論文 - 家村 俊一郎
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Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase.
Okatsu K, Iemura SI, Koyano F, Go E, Kimura M, Natsume T, Tanaka K, Matsuda N.
Biochem Biophys Res Commun. 2012年10月
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Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S.
Biochem Biophys Res Commun. 423 ( 1 ) 122 - 127 2012年6月
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Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications.
Kobayashi H, Harada H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura SI, Shin-Ya K, Doi T, Takahashi T, Natsume T, Imoto M, Sakakibara Y.
BMC Chem. Biol. 12 ( 2 ) 2012年4月（ ISSN:1472-6769 ）
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Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.
Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, Katagiri T.
J. Cell. Biochem. 113 ( 3 ) 808 - 814 2012年3月
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Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.
Mol. Cell. Biol. 31 ( 22 ) 4500 - 4512 2011年11月
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Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.
Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H.
Proc. Natl. Acad. Sci. U S A. 108 ( 38 ) 15846 - 15851 2011年9月
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Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.
Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH.
Cell Death Differ. 18 ( 8 ) 1326 - 1336 2011年8月
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Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.
Proc. Natl. Acad. Sci U S A. 108 ( 19 ) 7920 - 7925 2011年5月
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Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.
Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T.
J. Biol. Chem. 286 ( 8 ) 6311 - 6320 2011年2月
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Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.
Hanafusa H, Ishikawa K, Kedashiro S, Saigo T, Iemura S, Natsume T, Komada M, Shibuya H, Nara A, Matsumoto K.
Nat. Commun. 2 ( 158 ) 2011年1月
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A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.
Kunoh T, Noda T, Koseki K, Sekigawa M, Takagi M, Shin-ya K, Goshima N, Iemura S, Natsume T, Wada S, Mukai Y, Ohta S, Sasaki R, Mizukami T.
Mol. Cancer Ther. 9 ( 11 ) 2934 - 1942 2010年11月
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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.
Nature 466 ( 7309 ) 941 - 946 2010年8月
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Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.
Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N.
J. Biol. Chem. 285 ( 26 ) 20109 - 20116 2010年6月
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The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.
Nakamura T, Hayashi T, Mimori-Kiyosue Y, Sakaue F, Matsuura K, Iemura S, Natsume T, Akiyama T.
J. Biol. Chem. 285 ( 21 ) 16145 - 16154 2010年5月
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Novel thioredoxin-related transmembrane protein TMX4 has reductase activity.
Sugiura Y, Araki K, Iemura S, Natsume T, Hoseki J, Nagata K.
J. Biol. Chem. 285 ( 10 ) 7135 - 7142 2010年3月
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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.
Nat. Cell Biol. 12 ( 3 ) 213 - 223 2010年3月
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A novel type of E3 ligase for the Ufm1 conjugation system.
Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.
J. Biol. Chem. 285 ( 8 ) 5417 - 5427 2010年2月
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Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development.
Kotani T, Iemura S, Natsume T, Kawakami K, Yamashita M.
J. Biol. Chem. 285 ( 7 ) 5106 - 5116 2010年2月
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Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.
Ohnishi E, Goto T, Sato A, Kim MS, Iemura S, Ishitani T, Natsume T, Ohnishi J, Shibuya H.
Mol. Cell. Biol. 30 ( 3 ) 675 - 683 2010年2月
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SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.
Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.
PLoS One 5 ( 7 ) 2010年