サルコイドーシスの臨床研究

サルコイドーシスは、全身性肉芽腫性疾患であり、その診断には、組織学的に非乾酪性類上皮細胞肉芽腫の像がみられることが必要である。皮膚科が係るのは主に、

1)すでに肺や心にサルコイドーシスを疑う病変があり、診断確定のために、皮膚症状の有無についてコンサルトされる場合と、

2)皮膚病変からサルコイドーシスと診断され、こちらから他臓器病変を検索する場合、とであろう。

サルコイドーシスの皮膚病変は多彩であり、しかも人種差が認められる。また、皮膚病変は生検しやすいため、診断確定のための有力な手掛かりとなる。皮膚科医は、どこにどのような皮疹を予測しながら患者さんをみなければいけないか熟知しておく必要がある。さらに、どのようなタイプの皮疹が、他臓器病変と関連が高いかについても、知っておくことも重要である。

当教室では、これまで数多くの皮膚サルコイド病変を経験し、本邦人のサルコイドーシスの皮疹について報告してきた。特に近年は、教室症例の集計も報告している。

 サルコイドーシスに関する最近の業績

1. Yamamoto T, Chen K-R. "Perforating plaque-type pretibial sarcoidosis with granulomatous phlebitis." Am J Dermatopathol 42; 225-226, 2020.

2. Honda A, Matsumura N, Yamamoto T. "Transepidermal elimination in cutaneous sarcoid plaques on the face: a possible role of M2 type macrophage." Australas J Dermatol [Epub ahead of print]

3. Miura T, Kikuchi N, Yamamoto T. "Cutaneous sarcoidosis in 95 Japanese patients: a single institutional study." Eur J Dermatol 30; 205-206, 2020.

4. Ishikawa M, Yamamoto T. "Plaque psoriasis in a patient with lung sarcoidosis." Actas Dermosifiliogr (accepted)

5. Kato Y, Okabe H, Hoshi M, Yamamoto T. "Ulcerative sarcoidosis on the leg and scalp." Our Dermatol Online [Epub ahead of print]

6. Yamamoto T. "Subcutaneous sarcoidosis: a report of 13 cases and its association with extracutaneous sarcoidosis." Sarc Vasc Diffu Lung Dis 37;242-245, 2020.

7. Mori T, Yamamoto M, Kikuchi N, Yamamoto T. "Ulcerative necrobiosis lipoidica with granulomatous vasculitis in a patient with sarcoidosis." Int J Dermatol [Epub ahead of print]

8. Ito T, Yamamoto T. "Scalp sarcoidosis with alopecia areata showing Renbok phenomenon" J Dermatol [Epub ahead of print]

9. Norikawa N, Yamamoto T. "Subcutaneous sarcoidosis on the digit" Sarcoidosis Vasc Diffuse Lung Dis (accepted)

10. Endo M, Yamamoto T. "Nodular cystic fat necrosis in a patient with sarcoidosis." J Dermatol [Epub ahead of print]

11. Ishikawa M, Ohashi T, Eishi Y, Yamamoto T. "Palmoplantar pustulosis in a patient with sarcoidosis." Eur J Dermatol 30; 325-326, 2020.

12. Ishikawa M, Ohtsuka M, Yamamoto T. "Three cases of scalp sarcoidosis with alopecia." Actas Dermosifiliogr 109; 933-934, 2018.

13. Mori T, Yamamoto T. "Secondary calcification associated with subcutaneous sarcoidosis." J Dermatol 45; e282-e283, 2018.

14. Yamamoto T, Nishibu A, Eishi Y. "Transepidermal elimination of sarcoidal granuloma in the lesional skin of psoriasiform sarcoidosis." J Dermatol 44; 100-101, 2017.

15. Ohtsuka M, Matsumura N, Yamamoto T. "Sarcoidal granuloma presenting on tattoo: a report of a Japanese female patient and a review of Japanese published work." Sarcoidosis Vasc Diffuse Lung Dis 33; 83-89, 2016.

16. Miura T, Kato Y, Yamamoto T. "Ichthyosiform sarcoid: report of three cases from Japan and literature review." Sarcoid Vasc Diffuse Lung Dis 33; 392-397, 2016.

17. Yamamoto T, Okabe H. "Cutaneous sarcoid with livedoid changes in a patient with Hashimoto’s thyroiditis." Actas Dermosifiliogr 107; 876-878, 2016.

18. Kato Y, Ohtsuka M, Yamamoto T. "Cutaneous sarcoidosis concurrently involved in the sclerotic fingers of a patient with systemic sclerosis." J Dermatol 42; 331-333, 2015.

19. Ohashi T, Yamamoto T. "Subcutaneous sarcoidosis with underlying intramuscular granuloma." Indian J Dermatol 60: 107, 2015.

20. Yamamoto T, Yokozeki H. "Scalp sarcoidosis mimicking organoid nevus." Eur J Dermatol 25; 78-79, 2015.

21. Yamamoto T, Yokozeki H. "Subcutaneous sarcoidal granuloma underlying porokeratosis in a patient with sarcoid-lymphoma syndrome." Eur J Dermatol 25; 84-85, 2015.

22. Hanami Y, Yamamoto T. "Sarcoid reaction associated with basal cell carcinoma." J Dermatol 42; 1112-1113, 2015.

23. Ishikawa M, Yamamoto T. "Subcutaneous sarcoidal granuloma underlying superficial basal cell carcinoma." Indian J Dermatol 60; 638: 2015.

24. Ohashi T, Yamamoto T. "Subcutaneous sarcoidosis with underlying intramuscular granuloma." Indian J Dermatol 60: 107, 2015.

25. Miura T, Yamamoto T. "Post-herpes zoster sarcoidosis." J Dermatol 41: 270-271, 2014.

26. Nakamura-Wakatsuki T, Yamamoto T. "Sarcoidosis presenting erythema nodosum-like lesions: Report of two cases." Our Dermatol Online 4: 80-82, 2013.

27. Yamamoto T, Motoki Y. "Transepidermal elimination of sarcoidal granuloma in a patient with sarcoidosis and systemic sclerosis overlap" Eur J Dermatol 22: 286-287, 2012.