Associate Professor

Research Fields, Keywords

heme proteins, enzymology, X-ray crystallography

Mail Address

E-mail address

Current Affiliation Organization 【 display / non-display

  • Concurrently ,  Fukushima Medical University ,  Integrated Center for Science and Humanities ,  Associate Professor

  • Duty ,  School of Medicine (Human and Natural Sciences) ,  Department of Natural Sciences (The Section of Molecular and Cellular Biology) ,  Associate Professor

Career 【 display / non-display

  • 2004.04

    Research Associate; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

  • 2004.08

    Postdoctoral Researcher; University of California, Irvine

  • 2007.04

    Assistant Professor; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

  • 2011.03

    Associate Professor; Department of Natural Sciences, School of Medicine, Fukushima Medical University

Academic Society Affiliations 【 display / non-display

  • 2001.04

    The Japanese Biochemical Society ,  JAPAN

  • 2006.10

    The Biophysical Society of Japan ,  JAPAN

  • 2013.09

    Japan Radioisotope Association ,  JAPAN

Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • Functional Biochemistry

  • Radiation/Chemical Substance Influence Science

  • Structural Biochemistry

Qualification acquired 【 display / non-display

  • Chief Person of Radiation Handling (first and second kind) ,  2013.03

  • Health Supervisor (first kind) ,  2021.04

  • Hazardous Material Handler (first kind) ,  2016.08

  • Person in Charge of Poison and Deleterious Substance Handling ,  2016.10

  • X-ray Work Chief Person ,  2013.08

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Papers 【 display / non-display

  • Elucidation of the heme-binding site of heme-regulated eIF2α kinase (HRI) and the role of the regulatory motif in heme sensing by spectroscopic and catalytic studies of mutant proteins

    Igarashi, J., Murase, M., Iizuka, A., Pichierri, F., Martinkova, M., and Shimizu, T.

    J. Biol. Chem. ,  283 (27) 18782 - 18791 ,  2008.07

    Multiple Authorship


  • Activation of heme-regulated eukaryotic initiation factor 2α kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance Raman spectral studies

    Igarashi, J., Sato, A., Kitagawa, T., Yoshimura, T., Yamauchi, S., Sagami, I., and Shimizu, T.

    J. Biol. Chem. ,  279 (16) 15752 - 15762 ,  2004.04

    Multiple Authorship


  • A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification

    Igarashi, J., Kobayashi, K., and Matsuoka, A.

    J. Biol. Inorg. Chem. ,  16 (4) 599 - 609 ,  2011.05

    Multiple Authorship


  • Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors

    Igarashi, J., Li, H., Jamal, J., Ji, H., Fang, J., Lawton, G., Silverman, R. B., and Poulos, T. L.

    J. Med. Chem. ,  52 (7) 2060 - 2066 ,  2009.03

    Multiple Authorship


  • Identification and characterization of a redox sensor phosphodiesterase from Ferrovum sp. PN-J185 containing bacterial hemerythrin and HD-GYP domains.

    Kitanishi K., Igarashi J., Matsuoka A., and Unno M.

    Biochemistry ,  59 (8) 983 - 991 ,  2020.03

    Multiple Authorship ,  ISBN: 0006-2960

    DOI PubMed

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Books 【 display / non-display

  • Circadian Rhythms: Biology, Cognition and Disorders

    L. Golovlin, A. Maliszkewicz (Part:Emerging functions of heme in transcription associated with circadian rhythms) (Page:225-245)

    Nova Science ,  2012 ,  ISBN: 978-1-61470-010-4

    Kitanishi, K., Hayasaka, K., Harada, M., Nagata, R., Igarashi, J., Shimizu, T. ,  Hauppauge, NY, USA

  • Circadian Rhythms: Biology, Cognition and Disorders

    L. Golovlin, A. Maliszkewicz (Part:Heme binding characteristics of mouse Per1, a transcriptional regulatory factor associated with circadian rhythms) (Page:133-160)

    Nova Science ,  2012 ,  ISBN: 978-1-61470-010-4

    Nagata, R., Harada, M., Kitanishi, K., Igarashi, J., Shimizu, T.

  • Gas Sensors: Developments, Efficacy and Safety

    X. Qiu (Part:Novel effects of Mn2+ on the catalytic enhancement of the inactive form of the Fe(III) heme-bound Ec DOS, a heme-regulated phosphodiesterase from Escherichia coli) (Page:251-261)

    Nova Science ,  2012 ,  ISBN: 978-1-61470-829-2

    Honjo, A., Takahashi, H., Sekimoto, M., Igarashi, J., Shimizu, T.

  • Handbook of Porphyrin Science

    Kadish, K. M., Smith, K. M., and Guilard, R. (Part:Emerging Role of Heme as a Signal and the Gas-Sensing Site: Heme-Sensing and Gas-Sensing Proteins) (Page:399-460)

    World Scientific ,  2011.02 ,  ISBN: 978-981-4322-32-4

    Igarashi, J., Kitanishi, K., and Shimizu, T.

Presentations 【 display / non-display

  • Hoki myoglobin with unusual autoxidation behavior: Comparative analysis of native protein and H60V mutant.

    The 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan , 


  • Ligand sensing mechanism of globin domain of a heme-based oxygen-sensor enzyme, YddV, from Escherichia coli

    XIXth International Conference of Oxygen Binding and Sensing Protein , 


  • Crystal structure of isolated heme-bound globin domain of a heme-based oxygen-sensor, YddV, from Escherichia coli

    第53回日本生物物理学会年会 , 


  • Stability properties of myoglobin in the Argentinian hoki (Macruronus magellanicus).

    The 9th International Congress of Comparative Physiology and Biochemistry , 


  • Molecular mechanism of NO-induced catalytic activation of mouse heme-regulated eukaryotic initiation factor 2α kinase, HRI

    Pacifichem 2010 Congress , 


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