研究者詳細 - 家村　俊一郎

論文 - 家村　俊一郎

分割表示 >> ／全件表示117 件中 1 - 117 件目

Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteinsduring mitophagy.

Baba T, Tanimura S, Yamaguchi A, Horikawa K, Yokozeki M, Hachiya S, Iemura SI, Natsume T, Matsuda N, Takeda K

Biochimica et biophysica acta. Molecular cell research 119045 2021年4月（ ISSN:0167-4889 ）

NUDT21 Links Mitochondrial IPS-1 to RLR-Containing Stress Granules and Activates Host Antiviral Defense.

Aoyama-Ishiwatari S, Okazaki T, Iemura SI, Natsume T, Okada Y, Gotoh Y

Journal of immunology (Baltimore, Md. : 1950) 206 ( 1 ) 154 - 163 2021年1月（ ISSN:0022-1767 ）

Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.

Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T

Proceedings of the National Academy of Sciences of the United States of America 116 ( 47 ) 23653 - 23661 2019年11月（ ISSN:0027-8424 ）

FAM48A mediates compensatory autophagy induced by proteasome impairment.

Arata Y, Watanabe A, Motosugi R, Iemura SI, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S

Genes to cells : devoted to molecular & cellular mechanisms 2019年6月（ ISSN:1356-9597 ）

Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.

Hatta T, Iemura SI, Ohishi T, Nakayama H, Seimiya H, Yasuda T, Iizuka K, Fukuda M, Takeda J, Natsume T, Horikawa Y

Scientific reports 8 ( 1 ) 16756 2018年11月

MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs.

Okamoto K, Ohishi T, Kuroiwa M, Iemura SI, Natsume T, Seimiya H

Oncotarget 9 ( 88 ) 35844 - 35855 2018年11月

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.

Kim Y, Shiba-Ishii A, Nakagawa T, Iemura SI, Natsume T, Nakano N, Matsuoka R, Sakashita S, Lee S, Kawaguchi A, Sato Y, Noguchi M

Oncogene 37 ( 40 ) 5387 - 5402 2018年10月（ ISSN:0950-9232 ）

β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.

Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K

Biochimica et biophysica acta. General subjects 1862 ( 10 ) 2271 - 2280 2018年10月（ ISSN:0304-4165 ）

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase.

Yoneyama Y, Inamitsu T, Chida K, Iemura SI, Natsume T, Maeda T, Hakuno F, Takahashi SI

iScience 5 1 - 18 2018年7月

Nuclear export of ubiquitinated proteins via the UBIN-POST system.

Hirayama S, Sugihara M, Morito D, Iemura SI, Natsume T, Murata S, Nagata K

Proceedings of the National Academy of Sciences of the United States of America 115 ( 18 ) E4199 - E4208 2018年5月（ ISSN:0027-8424 ）

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.

Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T

Nature communications 8 ( 1 ) 1246 2017年11月

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.

Fujimori T, Suno R, Iemura SI, Natsume T, Wada I, Hosokawa N

Genes to cells : devoted to molecular & cellular mechanisms 22 ( 8 ) 684 - 698 2017年8月（ ISSN:1356-9597 ）

Tankyrase-binding protein TNKS1BP1 regulates actin cytoskeleton rearrangement and cancer cell invasion

Ohishi T., Yoshida H., Katori M., Migita T., Muramatsu Y., Miyake M., Ishikawa Y., Saiura A., Iemura S., Natsume T., Seimiya H.

Cancer Research 77 ( 9 ) 2328 - 2338 2017年5月（ ISSN:00085472 ）

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI

Biochemical and biophysical research communications 484 ( 3 ) 522 - 528 2017年3月（ ISSN:0006-291X ）

TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.

Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S

The Journal of biological chemistry 292 ( 10 ) 4099 - 4112 2017年3月（ ISSN:0021-9258 ）

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.

Kotani Y, Morito D, Sakata K, Ainuki S, Sugihara M, Hatta T, Iemura SI, Takashima S, Natsume T, Nagata K

Scientific reports 7 44293 2017年3月

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.

Ishida N, Nakagawa T, Iemura SI, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K

Molecular and cellular biology 37 ( 4 ) 2017年2月（ ISSN:0270-7306 ）

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

Goto T, Matsuzawa J, Iemura S, Natsume T, Shibuya H.

FEBS Letter 590 ( 9 ) 1291 - 1303 2016年5月

Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.

Saita S, Ishihara T, Maeda M, Iemura S, Natsume T, Mihara K, Ishihara N.

Genes to Cells 21 ( 5 ) 408 - 424 2016年3月

Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.

Fukuzono T, Pastuhov SI, Fukushima O, Li C, Hattori A, Iemura S, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.

Genes to Cells 21 ( 4 ) 311 - 324 2016年2月

TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

J. Cell. Biochem. 117 ( 2 ) 500 - 509 2015年12月

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.

Sci. Signal. 8 2015年11月

CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.

Kigoshi Y, Fukuda T, Endo T, Hayasaka N, Iemura S, Natsume T, Tsuruta F, Chiba T.

Sci Rep. 5 2015年8月

The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

Biochem. Biophys. Res. Commun. 462 ( 4 ) 383 - 388 2015年6月

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

ukushima T, Yoshihara H, Furuta H, Kamei H, Hakuno F, Luan J, Duan C, Saeki Y, Tanaka K, Iemura S, Natsume T, Chida K, Nakatsu Y, Kamata H, Asano T, Takahashi S.

Nat Commun. 6 2015年4月

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

PLoS One. 9 ( 11 ) 2014年11月

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H, Matsumoto M, Nakayama KI, Hatta T, Iemura S, Natsume T.

Nucleic Acids Res. 42 ( 15 ) 10037 - 10049 2014年8月

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.

Hayakawa N, Noguchi M, Takeshita S, Eviryanti A, Seki Y, Nishio H, Yokoyama R, Noguchi M, Shuto M, Shima Y, Kuribayashi K, Kageyama S, Eda H, Suzuki M, Hatta T, Iemura S, Natsume T, Tanabe I, Nakagawa R, Shiozaki M, Sakurai K, Shoji M, Andou A, Yamamoto T.

Bioorg Med Chem. 22 ( 11 ) 3021 - 3029 2014年6月

IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling.

Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H.

J Biol Chem. 288 ( 51 ) 36351 - 36360 2013年12月

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.

Hoshi T, Tezuka T, Yokoyama K, Iemura S, Natsume T, Yamanashi Y.

FEBS Lett. 587 ( 23 ) 3749 - 3754 2013年11月

Dynamic regulation of ero1α and peroxiredoxin 4 localization in the secretory pathway.

Kakihana T, Araki K, Vavassori S, Iemura S, Cortini M, Fagioli C, Natsume T, Sitia R, Nagata K.

J Biol Chem. 288 ( 41 ) 29586 - 29594 2013年10月

Ero1-α and pdis constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

Araki K., Iemura S., Kamiya Y., Ron D., Kato K., Natsume T., Nagata K.

Journal of Cell Biology 202 ( 6 ) 861 - 874 2013年9月（ ISSN:00219525 ）

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases.

Araki K, Iemura S, Kamiya Y, Ron D, Kato K, Natsume T, Nagata K.

J Cell Biol. 202 ( 6 ) 861 - 874 2013年9月

The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.

Tsuchiya Y, Taniguchi H, Ito Y, Morita T, Karim MR, Ohtake N, Fukagai K, Ito T, Okamuro S, Iemura S, Natsume T, Nishida E, Kobayashi A.

Mol Cell Biol. 33 ( 17 ) 3461 - 3472 2013年9月

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

Ono Y, Iemura S, Novak SM, Doi N, Kitamura F, Natsume T, Gregorio CC, Sorimachi H.

J Mol Biol. 425 ( 16 ) 2955 - 2972 2013年8月

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1

Ono Y., Iemura S., Novak S., Doi N., Kitamura F., Natsume T., Gregorio C., Sorimachi H.

Journal of Molecular Biology 425 ( 16 ) 2955 - 2972 2013年8月（ ISSN:00222836 ）

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling.

Goto T, Sato A, Shimizu M, Adachi S, Satoh K, Iemura S, Natsume T, Shibuya H

PLoS One 8 ( 4 ) 2013年4月

VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.

Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, Kakizuka A

PLoS One 8 ( 2 ) 2013年2月

RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT.

Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A.

Mol Cell. 48 ( 2 ) 182 - 194 2012年10月

The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5.

Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura SI, Natsume T, Kuranaga E, Miura M, Takeda K, Ichijo H.

Mol Cell. 2012年10月

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase.

Okatsu K, Iemura SI, Koyano F, Go E, Kimura M, Natsume T, Tanaka K, Matsuda N.

Biochem Biophys Res Commun. 2012年10月

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S.

Biochem Biophys Res Commun. 423 ( 1 ) 122 - 127 2012年6月

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications.

Kobayashi H, Harada H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura SI, Shin-Ya K, Doi T, Takahashi T, Natsume T, Imoto M, Sakakibara Y.

BMC Chem. Biol. 12 ( 2 ) 2012年4月（ ISSN:1472-6769 ）

Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.

Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, Katagiri T.

J. Cell. Biochem. 113 ( 3 ) 808 - 814 2012年3月

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.

Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.

Mol. Cell. Biol. 31 ( 22 ) 4500 - 4512 2011年11月

Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.

Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H.

Proc. Natl. Acad. Sci. U S A. 108 ( 38 ) 15846 - 15851 2011年9月

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.

Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH.

Cell Death Differ. 18 ( 8 ) 1326 - 1336 2011年8月

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.

Proc. Natl. Acad. Sci U S A. 108 ( 19 ) 7920 - 7925 2011年5月

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T.

J. Biol. Chem. 286 ( 8 ) 6311 - 6320 2011年2月

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.

Hanafusa H, Ishikawa K, Kedashiro S, Saigo T, Iemura S, Natsume T, Komada M, Shibuya H, Nara A, Matsumoto K.

Nat. Commun. 2 ( 158 ) 2011年1月

A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.

Kunoh T, Noda T, Koseki K, Sekigawa M, Takagi M, Shin-ya K, Goshima N, Iemura S, Natsume T, Wada S, Mukai Y, Ohta S, Sasaki R, Mizukami T.

Mol. Cancer Ther. 9 ( 11 ) 2934 - 1942 2010年11月

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.

Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.

Nature 466 ( 7309 ) 941 - 946 2010年8月

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N.

J. Biol. Chem. 285 ( 26 ) 20109 - 20116 2010年6月

The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.

Nakamura T, Hayashi T, Mimori-Kiyosue Y, Sakaue F, Matsuura K, Iemura S, Natsume T, Akiyama T.

J. Biol. Chem. 285 ( 21 ) 16145 - 16154 2010年5月

Novel thioredoxin-related transmembrane protein TMX4 has reductase activity.

Sugiura Y, Araki K, Iemura S, Natsume T, Hoseki J, Nagata K.

J. Biol. Chem. 285 ( 10 ) 7135 - 7142 2010年3月

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.

Nat. Cell Biol. 12 ( 3 ) 213 - 223 2010年3月

A novel type of E3 ligase for the Ufm1 conjugation system.

Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.

J. Biol. Chem. 285 ( 8 ) 5417 - 5427 2010年2月

Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development.

Kotani T, Iemura S, Natsume T, Kawakami K, Yamashita M.

J. Biol. Chem. 285 ( 7 ) 5106 - 5116 2010年2月

Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.

Ohnishi E, Goto T, Sato A, Kim MS, Iemura S, Ishitani T, Natsume T, Ohnishi J, Shibuya H.

Mol. Cell. Biol. 30 ( 3 ) 675 - 683 2010年2月

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.

Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.

PLoS One 5 ( 7 ) 2010年

The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes.

Yamazumi Y, Kamiya A, Nishida A, Nishihara A, Iemura S, Natsume T, Akiyama T.

Biochem. Biophys. Res. Commun. 389 ( 1 ) 100 - 104 2009年11月

Atg101, a novel mammalian autophagy protein interacting with Atg13.

Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N.

Autophagy 5 ( 7 ) 973 - 979 2009年10月

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.

Patrick MS, Oda H, Hayakawa K, Sato Y, Eshima K, Kirikae T, Iemura S, Shirai M, Abe T, Natsume T, Sasazuki T, Suzuki H.

Proc. Natl. Acad. Sci. U S A. 106 ( 38 ) 16345 - 16350 2009年9月

Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format.

Hashimoto J, Watanabe T, Seki T, Karasawa S, Izumikawa M, Seki T, Iemura S, Natsume T, Nomura N, Goshima N, Miyawaki A, Takagi M, Shin-Ya K.

J. Biomol. Screen. 14 ( 8 ) 970 - 979 2009年9月

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.

Takeda K, Komuro Y, Hayakawa T, Oguchi H, Ishida Y, Murakami S, Noguchi T, Kinoshita H, Sekine Y, Iemura S, Natsume T, Ichijo H.

Proc. Natl. Acad. Sci. U S A. 106 ( 30 ) 12301 - 12305 2009年7月

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S.

Cell 137 ( 5 ) 914 - 925 2009年5月

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.

Saita S, Shirane M, Natume T, Iemura S, Nakayama KI.

J. Biol. Chem. 284 ( 20 ) 13766 - 13777 2009年5月

Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.

Kiefer H, Mizutani A, Iemura S, Natsume T, Ando H, Kuroda Y, Mikoshiba K.

J. Biol. Chem. 284 ( 16 ) 10694 - 10705 2009年4月

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N.

Mol. Biol. Cell 20 ( 7 ) 1981 - 1991 2009年4月

Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.

Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T.

Oncogene 28 ( 10 ) 1357 - 1365 2009年3月

Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation.

Tachibana M, Kiyokawa E, Hara S, Iemura S, Natsume T, Manabe T, Matsuda M.

Exp. Cell Res. 315 ( 5 ) 863 - 876 2009年3月

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.

Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, Fan Y, Kikuchi A, Skoultchi AI, Nakayama KI.

Nat. Cell Biol. 11 ( 2 ) 172 - 182 2009年2月

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.

Tomita T, Kido T, Kurotani R, Iemura S, Sterneck E, Natsume T, Vinson C, Kimura S.

J. Biol. Chem. 283 ( 37 ) 25617 - 25627 2008年9月

The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.

Hara S, Kiyokawa E, Iemura S, Natsume T, Wassmer T, Cullen PJ, Hiai H, Matsuda M.

Mol. Biol. Cell 19 ( 9 ) 3823 - 3835 2008年9月

A parallel affinity purification method for selective isolation of polyubiquitinated proteins.

Ota K, Kito K, Iemura S, Natsume T, Ito T.

Proteomics 8 ( 15 ) 3004 - 3007 2008年8月

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.

Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N.

J. Cell Biol. 181 ( 3 ) 497 - 510 2008年5月

タンパク質のネットワーク解析から創薬へ（超高感度質量分析システムをどのように実現したか）

家村俊一郎, 夏目　徹

Synthesiology 1 ( 2 ) 123 - 129 2008年4月（ ISSN:1882-6229 ）

Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.

Hamuro J, Higuchi O, Okada K, Ueno M, Iemura S, Natsume T, Spearman H, Beeson D, Yamanashi Y.

J. Biol. Chem. 283 ( 9 ) 5518 - 5524 2008年2月

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K.

Cell 131 ( 6 ) 1149 - 1163 2007年12月

Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms.

Saijou E, Itoh T, Kim KW, Iemura S, Natsume T, Miyajima A.

J. Biol. Chem. 282 ( 44 ) 32327 - 32337 2007年11月

Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development.

Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H.

Mol. Cell. Biol. 27 ( 21 ) 7623 - 7630 2007年11月

XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway.

Lee RH, Iioka H, Ohashi M, Iemura S, Natsume T, Kinoshita N.

EMBO J. 26 ( 15 ) 3592 - 3606 2007年8月

Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility.

Iioka H, Iemura S, Natsume T, Kinoshita N.

Nat. Cell. Biol. 9 ( 7 ) 813 - 821 2007年7月

質量分析のためのサンプル調製（タンパク質ネットワーク大規模解析）

家村俊一郎, 夏目　徹

J. Mass Spectrom. Soc. Jpn. 55 ( 3 ) 165 - 171 2007年6月（ ISSN:13408097 ）

Anchoring of the 26S proteasome to the organellar membrane by FKBP38.

Nakagawa T, Shirane M, Iemura S, Natsume T, Nakayama KI.

Genes Cells 12 ( 6 ) 709 - 719 2007年6月

エピトープタグ発現法（質量分析のためのサンプル調製法）

家村俊一郎

“分子間相互作用解析ハンドブック”実験医学別冊 53 - 57 2007年

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway.

Kajino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan DL, Matsumoto K, Ninomiya-Tsuji J.

J. Biol. Chem. 281 ( 52 ) 39891 - 39896 2006年12月

Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.

Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S.

Mol. Cell 24 ( 6 ) 977 - 984 2006年12月

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.

Hamazaki J, Iemura S, Natsume T, Yashiroda H, Tanaka K, Murata S.

EMBO J. 25 ( 19 ) 4524 - 4536 2006年10月

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H.

J. Biol. Chem. 281 ( 30 ) 20749 - 20760 2006年7月

XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation.

Hyodo-Miura J, Yamamoto TS, Hyodo AC, Iemura S, Kusakabe M, Nishida E, Natsume T, Ueno N.

Dev. Cell. 11 ( 1 ) 69 - 79 2006年7月

Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y.

Nature 441 ( 7089 ) 46 - 52 2006年5月

Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.

Terasawa K, Yoshimatsu K, Iemura S, Natsume T, Tanaka K, Minami Y.

Mol. Cell. Biol. 26 ( 9 ) 3378 - 3389 2006年5月

A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy.

Hishiya A, Iemura S, Natsume T, Takayama S, Ikeda K, Watanabe K.

EMBO J. 25 ( 3 ) 554 - 564 2006年2月

Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.

Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y.

Genes Cells 11 ( 2 ) 143 - 151 2006年2月

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J. Biol. Chem. 280 ( 52 ) 42685 - 42693 2005年12月

A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.

Hirano Y, Hendil KB, Yashiroda H, Iemura S, Nagane R, Hioki Y, Natsume T, Tanaka K, Murata S.

Nature 437 ( 7063 ) 1381 - 1385 2005年10月

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.

Matsuda N, Azuma K, Saijo M, Iemura S, Hioki Y, Natsume T, Chiba T, Tanaka K, Tanaka K.

DNA Repair (Amst) 4 ( 5 ) 537 - 545 2005年5月

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.

Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K.

Proc. Natl. Acad. Sci. U S A. 102 ( 12 ) 4524 - 4529 2005年3月

An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites.

Bannai H, Fukatsu K, Mizutani A, Natsume T, Iemura S, Ikegami T, Inoue T, Mikoshiba K.

J. Biol. Chem. 279 ( 51 ) 53427-53434. 2004年12月

Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.

Ishigaki S, Hishikawa N, Niwa J, Iemura S, Natsume T, Hori S, Kakizuka A, Tanaka K, Sobue G.

J. Biol. Chem. 279 ( 49 ) 51376 - 51385 2004年12月

Skp2-mediated degradation of p27 regulates progression into mitosis.

Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI.

Dev. Cell. 6 ( 5 ) 661 - 672 2004年5月

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.

Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K.

EMBO J. 23 ( 9 ) 1977 - 1986 2004年5月

質量分析のためのタンパク質複合体プルダウン解析法

家村俊一郎, 夏目　徹

“注目のプロテオミクスの全貌を知る！”実験医学別冊 46 - 53 2003年

Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2.

Yuasa T, Kataoka H, Kinto N, Iwamoto M, Enomoto-Iwamoto M, Iemura S, Ueno N, Shibata Y, Kurosawa H, Yamaguchi A.

J. Cell. Physiol. 193 ( 2 ) 225 - 232 2002年11月

Action range of BMP is defined by its N-terminal basic amino acid core.

Ohkawara B, Iemura S, ten Dijke P, Ueno N.

Curr. Biol. 12 ( 3 ) 205 - 209 2002年2月

Follistatin inhibits the function of the oocyte-derived factor BMP-15.

Otsuka F, Moore RK, Iemura S, Ueno N, Shimasaki S.

Biochem. Biophys. Res. Commun. 289 ( 5 ) 961 - 966 2001年12月

Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand.

Itoh K, Udagawa N, Katagiri T, Iemura S, Ueno N, Yasuda H, Higashio K, Quinn JM, Gillespie MT, Martin TJ, Suda T, Takahashi N.

Endocrinology 142 ( 8 ) 3656 - 3662 2001年8月

Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina.

Sakuta H, Suzuki R, Takahashi H, Kato A, Shintani T, Iemura Si, Yamamoto TS, Ueno N, Noda M.

Science 293 ( 5527 ) 111 - 115 2001年7月

Dorsal spinal cord inhibits oligodendrocyte development.

Wada T, Kagawa T, Ivanova A, Zalc B, Shirasaki R, Murakami F, Iemura S, Ueno N, Ikenaka K.

Dev. Biol. 227 ( 1 ) 42 - 55 2000年11月

Characterization of follistatin isoforms in early Xenopus embryogenesis.

Yamamoto TS, Iemura S, Takagi C, Shimasaki S, Ueno N.

Int. J. Dev. Biol. 44 ( 4 ) 341 - 348 2000年6月

初期発生におけるBMP活性とその制御メカニズム

家村俊一郎, 澁谷浩司

“サイトカインの新たな機能と生命現象”実験医学増刊号 18 81 - 87 2000年

BMP結合タンパク質による負の制御機構

家村俊一郎, 上野直人

Molecular Medicine 37 662 - 669 2000年

Isolation and characterization of bone morphogenetic protein-binding proteins from the early Xenopus embryo.

Iemura S, Yamamoto TS, Takagi C, Kobayashi H, Ueno N.

J. Biol. Chem. 274 ( 38 ) 26843 - 26849 1999年9月

A functional bone morphogenetic protein system in the ovary.

Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF.

Proc. Natl. Acad. Sci. U S A. 96 ( 13 ) 7282 - 7287 1999年6月

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo.

Iemura S, Yamamoto TS, Takagi C, Uchiyama H, Natsume T, Shimasaki S, Sugino H, Ueno N.

Proc. Natl. Acad. Sci. U S A. 95 ( 16 ) 9337 - 9342 1998年8月

Interaction between soluble type I receptor for bone morphogenetic protein and bone morphogenetic protein-4.

Natsume T, Tomita S, Iemura S, Kinto N, Yamaguchi A, Ueno N.

J. Biol. Chem. 272 ( 17 ) 11535 - 11540 1997年4月（ ISSN:0021-9258 ）

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論文 - 家村 俊一郎

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論文 - 家村　俊一郎