ライフサイエンス / 機能生物化学  / 機能生物化学

東京医科歯科大学医学部　文部教官・助手

1989年4月 - 1997年1月

日本学術振興会特別研究員

1987年4月 - 1989年3月

日本癌学会

日本生化学会

日本分子生物学会

その他   日本学術振興会　科研費専門委員  

2019年7月 - 2022年7月   

文部科学省審議会委員  

2017年4月 - 現在   

米国薬理学会   Molecular Pharmacology, Editorial Associate Board  

2016年11月 - 現在   

日本学術振興会 科研費専門委員  

2016年10月 - 現在   

その他   日本学術振興会　科研費専門委員  

2016年7月 - 2018年6月   

日本分子生物学会   理事会 執行部（庶務幹事）  

2013年1月 - 2016年12月   

その他   日本学術振興会　科研費専門委員  

2011年10月 - 2014年3月   

その他   日本女性科学者の会　理事(提言委員長)  

2010年1月 - 2023年5月   

日本分子生物学会   男女共同参画委員  

2007年4月 - 現在   

日本分子生物学会   男女共同参画委員  

2007年4月 - 2012年12月   

CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.

Homma MK, Wada I, Suzuki T, Yamaki J, Krebs EG, Homma Y

Proc Natl Acad Sci USA   102 ( 43 )   15688 - 15693   2005年10月

Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein

Miwako Kato Homma, Dongxia Li, Edwin G. Krebs, Yasuhito Yuasa, Yoshimi Homma

Proc. Natl. Acad. Sci, U.S.A.   99 ( 9 )   5959 - 5964   2002年

Assessing the components of the CK2 complex in the nucleus during the cell cycle progression.

Miwako K. Homma, Takeshi Shibata, Toshiyuki Suzuki, Masato Ogura, Hiroko Kozuka-Hata, Masaaki Oyama and Yoshimi Homma.

Advances in Biochemistry in Health and Disease   12   197 - 226   2015年1月

Weight loss by a novel small-molecule, Ppc-1, derived from slime mold

Toshiyuki Suzuki, Haruhisa Kikuchi, Masato Ogura, Miwako K Homma, Yoshiteru Oshima and Yoshimi Homma.

PLOS One   10 ( 2 )   e0117088   2015年

Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation.

Kabuyama Y., Nakazawa N., Yamaki J., Homma M.K., and Homma Y.

Am. J. Physiol. Cell Physiol.   298 ( 1 )   107 - 113   2010年

Cell Cycle and activation of CK2

Miwako K. Homma and Yoshimi Homma.

Mol.Cell.Biochem.   316 ( 1-2 )   49 - 55   2008年4月

Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species.

Ogura M, Yamaki J, Homma MK and Homma Y.

FEBS Lett   588   2837 - 2843   2014年8月

Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis.

Takuya Kitamura, Yukihito Kabuyama, Akihisa Kamataki, Miwako K. Homma, Hideo Kobayashi, Shigeo Aota, Shin-ichi Kikuchi and Yoshimi Homma.

Am. J. Physiol. Cell Physiol.   294   C189-C196   2008年

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components.

Ogura M, Yamaki J, Homma MK and Homma Y.

Biochem J   447   281 - 289   2012年

Involvemnet of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.

Yukihito Kabuyama, Kengo Oshima, Takuya Kitamura, Miwako K. Homma, Junko Yamaki, Mitsuru Munakata, and Yoshimi Homma.

Genes to Cells   12   1235 - 1244   2007年

Opsonic complement component C3 in the solitary Ascidian, Halocynthia roretzi.

Masaru Nonaka, Kaoru Azumi, Xin Ji, Chisato Namikawa-Yamada, Makoto Sasaki et al.

Journal of Immunology   162   387 - 391   1999年

Involvement of EphB1 receptor/ephrinB2 in chronic neuropathic pain

Kobayashi H, Kitamura T, Sekiguchi M, Kabuyama Y, Homma MK, Konno S, Kikuchi S and Homma Y

Spine   in press   2007年

Regulatory role of CK2 during the progression of cell cycle.

Homma MK,and Homma Y

Mol Cell Biochem   274 ( 1-2 )   47 - 52   2005年4月

Early signaling events induced by 280-nm UV irradiation

Yukihito Kabuyama, Miwako K. Homma, Tomohiro Kurosaki, Yoshimi Homma

Eur. J. Biochem   269   664 - 670   2002年

Wavelength-specific activation of MAP kinase family proteins by monochromatic ultraviolet irradiation.

Y. Kabuyama, M.K. Homma, M. Sekimata, Y. Homma

Photochem. Photobiol.   73 ( 3 )   147 - 152   2001年

Involvement of ErbB-2 in rheumatoid synovial cell growth.

K. Satoh, S. Kikuchi, M. Sekimata, Y. Kabuyama, M.K. Homma, Y. Homma

Arthritis Rheum.   44 ( 2 )   260 - 265   2001年

Inhibition of phosphoinositide hydrolysis and cell growth of Swiss 3T3 cells by myristoylated phosphoinositide phospholipase C inhibitor peptides.

Miwako K. Homma, Motoo Yamasaki, Shinobu Ohmi-Imajoh, and Yoshimi Homma

J. Biochem.   122   738   1997年

Growth inhibition by phospholipase C inhibitor peptides of colorectal carunoma cells derived from familial adenomatous

Miwako K. Homma, Yoshimi Homma, Moto-o Yamasaki, Shinobu Ohmi-Imajoh, and Yasuhito Yuasa

Cell Growth & Differentiation   7   281 - 288   1996年

Sequential activation of MAP kinase cascade by angiotensin Ⅱ in opossum kidney cells.(共著)

Yoshio Terada, Kimio Tomita, Miwako K. Homma, Hiroshi Nonoguchi, Tianxin Yang, Takehisa Yamada, Yasuhito Yuasa, Edwin G. Krebs, and Fumiaki Marumo

kidney international   48   1801 - 1809   1995年

AVP-inhibits EGF-stimulated MAP kinase cascade in Madin-Darby canine kidney cells(共著)

Takehisa Yamada, Yoshio Terada, Miwako K. Homma, Hiroshi Nonoguchi, Sei Sasaki, Kimio Tomita, Yasuhito Yuasa, and Fumiaki Marumo

kidney international   48   745 - 752   1995年

Enhanced phosphoinositide metabolism in colorectal carcinoma cells derived from familial adenomarous polyposis patients

Miwako K. Homma, Yoshimi Homma, Masayoshi Namba, and Yasuhito Yuasa

J. Cellular Biochemistry   55   477 - 485   1994年

Sequential activation of Raf-1 kinase, MAP kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. (共著)

Yoshio Terada, Kimio Tomita, Miwako K. Homma, Hiroshi Nonoguchi, Tianxin Yang, Takehisa Yamada, Yasuhito Yuasa, Edwin G. Krebs, and Fumiaki Marumo

Journal of Biological Chemistry   269   31296 - 31301   1994年

Enhancement of PLC activity by tyrosine phosphorylation in human colorectal carcinomas.

Miwako K. Homma, Yoshimi Homma, Masayoshi Namba, and Yasuhito Yuasa

J. Cellular Biochemistry   17 ( A )   318   1993年

Effects of phorbor ester on mitogen-activated protein kinase kinase activity in wild-type and phorbor ester-resisitant EL4 thymoma cells.

Katrina C. Gause, Miwako K. Homma, Karen A. Licciardi, Rony Sager, Natalie G. Ahn, et al.

Journal of Biological Chemistry   268   16124 - 16129   1993年

Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain

Miwako Kato and Tadaomi Takenawa

Journal of Biological Chemistry   265   794 - 800   1990年

Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay

Yasuhito Yuasa, Takashi Kamiyama, Miwako Kato, Takeo Iwama, et al.

Oncogene   5   589 - 596   1990年

Dissapearance of phorbol acetate-induced translocation of diacylglycerol kinase in erbB-transformed cells

Miwako Kato, Sadaaki Kawai, and Tadaomi Takenawa

FEBS Letters   247   247 - 250   1989年

Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed fibroblasts

Ming Huang, Kazuhiro Chida, Nobuyuki Kamata, Kiyoshi Nose, Miwako Kato, et al.

Journal of Biological Chemistry   263   17975 - 17980   1988年

Effect of transforming growth factor-alpha on inositol phospholipid metabolism in human epidermal carcinoma cells

Miwako Kato, Tadaomi Takenawa, and Daniel R.Twardzik

Journal of Cellular Biochemistry   37   339 - 346   1988年

Altered signal transduction in erbB-transformed cells. An implication of enhanced inositol phospholipid metabolism in erbB-induced transformation

Miwako Kato, Sadaaki Kawai, and Tadaomi Takenawa

Journal of Biological Chemistry   262   5696 - 5704   1987年

Epidermal growth factor stimulates diacylglycerol kinase activity in isolated plasma membrane vesicles from A431 cells

Miwako Kato, Yoshimi Homma, Yoshitaka Nagai,and Tadaomi Takenawa

Biochem. Biophys. Res. Commun.   129   375 - 380   1985年

Role of enhanced inositol phospholipid metabolism in neutrophil activation.

Tadaomi Takenawa, Jun-ichi Ishitoya, Yoshimi Homma, Miwako Kato, and Yoshitaka Nagai.

Biochem. Pharmacol.   34   1931 - 1936   1985年

Maximizing the Potential of Scientists in Japan: Promoting equal participation for women scientists through leadership development

Homma M., Motohashi R., Ohtsubo H.

Genes to Cells   18 ( 7 )   529 - 532   2013年7月（ ISSN:13569597 ）

Japan's lagging gender equality

Homma M., Motohashi R., Ohtsubo H.

Science   340 ( 6131 )   428 - 429   2013年4月（ ISSN:00368075 ）

人生１００年時代、女性も男性も十分に能力発揮できる研究環境の実現 ～無意識のバイアスから自由に～例会シンポジウム2021とSJWS提言の分析に基づく考察

塩満典子、本間美和子、山田恵子、清水美穂、跡見順子

日本女性科学者の会学術誌   22 ( 1 )   86 - 106   2022年7月（ ISSN:1349-4449 ）

癌予後マーカーの開発と高感度化へ資する独自抗体について

山元想, 本間美和子

月刊　バイオインダストリー   41 ( 7 )   27 - 33   2024年7月

Primary pituitary malignant lymphoma that was difficult to differentiate from nonfunctioning pituitary adenoma: A case report

Murakami Y., Sato T., Jinguji S., Kjshida Y., Watanabe T., Suzuki O., Ikeda K., Homma M., Midorikavva S., Saito K.

Neurological Surgery   44 ( 9 )   779 - 784   2016年9月（ ISSN:03012603 ）

Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2

Masato Ogura, Haruhisa Kikuchi, Toshiyuki Suzuki, Junko Yamaki, Miwako K. Homma, Yoshiteru Oshima, Yoshimi Homma.

Biochem Pharmacol   105   55 - 65   2016年

Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells.

Masato Ogura, Takeshi Inoue, Junko Yamaki, Miwako K. Homma, Tomohiro Kurosaki, Yoshimi Homma

Eur J Immunol   2016年

Synthesis of plenylated quinolinecarboxylic acid derivatives and their anti-obesity activities.

Kikuchi H, Suzuki T, Ogura M, Homma MK, Homma Y and Oshima Y.

Bioorg Med Chem   23   66 - 72   2015年1月

KEY WORD炎症・免疫系

（ 範囲: ジアシルグリセロール）

先端医学社  1994年 

新生化学実験講座 第4巻 脂質II

日本生化学会（ 範囲: イノシトールリン酸産生反応）

東京化学同人  1991年 

臨床免疫

（ 範囲: 細胞増殖とイノシトールリン脂質シグナル伝達系）

科学評論社  1991年 

神経精神薬理

（ 範囲: 細胞内情報伝達とイノシトールリン脂質代謝の機能）

星和書店  1989年 

実験医学　増刊号

（ 範囲: リン脂質代謝異常と細胞癌化）

羊土社  1989年 

Phosphatidylinositol kinase and cell transformation

Adv. Second Messenger and Phosphoprotein Research  1989年 

癌と化学療法 PartII別冊

（ 範囲: 発癌遺伝子産物のシグナルトランスダクションにおけるイノシトールリン脂質代謝の役割　,）

癌と化学療法社  1986年 

日本女性科学者の会学術誌

一般社団法人　日本女性科学者の会（ 範囲: 例会シンポジウム2021「女性科学者への期待・女性科学者はなぜ増えないか」アンコンシャス・バイアスの解消とジェンダード・イノベーション）

一般社団法人　日本女性科学者の会  2022年3月 

Dry analysis of RNA-Seq data targeting CK2.

The 81th Annual Meeting of Japan Cancer Association  

CK2α as a prognostic factor in invasive ductal carcinomas of the breast: cancer recurrence prognosis by surgical sampling

The Lancet Summit: Cancer Care in Asia and Latin America  

Inhibition of CK2 activity by adenomatous polyposis coli (APC) protein.

Cold Spring Harbor Laboratory Meeting on Phosphorylation, Signaling and Disease   2007年5月  

Cell cycle-regulated phosphorylation and nuclear translocation of CK2

IUBMB  

Cell cycle-regulated phosphorylation and nuclear localization of CK2.

Cold Spring Harbor Laboratory Meeting on Cell Cycle  

Role of CK2 during the progression of cell cycle

Miami Nature Biotechnology Winter Symposium  

Regulatory role of CK2 during progression of cell cycle

The 4th International Conference on Protein Kinase CK2  

Evaluation of nucleolar CK2a-positive staining as a new prognostic factor for invasive ductal carcinoma of the breast.

ASBMB Sympojiumu: Emerging roles of the nucleolus  

The molecular functions of protein kinase CK2 in association with nuclear localization.

The 81th Annual Meeting of Japan Cancer Association  

Association of nucleolar CKa with poor prognosis for breast carcinomas.

Cell Press Symposium  

Intracellular localization of CK2a as a prognostic factor in invasive breast carcinomas.

第80回日本癌学会学術総会  

Nuclear localization of protein kinase CK2 as a prognostic factor for breast cancer.

The 79th Annual Meeting of Japan Cancer Association (Oral English Session)  

Alterations of intracellular signal transduction system in a rare liver carcinoma

The 78th Annual Meeting of the Japanese Cancer Association  

Phosphoproteomics analysis of nuclear protein kinase complexes associating with growth-related gene expression

The 77th Annual Meeting of the Japanese Cancer Association  

Phosphoproteomics analysis of nuclear protein kinase complexes associating with growth-related gene expression

The 77th Annual Meeting of the Japanese Cancer Association  

Protein Kinase Signaling System: Integrative studies of physiological approach and phosphoprotein analysis

ConBio 2017  

Protein Kinase Signaling System: Integrative studies of physiological approach and phosphoprotein analysis

ConBio 2017  

ゲノム編集細胞株を用いたCK2機能の解析

第39回日本分子生物学会年会  

ゲノム編集細胞株を用いたCK2機能の解析

第39回日本分子生物学会年会  

ゲノム編集細胞株を用いたCK2機能の解析

第39回日本分子生物学会年会  

Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.

The 8th International Conference on Protein Kinase CK2  

Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.

The 8th International Conference on Protein Kinase CK2  

Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.

The 8th International Conference on Protein Kinase CK2  

Function of protein kinase CK2 on cell cycle progression.

The 21st International Charles Heidelberger Symposium on Carcinogenesis,  

Function of protein kinase CK2 on cell cycle progression.

The 21st International Charles Heidelberger Symposium on Carcinogenesis,  

Function of protein kinase CK2 on cell cycle progression.

The 21st International Charles Heidelberger Symposium on Carcinogenesis,  

Role of protein kinase CK2 on cell cycle progression

University of Washington and Kobe University International Joint Symposium  

Role of protein kinase CK2 on cell cycle progression

University of Washington and Kobe University International Joint Symposium  

Role of protein kinase CK2 on cell cycle progression

University of Washington and Kobe University International Joint Symposium  

細胞周期進行と関連する核内CK2複合体解析

３７回日本分子生物学会年会   2014年11月  

細胞周期進行と関連する核内CK2複合体解析

３７回日本分子生物学会年会  

細胞周期進行と関連する核内CK2複合体解析

３７回日本分子生物学会年会  

Protein kinase CK2: its role in cell proliferation and cell cycle progression.

The 20th International Charles Heidelberger Symposium on Carcinogenesis  

Protein kinase CK2: its role in cell proliferation and cell cycle progression.

The 20th International Charles Heidelberger Symposium on Carcinogenesis  

Protein kinase CK2: its role in cell proliferation and cell cycle progression.

The 20th International Charles Heidelberger Symposium on Carcinogenesis  

Proteomics analysis of CK2 interacting proteins during the progression of cell cycle

The 7th International Conference on Protein Kinase CK2  

Important role of intramolecular phosphorylation for CK2 activity

The 7th International Conference on Protein Kinase CK2  

Important role of intramolecular phosphorylation for CK2 activity

The 7th International Conference on Protein Kinase CK2  

Proteomics analysis of CK2 interacting proteins during the progression of cell cycle

The 7th International Conference on Protein Kinase CK2  

Important role of intramolecular phosphorylation for CK2 activity

The 7th International Conference on Protein Kinase CK2  

Proteomics analysis of CK2 interacting proteins during the progression of cell cycle

The 7th International Conference on Protein Kinase CK2  

Autophosphorylation of CK2 at the N-terminal region is required for its catalytic activity.

Cold Spring Harbor Laboratory Symposium“Protein Data Bank 40th”  

Involvement of CK2 phosphorylation for its activity and nuclear localiztion during the cell cycle progression of normal human fibroblasts.

Keystone Symposia on “The Evolution of Protein Phosphorylation"   2011年1月  

Regulatory mechanisms involved in the activation of nuclear CK2

The 14th Meeting on Protein Phosphorylation and Cell Signaling  

CK2 changes its cellular localization during the progression of cell cycle

Cold Spring Harbor Laboratory Meeting on Cell Cycle  

Cell cycle-regulated phosphorylation and nuclear translocation of CK2.

5th International Conference on Protein Kinase CK2, Protien Kinase CK2 and Disease  

男女共同参画学協会連絡会 ワーキンググループ

2010年3月 - 2013年12月

先端技術の広報活動

2008年10月 - 2010年3月