Autonomous and intercellular chemokine signaling elicited from mesenchymal stem cells regulates migration of undifferentiated gastric cancer cells.

Daiki Okamoto, Natsuko Yamauchi, Gosuke Takiguchi, Michiru Nishita, Yoshihiro Kakeji, Yasuhiro Minami, Koki Kamizaki

Genes to cells : devoted to molecular & cellular mechanisms   27 ( 5 )   368 - 375   2022.3（ ISSN:1356-9597 ）

Characterization of morphological alterations in micropapillary adenocarcinoma of the lung using an established cell line.

Sonoda D, Kamizaki K, Matsuo Y, Aruga K, Mikubo M, Yamashita K, Nishita M, Minami Y, Satoh Y

Oncology reports   47 ( 1 )   2022.1（ ISSN:1021-335X ）

雄の外生殖器形成過程でWnt5aにみられる、各発生段階に応じた様々な機能(Stage-dependent function of Wnt5a during male external genitalia development)

Alcantara Mellissa C., Suzuki Kentaro, Acebedo Alvin R., Sakamoto Yuki, Nishita Michiru, Minami Yasuhiro, Kikuchi Akira, Yamada Gen

Congenital Anomalies   61 ( 6 )   212 - 219   2021.11（ ISSN:0914-3505 ）

Stage-dependent function of Wnt5a during male external genitalia development.

Alcantara MC, Suzuki K, Acebedo AR, Sakamoto Y, Nishita M, Minami Y, Kikuchi A, Yamada G

Congenital anomalies   61 ( 6 )   212 - 219   2021.7（ ISSN:0914-3505 ）

Oncogenic E6 and/or E7 proteins drive proliferation and invasion of human papilloma virus‑positive head and neck squamous cell cancer through upregulation of Ror2 expression.

Mehmet Ozgur Avincsal, Koki Kamizaki, Naoe Jimbo, Hirotaka Shinomiya, Ken-Ichi Nibu, Michiru Nishita, Yasuhiro Minami

Oncology reports   46 ( 1 )   2021.7（ ISSN:1021-335X ）

間葉系幹細胞に由来するCXCL16はSTAT3が媒介するRor1発現によって胃癌細胞の進行を促進する(Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1)

Ikeda Taro, Nishita Michiru, Hoshi Kyoka, Honda Takashi, Kakeji Yoshihiro, Minami Yasuhiro

Cancer Science   111 ( 4 )   1254 - 1265   2020.4（ ISSN:1347-9032 ）

癌浸潤の戦術　孤立性浸潤と集団性浸潤(Tactics of cancer invasion: solitary and collective invasion)

Nagai Tomoaki, Ishikawa Tomohiro, Minami Yasuhiro, Nishita Michiru

The Journal of Biochemistry   167 ( 4 )   347 - 355   2020.4（ ISSN:0021-924X ）

Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1.

Ikeda T, Nishita M, Hoshi K, Honda T, Kakeji Y, Minami Y

Cancer science   111 ( 4 )   1254 - 1265   2020.2（ ISSN:1347-9032 ）

Tactics of cancer invasion: solitary and collective invasion.

Nagai T, Ishikawa T, Minami Y, Nishita M

Journal of biochemistry   167 ( 4 )   347 - 355   2020.1（ ISSN:0021-924X ）

浸潤突起形におけるKIF1Cの機能

佐事武, 西田満, 西田満, 遠藤光晴, 岡田康志, 岡田康志, 岡田康志, 南康博

日本分子生物学会年会プログラム・要旨集(Web)   43rd   2020

Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.

Miao W, Sakai K, Sato H, Imamura R, Jangphattananont N, Takagi J, Nishita M, Minami Y, Matsumoto K

Cancer science   110 ( 10 )   3340 - 3349   2019.10（ ISSN:1347-9032 ）

肺癌において細胞外SEMAドメインにあるミスセンス突然変異によって生じるリガンド依存性MET活性化の障害(Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer)

Miao Wenyu, Sakai Katsuya, Sato Hiroki, Imamura Ryu, Jangphattananont Nawaphat, Takagi Junichi, Nishita Michiru, Minami Yasuhiro, Matsumoto Kunio

Cancer Science   110 ( 10 )   3340 - 3349   2019.10（ ISSN:1347-9032 ）

Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi-associated microtubules.

Aoki T, Nishita M, Sonoda J, Ikeda T, Kakeji Y, Minami Y

Cancer science   110 ( 4 )   1306 - 1316   2019.4（ ISSN:1347-9032 ）

Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants.

Weissenböck M, Latham R, Nishita M, Wolff LI, Ho HH, Minami Y, Hartmann C

Genes to cells : devoted to molecular & cellular mechanisms   24 ( 4 )   307 - 317   2019.4（ ISSN:1356-9597 ）

【Wntシグナルと骨】非古典的Wntシグナルと細胞応答

西田 満, 佐事 武, 南 康博

Clinical Calcium   29 ( 3 )   291 - 297   2019.2（ ISSN:0917-5857 ）

【Wntシグナルと骨】非古典的Wntシグナルと細胞応答

西田 満, 佐事 武, 南 康博

Clinical Calcium   29 ( 3 )   291 - 297   2019.2（ ISSN:0917-5857 ）

Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus.

Kishimoto K, Tamura M, Nishita M, Minami Y, Yamaoka A, Abe T, Shigeta M, Morimoto M

Nature communications   9 ( 1 )   2816   2018.7

Critical role of the Ror-family of receptor tyrosine kinases in invasion and proliferation of malignant pleural mesothelioma cells.

Saji T, Nishita M, Ogawa H, Doi T, Sakai Y, Maniwa Y, Minami Y

Genes to cells : devoted to molecular & cellular mechanisms   23 ( 7 )   606 - 613   2018.7（ ISSN:1356-9597 ）

Expression of Ror2 Associated with Fibrosis of the Submandibular Gland.

Takahashi D, Suzuki H, Kakei Y, Yamakoshi K, Minami Y, Komori T, Nishita M

Cell structure and function   42 ( 2 )   159 - 167   2017.12（ ISSN:0386-7196 ）

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.

Uehara S, Udagawa N, Mukai H, Ishihara A, Maeda K, Yamashita T, Murakami K, Nishita M, Nakamura T, Kato S, Minami Y, Takahashi N, Kobayashi Y

Science signaling   10 ( 494 )   2017.8（ ISSN:1945-0877 ）

Regulatory mechanisms and cellular functions of non-centrosomal microtubules.

Nishita M, Satake T, Minami Y, Suzuki A

Journal of biochemistry   162 ( 1 )   1 - 10   2017.7（ ISSN:0021-924X ）

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.

Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y

Scientific reports   7 ( 1 )   1   2017.1

ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.

Diaz-Horta O, Abad C, Sennaroglu L, Foster J 2nd, DeSmidt A, Bademci G, Tokgoz-Yilmaz S, Duman D, Cengiz FB, Grati M, Fitoz S, Liu XZ, Farooq A, Imtiaz F, Currall BB, Morton CC, Nishita M, Minami Y, Lu Z, Walz K, Tekin M

Proceedings of the National Academy of Sciences of the United States of America   113 ( 21 )   5993 - 8   2016.5（ ISSN:0027-8424 ）

Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation.

Qi X, Okinaka Y, Nishita M, Minami Y

Genes to cells : devoted to molecular & cellular mechanisms   21 ( 4 )   325 - 34   2016.4（ ISSN:1356-9597 ）

Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis.

Takiguchi G, Nishita M, Kurita K, Kakeji Y, Minami Y

Cancer science   107 ( 3 )   290 - 7   2016.3（ ISSN:1347-9032 ）

【知る・見る・活かす!シグナリング研究2015　シグナル伝達の要素発見から時空間ダイナミクスへ】(第2章)シグナリングから見た生命現象　その破綻と疾患の理解　Wnt5a-Ror2シグナルによるがんの浸潤制御

西田 満, 西尾 忠, 南 康博

実験医学   33 ( 10 )   1612 - 1616   2015.6（ ISSN:0288-5514 ）

Insight into the role of Wnt5a-induced signaling in normal and cancer cells.

Endo M, Nishita M, Fujii M, Minami Y

International review of cell and molecular biology   314   117 - 48   2015（ ISSN:1937-6448 ）

Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.

Homma Y, Kanno S, Sasaki K, Nishita M, Yasui A, Asano T, Ohashi K, Mizuno K

The Journal of biological chemistry   289 ( 38 )   26302 - 13   2014.9（ ISSN:0021-9258 ）

Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding.

Nishita M, Qiao S, Miyamoto M, Okinaka Y, Yamada M, Hashimoto R, Iijima K, Otani H, Hartmann C, Nishinakamura R, Minami Y

Molecular and cellular biology   34 ( 16 )   3096 - 105   2014.8（ ISSN:0270-7306 ）

尿管芽形成におけるWnt5a-Ror2シグナルの役割

西田 満, 喬 森, 宮本 真里, 沖中 由佳, 山田 真紀子, 飯島 一誠, 大谷 浩, Hartmann Christine, 西中村 隆一, 南 康博

発達腎研究会誌   22 ( 1 )   11 - 14   2014.4（ ISSN:0919-7532 ）

Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.

Doi R, Endo M, Yamakoshi K, Yamanashi Y, Nishita M, Fukada S, Minami Y

Genes to cells : devoted to molecular & cellular mechanisms   19 ( 4 )   287 - 96   2014.4（ ISSN:1356-9597 ）

Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene.

Mori K, Kitazawa R, Kondo T, Mori M, Hamada Y, Nishida M, Minami Y, Haraguchi R, Takahashi Y, Kitazawa S

PloS one   9 ( 7 )   e102797   2014

Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis.

Li X, Yamagata K, Nishita M, Endo M, Arfian N, Rikitake Y, Emoto N, Hirata K, Tanaka Y, Minami Y

Genes to cells : devoted to molecular & cellular mechanisms   18 ( 7 )   608 - 19   2013.7（ ISSN:1356-9597 ）

【Wntシグナルと骨】非古典的Wntシグナルの情報伝達と細胞応答

西田 満, 遠藤 光晴, 南 康博

Clinical Calcium   23 ( 6 )   809 - 815   2013.5（ ISSN:0917-5857 ）

Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.

Endo M, Doi R, Nishita M, Minami Y

Journal of cell science   125 ( Pt 8 )   2017 - 29   2012.4（ ISSN:0021-9533 ）

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

Maeda K, Kobayashi Y, Udagawa N, Uehara S, Ishihara A, Mizoguchi T, Kikuchi Y, Takada I, Kato S, Kani S, Nishita M, Marumo K, Martin TJ, Minami Y, Takahashi N

Nature medicine   18 ( 3 )   405 - 12   2012.2（ ISSN:1078-8956 ）

Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.

Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, Minami Y

The Journal of biological chemistry   287 ( 2 )   1588 - 99   2012.1（ ISSN:0021-9258 ）

Analysis of Wnt/planar cell polarity pathway in cultured cells.

Endo M, Nishita M, Minami Y

Methods in molecular biology (Clifton, N.J.)   839   201 - 14   2012（ ISSN:1064-3745 ）

Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition.

Ren D, Minami Y, Nishita M

Genes to cells : devoted to molecular & cellular mechanisms   16 ( 3 )   304 - 15   2011.3（ ISSN:1356-9597 ）

Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.

Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, Inaba D, Qiao S, Takada S, Kikuchi A, Minami Y

Molecular and cellular biology   30 ( 14 )   3610 - 9   2010.7（ ISSN:0270-7306 ）

Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells.

Nishita M, Enomoto M, Yamagata K, Minami Y

Trends in cell biology   20 ( 6 )   346 - 54   2010.6（ ISSN:0962-8924 ）

Ror2 is required for midgut elongation during mouse development.

Yamada M, Udagawa J, Matsumoto A, Hashimoto R, Hatta T, Nishita M, Minami Y, Otani H

Developmental dynamics : an official publication of the American Association of Anatomists   239 ( 3 )   941 - 53   2010.3（ ISSN:1058-8388 ）

Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases.

Minami Y, Oishi I, Endo M, Nishita M

Developmental dynamics : an official publication of the American Association of Anatomists   239 ( 1 )   1 - 15   2010.1（ ISSN:1058-8388 ）

Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.

Enomoto M, Hayakawa S, Itsukushima S, Ren DY, Matsuo M, Tamada K, Oneyama C, Okada M, Takumi T, Nishita M, Minami Y

Oncogene   28 ( 36 )   3197 - 208   2009.9（ ISSN:0950-9232 ）

Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development.

He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen Y

Development (Cambridge, England)   135 ( 23 )   3871 - 9   2008.12（ ISSN:0950-1991 ）

Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.

Nomachi A, Nishita M, Inaba D, Enomoto M, Hamasaki M, Minami Y

The Journal of biological chemistry   283 ( 41 )   27973 - 81   2008.10（ ISSN:0021-9258 ）

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.

Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H

Developmental cell   15 ( 1 )   23 - 36   2008.7（ ISSN:1534-5807 ）

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.

Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P

BMC molecular biology   9   11   2008.1

Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2.

Yamamoto H, Yoo SK, Nishita M, Kikuchi A, Minami Y

Genes to cells : devoted to molecular & cellular mechanisms   12 ( 11 )   1215 - 23   2007.11（ ISSN:1356-9597 ）

Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration.

Nishita M, Yoo SK, Nomachi A, Kani S, Sougawa N, Ohta Y, Takada S, Kikuchi A, Minami Y

The Journal of cell biology   175 ( 4 )   555 - 62   2006.11（ ISSN:0021-9525 ）

[Role of cofilin phosphorylation in cell migration].

Nishita M, Mizuno K

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   51 ( 6 Suppl )   516 - 21   2006.5（ ISSN:0039-9450 ）

MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.

Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K

The EMBO journal   25 ( 4 )   713 - 26   2006.2（ ISSN:0261-4189 ）

Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.

Nishita M, Tomizawa C, Yamamoto M, Horita Y, Ohashi K, Mizuno K

The Journal of cell biology   171 ( 2 )   349 - 59   2005.10（ ISSN:0021-9525 ）

The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon.

Kani S, Oishi I, Yamamoto H, Yoda A, Suzuki H, Nomachi A, Iozumi K, Nishita M, Kikuchi A, Takumi T, Minami Y

The Journal of biological chemistry   279 ( 48 )   50102 - 9   2004.11（ ISSN:0021-9258 ）

Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing.

Tomiyoshi G, Horita Y, Nishita M, Ohashi K, Mizuno K

Genes to cells : devoted to molecular & cellular mechanisms   9 ( 6 )   591 - 600   2004.6（ ISSN:1356-9597 ）

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.

Nagata-Ohashi K, Ohta Y, Goto K, Chiba S, Mori R, Nishita M, Ohashi K, Kousaka K, Iwamatsu A, Niwa R, Uemura T, Mizuno K

The Journal of cell biology   165 ( 4 )   465 - 71   2004.5（ ISSN:0021-9525 ）

Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion.

Nishita M, Wang Y, Tomizawa C, Suzuki A, Niwa R, Uemura T, Mizuno K

The Journal of biological chemistry   279 ( 8 )   7193 - 8   2004.2（ ISSN:0021-9258 ）

Involvement of NLK and Sox11 in neural induction in Xenopus development.

Hyodo-Miura J, Urushiyama S, Nagai S, Nishita M, Ueno N, Shibuya H

Genes to cells : devoted to molecular & cellular mechanisms   7 ( 5 )   487 - 96   2002.5（ ISSN:1356-9597 ）

Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis.

Nishita M, Aizawa H, Mizuno K

Molecular and cellular biology   22 ( 3 )   774 - 83   2002.2（ ISSN:0270-7306 ）

Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.

Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T

Genes & development   14 ( 14 )   1741 - 9   2000.7（ ISSN:0890-9369 ）

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, Cho KW

Nature   403 ( 6771 )   781 - 5   2000.2（ ISSN:0028-0836 ）

Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.

Nishita M, Ueno N, Shibuya H

Genes to cells : devoted to molecular & cellular mechanisms   4 ( 10 )   583 - 91   1999.10（ ISSN:1356-9597 ）

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.

Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E

The Journal of biological chemistry   274 ( 38 )   27161 - 7   1999.9（ ISSN:0021-9258 ）

The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.

Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K

Nature   399 ( 6738 )   798 - 802   1999.6（ ISSN:0028-0836 ）

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.

Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K

The EMBO journal   18 ( 1 )   179 - 87   1999.1（ ISSN:0261-4189 ）

Nuclear translocation and increased expression of Bax and disturbance in cell cycle progression without prominent apoptosis induced by hyperthermia.

Nishita M, Inoue S, Tsuda M, Tateda C, Miyashita T

Experimental cell research   244 ( 1 )   357 - 66   1998.10（ ISSN:0014-4827 ）

BRAM1, a BMP receptor-associated molecule involved in BMP signalling.

Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H

Genes to cells : devoted to molecular & cellular mechanisms   3 ( 4 )   257 - 64   1998.4（ ISSN:1356-9597 ）

Induction of lateral outgrowths on the chelae of the crayfish, Procambarus clarkii (Girard).

Murayama, O., Nakatani, I., and Nishita, M.

Crustacean Res.   23   69 - 73   1994

Lippincott's Illustrated Reviews

2008 

Lippincott's Illustrated Reviews

2005 

Ror1 promotes invasion of lung adenocarcinoma cells through small GTPase Rif-mediated filopodia formation.

ASCB/EMBO 2018 meeting  

IFT20は大腸がん細胞の集団的浸潤における先導細胞の極性を制御する

第41回日本分子生物学会年会  

Ror1はSmgGDS-Rif経路を介して肺腺がん細胞の糸状突起形成と浸潤を促進する

第77回日本癌学会学術総会  

Rif低分子量Gタンパク質による核膜タンパク質の動態制御と老化との関連

AMED「老化メカニズムの解明・制御プロジェクト」第1回リトリート  

Novel role of Ror2 signaling in regulating Golgi structure and polarity for tumor cell invasion

International Joint Symposium in Kobe 2017 University of Washington University of Oslo and Kobe University  

がん細胞浸潤におけるRor2受容体型チロシンキナーゼの新たな機能

第39回日本分子生物学会年会  

IFT20はゴルジ体における微小管形成を促進することでRor2シグナル依存的ながん細胞浸潤を制御する

第39回日本分子生物学会年会  

Ror2受容体型チロシンキナーゼのがんー胎児タンパク質としての機能

第75回日本癌学会総会学術総会  

Wnt5a-Ror2シグナルは繊毛タンパク質IFT20の発現誘導を介してがん細胞の浸潤を制御する

第38回日本分子生物学会年会  

Novel role for Wnt5a-Ror2 signaling in regulating polarity and structure of the Golgi apparatus in osteosarcoma cells.

University of Washington-Kobe University Joint Symposium on Cell Signaling  

Wnt5a-Ror2 signaling induces expression of the ciliary protein IFT20 to regulate the integrity of the Golgi apparatus and reorientation of the centrosome during tumor cell invasion

新学術領域研究「上皮管腔組織形成」 第2回国際シンポジウム  

Role of Wnt5a-Ror signaling in morphogenesis of the metanephric mesenchyme during ureteric budding

新学術領域研究「上皮管腔組織形成」 第2回国際シンポジウム  

繊毛タンパク質IFT20による骨肉腫細胞の浸潤制御

第7回シグナルネットワーク研究会  

Role of Wnt5a-Ror2 signaling in tumor invasion

University of Washington and Kobe University International Joint Symposium  

Role of Wnt5a-Ror2 signaling in patterning the metanephric mesenchyme during ureteric budding

Keystone Symposia "Developmental Pathways and Cancer: Wnt, Notch and Hedgehog(J7)"  

尿管芽形成におけるWnt5a-Ror2シグナルの役割と腎尿路奇形

第22回発達腎研究会  

炎症性サイトカインによりアストロサイトで発現誘導されるRor1受容体の機能解析

2013年度包括脳ネットワーク夏のワークショップ  

Roles of Wnt/PCP signaling in pathological conditions of epithelial tubular tissues

First International Meeting for Epithelial Tubulology  

マウス腎臓発生におけるWnt5a・Ror2シグナルの役割

第35回日本分子生物学会年会  

The Role of Ror-Family Receptor Tyrosine Kinases in Maintaining Neocortical Neural Progenitor Cells

1st International Symposium Neocortical Organization  

Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex

第63回日本細胞生物学会大会  

Wnt5a-Ror2シグナルによる細胞極性•移動制御とがんの浸潤

第62回日本細胞生物学会大会  

Ror2受容体型チロシンキナーゼによる細胞極性・移動制御におけるタンパク質リン酸化の役割

第82回日本生化学会大会  

Ror2受容体型チロシンキナーゼを介したWnt5aシグナル伝達制御

第1回シグナルネットワーク研究会  

受容体型チロシンキナーゼRor2はアクチン結合蛋白質filamin Aを介してWnt5aによるc-Jun N-terminalキナーゼの活性化と細胞極性・移動を制御する

第31回日本分子生物学会第81回日本生化学会大会合同大会  

Wnt5a/Ror2シグナルによるDishevelledの動態制御

第31回日本分子生物学会年会 第81回日本生化学会大会 合同大会  

Wnt5a/Ror2シグナルによる細胞運動制御

第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会  

Wnt5a/Ror2経路はMMP-13を介して骨肉腫細胞のinvadopodia形成と浸潤を制御する

第31回日本分子生物学会年会 第81回日本生化学会大会 合同大会  

Regulation of Dishevelled in Wnt5a/Ror2 signaling

第２回日韓共同研究プログラム合同ミーティング  

Ror2 regulates cytoskeletal rearrangements to mediate Wnt5a-induced polarized cell migration

第30回日本分子生物学会  

Ror2 receptor tyrosine kinase and its implication in human diseases

日韓共同研究プログラム第１回二国間会議  

Role of Ror2 receptor tyrosine kinase in the regulation of Wnt5a-induced cell polarization and migration

日韓共同研究プログラム第１回二国間会議  

Roles of receptor tyrosine kinase Ror2 in Wnt5a-induced non-canonical Wnt signaling

WNT2007INLAJOLLA  

Wnt5aによる細胞移動におけるRor2の機能解析

日本分子生物学会2006フォーラム  

Roles for Ror2 receptor tyrosine kinase in the regulation of Wnt5a signaling and cell migration

2006 international symposium of kobe university 21st century COE program on signsl transduction in memory of Prof. Yasutomi Nkaishizu  

Regulation of Wnt5a-induced cell migration by Ror2 receptor tyrosine kinase

20th IUBMB Congress  

Roles for Ror2 receptor tyrosine kinase in the regulation of Wnt5a signaling and cell migration

2006 international symposium of kobe university 21st century COE program on signsl transduction in memory of Prof. Yasutomi Nishizuka  

受容体型チロシンキナーゼRor2によるWnt/PCP経路の制御とその細胞運動における役割

第28回日本分子生物学会  

Ror2-mediated cytoskeletal reorganization by differential regulation of Dishevelled proteins

第58回日本細胞生物学会大会  

受容体型チロシンキナーゼRor2の細胞外・細胞内ドメイン依存的機能によるWntシグナルおよび細胞骨格系の制御

第52回日本生化学会近畿支部例会  

PI3-kinase-Mediated Activation of Cofilin Phosphatase Slingshot-1L Controls Insulin-induced Membrane Protrusion

the 43rd American Society for Cell Biology Annual Meeting  

Phosphorylation and activation of LIM-kinase 1 by p38 MAP-kinase in vascular endothelial growth factor-induced actin reorganization

The Gordon Research Conference on Mechanisms of Cell Signalling  

集団的がん細胞浸潤を司るリーダー細胞の特性解明

2020.4 - 2021.3

がん細胞浸潤におけるゴルジ体内タンパク質輸送の分子機構

2018.4 - 2020.3

西田 満

Functional analysis of Ror1-Rif signaling in malignant progression of non-small cell lung cancer cells

Grant number：17K08634  2017.4 - 2020.3

Grant-in-Aid for Scientific Research (C)

Nishita Michiru

Analysis of molecular mechanisms of Wnt5a-Ror signaling in repair after tissue damage, inflammation, and cancer progression

Grant number：16H05152  2016.4 - 2019.3

Grant-in-Aid for Scientific Research (B)

Minami Yasuhiro

Wnt5a/Ror2シグナルと一次繊毛の機能連関による腎上皮細胞の極性制御

2015.4 - 2017.3

Ｒｉｆによるエメリンの分解制御とその核膜動態における役割

2013.4 - 2016.3

後腎間葉の細胞移動による尿管芽誘導機構

2013.4 - 2015.3

上皮間葉転換を伴う炎症や癌の進展におけるＷｎｔ５ａ－Ｒｏｒシグナルの分子病態解析

2012.4 - 2015.3

A-STEP「肺および腎線維化の病態解明と阻害薬開発のための新規マウスモデルの開発」

2011

Ror1-mediated signaling and its role in development and cancer

Grant number：22790291  2010

Grant-in-Aid for Young Scientists (B)

NISHITA Michiru

Functional analyses of receptor tyrosine kinases, Ror1 and Ror2, in Wnt signalin

Grant number：21390080  2009 - 2011

Grant-in-Aid for Scientific Research (B)

MINAMI Yasuhiro, NISHITA Michiru, ENDO Mitsuharu

Analysis of regulatory mechanisms for cell migration and cell polarity by Wnt5a and Ror2 receptor tyrosine kinase

Grant number：19390076  2007 - 2008

Grant-in-Aid for Scientific Research (B)

MINAMI Yasuhiro

Roles of Wnt5a-Ror2 in actin dynamics and cell migration

Grant number：19790233  2007

Grant-in-Aid for Young Scientists (B)

NISHITA Michiru

Molecular mechanism of DNA damage-induced responses and its failure by carcinogenesis

Grant number：17014062  2005 - 2009

Grant-in-Aid for Scientific Research on Priority Areas

MINAMI Yasuhiro, YODA AKINORI, NISHITA MICHIRU, ENDO MITSUHARU, YAMAGATA KAORU

Ｒｏｒ２受容体型チロシンキナーゼによる細胞運動の制御機構

Grant number：17790211  2005

若手研究(B)

西田 満