも有用であることを報告しました。（J Am Heart Assoc 2020: e016689; CJC Open 2021: 778-786; J Am Heart Assoc 2023: e029857）


（データセットより作成）

肝臓からはヘパトカインと呼ばれるホルモンが分泌され全身でさまざまな作用を発揮します。我々はこれまでにfetuin-A、selenoprotein Pといったヘパトカインが心不全の血行動態とどのように関連しているのかを研究してきました。これらのヘパトカインの血清濃度は肝臓のうっ血ではなく低灌流と関連しており、低灌流にて前者は低下、後者は上昇しいずれも不良な予後の予測因子であることを報告しました。（Clin Res Cardiol 2022: 1104-1112; J Am Heart Assoc 2022: e024901）


（データセットより作図）

心不全と睡眠との関係

睡眠呼吸障害は低酸素血症や胸腔内圧の陰圧化などを来し心臓や血管に多大な負荷をかけます。心不全の半数以上に睡眠呼吸障害が合併するとされています。我々は睡眠呼吸障害の検出や睡眠呼吸障害による不整脈など多方面への影響にホルター心電図が有用であることを明らかにしてきました。また、呼吸補助療法・陽圧換気療法を行うことで、心不全の心機能、血管機能、呼吸機能、腎機能の多面的な改善に加え、予後が改善する可能性があることを報告しています。（Eur J Heart Fail 2013: 543-50）


（データセットより作図）

現在、睡眠検査のためのポリソムノグラフィの機器の一部には心臓から指先へ脈波が伝播する時間（PTT）を利用して非侵襲的に一心迫毎の血圧（PTT血圧）を測定する機能が組み込まれています。心不全患者の夜間の一心迫毎の血圧の臨床的意義を調査したところ、血圧低値は動脈スティフネス（血管抵抗）ではなく心機能の低下と関連しており、一心迫ごとの変動の大きさ（超短期的血圧変動）は既存のリスク因子との相関は弱く超短期的血圧変動自体に注目する必要があり、いずれも患者予後と関連していることがわかりました。（J Am Heart Assoc 2025: e039917; Hypertens Res 2025: 1305-1314）


（データセットより作図）

心不全と脳機能との関係

一般集団と比べ心不全患者ではうつ病や不安障害の頻度が高いと報告されています。近年、近赤外分光法（NIRS）による非侵襲的な脳血流や脳活動の評価が可能となりました。本学神経精神医学講座との共同研究により心不全患者の脳活動とうつ症状、不安状態、認知機能との関係を検討しました。その結果、対照群と比べて心不全患者では前頭部の脳活動が低下していることや、前頭部の脳活動低下が認知機能や言語流暢性の低下や不安状態と関連している可能性が示唆されました。（J Am Heart Assoc 2020: e014564）


（データセットより作図）

トランスレーショナル研究

臨床現場で生じたクリニカルクエスチョンを起点とした基礎・臨床融合型研究にも取り組んでいます。基礎研究で検証し、その成果を臨床へフィードバックできるよう研究を進めています。詳細は下記をご覧ください。
https://www.fmu.ac.jp/education/medicine/department/cardiovascular/research/research-f/hf.html

これまでの主な業績

  1. 1.Suzuki Y, Misaka T, Sato Y, Okochi S, Ogawara R, Ichimura S, Yokokawa T, Sato A, Shimizu T, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yoshihisa A, Takeishi Y: Association between serum potassium variability during hospitalization and clinical outcomes in patients with heart failure. Eur J Intern Med 141: 106408, 2025
  2. 2.Sato Y, Yoshihisa A, Ohashi N, Takeishi R, Sekine T, Nishiura K, Ogawara R, Ichimura S, Kimishima Y, Yokokawa T, Miura S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Nakazato K, Takeishi Y: Association of nighttime very short-term blood pressure variability determined by pulse transit time with adverse prognosis in patients with heart failure. Hypertens Res 48: 1305-1314, 2025
  3. 3.Ohashi N, Sato Y, Yoshihisa A, Takeishi R, Misaka T, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Nakazato K, Takeishi Y: Nighttime systolic blood pressure determined by pulse transit time predicts cardiac events in patients with heart failure. J Am Heart Assoc 14: e039917, 2025
  4. 4.Abe S, Yoshihisa A, Ohara H, Sugawara Y, Sato Y, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Nakazato K, Takeishi Y: Calcium-phosphorus product is associated with adverse prognosis in hospitalized patients with heart failure and chronic kidney disease. Int Heart J 65: 84-93, 2024
  5. 5.Misaka T, Sato Y, Sugawara Y, Ogawara R, Ichimura S, Tomita Y, Anzai F, Yokokawa T, Sato A, Shimizu T, Sato T, Oikawa M, Kobayashi A, Yoshihisa A, Takeishi Y: Elevated blood bicarbonate levels and long-term adverse outcomes in patients with chronic heart failure. ESC Heart Fail 11: 4420-4426, 2024
  6. 6.Sato Y, Yoshihisa A, Nozaki Y, Ohara H, Sugawara Y, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Nakazato K, Takeishi Y: Geriatric nutritional risk index predicts bleeding event in patients with heart failure. ESC Heart Fail 11: 702-708, 2024
  7. 7.Sato Y, Yoshihisa A, Sugawara Y, Misaka T, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Nakazato K, Takeishi Y: Malnutrition stratified by marasmus and kwashiorkor in adult patients with heart failure. Sci Rep 14: 19722, 2024
  8. 8.Ichimura S, Misaka T, Ogawara R, Tomita Y, Anzai F, Sato Y, Miura S, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yoshihisa A, Takeishi Y: Neutrophil extracellular traps in myocardial tissue drive cardiac dysfunction and adverse outcomes in patients with heart failure with dilated cardiomyopathy. Circ Heart Fail 17: e011057, 2024
  9. 9.Katahira M, Fukushima K, Kiko T, Yamakuni R, Endo K, Yoshihisa A, Ishii S, Ito H, Takeishi Y: Prognostic significance of left atrial strain combined with left ventricular strain using cardiac magnetic resonance feature tracking in patients with heart failure with preserved ejection fraction. Heart Vessels 39: 404-411, 2024
  10. 10.Tomita Y, Misaka T, Sugawara Y, Ichijo Y, Anzai F, Sato Y, Kimishima Y, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yoshihisa A, Takeishi Y: Reduced fetuin-A levels are associated with exercise intolerance and predict the risk of adverse outcomes in patients with heart failure: The role of cardiac-hepatic-peripheral interaction. J Am Heart Assoc 13: e035139, 2024
  11. 11.Misaka T, Yoshihisa A, Yokokawa T, Takeishi Y: Effects of continuous positive airway pressure on very short-term blood pressure variability associated with sleep-disordered breathing by pulse transit time-based blood pressure measurements. J Hypertens 41: 733-740, 2023
  12. 12.Ohara H, Yoshihisa A, Ishibashi S, Matsuda M, Yamadera Y, Sugawara Y, Ichijo Y, Sato Y, Misaka T, Sato T, Oikawa M, Kobayashi A, Takeishi Y: Hepatic venous stasis index reflects hepatic congestion and predicts adverse outcomes in patients with heart failure. J Am Heart Assoc 12: e029857, 2023
  13. 13.Nozaki Y, Yoshihisa A, Sato Y, Ohara H, Sugawara Y, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Nakazato K, Takeishi Y: Persistent hypochloremia is associated with adverse prognosis in patients repeatedly hospitalized for heart failure. J Clin Med 12: 1257, 2023
  14. 14.Nishiura K, Yokokawa T, Misaka T, Ichimura S, Tomita Y, Miura S, Shimizu T, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yoshihisa A, Takeishi Y: Prognostic role of circulating LTBP-2 in patients with dilated cardiomyopathy: a novel biomarker reflecting extracellular matrix LTBP-2 accumulation. Can J Cardiol 39: 1436-1445, 2023
  15. 15.Misaka T, Yoshihisa A, Ichijo Y, Ishibashi S, Matsuda M, Yamadera Y, Ohara H, Sugawara Y, Anzai F, Sato Y, Abe S, Sato T, Oikawa M, Kobayashi A, Takeishi Y: Prognostic significance of spleen shear wave elastography and dispersion in patients with heart failure: the crucial role of cardio-splenic axis. Clin Res Cardiol 112: 942-953, 2023
  16. 16.Sato Y, Yoshihisa A, Ide T, Tohyama T, Enzan N, Matsushima S, Tsutsui H, Takeishi Y: Regional variation in the clinical practice and prognosis in patients with heart failure with reduced ejection fraction in Japan - A report from the Japanese Registry of Acute Decompensated Heart Failure (JROADHF). Circ J 87: 1380-1391, 2023
  17. 17.Sato Y, Yoshihisa A, Takeishi R, Ohara H, Sugawara Y, Ichijo Y, Hotsuki Y, Watanabe K, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Nakazato K, Takeishi Y: B-type natriuretic peptide is associated with the occurrence of bleeding events in heart failure patients with a history of coronary artery disease. J Cardiol 80: 88-93, 2022
  18. 18.Vergaro G, Aimo A, Jr JL, Richards AM, Lam CS, Latini R, Staszewsky L, Anand IS, Ueland T, Rocca HP, Bayes-Genis A, Lup n J, Boer RA, Yoshihisa A, Takeishi Y, Gustafsson I, Eggers KM, Huber K, Gamble GD, Leong KT, Yeo PS, Ong HY, Jaufeerally F, Ng TP, Troughton R, Doughty RN, Emdin M, Passino C: Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease. J Cardiovasc Med 23: 28-36, 2022
  19. 19.Vergaro G, Gentile F, Aimo A, Jr JL, Richards AM, Lam CS, Boer RA, Meems LM, Latini R, Staszewsky L, Anand IS, Cohn JN, Ueland T, Gullestad L, Aukrust P, Rocca HP, Bayes-Genis A, Lup n J, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Gamble GD, Ling LH, Leong KT, Yeo PS, Ong HY, Jaufeerally F, Ng TP, Troughton R, Doughty RN, Devlin G, Lund M, Giannoni A, Passino C, Emdin M: Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Fail 9: 2084-2095, 2022
  20. 20.Oikawa M, Yaegashi D, Yokokawa T, Misaka T, Sato T, Kaneshiro T, Kobayashi A, Yoshihisa A, Nakazato K, Ishida T, Takeishi Y: D-dimer is a predictive factor of cancer therapeutics-related cardiac dysfunction in patients treated with cardiotoxic chemotherapy. Front Cardiovasc Med 8: 807754, 2022
  21. 21.Tomita Y, Misaka T, Yoshihisa A, Ichijo Y, Ishibashi S, Matsuda M, Yamadera Y, Ohara H, Sugawara Y, Hotsuki Y, Watanabe K, Anzai F, Sato Y, Sato T, Oikawa M, Kobayashi A, Takeishi Y: Decreases in hepatokine Fetuin-A levels are associated with hepatic hypoperfusion and predict cardiac outcomes in patients with heart failure. Clin Res Cardiol 111: 1104-1112, 2022
  22. 22.Takeishi R, Misaka T, Ichijo Y, Ishibashi S, Matsuda M, Yamadera Y, Ohara H, Sugawara Y, Hotsuki Y, Watanabe K, Anzai F, Sato Y, Sato T, Oikawa M, Kobayashi A, Yamaki T, Nakazato K, Yoshihisa A, Takeishi Y: Increases in hepatokine selenoprotein P levels are associated with hepatic hypoperfusion and predict adverse prognosis in patients with heart failure. J Am Heart Assoc 11: e024901, 2022
  23. 23.Amami K, Yamada S, Yoshihisa A, Kaneshiro T, Hijioka N, Nodera M, Nehashi T, Takeishi Y: Predictive impacts of chronic kidney disease and cardiac sympathetic nervous activity on lethal arrhythmic events in chronic heart failure. Ann Noninvas Electro 27: e12900, 2022
  24. 24.Sugawara Y, Yoshihisa A, Takeishi R, Ohara H, Anzai F, Hotsuki Y, Watanabe K, Sato Y, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Nakazato K, Takeishi Y: Prognostic effects of changes in right ventricular fractional area change in patients with heart failure. Circ J 86: 1982-1989, 2022
  25. 25.Hoshide S, Yoshihisa A, Tsuchida F, Mizuno H, Teragawa H, Kasai T, Koito H, Ando S, Watanabe Y, Takeishi Y, Kario K: Pulse transit time-estimated blood pressure: a comparison of beat-to-beat and intermittent measurement. Hypertens Res 45: 1001-1007, 2022
  26. 26.Ohara H, Yoshihisa A, Horikoshi Y, Ishibashi S, Matsuda M, Yamadera Y, Sugawara Y, Ichijo Y, Hotsuki Y, Watanabe K, Sato Y, Misaka T, Kaneshiro T, Oikawa M, Kobayashi A, Takeishi Y: Renal venous stasis index reflects renal congestion and predicts adverse outcomes in patients with heart failure. Front Cardiovasc Med 9: 772466, 2022
  27. 27.Takeishi R, Yoshihisa A, Hotsuki Y, Anzai F, Sato Y, Sumita Y, Nakai M, Misaka T, Takeishi Y: Temporal trends in the practice pattern for sleep-disordered breathing in patients with cardiovascular diseases in Japan - Insights from the Japanese registry of all cardiac and vascular diseases - diagnosis procedure combination. Circ J 86: 1428-1436, 2022
  28. 28.Yokokawa T, Yoshihisa A, Misaka T, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Anti-mitochondrial antibodies in patients with dilated cardiomyopathy. Intern Med 60, 201-208, 2021
  29. 29.Sato Y, Yoshihisa A, Ichijo Y, Watanabe K, Hotsuki Y, Kimishima Y, Yokokawa T, Misaka T, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Takeishi Y. Cardio-ankle vascular index predicts post-discharge stroke in patients with heart failure. J Atheroscler Thromb 28, 766-775, 2021
  30. 30.Watanabe K, Yoshihisa A, Sato Y, Hotsuki Y, Anzai F, Ichijo Y, Kimishima Y, Yokokawa T, Misaka T, Kaneshiro T, Oikawa M, Kobayashi A, Takeishi Y. Cardio-ankle vascular index reflects impaired exercise capacity and predicts adverse prognosis in patients with heart failure. Front Cardiovasc Med 8, 631807, 2021
  31. 31.Suzuki S, Yoshihisa A, Yokokawa T, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Tsuda A, Tsuda T, Ishibashi T, Konno I, Yamaguchi O, Machii H, Nozaki N, Niizeki T, Miyamoto T, Takeishi Y, on behalf of the multicenter randomized trial investigators. Comparison between febuxostat and allopurinol uric acid-lowering therapy in patients with chronic heart failure and hyperuricemia: a multicenter randomized controlled trial. J Int Med Res 49, 3000605211062770, 2021
  32. 32.Sato Y, Yoshihisa A, Maki T, Takeishi Y. Effects of daily alcohol intake on glomerular filtration rate during three years. Fukushima J Med Sci 67, 1-7, 2021
  33. 33.Sugawara Y, Yoshihisa A, Ishibashi S, Matsuda M, Yamadera Y, Ohara H, Ichijo Y, Watanabe K, Hotsuki Y, Anzai F, Sato Y, Kimishima Y, Yokokawa T, Misaka T, Yamada S, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Takeishi Y. Liver congestion assessed by hepatic vein waveforms in patients with heart failure. CJC Open 3, 778-786, 2021
  34. 34.Abe S, Yoshihisa A, Ichijo Y, Kimishima Y, Yokokawa T, Misaka T, Sato T, Oikawa M, Kobayashi A, Kaneshiro T, Nakazato K, Takeishi Y. Serum TRACP5b, a marker of bone resorption, is associated with adverse cardiac prognosis in hospitalized patients with heart failure. CJC Open 3, 470-478, 2021
  35. 35.Sato Y, Yoshihisa A, Takeishi R, Ohara H, Sugawara Y, Ichijo Y, Hotsuki Y, Watanabe K, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Nakazato K, Takeishi Y. Simplified academic research consortium for high bleeding risk (ARC-HBR) definition predicts bleeding events in patients with heart failure. Circ J 86, 147-155, 2021
  36. 36.Sato Y, Yoshihisa A, Watanabe K, Hotsuki Y, Kimishima Y, Yokokawa T, Misaka T, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Takeishi Y. Association between platelet distribution width and prognosis in patients with heart failure. PLoS One 15, e0244608, 2020
  37. 37.Sato Y, Yoshihisa A, Hotsuki Y, Watanabe K, Kimishima Y, Kiko T, Kanno Y, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. Associations of benzodiazepine with adverse prognosis in heart failure patients with insomnia. J Am Heart Assoc 9, e013982, 2020
  38. 38.Sato Y, Yoshihisa A, Kimishima Y, Yokokawa T, Abe S, Shimizu T, Misaka T, Yamada S, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Atrial fibrillation is associated with impaired exercise capacity and adverse prognosis in patients with heart failure with mid-range ejection fraction. Eur J Prev Cardiol 27, 2322-2325, 2020
  39. 39.Hotsuki Y, Sato Y, Yoshihisa A, Watanabe K, Kimishima Y, Kiko T, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Takeishi Y. B-type natriuretic peptide is associated with post-discharge stroke in hospitalized patients with heart failure. ESC Heart Fail 7, 2508-2515, 2020
  40. 40.Misaka T, Niimura Y, Yoshihisa A, Wada K, Kimishima Y, Yokokawa T, Abe S, Oikawa M, Kaneshiro T, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Clinical impact of sleep-disordered breathing on very short-term blood pressure variability determined by pulse transit time. J Hypertens 38, 1703-1711, 2020
  41. 41.Yoshihisa A, Ishibashi S, Matsuda M, Yamadera Y, Ichijo Y, Sato Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Clinical implications of hepatic hemodynamic evaluation by abdominal ultrasonographic imaging in patients with heart failure. J Am Heart Assoc 9, e016689, 2020
  42. 42.Yoshihisa A, Ichijo Y, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Comprehensive clinical characteristics of hospitalized patients with mid-range left ventricular ejection fraction. Eur J Prev Cardiol 27, 2084-2088, 2020
  43. 43.Hotsuki Y, Sato Y, Yoshihisa A, Watanabe K, Kimishima Y, Kiko T, Yokokawa T, Misaka T, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Takeishi Y. Glasgow-blatchford score predicts post-discharge gastrointestinal bleeding in hospitalized patients with heart failure. J Clin Med 9, 4083, 2020
  44. 44.Ichijo Y, Kono S, Yoshihisa A, Misaka T, Kaneshiro T, Oikawa M, Miura I, Yabe H, Takeishi Y. Impaired frontal brain activity in patients with heart failure assessed by near-infrared spectroscopy. J Am Heart Assoc 9, e014564, 2020
  45. 45.Yoshihisa A, Kanno Y, Ichijo Y, Sato Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Incidence and subsequent prognostic impacts of gastrointestinal bleeding in patients with heart failure. Eur J Prev Cardiol 27, 664-666, 2020
  46. 46.Yoshihisa A, Watanabe K, Sato Y, Ishibashi S, Matsuda M, Yamadera Y, Ichijo Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y. Intrarenal Doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure. Sci Rep 10, 22257, 2020
  47. 47.Sato Y, Yoshihisa A, Kimishima Y, Yokokawa T, Abe S, Shimizu T, Misaka T, Yamada S, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Prognostic factors in heart failure patients with cardiac cachexia. J Geriatr Cardiol 17, 26-34, 2020
  48. 48.Oikawa M, Yoshihisa A, Sato Y, Nagai T, Yoshikawa T, Saito Y, Yamamoto K, Takeishi Y, Anzai T. Prognostic impact of moderate mitral regurgitation on hospitalized heart failure patients with preserved ejection fraction: A report from the JASPER Registry. Heart Vessels 35, 1087-1094, 2020
  49. 49.Yoshihisa A, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Prognostic impacts of changes in left ventricular ejection fraction in heart failure patients with preserved left ventricular ejection fraction. Open Heart 7, e001112, 2020
  50. 50.Abe S, Yoshihisa A, Ichijo Y, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Recovered left ventricular ejection fraction and its prognostic impacts in hospitalized heart failure patients with reduced ejection fraction. Int Heart J 61, 281-288, 2020
  51. 51.Ohara H, Yoshihisa A, Ishibashi S, Matsuda M, Yamadera Y, Sugawara Y, Ichijo Y, Hotsuki Y, Watanabe K, Anzai F, Sato Y, Kimishima Y, Yokokawa T, Misaka T, Sato T, Oikawa M, Kobayashi A, Takeishi Y. Shear wave dispersion predicts liver fibrosis and adverse outcomes in patients with heart failure. J Clin Med 9, 3953, 2020
  52. 52.Yoshihisa A, Sato Y, Kimishima Y, Ichijo Y, Yokokawa T, Misaka T, Sato T, Oikawa M, Kobayashi A, Nakazato K, Takeishi Y. Soluble fibrin monomer complex is associated with cardio- and cerebrovascular events in patients with heart failure. Int J Cardiol Heart Vasc 32, 100697, 2020
  53. 53.Yoshihisa A. Altered gut flora and gut microbiome-derived metabolites in heart failure patients in the compensated and decompensated phases. Circ J 83, 30-31, 2019
  54. 54.Yokokawa T, Ichimura S, Hijioka N, Kaneshiro T, Yoshihisa A, Kunii H, Nakazato K, Ishida T, Suzuki O, Ohno S, Aiba T, Ohtani H, Takeishi Y. Case reports of a c.475G>T, p.E159* lamin A/C mutation with a family history of conduction disorder, dilated cardiomyopathy and sudden cardiac death. BMC Cardiovasc Disord 19, 298, 2019
  55. 55.Yokokawa T, Yoshihisa A, Kanno Y, Abe S, Misaka T, Yamada S, Kaneshiro T, Sato T, Oikawa M, Kobayashi A, Nakazato K, Ishida T, Takeishi Y. Circulating acetoacetate is associated with poor prognosis in heart failure patients. Int J Cardiol Heart Vasc 25, 100432, 2019
  56. 56.Yokokawa T, Sugimoto K, Nakazato K, Misaka T, Oikawa M, Kobayashi A, Yoshihisa A, Yamaki T, Kunii H, Ishida T, Takeishi Y. Electrocardiographic criteria of right ventricular hypertrophy in patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty. Intern Med 58, 2139-2144, 2019
  57. 57.Yoshihisa A, Sato T, Kajimoto K, Sato N, Takeishi Y, on behalf of the Acute Decompensated Heart Failure Syndromes (ATTEND) investigators. Heterogeneous impact of the body mass index on in-hospital mortality in acute heart failure syndromes: An analysis from the ATTEND Registry. Eur Heart J Acute Cardiovasc Care 8, 589-598, 2019
  58. 58.Sato Y, Yoshihisa A, Oikawa M, Nagai T, Yoshikawa T, Saito Y, Yamamoto K, Takeishi Y, Anzai T. Hyponatremia at discharge is associated with adverse prognosis in acute heart failure syndromes with preserved ejection fraction: a report from the JASPER registry. Eur Heart J Acute Cardiovasc Care 8, 623-633, 2019
  59. 59.Sato Y, Yoshihisa A, Kimishima Y, Kiko T, Kanno Y, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Takeishi Y. Low T3 syndrome is associated with high mortality in hospitalized patients with heart failure. J Card Fail 25, 195-203, 2019
  60. 60.Misaka T, Yoshihisa A, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Takeishi Y. Plasma levels of melatonin in dilated cardiomyopathy. J Pineal Res 66, e12564, 2019
  61. 61.Yoshihisa A, Ichijo Y, Watanabe K, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Ishida T, Takeishi Y. Prior history and incidence of cancer impacts on cardiac prognosis in hospitalized patients with heart failure. Circ J 83, 1709-1717, 2019
  62. 62.Sato Y, Yoshihisa A, Oikawa M, Nagai T, Yoshikawa T, Saito Y, Yamamoto K, Takeishi Y, Anzai T. Prognostic impact of chronic obstructive pulmonary disease on adverse prognosis in hospitalized heart failure patients with preserved ejection fraction - A report from the JASPER registry. J Cardiol 73, 459-465, 2019
  63. 63.Yoshihisa A, Misaka T, Kanno Y, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y. Prognostic impact of restless legs syndrome on patients with heart failure. Int Heart J 60, 1098-1105, 2019
  64. 64.Sato Y, Yoshihisa A, Oikawa M, Nagai T, Yoshikawa T, Saito Y, Yamamoto K, Takeishi Y, Anzai T. Prognostic impact of worsening renal function in hospitalized heart failure patients with preserved ejection fraction: A report from the JASPER Registry. J Card Fail 25, 631-642, 2019
  65. 65.Sato Y, Yoshihisa A, Oikawa M, Nagai T, Yoshikawa T, Saito Y, Yamamoto K, Takeishi Y, Anzai T. Relation of systolic blood pressure on the following day with post-discharge mortality in hospitalized heart failure patients with preserved ejection fraction -A Report from the JASPER Registry-. Int Heart J 60, 876-885, 2019
  66. 66.Yoshihisa A, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Takeishi Y. Soluble neprilysin does not correlate with prognosis in pulmonary hypertension. ESC Heart Fail 6, 291-296, 2019
  67. 67.Yokokawa T, Sugimoto K, Yoshihisa A, Goto T, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. The fibrosis-4 index is useful for predicting mortality in patients with pulmonary hypertension due to left heart disease. Int Heart J 60, 1147-1153, 2019
  68. 68.Takiguchi M, Ohira T, Nakano H, Yumiya Y, Yamaki T, Yoshihisa A, Nakazato K, Suzuki H, Ishikawa T, Yasumura S, Kamiya K, Takeishi Y. Trends in the incidence of sudden deaths and heart diseases in Fukushima after the Great East Japan Earthquake. Int Heart J 60, 1253-1258, 2019
  69. 69.Kimishima Y, Yoshihisa A, Kiko T, Yokokawa T, Miyata-Tatsumi M, Misaka T, Oikawa M, Kobayashi A, Takeishi Y. Utility of B-type natriuretic peptide for detecting cardiac involvement in immunoglobulin amyloidosis. Int Heart J 60, 1106-1112, 2019
  70. 70.Sato A, Yoshihisa A, Miyata‑Tatsumi M, Oikawa M, Kobayashi A, Ishida T, Ohtake T, Takeishi Y. Valvular heart disease as a possible predictor of trastuzumab‑induced cardiotoxicity in patients with breast cancer. Mol Clin Oncol 10, 37-42, 2019
  71. 71.Kiko T, Yoshihisa A, Kanno Y, Yokokawa T, Abe S, Miyata-Tatsumi M, Misaka T, Oikawa M, Kobayashi A, Ishida T, Takeishi Y. A multiple biomarker approach in patients with cardiac sarcoidosis. Int Heart J 59, 996-1001, 2018
  72. 72.Suzuki S, Yoshihisa A, Sato Y, Watanabe S, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y. Association between sleep-disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction. ESC Heart Fail 5, 284-291, 2018
  73. 73.Yoshihisa A, Abe S, Kiko T, Kimishima Y, Sato Y, Watanabe S, Kanno Y, Miyata-Tatsumi M, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. Association of serum zinc level with prognosis in patients with heart failure. J Card Fail 24, 375-383, 2018
  74. 74.Yoshihisa A, Sato Y, Sato T, Suzuki S, Oikawa M, Takeishi Y. Better clinical outcome with direct oral anticoagulants in hospitalized heart failure patients with atrial fibrillation. BMC Cardiovasc Disord 18, 11, 2018
  75. 75.Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Shimouchi A, Takeishi Y. Change of exhaled acetone concentration levels in patients with acute decompensated heart failure. Int Heart J 59, 808-812, 2018
  76. 76.Suzuki S, Yoshihisa A, Sato Y, Kanno Y, Watanabe S, Abe S, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. Clinical significance of get with the guidelines-heart failure risk score in patients with chronic heart failure after hospitalization. J Am Heart Assoc 7, e008316, 2018
  77. 77.Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. Feasibility of skin acetone analysis in patients with cardiovascular diseases. Fukushima J Med Sci 64, 60-63, 2018
  78. 78.Yoshihisa A. Impact of anemia on left ventricular reverse remodeling in response to carvedilol. Circ J 82, 646-647, 2018
  79. 79.Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Ishida T, Takeishi Y. Impact of nutritional indices on mortality in patients with heart failure. Open Heart 5, e000730, 2018
  80. 80.Yoshihisa A, Kimishima Y, Kiko T, Sato Y, Watanabe S, Kanno Y, Abe S, Miyata-Tatsumi M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Ishida T, Takeishi Y. Liver fibrosis marker, 7S domain of collagen type IV, in patients with pre-capillary pulmonary hypertension. Int J Cardiol 258, 269-274, 2018
  81. 81.Oikawa M, Kobayashi A, Wada K, Sato T, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y. Novel parameter to predict left ventricular filling pressure: product of log B-Type natriuretic peptide and ratio of mitral inflow early and late diastolic filling velocities. J Card Fail 24, 29-32, 2018
  82. 82.Yoshihisa A, Abe S, Sato Y, Watanabe S, Yokokawa T, Miura S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Saitoh S, Takeishi Y. Plasma volume status predicts prognosis in patients with acute heart failure syndromes. Eur Heart J Acute Cardiovasc Care 7, 330-338, 2018
  83. 83.Yoshihisa A, Suzuki S, Sato Y, Kanno Y, Abe S, Miyata M, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. Relation of testosterone levels to mortality in men with heart failure. Am J Cardiol 121, 1321-1327, 2018
  84. 84.Sato Y, Yoshihisa A, Kimishima Y, Kiko T, Watanabe S, Kanno Y, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. Subclinical hypothyroidism is associated with adverse prognosis in heart failure patients. Can J Cardiol 34, 80-87, 2018
  85. 85.Yoshihisa A, Kiko T, Sato T, Oikawa M, Kobayashi A, Takeishi Y. Urinary N-terminal fragment of titin is a marker to diagnose muscular dystrophy in patients with cardiomyopathy. Clin Chim Acta 484, 226-230, 2018
  86. 86.Yoshihisa A, Kimishima Y, Kiko T, Sato Y, Watanabe S, Kanno Y, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y. Usefulness of urinary N-terminal fragment of titin to predict mortality in dilated cardiomyopathy. Am J Cardiol 121, 1260-1265, 2018
  87. 87.Yoshihisa A, Suzuki S, Takeishi Y. VEGF165b elevation in pulmonary arterial hypertension patients, causative or adaptive? -Reply-. Int J Cardiol 256, 32, 2018
  88. 88.Yoshihisa A, Watanabe S, Yokokawa T, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y. Associations between acylcarnitine to free carnitine ratio and adverse prognosis in heart failure patients with reduced or preserved ejection fraction. ESC Heart Fail 4, 360-364, 2017
  89. 89.Yoshihisa A, Takiguchi M, Kanno Y, Sato A, Yokokawa T, Miura S, Abe S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y. Associations of acid suppressive therapy with cardiac mortality in heart failure patients. J Am Heart Assoc 6, e005110, 2017
  90. 90.Sato T, Yoshihisa A, Kanno Y, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y. Cardiopulmonary exercise testing as prognostic indicators: Comparisons among heart failure patients with reduced, mid-range and preserved ejection fraction. Eur J Prev Cardiol 24, 1979-1987, 2017
  91. 91.Yokokawa T, Ichijo Y, Houtsuki Y, Matsumoto Y, Oikawa M, Yoshihisa A, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Shimouchi A, Takeishi Y. Change of exhaled acetone concentration in a diabetic patient with acute decompensated heart failure. Int Heart J 58, 828-830, 2017
  92. 92.Yokokawa T, Yoshihisa A, Kanno Y, Sato T, Suzuki S, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y. Clinical features in extremely elderly patients with heart failure. Geriatr Gerontol Int 17, 2194-2199, 2017
  93. 93.Yoshihisa A, Sato Y, Watanabe S, Yokokawa T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y. Decreased cardiac mortality with nicorandil in patients with ischemic heart failure. BMC Cardiovasc Disord 17, 141, 2017
  94. 94.Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Shimouchi A, Takeishi Y. Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus. BMC Cardiovasc Disord 17, 280, 2017
  95. 95.Sato Y, Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Misaka T, sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y. Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure. Open Heart 4, e000598, 2017
  96. 96.Suzuki S, Yoshihisa A, Kanno Y, Watanabe S, Takiguchi M, Miura S, Yokokawa T, Sato T, Oikawa M, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y. Prognostic impact of living in temporary housing in Fukushima after the Great East Japan Earthquake. J Card Fail 23, 90-92, 2017
  97. 97.Oikawa M, Kobayashi A, Sato T, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y. The usefulness of combined assessment of E/E' ratio and transmitral flow pattern to interpret cardiac condition. Fukushima J Med Sci 63, 16-21, 2017
  98. 98.Yoshihisa A, Kanno Y, Takeishi Y: Insomnia and cardiac events in patients with heart failure　-Reply. Circ J 81, 126, 2016
  99. 99.Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Associations of dipeptidyl peptidase-4 inhibitors with mortality in hospitalized heart failure patients with diabetes mellitus. ESC Heart Fail 3, 77-85, 2016
  100. 100.Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Yokokawa T, Sato A, Miura S, Shimizu T, Abe S, Sato T, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Associations with eicosapentaenoic acid to arachidonic acid ratio and mortality in hospitalized heart failure patients. J Card Fail 22, 962-969, 2016
  101. 101.Oikawa M, Sakamoto N, Kobayashi A, Suzuki S, Yoshihisa A, Yamaki T, Nakazato K, Suzuki H, Saitoh S, Kiko Y, Nakano H, Hayashi T, Kimura A, Takeishi Y: Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and zebra body. BMC Cardiovasc Disord 16, 83, 2016
  102. 102.Yoshihisa A, Suzuki S, Kanno Y, Takiguchi M, Sato A, Miura S, Masuda A, Yokokawa T, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Sato T, Oikawa M, Saitoh S, Takeishi Y: Prognostic significance of periodic leg movements during sleep in heart failure patients. Int J Cardiol 212, 11-13, 2016
  103. 103.Kanno Y, Yoshihisa A, Watanabe S, Takiguchi M, Yokokawa T, Sato A, Miura S, Shimizu T, Nakamura Y, Abe S, Sato T, Suzuki S, Oikawa M, Saitoh S, Takeishi Y: Prognostic significance of insomnia in heart failure. Circ J 80, 1571-1577, 2016
  104. 104.Sugimoto K, Yoshihisa A, Nakazato K, Jin Y, Suzuki S, Yokokawa T, Misaka T, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y: Pulmonary arterial capacitance predicts cardiac events in pulmonary hypertension due to left heart disease. PLOS ONE 11, e0165603, 2016
  105. 105.Yoshihisa A, Watanabe S, Kanno Y, Takiguchi M, Sato A, Yokokawa T, Miura S, Shimizu T, Abe S, Sato T, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: The CHA2DS2-VASc score as a predictor of high mortality in hospitalized heart failure patients. ESC Heart Fail 3, 261-269, 2016
  106. 106.Miura S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Association of hypocalcemia with mortality in hospitalized patients with heart failure and chronic kidney disease. J Card Fail 21, 621-627, 2015
  107. 107.Yoshihisa A, Suzuki S, Yamauchi H, Sato T, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Beneficial effects of positive airway pressure therapy for sleep-disordered breathing in heart failure patients with preserved left ventricular ejection fraction. Clin Cardiol 38, 413-421, 2015
  108. 108.Sato T, Yamauchi H, Kanno Y, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Comparisons of prognostic factors between young and elderly patients with chronic heart failure. Geriatr Gerontol Int 15, 435-442, 2015
  109. 109.Shimizu T, Yoshihisa A, Iwaya S, Abe S, Sato T, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Cyclic variation in heart rate score by holter electrocardiogram as screening for sleep-disordered breathing in subjects with heart failure. Resp Care 60, 72-80, 2015
  110. 110.Miyata M, Yoshihisa A, Yamauchi H, Owada T, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Impact of sleep-disordered breathing on myocardial damage and metabolism in patients with chronic heart failure. Heart Vessels 30, 318-324, 2015
  111. 111.Nakamura Y, Kunii H, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Impact of peripheral artery disease on prognosis in hospitalized heart failure patients. Circ J 79, 785-793, 2015
  112. 112.Shimizu T, Yoshihisa A, Kanno Y, Takiguchi M, Sato A, Miura S, Nakamura Y, Yamauchi H, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Relationship of hyperuricemia with mortality in heart failure patients with preserved ejection fraction. Am J Physiol Heart Circ Physiol 309, H1123-H1129, 2015
  113. 113.Sato T, Yamauchi H, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Serum cholinesterase is an important prognostic factor in chronic heart failure. Heart Vessels 30, 204-210, 2015
  114. 114.Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y: Vasopressin V2 receptor antagonist tolvaptan is effective in heart failure patients with reduced left ventricular systolic function and low blood pressure. Int Heart J 56, 213-218, 2015
  115. 115.Suzuki S, Yoshihisa A, Miyata M, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Adaptive servo-ventilation therapy improves prognosis in heart failure patients with anemia and sleep-disordered breathing. Int Heart J 55, 342-349, 2014
  116. 116.Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease. J Cardiol 64, 256-264, 2014
  117. 117.Nakamura Y, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: High-sensitivity cardiac troponin T predicts non-cardiac mortality in heart failure. Circ J 78, 890-895, 2014
  118. 118.Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Suzuki H, Saitoh S, Takeishi Y: Impact of body mass index on mortality in heart failure patients. Eur J Clin Invest 44, 1197-1205, 2014
  119. 119.Yoshihisa A, Suzuki S, Takiguchi M, Shimizu T, Abe S, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Impact of sleep-disordered breathing on heart rate turbulence in heart failure patients. PLOS ONE 9, e101307, 2014
  120. 120.Abe S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y: Liver dysfunction assessed by model for end-stage liver disease excluding INR (MELD-XI) scoring system predicts adverse prognosis in heart failure. PLOS ONE 9, e100618, 2014
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文責:佐藤　悠

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