The Wistar Institute gene expression and regulation program (Nishikura lab) 　Postdoctoral Fellow

2009.7 - 2012.10

独立行政法人 放射線医学総合研究所 　博士研究員

2007.7 - 2009.6

大阪府立大学 産学官連携イノベーションセンター　研究員

2007.4 - 2007.5

Cytogenetic Biodosimetry in Radiation Emergency Medicine: 2. Biosafety and Chemical Safety in Biodosimetry Laboratory

Kosuke Kasai, Yu Abe, Valerie Goh Swee Ting, Mai Tran Thanh, Yohei Fujishima, Ryo Nakayama, Kai Takebayashi, Akifumi Nakata, Kentaro Ariyoshi, Hiroyuki Hanada, Mitsuaki A. Yoshida, Katsuhiro Ito, Tomisato Miura

Radiation Environment and Medicine   11 ( 1 )   34 - 39   2022.3

Evaluation of Global DNA Methylation and Gene Expression of Izumo1 and Izumo1r in Gonads after High- and Low-Dose Radiation in Neonatal Mice

Akifumi Nakata, Keisuke Sato, Yohei Fujishima, Valerie Goh Swee Ting, Kanade Nakayama, Kentaro Ariyoshi, Chizuru Tsuruoka, Yi Shang, Daisuke Iizuka, Shizuko Kakinuma, Hideaki Yamashiro, Tomisato Miura

Biology   2021.12

Radiation emergency medical preparedness for cytogenetic biodosimetry in Hirosaki University, Japan

Tomisato Miura, Goh Valerie Swee Ting, Yohei Fujishima, Kai Takebayashi, Ryo Nakayama, Kosuke Kasai, Kentaro Ariyoshi, Takakiyo Tsujiguchi, Mitsuaki A. Yoshida

AIP Conference Proceedings   2021.11

Cytokinesis-block micronucleus assay performed in 0 and 2 Gy irradiated whole blood and isolated PBMCs in a 6-well transwell co-culture system

Valerie Swee Ting Goh, Kai Takebayashi, Ryo Nakayama, Yohei Fujishima, Mitsuaki A Yoshida, Kosuke Kasai, Kentaro Ariyoshi, Tomisato Miura

International Journal of Radiation Biology   2021.9

Morphological reproductive characteristics of testes and fertilization capacity of cryopreserved sperm after the Fukushima accident in raccoon (Procyon lotor)

Kazuki Komatsu, Tsugumi Iwasaki, Kosuke Murata, Hideaki Yamashiro, Goh Swee Ting Valerie, Ryo Nakayama, Yohei Fujishima, Takumi Ono, Yasushi Kino, Yoshinaka Simizu, Atsushi Takahashi, Hisashi Shinoda, Kentaro Ariyoshi, Kosuke Kasai, Masatoshi Suzuki, Maria Grazia Palmerini, Manuel Belli, Guido Macchiarelli, Toshitaka Oka, Manabu Fukumoto, Mitsuaki A Yoshida, Akifumi Nakata, Tomisato Miura

Reproduction in Domestic Animals   56 ( 3 )   484 - 497   2021.5

Human resource development for cytogenetic biodosimetry at Hirosaki University

Tomisato Miura, Kosuke Kasai, Yu Abe, Yohei Fujishima, Valerie Goh, Swee Ting, Ryo Nakayama, Kai Takebayashi, Naomi Sasaki, Kentaro Ariyoshi, Akifumi Nakata, Takakiyo Tsujiguchi, Katsuhiro Ito, Hiroyuki Hanada, Mitsuaki A. Yoshida

Radiation Environment and Medicine   10 ( 2 )   2021.4

ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

Yusuke Shiromoto, Masayuki Sakurai, Moeko Minakuchi, Kentaro Ariyoshi, Kazuko Nishikura

Nature Communications   2021.3

放射線誘発バイスタンダー効果およびレスキュー効果の実態と今後の展望

菓子野 元郎, 熊谷 純, 有吉 健太郎, 小嶋 光明

放射線生物研究   56 ( 2 )   19 - 36   2021.3

Transition of Radioactive Cesium Deposition in Reproductive Organs of Free-Roaming Cats in Namie Town, Fukushima

Yohei Fujishima, Yasushi Kino, Takumi Ono, Valerie Swee Ting Goh, Akifumi Nakata, Kentaro Ariyoshi, Kosuke Kasai,Tadashi Toyoda,Toru Akama, Hirofumi Tazoe, Masatoshi Yamada,Mitsuaki A. Yoshida, Tomisato Miura

Int. J. Environ. Res. Public Health   2021.2

Improved harvest and fixation methodology for isolated human peripheral blood mononuclear cells in cytokinesis-block micronucleus assay

Valerie Swee Ting Goh, Ryo Nakayama, William F Blakely, Yu Abe, Christelle En Lin Chua, Zi Huai Chew , Akifumi Nakata, Yohei Fujishima, Mitsuaki A Yoshida, Kosuke Kasai, Kentaro Ariyoshi, Tomisato Miura

International Journal of Radiation Biology   97 ( 2 )   194 - 207   2021.2

Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation

Kentaro Ariyoshi, Yota Hiroyama, Naoya Fujiwara, Tomisato Miura, Kosuke Kasai, Akifumi Nakata, Yohei Fujishima, Valerie Swee Ting Goh, Mitsuaki A Yoshida

Journal of Radiation Research   62 ( 1 )   73 - 78   2021.1

Metal coordination by L-amino acid oxidase derived from flounder Platichthys stellatus is structurally essential and regulates antibacterial activity

Kosuke Kasai, Yudai Ito, Akihide Nitta, Kentaro Ariyoshi, Toshiya Nakamura, Tomisato Miura

Applied Microbiology and Biotechnology   2020.9

Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability

Kentaro Ariyoshi, Tomisato Miura, Kosuke Kasai, Valerie Swee Ting Goh, Yohei Fujishima, Akifumi Nakata, Atsushi Takahashi, Yoshinaka Shimizu, Hisashi Shinoda, Hideaki Yamashiro, Colin Seymour, Carmel Mothersill, Mitsuaki A Yoshida

International Journal of Radiation Biology   2020.8

From tangled banks to toxic bunnies; a reflection on the issues involved in developing an ecosystem approach for environmental radiation protection

Carmel E Mothersill, Deborah H. Oughton, Paul N. Schofield, Michael Abend, Christelle Adam-Guillermin, Kentaro Ariyoshi, Nicholas A. Beresford, Andrea Bonisoli-Alquati, Jason Cohen, Yuri Dubrova, Stanislav A. Geras’kin, Tanya Helena Hevrøy, Kathryn A. Higley, Nele Horemans, Awadhesh N. Jha, Lawrence A. Kapustka, Juliann G. Kiang, Balázs G. Madas, Gibin Powathil, Elena I. Sarapultseva, Colin B. Seymour, Nguyen T. K. Vo, Michael D. Wood

International Journal of Radiation Biology   2020.7

Cellular kinetics of hematopoietic cells with Sfpi1 deletion are present at different frequencies in bone-marrow and spleen in X-irradiated mice

Reo Etani, Mitsuaki Ojima, Kentaro Ariyoshi, Yohei Fujishima, Michiaki Kai

International Journal of Radiation Biology   2020.7

Assessment of chromosome aberrations in large Japanese field mice (Apodemus speciosus) in Namie Town, Fukushima

Yohei Fujishima, Akifumi Nakata, Risa Ujiie, Kosuke Kasai, Kentaro Ariyoshi, Valerie Swee Ting Goh, Kojun Suzuki, Hirofumi Tazoe, Masatoshi Yamada, Mitsuaki A. Yoshida, Tomisato Miura

International Journal of Radiation Biology   2020.6

Analysis of Radioactive Elements in Testes of Large Japanese Field Mice Using an Electron Probe Micro-Analyser after the Fukushima Accident

Takuya Ohdaira, Kanna Meguro, Kazuki Komatsu, Rina Syoji, Yohei Fujishima, Valerie Swee, Ting Goh, Kosuke Kasai, Kentaro Ariyoshi, Akifumi Nakata, Yusuke Urushihara, Kazuma Koarai, Yasushi Kino, Tsutomu Sekine, Masatoshi Suzuki, Atsushi Takahasi, Yoshinaka Shimizu, Hisashi Shinoda, Mitsuaki A. Yoshida, Manabu Fukumoto, Hideaki Yamashiro, Tomisato Miura

IntecOpen   2020.1

Construction of fluorescence in situ hybridization (FISH) translocation dose-response calibration curve with multiple donor data sets using R, based on ISO 20046:2019 recommendations.

Valerie Swee Ting Goh, Yohei Fujishima, Yu Abe, Akira Sakai, Mitsuaki A. Yoshida, Kentaro Ariyoshi, Kosuke Kasai, Ruth C. Wilkins, William Francis Blakely, Tomisato Miura

International Journal of Radiation Biology   2019.9

Dose-Rate-Dependent PU.1 Inactivation to Develop Acute Myeloid Leukemia in Mice through Persistent Stem Cell Proliferation after Acute or Chronic Gamma Irradiation.

Ojima Mitsuaki, Hirouchi Tokuhisas, Etani Reo, Ariyoshi Kentaro, Kai Michiaki.

Radiation Research   2019.9

Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles

Kentaro Ariyoshi, Tomisato Miura, Kosuke Kasai, Yohei Fujishima, Akifumi Nakata, Mitsuaki Yoshida

Scientific Reports   2019.6

Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells.

Ariyoshi K, Miura T, Kasai K, Akifumi N, Fujishima Y, Yoshida MA

Radiation Research   2018.10（ ISSN:0033-7587 ）

Influence of anticoagulants and storage temperatures on blood counts and mitotic index of blood samples collected for cytogenetic biodosimetry.

Fujishima Y, Kanahama S, Hagino S, Natsubori S, Saito H, Azumaya A, Ariyoshi K, Nakata A, Kasai K, Yamada K, Mariya Y, Yoshida MA, Miura T

International journal of radiation biology   95 ( 2 )   1 - 21   2018.10（ ISSN:0955-3002 ）

Radiation-induced bystander effect in large Japanese field mouse (Apodemus speciosus) embryonic cells

Ariyoshi Kentaro, Miura Tomisato, Kasai Kosuke, Akifumi Nakata, Fujishima Yohei, Yoshida Mitsuaki A.

Radiation and Environmental Biophysics   57 ( 3 )   223 - 231   2018.8（ ISSN:0301-634X ）

Dynamic landscape and regulation of RNA editing in mammals

Nature   550 ( 7675 )   249 - +   2017.10（ ISSN:0028-0836 ）

Rapid isolation of murine primary hepatocytes for chromosomal analysis

Ariyoshi Kentaro, Fujishima Yohei, Miura Tomisato, Shang Yi, Kakinuma Shizuko, Yoshiya Shimada, Kasai Kosuke, Nakata Akifumi, Tachibana Akira, Yoshida Mitsuaki A.

In Vitro Cellular & Developmental Biology - Animal   53 ( 5 )   474 - 478   2017.5（ ISSN:1071-2690 ）

細胞遺伝学的被ばく線量評価における抗凝固剤および血液保存温度の影響

金浜 朱希, 藤嶋 洋平, 川森 詩織, 成田 房恵, 萩野 繁樹, 有吉 健太郎, 吉田 光明, 山田 恭吾, 真里谷 靖, 三浦 富智

青臨技会誌   41   24 - 27   2016.12（ ISSN:1340-3060 ）

Induction of genomic instability and activation of autophagy in artificial human aneuploid cells

Ariyoshi Kentaro, Miura Tomisato, Kasai Kosuke, Fujishima Yohei, Oshimura Mitsuo, Yoshida Mitsuaki A.

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis   790   19 - 30   2016.8（ ISSN:0027-5107 ）

Promoted instability in an X-ray irradiated chromosome transferred into Werner syndrome cells.

Ariyoshi K, Suzuki K, Watanabe M, Kodama S.

Radiation Emergency Medicine   4   40 - 46   2015

成体期と異なる発達期の組織の放射線応答

有吉健太郎、柿沼志津子、島田義也

放射線科学   58 ( 3 )   6 - 7   2015

放射線被ばくによるマウス骨髄性白血病発症機構の考察

有吉 健太郎, 柿沼 志津子, 島田 義也

放射線生物研究   49 ( 3 )   284 - 292   2014.9（ ISSN:0441-747X ）

造血幹細胞と前駆細胞の生存に対する照射年齢の影響(Effect of age at exposure on hematopoietic stem and progenitor survival)

Ariyoshi Kentaro, Shimada Yoshiya

Annual Report of the National Institute of Radiological Science   ( 52 )   60 - 61   2014.8（ ISSN:0439-5956 ）

Age Dependence of Hematopoietic Progenitor Survival and Chemokine Family Gene Induction after Gamma Irradiation in Bone Marrow Tissue in C3H/He Mice

Ariyoshi Kentaro, Takabatake Takashi, Shinagawa Mayumi, Kadono Kyoko, Daino Kazuhiro, Imaoka Tatsuhiko, Kakinuma Shizuko, Nishimura Mayumi, Shimada Yoshiya

Radiation Research   181 ( 3 )   302 - 313   2014.3（ ISSN:0033-7587 ）

放射線被ばくによるマウス骨髄性白血病発症機構の考察

有吉健太郎、柿沼志津子、島田義也

放射線生物研究   49   284 - 292   2014

Antagonistic and stimulative roles of ADAR1 in RNA silencing.

Nishikura K, Sakurai M, Ariyoshi K, Ota H

RNA Biology   10 ( 8 )   1240 - 1247   2013.8（ ISSN:1547-6286 ）

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

Ota Hiromitsu, Sakurai Masayuki, Gupta Ravi, Valente Louis, Wulff Bjorn-Erik, Ariyoshi Kentaro, Iizasa Hisashi, Davuluri Ramana V., Nishikura Kazuko

Cell   153 ( 3 )   575 - 589   2013.4（ ISSN:0092-8674 ）

Specifications of a neutron exposure accelerator system for biological effects experiments (NASBEE) in NIRS

Suda Mitsuru, Hagihara Takuya, Suya Noriyoshi, Hamano Tsuyoshi, Takada Masashi, Konishi Teruaki, Maeda Takeshi, Ohmachi Yasushi, Kakinuma Shizuko, Ariyoshi Kentaro, Shimada Yoshiya, Imaseki Hitoshi

Radiation Physics and Chemistry   78 ( 12 )   1216 - 1219   2009.12（ ISSN:0969-806X ）

Introduction of a Normal Human Chromosome 8 Corrects Abnormal Phenotypes of Werner Syndrome Cells Immortalized by Expressing an hTERT Gene

Ariyoshi Kentaro, Suzuki Keiji, Goto Makoto, Oshimura Mitsuo, Ishizaki Kanji, Watanabe Masami, Kodama Seiji

Journal of Radiation Research   50 ( 3 )   253 - 259   2009.5（ ISSN:0449-3060 ）

Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells

Ariyoshi Kentaro, Suzuki Keiji, Goto Makoto, Watanabe Masami, Kodama Seiji

Journal of Radiation Research   48 ( 3 )   219 - 231   2007.5（ ISSN:0449-3060 ）

Telomere biology: Implications for radiation carcinogenesis.

Int. Congr. Series   1299   242 - 247   2007

DNA損傷応答とテロメア維持機構の不可解な相関

有吉健太郎、渡邉正己、児玉靖司

放射線生物研究   41   264 - 272   2006

放射性物質汚染地域に生息するアカネズミ骨髄前駆細胞への放射線影響解析

日本放射線影響学会第60回大会  

Autophagy protects from aneuploidy-induced genomic instability

日本放射線影響学会第59回大会  

放射線誘発悪性腫瘍の発生に関する染色体異常の解析

日本放射線影響学会第59回大会  

Absence of Radiation Induced Genomic Instability in Hematopoietic Stem Cells of Infant Mouse

15th International Congress of Radiation Research  

Current Status of Cytogenetic Biodosemetry in Radiation Emergency Medicine

FNCA Workshop on Radiation Oncology Open lecture  

Absence of radiation induced genomic instability in hematopoietic stem cells of infant mouse

日本放射線影響学会第57回大会  

X線被ばく染色体の不安定性解析

第41回放射線影響懇話会  

Radiation-induced marked reduction in hematopoietic progenitor cells in infant leukemia prone C3H/He mouse

14th International Congress of Radiation Research  

幼児-発達期C3H/Heマウス由来造血幹細胞/前駆細胞の放射線感受性

第31回日本分子生物学会年会  

骨髄中の造血幹細胞・造血前駆細胞に対する被ばく時年齢依存的放射線感受性

日本放射線影響学会第51回大会  

ウェルナー症候群細胞でみられた染色体異常とDNA二重鎖切断の亢進

第30回日本分子生物学会年会  

ウェルナー症候群細胞でみられた染色体異常とDNA二重鎖切断の亢進

第30回日本分子生物学会年会  

Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells

13th International Congress of Radiation Research  

ウェルナー症候群細胞におけるテロメア脆弱性

日本放射線影響学会第49回大会  

ウェルナー症候群細胞における染色体不安定化メカニズムの解析

第28回日本分子生物学会  

ウェルナー症候群細胞に導入した被ばく染色体の不安定性解析

日本放射線影響学会第48 回大会  

ウェルナー症候群細胞にみられる異常形質のWRN遺伝子発現による相補性解析

日本放射線影響学会第46 回大会  

放射線被ばくマウスの組織・臓器における染色体異常解析

2019.4 - 2020.3

RNA 編集酵素 ADAR1 の関与する DNA 修復機構の解明

2019.3 - 2020.4

福島県浪江町に生息するプラナリアを用いた低線量放射線の影響調査

2018.4 - 2019.3

放射線影響モデル動物を利用した生物影響解明のための多元的アプローチ

2017.4 - 2019.3

三浦富智、有吉健太郎

放射線被ばくマウスの組織・臓器における染色体異常解析

2017.4 - 2018.3

細胞同調法及びFISH法を応用した新たな高精度染色体線量評価法の確立

2016.4 - 2018.3

吉田光明、有吉健太郎

メタボリックシンドロームに適用する被ばく線量評価用検量線は必要か?

2016.4 - 2018.3

三浦富智、有吉健太郎

RNA編集酵素ADAR1が関与するゲノム安定化機構の解明

2016.4 - 2018.3

放射線被ばくマウスの組織・臓器における染色体異常解析

2016.4 - 2017.3

低線量率放射線長期連続照射によるマウス急性骨髄生白血病の起因となるPU.1遺伝子変異の線量率依存性の解析〜放射線発がんの線量率効果の仕組みを考える〜

2015.4 - 2017.3

甲斐倫明、有吉健太郎

RNA編集とDNA修復のクロストーク

2015.4 - 2016.3

マウス組織幹細胞・前駆細胞における放射線被ばく後のDNA損傷修復動態に関する研究

2009.4 - 2010.3

弘前大学生体応答科学研究センター委員

2014.4 - 2019.9

NHKスペシャル「被曝の森～原発事故５年目の記録～」

2014.4 - 2016.3