Abstract/References
Different prognostic outcomes in two cases of FDG-PET/CT-Positive and -negative cardiac angiosarcoma
Ryo Yamakuni, Shiro Ishii, Shoki Yamada, Junko Hara, Hiroki Suenaga, Shigeyasu Sugawara, Hirofumi Sekino, Takayoshi Yamaki, Keiichi Ishida, Yuko Hashimoto, Hiroshi Ito
Author information
- Ryo Yamakuni
Department of Radiology and Nuclear Medicine, Fukushima Medical University - Shiro Ishii
Department of Radiology and Nuclear Medicine, Fukushima Medical University - Shoki Yamada
Department of Diagnostic Pathology, Fukushima Medical University - Junko Hara
Department of Radiology and Nuclear Medicine, Fukushima Medical University - Hiroki Suenaga
Department of Radiology and Nuclear Medicine, Fukushima Medical University - Shigeyasu Sugawara
Department of Radiology and Nuclear Medicine, Fukushima Medical University - Hirofumi Sekino
Department of Radiology and Nuclear Medicine, Fukushima Medical University - Takayoshi Yamaki
Department of Cardiovascular Medicine, Fukushima Medical University - Keiichi Ishida
Department of Cardiovascular Surgery, Fukushima Medical University - Yuko Hashimoto
Department of Diagnostic Pathology, Fukushima Medical University - Hiroshi Ito
Department of Radiology and Nuclear Medicine, Fukushima Medical University
Abstract
Cardiac angiosarcoma is a rare malignant tumor with a poor prognosis, characterized by the high uptake of 18F-fluorodeoxyglucose (FDG). This case report presents two cases of cardiac angiosarcoma with a marked difference in FDG uptake and prognosis.
Case Summary:
Case 1: A 40-year-old male presented with syncope. Ultrasound echocardiography demonstrated a cardiac tumor with a high uptake of 18F-FDG (maximum standardized uptake value=9.2). The patient underwent heart catheterization and tumor biopsy. The pathological result was high-grade angiosarcoma, and the MIB-1(Ki-67) proliferation index was approximately 20%. Systemic chemotherapy was administered; however, the patient died 2 years and 5 months after disease onset.
Case 2: A 65-year-old female had a right atrial tumor incidentally diagnosed during routine ultrasound echocardiography. The tumor exhibited a low uptake of 18F-FDG (maximum standardized uptake value=1.8). Open heart surgery was performed, and the tumor was completely resected. Histological analysis revealed low-grade angiosarcoma, and the MIB-1(Ki-67) proliferation index was less than 5%. The patient was followed-up and had not relapsed 2 years after surgery.
Conclusion: 18F-FDG uptake may reflect pathological tumor grade and prognosis in cardiac angiosarcoma.
References
- Aboud A, Farha K, Hsieh WC, et al. Prognostic factors for long-term survival after surgical resection of primary cardiac sarcoma. Thorac Cardiovasc Surg, 67(8):665-671, 2019.
- Misaki T, Ishizu K, Ishimori T, Takashi K. Gamut of FDG-PET. Japanese J Nucl Med, 49(4):357-389, 2012.
- Kato A, Nakamoto Y, Ishimori T, Saga T, Togashi K. Prognostic value of quantitative parameters of 18F-FDG PET/CT for patients with angiosarcoma. AJR Am J Roentgenol, 214(3):649-657, 2020.
- Bromińska B, Czepczyński R, Gabryel P, et al. 18F-FDG PET/CT and nestin expression as prognostic tools in pulmonary neuroendocrine tumours. Nucl Med Commun, 40(4):353-360, 2019.
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