Updated on 2023/08/03

写真a

 
HASHIMOTO Yasuhiro
 
Organization
School of Medicine (Clinical Medicine) Department of Neurosurgery Postdoctoral Researcher
School of Medicine (Life Sciences and Social Medicine) Department of Hygiene and Preventive Medicine Postdoctoral Researcher
Title
Postdoctoral Researcher

Degree

  • 博士(医学) ( 1983.3   東京大学 )

Research Interests

  • Alzheimer Disease,Dementia,Diagnosis Marker,Normal Pressure Hydrocephalus,Cancer antigen,Carbohydrate Moiety,Natural Killer Cell,Siglec

Research Areas

  • Life Science / Pathological biochemistry  / Diagnosis of Dementia

  • Life Science / Functional biochemistry  / Biochemistry

  • Life Science / Structural biochemistry  / Glycobiology

Education

  • The University of Tokyo   Graduate School, Division of Medical Sciences

    - 1983.3

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    Country: Japan

Research History

  • Fukushima Medical University   School of Medicine (Life Sciences and Social Medicine) Department of Forensic Medicine   Postdoctoral Researcher

    2020.4 - 2023.3

  • Fukushima Medical University   School of Nursing Department of Human Life Sciences   Postdoctoral Researcher

    2019.4 - 2020.3

  • Fukushima Medical University   Fukushima Medical University Directors   Professor

    2016.4 - 2017.3

  • 福島県立医科大学   医学部生化学講座   主任教授

    2007.4 - 2019.3

  • 理化学研究所 フロンティア研究システム 糖鎖機能研究チーム チームリーダー

    1999.10 - 2007.9

  • 東京都臨床医学総合研究所 副参事研究員

    1994.4 - 1999.9

  • University of Massachusetts Medical Center, Visiting Assistant Professor

    1988.11 - 1991.3

  • 東京都臨床医学総合研究所 主任研究員

    1986.4 - 1994.3

  • 東京都臨床医学総合研究所 研究員

    1983.4 - 1986.3

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Professional Memberships

  • 日本頭痛学会

    2018.5 - Now

  • 東北糖鎖研究会

    2007 - Now

  • 日本神経科学会

    2000 - Now

  • 日本糖質学会

    1985.4 - Now

  • 日本生化学会

    1980.4 - Now

  • 福島医学会

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Committee Memberships

  • 東北糖鎖研究会   世話人代表  

    2016.8   

  • 福島医学会   庶務幹事  

       

  • 日本糖質学会   評議員  

       

Papers

  • Brain-derived major glycoproteins are possible biomarkers for altered metabolism of cerebrospinal fluid in neurological diseases

    Hoshi Kyoka, Kanno Mayumi, Goto Aya, Ugawa Yoshikazu, Furukawa Katsutoshi, Arai Hiroyuki, Miyajima Masakazu, Takahashi Koichi, Hattori Koraro, Kan Keiichi, Saito Takashi, Yamaguchi Yoshiki, Mitsufuji Takashi, Araki Nobuo, Abe Mitsunari, Hashimoto Yasuhiro

    International Journal of Molecular Sciences   24   6084   2023

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/ijms24076084

  • Expression of transferrin protein and messenger RNA in neural cells of mouse and human brain tissue

    Abe Eriko, Fuwa Takashi J., Hoshi Kyoka, Saito Takashi, Murakami Takenobu, Miyajima Masakazu, Ogawa Norihiro, Akatsu Hiroyasu, Hashizume Yoshio, Hashimoto Yasuhiro, Honda Takashi

    Metabolites   12   594   2022

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/metabo12070594

  • High correlation among brain-derived major protein levels in cerebrospinal fluid; Implication for amyloid-beta and tau protein changes in Alzheimer’s disease

    Hoshi Kyoka, Kanno Mayumi, Abe Mitsunari, Murakami Takenobu, Ugawa Yoshikaz, Goto Aya, Honda Takashi, Saito Takashi, Saido Takaomi C., Yamaguchi Yoshiki , Miyajima Masakazu, Furukawa Katsutoshi, Arai Hiroyuki, Hashimoto Yasuhiro

    Metabolites   12   355   2022

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/metabo12040355

  • Transferrin biosynthesized in the brain is a novel biomarker for Alzheimer’s disease

    Hoshi Kyoka, Ito Hiromi, Abe Eriko, Fuwa Takashi J, Kanno Mayumi, Murakami Yuta, Abe Mitsunari, Murakami Takenobu, Yoshihara Akioh, Ugawa Yoshikazu, Saito Takashi, Saido Takaomi C., Matsumoto Kana, Yamaguchi Yoshiki, Furukawa Katsutoshi, Arai Hiroyuki, Kanai Mitsuyasu, Miyajima Masakazu, Arai Hajime, Ogawa Norihiro, Akatsu Hiroyasu, Hashizume Yoshio, Tateno Hiroaki, Honda Takashi, Hashimoto Yasuhiro

    Metabolites   11   616   2021

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/metabo11090616

  • Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension

    Iijima Junko, Hoshi Kyoka, Ito Hiromi, Kanno Mayumi, Murakami Yuta, Takahashi Koichi, Matsumoto Kana, Yamaguchi Yoshiki, Nakajima Madoka, Miyajima Masakazu, Arai Hajime, Kanai Mitsuyasu, Kitazume Shinobu, Honda Takashi, Hashimoto Yasuhiro

    Fukushima Journal of Medical Science   67 ( 2 )   64 - 70   2021

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.5387/fms.2020-19

  • Quantitative analysis of beta1,6GlcNAc-branched N-glycans of beta4 integrin in cutaneous squamous cell carcinoma

    Kariya Yoshinobu, Oyama Midori, Ohtsuka Mikio, Kikuchi Nobuyuki, Hashimoto Yasuhiro, Yamamoto Toshiyuki

    Fukushima Journal of Medical Science   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.5387/fms.2020-12

  • Soluble protein tyrosine phosphatase receptor type Z (PTPRZ) in cerebrospinal fluid is a potential diagnostic marker for glioma.

    Yamanoi Yu, Fujii Masakazu, Murakami Yuta, Nagai Kenichiro, Hoshi Kyoka, Hashimoto Yasuhiro, Honda Takashi, Saito Kiyoshi, Kitazume Shinobu

    Neuro-oncology Advances   2 ( 1 )   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/noajnl/vdaa005. eCollection Jan-Dec 2020.

  • 脳脊髄液減少症における髄液バイオマーカー

    村上友太, 星 京香, 伊藤浩美, 橋本康弘

    脳神経内科   92 ( 4 )   397 - 404   2020

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Brain-type transferrin as a glycan biomarker

    Murakami Yuta, Saito Kiyoshi, Takahashi Koichi, Araki Nobuo, Hashimoto Yasuhiro

    The Sutonomic Nervous System, Journal of the Japan Society of Neurovegetative Research   in press   2019

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases

    Murakami Yuta, Saito Kiyoshi, Ito Hiromi, Hashimoto Yasuhiro

    Proceedings of the Japan Academy, Series B   95   198 - 210   2019( ISSN:0386-2208

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.2183/pjab.95.015

  • Ratio of alpha 2-macroglobulin levels in cerebrospinal fluid and serum: an expression of neuroinflammation in acute disseminated encephalomyelitis

    Suzuki Yuichi, Hashimoto Koichi, Hoshi Kyoka, Ito Hiromi, Kariya Yoshinobu, Miyazaki Kyohei, Sato Masatoki, Kawasaki Yukihiko, Yoshida Mari, Honda Takashi, Hashimoto Yasuhiro, Hosoya Mitsuaki

    J. Pediatric Neurology   98   61 - 67   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Ratio of alpha 2-macroglobulin levels in cerebrospinal fluid and serum: an expression of neuroinflammation in acute disseminated encephalomyelitis.

    Suzuki Yuichi, Hashimoto Koichi, Hoshi Kyoka, Ito Hiromi, Kariya Yoshinobu, Miyazaki Kyohei, Sato Masatoki, Kawasaki Yukihiko, Yoshida Mari, Honda Takashi, Hashimoto Yasuhiro, Hosoya Mitsuaki

    J. Pediatric Neurology   98   61 - 67   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid.

    Murakami Yuta, Takahashi Koichi, Hoshi Kyoka, Ito Hiromi, Kanno Mayumi, Saito Kiyoshi, Nollet Kenneth, Yamaguchi Yoshiki, Miyajima Masakazu, Arai Hajime, Hashimoto Yasuhiro, Mima Tatsuo

    BBA General Subjects   1862   1835 - 1842   2018.8( ISSN:0304-4165

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bbagen. 2018.03.027

  • Beta4-integrin/P13K signaling promotes tumor progression through Galectin-3-N-glycan complex.

    Kariya Yukiko, Oyama Midori, Hashimoto Yasuhiro, Gu Jianguo , Kariya Yoshinobu

    Molecular Cancer Research   16 ( 6 )   1024 - 1034   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1158/1541-7786.MCR-17-0365 Epub 1028 Mar 16

  • Brain-type transferrin as a marker for spontaneous intracranial hypotension

    Murakami Yuta, Takahashi Koichi, Hoshi Kyoka, Ito Hiromi, Saito Kiyoshi, Miyajima Masakazu, Arai Hajime, Mima Tatsuo, Hashimoto Yasuhiro

    Japanese Journal of Headache   45 ( 1 )   25 - 33   2018

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Lectin-based assay for glycoform-specific detection of alpha2,6sialylated transferrin and carcinoembryonic antigen in tissue and body fluid.

    Ito Hiromi, Hoshi Kyoka, Honda Takashi, Hashimoto Yasuhiro

    Molecules   23   1314 - 1314   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/molecules23061314

  • Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin.

    Oyama Midori, Kariya Yoshinob, Kariya Yukiko, Matsumoto Kana, Kanno Mayumi, Yamaguchi Yoshiki, Hashimoto Yasuhiro

    Biochemical Journal   475   1583 - 1585   2018

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  • Rapid increase of “brain-type” transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery.

    Murakami Yuta, Matsumoto Yuka, Hoshi Kyoka, Ito Hiromi, Fuwa Takashi J., Yamaguchi Yoshiki, Nakajima Madoka, Miyajima Masakazu, Arai Hajime, Nollet Kenneth, Kato Naho, Nishikata Rie, Kuroda Naohito, Honda Takashi, Sakuma Jun, Saito Kiyoshi, Hashimoto Yasuhiro

    Journal of Biochemistry   164 ( 3 )   206 - 213   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvy043

  • Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production

    Akasaka-Manya Keiko, Kawamura Masaki, Tsumoto Hiroki, Saitoh Yuko, Kitazume Shinobu, Hatsuda Hiroyuki, Miura Yuri, Hisanaga Shinichi, Murayama Shigeo, Hashimoto Yasuhiro*, Manya Hiroshi, Endo Tamao

    Journal of Biochemistry   161 ( 1 )   99 - 111   2017.1( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvw056. Epub 2016 Oct 19

  • Evaluation of blood-brain barrier function by quotient alpha2macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus

    Asano Tomoyuki, Ito Hiromi, Kariya Yoshinobu, Hoshi Kyoka, Yoshihara Akioh, Ugawa Yoshikazu, Sekine Hideharu, Hirohata Shunsei, Yamaguchi Yoshiki, Sato Shuzo, Kobayashi Hiroko , Migita Kiyoshi, Ohira Hiromasa, Hashimoto Yasuhiro, Wwatanabe Hiroshi

    PlosOne   12 ( 10 )   e0186414   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0186414. eCollection 2017

  • A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases

    Hoshi Kyoka, Matsumoto Yuka, Ito Hiromi, Saito Kiyoshi, Honda Takashi, Yamaguchi Yoshiki, Hashimoto Yasuhiro

    BBA-General Subjects   1861   2473 - 2478   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bbagen. 2017.07.005

  • Lectin inhibits antigen-antibody reactioon in a glycoform-specific manner: Application for detecting alpha2,6sialylated-carcinoembryonic antigen

    Ito Hiromi*, Hoshi Kyoka*, Osuka Fumihiko*, Gotoh Mitsukazu*, Saito Takuro*, Hojo Hiroshi*, Suzuki Rei*, Ohira Hiromasa*, Honda Takashi*, Hashimoto Yasuhiro*

    PROTEOMICS   16 ( 24 )   3081 - 3084   2016.12( ISSN:1615-9853

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/pmic.201600117

  • Subgroup differences in "brain-type" transferrin and alpha-synuclein in Parkinson's disease

    Yoshihara Akioh*, Fukatsu Masahiko*, Hoshi Kyoka*, Ito Hiromi*, Nollet Kenneth*, Yamaguchi Yoshiki, Ishii Ryotaro, Tokuda Takahiko, Miyajima Masakazu, Arai Hajime, Kato Takeo, Furukawa Katsutoshi, Arai Hiroyuki, Kikuchi Akio, Takeda Atsushi, Ugawa Yoshikazu* and Hashimoto Yasuhiro*

    Journal of Biochemistry   160 ( 2 )   87 - 91   2016.8( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvw015

  • 認知症における糖鎖バイオマーカー

    星京香*, 吉原章王*, 伊藤浩美*, 宮嶋雅一, 新井一, 宇川義一*, 橋本康弘*

    老年期認知症研究会誌   21 ( 7 )   17 - 19   2016

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 糖鎖バイオマーカーによる特発性正常圧水頭症と神経変性疾患の鑑別

    星京香*, 吉原章王*, 深津真彦*, 金子知香子, 伊藤浩美*, 橋本康弘*

    生体の科学   67 ( 5 )   498 - 499   2016

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • アルツハイマー病の発症メカニズム:髄液糖鎖マーカーの探索

    橋本康弘、星京香

    日本臨床検査医学会東北支部会誌   25 ( 1 )   7 - 13   2016

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  • Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica

    Yoshinobu Kariya*, Yukiko Kariya*, Toshie Saito*, Shuhei Nishiyama, Takashi Honda*, Keiko Tanaka, Mari Yoshida, Kazuo Fujihara and Yasuhiro Hashimoto*

    BBA Clinical   15 ( 3 )   126 - 134   2015.6( ISSN:22146474

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.bbacli.2015.01.003

  • In situ visualization of a glycoform of transferrin: Localization of α2,6-sialylated transferrin in the liver

    Yuka Matsumoto*, Toshie Saito*, Kyoka Hoshi*, Hiromi Ito*, Yoshinobu Kariya*, Masamichi Nagae, Yoshiki Yamaguchi, Yoshiaki Hagiwara, Noriaki Kinoshita, Ikuo Wada*, Kiyoshi Saito*, Takashi Honda* and Yasuhiro Hashimoto*

    Journal of Biochemistry   157 ( 4 )   211 - 6   2015.4( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1093/jb/mvu071.

  • An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

    Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto*, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo and Naoyuki Taniguchi

    EMBO Molecular Medicine   7 ( 2 )   175 - 189   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.15252/emmm.201404438.

  • Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties

    Yoshinobu Kariya*, Mayumi Kanno*, Kana Matsumoto-Morita, Midori Konno*, Yoshiki Yamaguchi and Yasuhiro Hashimoto*

    Biochem. J.   463 ( 1 )   93 - 102   2014.10( ISSN:0264-6021

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1042/BJ20140060.

  • Structural change of N-glycan exposes hydrophobic surface of human transferrin

    Masamichi Nagae, Kana Morita-Matsumoto, Seisuke Arai, Ikuo Wada*, Yuka Matsumoto*, Kiyoshi Saito*, Yasuhiro Hashimoto* and Yoshiki Yamaguchi

    Glycobiology   24 ( 8 )   693 - 702   2014.8( ISSN:0959-6658

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1093/glycob/cwu033

  • 糖鎖バイオマーカーの新しいハイスループット測定法

    星京香*、橋本康弘*

    医学のあゆみ   249 ( 8 )   676 - 681   2014.5

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  • 認知症髄液マーカーの非侵襲的な採取:髄液と鼻粘膜下の交通の利用

    橋本康弘*、荒井啓行、古川勝敏、奈良清光*、苅谷慶喜*、伊藤浩美*、星 京香*

    平成25年度加齢医学研究拠点共同利用・共同研究報告書   124 - 125   2014

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  • Lectin-dependent inhibition of antigen-antibody reaction: application for measuringα2,6-sialylated glycoforms of transferrin

    Kyoka Hoshi*, Yoshinobu Kariya*, Kiyomitsu Nara*, Hiromi Ito*, Kana Matsumoto, Masamichi Nagae, Yoshiki Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Atsushi Kuno, Hisashi Narimatsu, Keiro Shirotani and Yasuhiro Hashimoto*

    Journal of Biochemistry   154 ( 3 )   229 - 232   2013.9( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1093/jb/mvt065

  • 髄液中トランスフェリンと特発性性正常圧水頭症

    橋本康弘*、本多たかし*、古川勝敏、荒井啓行、宮嶋雅一、新井一

    Clinical Neuroscience   31 ( 5 )   618 - 619   2013

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  • 第10章 脳脊髄液バイオマーカー

    本多たかし*、北爪しのぶ、松本由香*、齋藤 清*、宮嶋雅一、新井 一、古川勝敏、荒井啓行、橋本康弘*

    臨床認知症 特集:アルツハイマー病の早期診断   2 ( 2 )   35 - 40   2013

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  • iNPHマーカーとしての髄液トランスフェリン

    松本由香*、齋藤 清*、本多たかし*、中島 円、宮嶋雅一、新井 一、橋本康弘*

    iNPH Now   10   2013

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  • A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH

    FUTAKAWA, Satoshi*; NARA, Kiyomitsu*; MIYAJIMA, Masakazu; KUNO, Atsushi; ITO, Hiromi*; KAJI, Hiroyuki; SHIROTANI, Keiro*; HONDA, Takashi*; TOHYAMA, Yuriko*; HOSHI, Kyoka*; HANZAWA, Yusuke*; KITAZUME, Shinobu; IMAMAKI, Rie; FURUKAWA, Katsutoshi; TASAKI, Kazuhiro*; ARAI, Hiroyuki; YUASA, Tatsuhiko; ABE, Masafumi*; ARAI, Hajime; NARUMATSU, Hisashi; HASHIMOTO, Yasuhiro*

    Neurobiology of Aging   33 ( 8 )   1807 - 1815   2012

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    DOI : 10.1016/j.neurobiolaging.2011.02.023

  • 認知症の髄液糖鎖マーカー

    橋本康弘*、菊池一郎、宮嶋雅一、新井一、古川勝敏、荒井啓行、松本由香*、齋藤清*、城谷圭朗*

    Cognition and Dementia   11 ( 2 )   35 - 40   2012

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  • Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors siglec-7 and -9

    MIYAZAKI, Keiko; SAKUMA, Keiichiro; KAWAMURA, I Yuki; IZAWA, Mineko; OHMORI, Katsuyuki; MITSUKI, Motoaki; YAMAJI, Toshiyuki; HASHIMOTO, Yasuhiro*; SUZUKI, Akemi; SAITO, Yukio; DOHI, Taeko; KANNAGI, Reiji

    J. Immunology   188 ( 9 )   4690 - 700   2012

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    DOI : 10.4049/jimmunol.1100605

  • Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

    KAKUDA, Nobuto; SHOJI, Mikio; ARAI, Hiroyuki; FURUKAWA, Katsutoshi; IKEUCHI, Takeshi; AKAZAWA, Kohei; TAKAMI, Mako; HATSUTA, Hiroyuki; MURAYAMA, Shigeo; HASHIMOTO, Yasuhiro*; MIYAJIMA, Masakazu; ARAI, Hajime; NAGASHIMA, Yu; YAMAGUCHI, Haruyasu; KUWANO, Ryozo; NAGAIKE, Kazuhiro

    ENBO Molecular Medicine   4 ( 4 )   344 - 52   2012

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1002/emmm.201200214

  • High Throughput ELISAs to Measure an Unique Glycan on Transferrin in Cerebrospinal fluid : A Possible Extension Toward Alzheimer's Disease Biomarker Development

    SHIROTANI, Keiro*; FUTAKAWA, Satoshi*; NARA, Kiyomitsu*; HOSHI, Kyoka*; SAITO, Toshie*; TOHYAMA, Yuriko*; KITAZUME, Shinobu; YUASA, Tatsuhiko; MIYAJIMA, Masakazu; ARAI, Hajime; KUNO, Atsushi; NARIMATSU, Hisashi; HASHIMOTO, Yasuhiro*

    International Journal of Alzheimer's Disease   352787   2011.8

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    DOI : 10.4061/2011/352787

    PubMed

  • Leucine-rich α-2-glycoprotein is a marker for idiopathic normal pressure hydrocephalus

    NAKAJIMA, Madoka; MIYAJIMA, Masakazu; OGINO, Ikuko; WATANABE, Maki; MIYATA, Haruko; Kostadin L. Karagiozov; ARAI, Hajime; HAGIWARA, Yoshiaki; SEGAWA, Tatsuya; KOBAYASHI, Kyoko; HASHIMOTO, Yasuhiro*

    Acta Neurochirurgica   153 ( 6 )   1339 - 46   2011

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1007/s00701-011-0963-z

  • 認知症の糖鎖マーカー:特発性正常圧水頭症を例として

    二川了次*, 橋本康弘*

    脳21   14 ( 1 )   32 - 36   2011

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  • 認知症の髄液学-診断マーカーとしての糖鎖修飾-

    二川了次*, 奈良清光*, 城谷圭朗*, 本多たかし*, 橋本康弘*

    日本臨床   69 ( 8 )   69 - 73   2011

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  • 糖タンパク質糖鎖をマーカーとする認知症の診断:特発性正常圧水頭症の新規マーカー

    橋本康弘*、奈良清光*、二川了次*、星京香*、城谷圭朗*、本多たかし*、田﨑和洋*、阿部正文*、久野敦、平林淳、伊藤浩美*、成松久、新井一、宮嶋雅一、湯浅龍彦

    老年期認知症研究会誌   18   115 - 116   2011

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  • Inhibition of ganglioside synthesis reduces the neuronal survival activity of astrocytes

    AKASAKO, Yuko; NARA, Kiyomitsu*; NAGAI, Yoshitaka; HASHIMOTO, Yasuhiro*

    Neuroscience Letters   488 ( 2 )   199 - 203   2011

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    DOI : 10.1016/j.neulet.2010.11.029

  • “病因・病態解明に向けて(B)髄液バイオマーカー”、特発性正常圧水頭症(iNPH)病態研究最近の進歩

    橋本康弘*, 二川了次*, 宮嶋雅一, 北爪しのぶ, 奈良清光*, 城谷圭朗*, 久野敦, 伊藤浩美*, 本多たかし*, 古川勝敏, 田﨑和洋*, 荒井啓行, 湯浅龍彦, 阿部正文*, 成松久, 新井一

    臨床神経学   50 ( 11 )   971 - 972   2010

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  • Siglec-7 mediates non-apoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937

    MITSUKI, Motoaki; NARA, Kiyomitsu*; YAMAJI, Toshiyuki; ENOMOTO, Ayako; KANNO, Mayumi*; YAMAGUCHI, Yoshiki; YAMADA, Akane; WAGURI, Satoshi*; HASHIMOTO, Yasuhiro*

    Glycobiology   20 ( 3 )   395 - 402   2010

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1093/glycob/cwp195.

  • Characterization of Rice Nucleotide Sugar Transporters Capable of Transporting UDP-Galactose and UDP-Glucose

    SEINO, Junichi; ISHII, Kumiko; NAKANO, Takeshi; ISHIDA, Nobuhiro; TSUJIMOTO, Masafumi; HASHIMOTO, Yasuhiro*; TAKASHIMA, Shou

    Journal of Biochemistry   148 ( 1 )   35 - 46   2010

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    DOI : 10.1093/jb/mvq031.

  • <alpha>2,6-Sialic acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling

    KITAZUME, Shinobu; IMAMAKI, Rie; OGAWA, Kazuko; KOMI, Yusuke; FUTAKAWA, Satoshi*; KOJIMA, Soichi; HASHIMOTO, Yasuhiro*; Marth, Jamey D; Paulson, James C; TANIGUCHI, Naoyuki

    Journal of Biological Chemistry   285 ( 9 )   6515 - 21   2010

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    DOI : 10.1074/jbc.M109.073106.

  • Brain endothelial cells produce amyloid-beta from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form

    KITAZUME, Shinobu; TACHIDA, Yuriko; KATO, Masaki; YAMAGUCHI, Yoshiki; HONDA, Takashi*; HASHIMOTO, Yasuhiro*; WADA, Yoshinao; SAITO, Takashi; IWATA, Nobuhisa; SAIDO, Takaomi; TANIGUCHI, Naoyuki

    Journal of Biological Chemistry   285 ( 51 )   40097 - 103   2010

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1074/jbc.M110.144626.

  • Molecular insights into β-galactoside <alpha>2,6-sialyltransferase secretion in vivo

    Shinobu Kitazume, Kazuko Ogawa, Satoshi Futakawa, Yoshiaki Hagiwara, Hajime Takikawa, Michio Kato, Akinori Kasahara, Eiji Miyoshi, Naoyuki Taniguchi, Yasuhiro Hashimoto

    Glycobiology   19 ( 5 )   479 - 487   2009

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    DOI : 10.1093/glycob/cwp003.

  • Development of sandwich enzyme-linked immunosorbent assay systems for plasma β-galactoside <alpha>2,6-sialyltransferase, a possible hepatic disease biomarker

    Satoshi Futakawa; Shinobu Kitazume; Ritsuko Oka; Kazuko Ogawa; Yoshiaki, Hagiwara; Akinori Kinoshita, and Kazuya Miyashita, and Yasuhiro Hashimoto

    Analytica Chimica Acta   631   116 - 120   2009

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.acta.2008.10.028.

  • Interleukin-1beta upregulates TACE to enhance alpha-cleavage of APP in neurons: Resulting decrease of Abeta producton

    Yuriko Tachida, Kazuhiko Nakagawa, Takashi Saito, Takaomi C. Saido, Gaku Sakaguchi, Akira Kato, Shinobu Kitazume, and Yasuhiro Hashimoto

    J. Neurochem.   104 ( 5 )   1387 - 1393   2008

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  • Simultaneous Tracking of Capsid, Tegument and Envelope Protein Localization in Living Cells Infected with Triple Fluorescent Herpes Simplex Virus

    Ken Sugimoto, Masashi Uema, Hiroshi Sagara, Michiko Tanaka,Tetsutaro Sata, Yasuhiro Hashimoto, and Yasushi Kawaguchi

    Journal of Virology   82 ( 11 )   5198 - 5211   2008

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    DOI : 10.1128/JVI.02681-07.

  • アルツハイマー病βセクレターゼによる糖転移酵素のプロセシングによる糖鎖発現の調節

    北爪しのぶ、橋本康弘

    遺伝子医学MOOK 11「臨床糖鎖バイオマーカーの開発-糖鎖機能の解明とその応用」   0   0   2008

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  • 糖転移酵素の修飾機構と意義

    北爪しのぶ、橋本康弘

    蛋白質核酸酵素 増刊号 糖鎖情報の独自性と普遍性   53 ( 12 )   1456 - 1459   2008

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  • Germinal Center Marker GL7 Probes Activation-Dependent Repression of N-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation

    Yuko Naito, Hiromu Takematsu, Susumu Koyama, Shizu Miyake, Harumi Yamamoto, Reiko Fujinawa, Manabu Sugai, Yasushi Okuno, Gozoh Tsujimoto, Toshiyuki Yamaji, Yasuhiro Hashimoto, Shigeyoshi Itohara, Toshisuke Kawasaki, Akemi Suzuki, and Yoasunori Kozutsumi

    Molecular and Cellular Biology   27 ( 8 )   3008 - 3022   2007

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Books

  • Annual Review神経2015

    鈴木則宏、祖父江 元、荒木信夫、宇川義一、川原信隆(脳型トランスフェリンの基礎と臨床:疾患マーカーとしての糖鎖修飾)

    (株)中外医学社  2015.1 

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    Responsible for pages:100-106   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:Hashimoto Yasuhiro, Hoshi Kyoka, Honda Takashi, Arai Hajime, Miyajima Masakazu, Arai Hiroyuki, Furukawa Katsutoshi   Publication place:東京  

  • Methods of Molecular Biology: Lectin purification and analysis

    Hirabayashi Jun(Simple and rapid detection of glycoforms by "Lectin Inhibition" assay)

    Springer Nature Japan  2020 

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    Responsible for pages:Chapter 17   Language:English   Book type:Scholarly book

    Authors name of the chapter and paper which it took charge of:Hoshi Kyoka, Hashimoto Yasuhiro, Ito Hiromi   Publication place:Tokyo  

  • Methods of Molecular Biology: Lectin purification and analysis

    Hirabayashi Jun(Glycoform-specific visualization in immunohistochemistry by "Lectin inhibition")

    Springer Nature Japan  2020 

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    Responsible for pages:chapter 18   Language:English   Book type:Scholarly book

    Authors name of the chapter and paper which it took charge of:Ito Hiromi, Hoshi Kyoka, Hashimoto Yasuhiro, Honda Takashi   Publication place:Tokyo  

  • Modeling and Simulation in Engineering

    (3D modeling of a natural killer receptor, Siglec-7: critical amino acids for glycan-binding and cell death-inducing activity)

    INTECH  2012  ( ISBN:978-953-307-95

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    Responsible for pages:103-116   Language:English  

    Authors name of the chapter and paper which it took charge of:YAMAJI, Toshiyuki; YAMAGUCHI, Yoshiki; MITSUKI, Motoaki; TAKASHIMA, Shou; WAGURI, Satoshi*; HASHIMOTO, Yasuhiro*; NARA, Kiyomitsu*   Publication place:Croatia  

  • Glycoscience: Biology and Medicine

    Naoyuki Taniguchi, Tamao Endo, Gerald Hart, Peter Seeberger, Chi-Huey Wong(A Glycan Marker for Idiopathic Normal Pressure Hydrocephalus)

    Springer Verlag Tokyo  2014 

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    Responsible for pages:1-7   Language:English  

    Authors name of the chapter and paper which it took charge of:Kyoka Hoshi*, Yuka Matsumoto*, Toshie Saito*, Hiromi Ito*, Yoshinobu Kariya*, Yoshiki Yamaguchi, Katsutoshi Furukawa, Hiroyuki Arai, Masakazu Miyajima, Hajime Arai, Hisashi Narimatsu, Kiyoshi Saito*, Takashi Honda* and Yasuhiro Hashimoto*   Publication place:Tokyo  

  • 糖鎖を知る-その素顔と病気への挑戦

    (アルツハイマー病の原因酵素が糖鎖を変えていた)

    (独)科学技術振興機構  2010 

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    Responsible for pages:122-128   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:Hashimoto Yasuhiro, Kitazume Shinobu   Publication place:東京  

  • Experimental Glycoscience

    (Processing of glycosyltransferases by Alzheimer's βsecretase( BACE1))

    2008 

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    Responsible for pages:192-194   Language:English  

    Authors name of the chapter and paper which it took charge of:Shinobu Kitazume, Shou Takashima and Yasuhiro Hashimoto   Publication place:  

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Presentations

  • 高マンノース糖鎖を持つトランスフェリンは神経細胞に由来しアルツハイマー病の髄液マーカーとなる

    第16回東北糖鎖研究会  

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    Event date: 2022.10

  • 新規アルツハイマー病マーカー:神経細胞由来の高マンノース糖鎖含有トランスフェリン

    第41回日本糖質学会年会  

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    Event date: 2022.9 - 2022.10

  • 神経細胞が生合成するトランスフェリンはアルツハイマー病マーカーとなる

    第40回日本認知症学会学術集会  

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    Event date: 2021.11

  • グリオーマの診断マーカー候補、可溶型プロテインチロシンホスファターゼsAPPZ1

    第40回日本糖質学会年会  

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    Event date: 2021.10

  • 脳脊髄液中のトランスフェリン糖鎖異性体及びそのmRNA・タンパク質の脳内における発現

    第40回日本糖質学会年会  

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    Event date: 2021.10

  • “脳型”トランスフェリンは特発性正常圧水頭症の診断及び認知症の予後マーカーとなる

    第37回日本神経治療学会  

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    Event date: 2019.11

  • TMS can detect abnormal synaptic plasticity associated with amyloid-beta and Tau pathology in early staged dementia

    第60回日本神経学会学術大会  

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    Event date: 2019.5

  • TMS can detect abnormal synaptic plasticity associated with amyloid-beta and Tau pathology in early staged dementia.

    3rd International Brain Stimulation Conference  

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    Event date: 2019.2

  • 脳脊髄液減少症における髄液バイオマーカー

    第71回日本自律神経学会総会  

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    Event date: 2018.10

  • Novel CSF biomarkers for diagnosing Spontaneous intracranial hypotension: combination of lipocalin-type prostaglandin D synthase & brain-type transferrin.

    The 10th Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders (Hydrocephalus 2018)  

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    Event date: 2018.10

  • 新しい脳脊髄液代謝マーカーによる脳脊髄液漏出症の診断

    BIO Japan 2018  

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    Event date: 2018.10

  • 髄液糖鎖マーカーとしての脳型トランスフェリン

    第12回東北糖鎖研究会  

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    Event date: 2018.9

  • 髄液代謝異常症とトランスフェリン糖鎖異性体

    第37回日本糖質学会年会  

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    Event date: 2018.8

  • 髄液産生マーカーとしてのトランスフェリン

    京都髄液フォーラム2018  

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    Event date: 2018.8

  • インテグリンαvβ3は強力なEMT促進因子である

    福岡大学病院  

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    Event date: 2018.6

  • 新しい髄液代謝マーカー:髄液過剰による認知症及び髄液漏出症の診断

    BIO tech 2018  

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    Event date: 2018.6

  • 脈絡叢組織に対するレクチン染色を用いた形態学的検討

    第19回日本正常圧水頭症学会  

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    Event date: 2018.2

  • 脳脊髄液減少症と脳型トランスフェリン

    第17回日本脳脊髄液圧減少症研究会  

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    Event date: 2018.2

  • HPVワクチン関連免疫異常症候群に髄液異常の合併が疑われた6例

    第17回日本脳脊髄液圧減少症研究会  

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    Event date: 2018.2

  • 特発性正常圧水頭症における髄液トランスフェリンの定量及び形態学的検討

    第10回日本水頭症脳脊髄液学会  

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    Event date: 2017.11

  • レクチン阻害法による糖鎖アイソフォームの測定

    東北糖鎖研究会・東京糖鎖研究会合同シンポジウム(第11回東北糖鎖研究会・GlycoTOKYO 2017)  

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    Event date: 2017.11

  • 脳脊髄液減少症(特発性低髄液圧症候群)と髄液型トランスフェリン

    第45回日本頭痛学会総会  

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    Event date: 2017.11

  • Effect of Site-specific O-glycosylation in Osteopontin on its Cell Adhesion Activity and Phosphorylation.

    International Osteopontin Conference  

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    Event date: 2017.11

  • Contribution of O-glycosylation and phosphorylation in osteopontin to its functional activities.

    International Osteopontin Conference  

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    Event date: 2017.11

  • 脳脊髄液減少症のバイオマーカーについて

    AMED障害者対策総合研究開発事業「脳脊髄液減少症における自律神経機能異常の関与の検討」シンポジウム  

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    Event date: 2017.10

  • A CSF biomarker for diagnosing spontaneous intracranial hypotension

    The 9th Meeting of the Internaional Society for Hydrocephalus and Cerebrospinal Fluid Disorders (Hydrocephalus 2017)  

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    Event date: 2017.9

  • CNS-derived biomarkers: Their decrease in iNPH and increase in SIH, spontaneous intracranial hypotention

    Hydrocephalus Round Table in Kobe  

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    Event date: 2017.9

  • 髄液鼻漏を合併する脳脊髄液減少症に対するシャント手術

    第16回日本脳脊髄液減少症研究会  

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    Event date: 2017.3

  • 脳脊髄液減少症における自律神経機能異常の関与の検討について

    第16回日本脳脊髄液減少症研究会  

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    Event date: 2017.3

  • 髄液バイオマーカーによる特発性低髄液圧症候群の診断

    第18回日本正常圧水頭症学会  

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    Event date: 2017.2

  • 糖鎖プローブとしてのレクチン:認知症の糖鎖マーカーの検出

    第2回レクチン技術研究会  

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    Event date: 2016.12

  • 特発性低髄液圧症候群の診断における新たな髄液バイオマーカーの模索

    第9回日本水頭症脳脊髄液学会  

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    Event date: 2016.11

  • 特発性低髄液圧症候群の診断における髄液中バイオマーカー

    日本脳神経外科学会 第75回学術総会  

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    Event date: 2016.9 - 2016.10

  • 部位特異的O-結合型糖鎖修飾がオステオポンチンの細胞接着活性に与える影響

    第89回日本生化学会大会  

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    Event date: 2016.9

  • ホルマリン固定大腸癌由来のα2,6シアリル化癌胎児性抗原の検出

    第89回日本生化学会大会  

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    Event date: 2016.9

  • 髄液中トランスフェリン糖鎖アイソフォームと疾患

    第89回日本生化学会大会  

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    Event date: 2016.9

  • ホルマリン固定大腸癌由来のα2,6シアリル化癌胎児性抗原の検出

    第10回東北糖鎖研究会  

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    Event date: 2016.8

  • 髄液中トランスフェリン糖鎖アイソフォームと疾患

    第10回東北糖鎖研究会  

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    Event date: 2016.8

  • 特発性低髄液圧症候群の診断における糖鎖バイオマーカーの有用性の検討

    第17回日本正常圧水頭症学会  

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    Event date: 2016.3

  • 特発性低髄液圧症候群の糖鎖バイオマーカー

    第15回日本脳脊髄液減少症研究会  

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    Event date: 2016.3

  • 特発性低髄液圧症候群の診断における糖鎖バイオマーカーの探索

    第8回日本水頭症脳脊髄液学会  

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    Event date: 2015.11

  • 認知症における糖鎖バイオマーカー

    第21回東北老年期認知症研究会  

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    Event date: 2015.11

  • Subgroup differences in "brain-type transferrin and alpha-synuclein in Parkinson's disease and multiple system atrophy

    7th Asian Community of Glycoscience and Glycotechnology Conference (ACGG)  

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    Event date: 2015.11

  • Upregulation of C3 and alpha-2-Macroglobulin in cerebrospinal fluid of neuropsychiatric systemic lupus erythematosus

    18th Annual Meeting of American College of Rheumatology  

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    Event date: 2015.11

  • 髄液α2マクログロブリンは神経炎症マーカーになりうる

    第47回日本小児感染症学会総会・学術集会  

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    Event date: 2015.10

  • 髄液中トランスフェリン測定の意義

    第9回東北糖鎖研究会発表会  

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    Event date: 2015.9

  • 認知症の糖鎖バイオマーカー

    S.T.R. Medical Conference  

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    Event date: 2015.8

  • アルツハイマー病の発症メカニズム

    第47回日本臨床検査医学会東北支部総会  

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    Event date: 2015.7

  • 糖鎖欠損によるオステオポンチンの細胞接着活性とリン酸化修飾への影響

    第47回日本結合組織学会学術大会  

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    Event date: 2015.5

  • 脳脊髄液中オステオポンチンの視神経脊髄炎病態への関与

    第47回日本結合組織学会学術大会  

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    Event date: 2015.5

  • 特発性正常圧水頭症における糖鎖バイオマーカーとその臨床症状との関係

    第16回日本正常圧水頭症学会  

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    Event date: 2015.2

  • 疾患の解明と治療・創薬のための糖鎖科学(疾患と糖鎖)

    KAST平成26年度教育講座「糖鎖科学・糖鎖工学の基礎から応用」  

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    Event date: 2015.1

  • High throughput detection of an alpha2,6-sialylated glycoform of transferrin in cerebrospinal fluid: Application for dementia diagnosis

    SFG-JSCR 2014  

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    Event date: 2014.11

  • 特発性正常圧水頭症の糖鎖バイオマーカー

    第7回日本水頭症脳脊髄液学会  

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    Event date: 2014.10

  • α2,6シアル酸化トランスフェリンの迅速測定及び免疫組織化学

    第8回東北糖鎖研究会  

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    Event date: 2014.10

  • Bisecting GlcNAc欠損によるアルツハイマー病抑制に関する研究

    第33回日本糖質学会年会  

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    Event date: 2014.8

  • レクチンによる抗原-抗体反応の阻害:髄液トランスフェリン糖鎖アイソフォームの測定

    第33回日本糖質学会年会  

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    Event date: 2014.8

  • Lack of bisected glycan relocates BACE1 to lysosomal degradation and robustly reduces Aβ generation

    International Conference on Alzheimer's Disease - ICAD 2014  

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    Event date: 2014.7

  • 髄液中α2,6-シアル酸化トランスフェリンの迅速測定

    第15回日本正常圧水頭症学会  

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    Event date: 2014.2

  • 疾患の解明と治療・創薬のための糖鎖科学(疾患と糖鎖)

    KAST平成25年度教育講座「糖鎖科学・糖鎖工学の基礎から応用」  

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    Event date: 2014.1

  • A unique “brain-type" glycan on human transferrin in the cerebrospinal fluid

    International Symposium on Glyco-neuroscience  

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    Event date: 2014.1

  • 特発性正常圧水頭症における手術前後の髄液型トランスフェリンの推移

    厚生労働科学研究費補助金難治性疾患克服研究事業「特発性正常圧水頭症の病因・病態と診断・治療に関する研究」班会議  

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    Event date: 2013.11

  • 髄液型糖鎖と中枢神経疾患

    第11回JCGGシンポジウム  

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    Event date: 2013.10

  • SSAレクチンによる抗原-抗体反応の阻害:髄液中α2,6-シアル酸化トランスフェリン測定への応用

    第7回東北糖鎖研究会  

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    Event date: 2013.9

  • オステオポンチン上O型糖鎖のリン酸化および細胞接着活性に及ぼす影響

    第86回日本生化学会大会  

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    Event date: 2013.9

  • 認知症マーカーとしてのα2,6シアル酸化トランスフェリンの新規測定法

    第86回日本生化学会大会  

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    Event date: 2013.9

  • 糖鎖アイソフォームの新しい測定法の開発

    夏の領域班会議(新学術領域:神経糖鎖班会議)  

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    Event date: 2013.7

  • 認知症の糖鎖バイオマーカーのハイスループット測定法

    日本薬学会第133年会  

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    Event date: 2013.3

  • 特発性正常圧水頭症における手術前後の髄液型トランスフェリンの推移

    第14回日本正常圧水頭症学会  

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    Event date: 2013.2

  • iNPHマーカーとしての髄液トランスフェリン

    第14回日本正常圧水頭症学会プレナリーセミナー  

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    Event date: 2013.2

  • 疾患の解明と治療・創薬のための糖鎖科学(疾患と糖鎖)

    KAST 平成24年度教育講座「糖鎖科学・糖鎖工学の基礎から応用」  

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    Event date: 2013.1

  • iNPHマーカーである脳型トランスフェリンはシャント手術後に正常化する

    厚生労働科学研究費補助金難治性疾患克服研究事業「特発性正常圧水頭症の病因・病態と診断・治療に関する研究」班会議  

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    Event date: 2012.11

  • A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH

    Hydrocephalus 2012 Kyoto  

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    Event date: 2012.10

  • 脳型糖タンパク質の中枢神経疾患マーカーとしての意義

    第6回東北糖鎖研究会  

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    Event date: 2012.10

  • 髄液に特徴的な脳型トランスフェリンの認知症マーカーとしての意義

    第31回日本糖質学会年会  

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    Event date: 2012.9

  • 認知症マーカーとしての髄液トランスフェリン

    包括脳夏のワークショップ(新学術領域:神経糖鎖班会議)  

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    Event date: 2012.7

  • 認知症の髄液診断マーカー

    第14回脳教カンファランス  

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    Event date: 2012.7

  • 次世代ポストゲノムの時代、糖鎖研究はおもしろい

    第75回日本皮膚科学会東京支部学会  

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    Event date: 2012.2

  • 疾患の解明と治療・創薬のための糖鎖科学(疾患と糖鎖)

    KAST平成23年度教育講座「糖鎖科学・糖鎖工学の基礎から応用」  

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    Event date: 2012.1

  • 神経細胞の糖鎖認識による髄液糖タンパク質の直接取り込み機構の解析

    新学術領域:神経糖鎖生物学「冬の領域班会議」  

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    Event date: 2012.1

  • 認知症糖鎖マーカーのハイスループット測定法

    第5回東北糖鎖研究会  

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    Event date: 2011.12

  • 特発性正常圧水頭症マーカーの開発

    NEDO糖鎖プロジェクト成果報告会  

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    Event date: 2011.11

  • 特発性正常圧水頭症の髄液糖鎖マーカー:脳型糖鎖を持つトランスフェリンの減少

    厚生労働科学研究費補助金難治性疾患克服研究事業「特発性正常圧水頭症の病因・病態と診断・治療に関する研究」班会議  

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    Event date: 2011.11

  • Siglec-7 induced nonapototic cell death

    The 31st Naito Conference  

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    Event date: 2011.9

  • IgM抗体のIgG化とFab5量体化

    第30回日本糖質学会年会  

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    Event date: 2011.7

  • 脳脊髄液中の糖鎖マーカーによる“治る”認知症の鑑別診断

    平成22年度MGプロジェクト研究開発委員会  

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    Event date: 2011.1

  • A unique N-glycan on human transferrin in cerebrospinal fluid: a possible biomarker for idiopathic normal pressure hydrocephalus

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    Event date: 2010.12

  • 特発性正常圧水頭症の糖鎖マーカー

    厚生労働科学研究費補助金難治性疾患克服研究事業「正常圧水頭症の疫学・病態と治療に関する研究」班会議  

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    Event date: 2010.11

  • 認知症の早期診断:髄液中バイオマーカーの研究

    会津医学会学術講演会  

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    Event date: 2010.11

  • 髄液に特徴的な糖鎖マーカーの認知症における変化

    第5回糖鎖産業技術フォーラム(GLIT)in Bio Japan 2010  

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    Event date: 2010.9

  • 認知症の糖鎖診断マーカーの開発

    MGプロジェクト22年度 細胞糖鎖マーカー・腫瘍外疾患マーカー分科会  

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    Event date: 2010.9

  • 髄液中の糖鎖バイオマーカーによる認知症の鑑別

    第24回老年期認知症研究会  

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    Event date: 2010.7

  • A Unique N-glycan in cerebrospinal fluid: a Possible Biomarker for abnormal CSF metabolism: Idiopathic Normal Pressure Hydrocephalus

    The 28th Naito Conference  

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    Event date: 2010.7

  • 認知症の生化学

    平成22年度 福島県立医科大学医学部同窓会・相双支部 総会  

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    Event date: 2010.6

  • 特発性正常圧水頭症:病因・病態解明に向けて(B)髄液バイオマーカー

    第51回日本神経学会総会  

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    Event date: 2010.5

  • がん糖鎖によるシグレック-7を介した免疫細胞死の誘導

    第5回 臨床糖鎖研究会  

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    Event date: 2010.3

  • 脳脊髄液中の糖タンパク質糖鎖をマーカーとする正常圧水頭症の診断方法

    鎌ヶ谷シンポジウム「認知症研究の最前線」  

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    Event date: 2009.5

  • 糖鎖をマーカーとする認知症の診断

    福島県立医科大学医師会・第4回臨床基礎研究交流会「アルツハイマー病:臨床から基礎へ」  

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    Event date: 2009.4

  • Siglec-7-dependent inhibitory signaling", CREST International Symposium "Acquired Immunity and Glycobiology

    CREST International Symposium "Acquired Immunity and Glycobiology"  

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    Event date: 2009.3

  • Aglycan marker in Cerebrospinal fluid for Idiopathic normal pressure hydrocephalus

    Clinical and translational research on cancer  

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    Event date: 2009.3

  • 疾患の解明と治療・創薬のための糖鎖科学―1(疾患と糖鎖)

    財団法人神奈川科学技術アカデミー(KAST)平成20年度教育講座「糖鎖科学・糖鎖工学への招待」  

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    Event date: 2009.1

  • Aglycan marker of Cerebrospinal fluid for neuronal diseases

    International Symposium on Systems Glycobiology  

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    Event date: 2008.12

  • Binding specificity of siglec-7-Fc prepared from various animal cell lines

    81th Annual Meeting of Japanese Biochemical Society  

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    Event date: 2008.12

  • ベータ・セクレターゼ活性をモニターするためのバイオマーカーの検索

    文部科学省特定領域研究「統合脳」第5領域冬のシンポジウム  

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    Event date: 2008.12

  • 髄液中の糖タンパク質の糖鎖に注目したバイオマーカーの検索

    第81回日本生化学会大会 シンポジウム  

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    Event date: 2008.12

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Industrial property rights

  • 髄液型糖タンパク質の富化及び分離方法、並びにその方法を用いた中枢神経系疾患用マーカーの探索方法及び中枢神経系疾患用マーカー

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    Property type:Patent

    Application no:特願2010-280753  Date applied:2010.12

    Publication no:特開2012-081701  Date published:2012.6

  • アミロイドβペプチド蓄積を伴う疾患の診断の為の可溶型アミロイドβ前駆体タンパク質770β切断産物の検出方法

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    Property type:Patent

    Application no:特願2010-171122  Date applied:2010.7

    Publication no:特開2012-015050  Date published:2012.2

  • 糖鎖バイオマーカーによる特発性正常圧水頭症の診断

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    Property type:Patent

    Application no:特願2008-293940  Date applied:2008.11

    Publication no:特開2010-121980  Date published:2010.6

Awards

  • 福島医学会賞

    2011.1  

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    Country:Japan

Research Projects

  • 脳脊髄液減少症の病態生理と診断法の開発

    2020.4 - 2021.3

  • 膵がん関連疾患のスクリーニング方法の開発

    2020.4 - 2021.3

  • グリオーマの体外診断薬の開発

    2019.4 - 2021.3

  • 膵がん関連疾患のスクリーニング方法の開発

    2019.4 - 2020.3

  • 髄液産生マーカーの迅速測定キットの開発

    2019.4 - 2020.3

  • 脳脊髄液減少症の病態生理と診断法の開発

    2019.4 - 2020.3

  • 脳脊髄液減少症における自律神経異常の関与の検討

    2017.4 - 2019.3

    荒木信夫、山元敏正、田村直俊、光藤尚、椎橋実智男、古谷友嗣、池田桂、川崎一史、大塚美恵子、橋本洋一郎、中根俊成、橋本康弘

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