Updated on 2024/08/05
医学修士 ( 東京大学 )
医学博士 ( 東京大学 )
growth signal transduction
cell cycle
Inositol Phospholipid
Intracellular signal transduction system
Invasive Ductal Carcinoma of the Breast
kinase
casein kinase 2
gene expression
Phospholipase C
CK2, Casein Kinase 2, Kinases, Cell Cycle, Growth Signal Transduction, Gene Expression, Chromatin Dynamics, Phospholipase C, Inositol Phospholipid, Intracellular Signal Transduction System, Familial Adenomatous Polyposis Coli, Colon Cancer, APC, EIF5
eIF5
APC
Adenomatous Polyposis Coli
Life Science / Functional biochemistry / Functional Biochemistry
Life Science / Medical biochemistry / Medical Science
Life Science / Molecular biology / Molecular Biology
Life Science / Pathological biochemistry
Life Science / Structural biochemistry / Structural Biochemistry
Life Science / Functional biochemistry / Functional Biochemistry
Fukushima Medical University Associate Professor
2017.2 - Now
福島県立医科大学医学部 講師
2005.10 - Now
Fukushima Medical University School of Medicine
2005.10 - Now
福島県立医科大学医学部 助手
1997.2 - Now
Fukushima Medical University School of Medicine
1997.2 - Now
東京医科歯科大学医学部 文部教官・助手
1989.4 - 1997.1
日本学術振興会特別研究員
1987.4 - 1989.3
Japan Biochemical Society
1981.4 - Now
Japanese Cancer Association
1985.4 - Now
日本分子生物学会
2007.1 - Now
American Society of Phrmacology and Experimental Biology
2016.10 - Now
American Society of Phrmacology and Experimental Biology
Japanese Cancer Association
Japan Biochemical Society
日本分子生物学会
その他 文部科学省 国立研究開発法人量子科学研究機構審議会 部会委員
2017.4 - Now
日本癌学会 評議員
2022.1 - Now
日本癌学会 Cancer Science Associate Editor
2022.1 - 2024.12
その他 日本学術会議 総合工学委員会 小委員会委員
2021.4 - Now
その他 日本学術振興会 科研費専門委員
2020.4 - 2022.7
その他 日本学術振興会 科研費専門委員
2019.7 - 2022.7
文部科学省審議会委員
2017.4 - Now
米国薬理学会 Molecular Pharmacology, Editorial Associate Board
2016.11 - Now
日本学術振興会 科研費専門委員
2016.10 - Now
その他 日本学術振興会 科研費専門委員
2016.7 - 2018.6
日本分子生物学会 理事会 執行部（庶務幹事）
2013.1 - 2016.12
その他 日本学術振興会 科研費専門委員
2011.10 - 2014.3
その他 日本女性科学者の会 理事(提言委員長)
2010.1 - 2023.5
日本分子生物学会 男女共同参画委員
2007.4 - Now
Committee type：Academic society
日本分子生物学会 男女共同参画委員
2007.4 - 2012.12
Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2α complexes
Miwako K. Homma, Ryuichiro Nakato, Atsushi Niida, Masashige Bando, Katusnori Fujiki, Naoko Yokota, So Yamamoto, Takeshi Shibata, Motoki Takagi, Junko Yamaki, Hiroko Kozuka-Hata, Masaaki Oyama, Katsuhiko Shirahige, Yoshimi Homma.
Life Science Alliance 2024 ( 7 ) e202302077 2024.1
Homma M.K., Hashimoto Y., Homma Y., Nomizu T.
The Lancet. Oncology 23 2022.7
Intracellular localization of CK2a as a prognostic factor in invasive breast carcinomas
Miwako K. Homma, Yuichiro Kiko, Yuko Hashimoto, Miki Nagatsuka, Naoto Katagata, Sei-ichiro Masui, Yoshimi Homma, Tadashi Nomizu.
Cancer Science 112 ( 2 ) 619 - 628 2021.2
cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma
Kevin M. Riggle, Kimberly J. Riehle, Heidi L. Kenerson, Rigney Turnham, Miwako K. Homma, Machiko Kazami, Bret Samelson, Renay Bauer, G. Stanley McKnight, John D. Scott, Reymond S. Yeung.
Pediatric Res. 80 ( 1 ) 110 - 118 2016.7
Homma M., Shibata T., Suzuki T., Ogura M., Kozuka-Hata H., Oyama M., Homma Y.
Protein Kinase CK2 Cellular Function in Normal and Disease States 12 197 - 226 2015.1
CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.
Proc Natl Acad Sci USA 102 ( 43 ) 15688 - 15693 2005.10
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein
Proc. Natl. Acad. Sci, U.S.A. 99 ( 9 ) 5959 - 5964 2002
Assessing the components of the CK2 complex in the nucleus during the cell cycle progression.
Miwako K. Homma, Takeshi Shibata, Toshiyuki Suzuki, Masato Ogura, Hiroko Kozuka-Hata, Masaaki Oyama and Yoshimi Homma.
Advances in Biochemistry in Health and Disease 12 197 - 226 2015.1
Weight loss by a novel small-molecule, Ppc-1, derived from slime mold
Toshiyuki Suzuki, Haruhisa Kikuchi, Masato Ogura, Miwako K Homma, Yoshiteru Oshima and Yoshimi Homma.
PLOS One 10 ( 2 ) e0117088 2015
Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation.
Kabuyama Y., Nakazawa N., Yamaki J., Homma M.K., and Homma Y.
Am. J. Physiol. Cell Physiol. 298 ( 1 ) 107 - 113 2010
Cell Cycle and activation of CK2
Miwako K. Homma and Yoshimi Homma.
Mol.Cell.Biochem. 316 ( 1-2 ) 49 - 55 2008.4
Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species.
Ogura M, Yamaki J, Homma MK and Homma Y.
FEBS Lett 588 2837 - 2843 2014.8
Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis.
Takuya Kitamura, Yukihito Kabuyama, Akihisa Kamataki, Miwako K. Homma, Hideo Kobayashi, Shigeo Aota, Shin-ichi Kikuchi and Yoshimi Homma.
Am. J. Physiol. Cell Physiol. 294 C189-C196 2008
Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components.
Ogura M, Yamaki J, Homma MK and Homma Y.
Biochem J 447 281 - 289 2012
Involvemnet of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.
Yukihito Kabuyama, Kengo Oshima, Takuya Kitamura, Miwako K. Homma, Junko Yamaki, Mitsuru Munakata, and Yoshimi Homma.
Genes to Cells 12 1235 - 1244 2007
Opsonic complement component C3 in the solitary Ascidian, Halocynthia roretzi.
Journal of Immunology 162 387 - 391 1999
Involvement of EphB1 receptor/ephrinB2 in chronic neuropathic pain
Kobayashi H, Kitamura T, Sekiguchi M, Kabuyama Y, Homma MK, Konno S, Kikuchi S and Homma Y
Spine in press 2007
Regulatory role of CK2 during the progression of cell cycle.
Homma MK,and Homma Y
Mol Cell Biochem 274 ( 1-2 ) 47 - 52 2005.4
Early signaling events induced by 280-nm UV irradiation
Eur. J. Biochem 269 664 - 670 2002
Wavelength-specific activation of MAP kinase family proteins by monochromatic ultraviolet irradiation.
Photochem. Photobiol. 73 ( 3 ) 147 - 152 2001
Involvement of ErbB-2 in rheumatoid synovial cell growth.
Arthritis Rheum. 44 ( 2 ) 260 - 265 2001
Inhibition of phosphoinositide hydrolysis and cell growth of Swiss 3T3 cells by myristoylated phosphoinositide phospholipase C inhibitor peptides.
Miwako K. Homma, Motoo Yamasaki, Shinobu Ohmi-Imajoh, and Yoshimi Homma
J. Biochem. 122 738 1997
Growth inhibition by phospholipase C inhibitor peptides of colorectal carunoma cells derived from familial adenomatous
Miwako K. Homma, Yoshimi Homma, Moto-o Yamasaki, Shinobu Ohmi-Imajoh, and Yasuhito Yuasa
Cell Growth & Differentiation 7 281 - 288 1996
Sequential activation of MAP kinase cascade by angiotensin Ⅱ in opossum kidney cells.(共著)
Yoshio Terada, Kimio Tomita, Miwako K. Homma, Hiroshi Nonoguchi, Tianxin Yang, Takehisa Yamada, Yasuhito Yuasa, Edwin G. Krebs, and Fumiaki Marumo
kidney international 48 1801 - 1809 1995
AVP-inhibits EGF-stimulated MAP kinase cascade in Madin-Darby canine kidney cells(共著)
Takehisa Yamada, Yoshio Terada, Miwako K. Homma, Hiroshi Nonoguchi, Sei Sasaki, Kimio Tomita, Yasuhito Yuasa, and Fumiaki Marumo
kidney international 48 745 - 752 1995
Enhanced phosphoinositide metabolism in colorectal carcinoma cells derived from familial adenomarous polyposis patients
Miwako K. Homma, Yoshimi Homma, Masayoshi Namba, and Yasuhito Yuasa
J. Cellular Biochemistry 55 477 - 485 1994
Sequential activation of Raf-1 kinase, MAP kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. (共著)
Yoshio Terada, Kimio Tomita, Miwako K. Homma, Hiroshi Nonoguchi, Tianxin Yang, Takehisa Yamada, Yasuhito Yuasa, Edwin G. Krebs, and Fumiaki Marumo
Journal of Biological Chemistry 269 31296 - 31301 1994
Enhancement of PLC activity by tyrosine phosphorylation in human colorectal carcinomas.
Miwako K. Homma, Yoshimi Homma, Masayoshi Namba, and Yasuhito Yuasa
J. Cellular Biochemistry 17 ( A ) 318 1993
Effects of phorbor ester on mitogen-activated protein kinase kinase activity in wild-type and phorbor ester-resisitant EL4 thymoma cells.
Journal of Biological Chemistry 268 16124 - 16129 1993
Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain
Journal of Biological Chemistry 265 794 - 800 1990
Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay
Oncogene 5 589 - 596 1990
Dissapearance of phorbol acetate-induced translocation of diacylglycerol kinase in erbB-transformed cells
Miwako Kato, Sadaaki Kawai, and Tadaomi Takenawa
FEBS Letters 247 247 - 250 1989
Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed fibroblasts
Journal of Biological Chemistry 263 17975 - 17980 1988
Effect of transforming growth factor-alpha on inositol phospholipid metabolism in human epidermal carcinoma cells
Miwako Kato, Tadaomi Takenawa, and Daniel R.Twardzik
Journal of Cellular Biochemistry 37 339 - 346 1988
Altered signal transduction in erbB-transformed cells. An implication of enhanced inositol phospholipid metabolism in erbB-induced transformation
Miwako Kato, Sadaaki Kawai, and Tadaomi Takenawa
Journal of Biological Chemistry 262 5696 - 5704 1987
Epidermal growth factor stimulates diacylglycerol kinase activity in isolated plasma membrane vesicles from A431 cells
Miwako Kato, Yoshimi Homma, Yoshitaka Nagai,and Tadaomi Takenawa
Biochem. Biophys. Res. Commun. 129 375 - 380 1985
Role of enhanced inositol phospholipid metabolism in neutrophil activation.
Tadaomi Takenawa, Jun-ichi Ishitoya, Yoshimi Homma, Miwako Kato, and Yoshitaka Nagai.
Biochem. Pharmacol. 34 1931 - 1936 1985
Homma M., Motohashi R., Ohtsubo H.
Genes to Cells 18 ( 7 ) 529 - 532 2013.7（ ISSN:13569597 ）
Japan's lagging gender equality
Homma M., Motohashi R., Ohtsubo H.
Science 340 ( 6131 ) 428 - 429 2013.4（ ISSN:00368075 ）
Realizing a research environment where both women and men can fully demonstrate their abilities in the era of 100-year life
Noriko Shiomitsu, Miwako Kato Homma, Keioko Yamada, Miho Shimizu, Yoriko Atomi
Journal of the Society of Japanese Womesn Scientists 22 ( 1 ) 86 - 106 2022.7（ ISSN:1349-4449 ）
Development of a prognostic cancer marker and monoclonal antibodies that contribute to higher sensitivity
So Yamamoto, Miwako Kato Homma
Bio R&D 41 ( 7 ) 27 - 33 2024.7
Murakami Y., Sato T., Jinguji S., Kjshida Y., Watanabe T., Suzuki O., Ikeda K., Homma M., Midorikavva S., Saito K.
Neurological Surgery 44 ( 9 ) 779 - 784 2016.9（ ISSN:03012603 ）
Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2
Masato Ogura, Haruhisa Kikuchi, Toshiyuki Suzuki, Junko Yamaki, Miwako K. Homma, Yoshiteru Oshima, Yoshimi Homma.
Biochem Pharmacol 105 55 - 65 2016
Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells.
Masato Ogura, Takeshi Inoue, Junko Yamaki, Miwako K. Homma, Tomohiro Kurosaki, Yoshimi Homma
Eur J Immunol 2016
Synthesis of plenylated quinolinecarboxylic acid derivatives and their anti-obesity activities.
Kikuchi H, Suzuki T, Ogura M, Homma MK, Homma Y and Oshima Y.
Bioorg Med Chem 23 66 - 72 2015.1
生物工学
日本生物工学学会（自分の殻を破って）
日本生物工学学会 2010
Journal of Society for Japanese Women Scientists
2008 （ ISBN:1346-9827 ）
バイオサイエンス用語ライブラリ・細胞内シグナル伝達 第2版
山本雅（APC）
羊土社 1999
癌と化学療法 別冊
日本臨床腫瘍研究会編（ホスホリパーゼC阻害ペプチド）
癌と化学療法社 1997
バイオサイエンス用語ライブラリー・細胞内シグナル伝達
山本雅（APC）
羊土社 1995
KEY WORD炎症・免疫系
（ジアシルグリセロール）
先端医学社 1994
新生化学実験講座 第4巻 脂質II
日本生化学会（イノシトールリン酸産生反応）
東京化学同人 1991
臨床免疫
（細胞増殖とイノシトールリン脂質シグナル伝達系）
科学評論社 1991
神経精神薬理
（細胞内情報伝達とイノシトールリン脂質代謝の機能）
星和書店 1989
実験医学 増刊号
（リン脂質代謝異常と細胞癌化）
羊土社 1989
Phosphatidylinositol kinase and cell transformation
Adv. Second Messenger and Phosphoprotein Research 1989
癌と化学療法 PartII別冊
（発癌遺伝子産物のシグナルトランスダクションにおけるイノシトールリン脂質代謝の役割 ,）
癌と化学療法社 1986
一般社団法人 日本女性科学者の会（例会シンポジウム2021「女性科学者への期待・女性科学者はなぜ増えないか」アンコンシャス・バイアスの解消とジェンダード・イノベーション）
一般社団法人 日本女性科学者の会 2022.3
Development of A Prognostic Marker and Monoclonal Antibodies that Contribute to Versatility and High Sensitivity
The 28th Annual Meeting of Japanese Association for Molecular Target Therapy of Cancer
Upregulation of protein kinases for cancer signaling in the Fibrolamellar Hepatocellular Carcinoma model system
The 46th Annual Meeting of the Molecular Biology Society of Japan 2023.12
CK2α in the nucleoli as a prognostic factor for solid carcinomas
The 25th International Charles Heidelberger Symposia on Cancer Research 2023.11
Assessing molecular function of protein kinase CK2 in the nucleus and nucleolus
Workshop on Cancer Research for Well-Being 2023.7
Nuclear and nucleolar localization of protein kinase CK2 as a new prognostic factor for solid cancers.
The 82th Annual Meeting of Japan Cancer Association 2023.9
Dry analysis of RNA-Seq data targeting CK2.
The 81th Annual Meeting of Japan Cancer Association
CK2α as a prognostic factor in invasive ductal carcinomas of the breast: cancer recurrence prognosis by surgical sampling
The Lancet Summit: Cancer Care in Asia and Latin America
Inhibition of CK2 activity by adenomatous polyposis coli (APC) protein.
Cold Spring Harbor Laboratory Meeting on Phosphorylation, Signaling and Disease 2007.5
Cell cycle-regulated phosphorylation and nuclear translocation of CK2
IUBMB
Cell cycle-regulated phosphorylation and nuclear localization of CK2.
Cold Spring Harbor Laboratory Meeting on Cell Cycle
Role of CK2 during the progression of cell cycle
Miami Nature Biotechnology Winter Symposium
Regulatory role of CK2 during progression of cell cycle
The 4th International Conference on Protein Kinase CK2
Evaluation of nucleolar CK2a-positive staining as a new prognostic factor for invasive ductal carcinoma of the breast.
ASBMB Sympojiumu: Emerging roles of the nucleolus
The molecular functions of protein kinase CK2 in association with nuclear localization.
The 81th Annual Meeting of Japan Cancer Association
Association of nucleolar CKa with poor prognosis for breast carcinomas.
Cell Press Symposium
Intracellular localization of CK2a as a prognostic factor in invasive breast carcinomas.
第80回日本癌学会学術総会
Nuclear localization of protein kinase CK2 as a prognostic factor for breast cancer.
The 79th Annual Meeting of Japan Cancer Association (Oral English Session)
Alterations of intracellular signal transduction system in a rare liver carcinoma
The 78th Annual Meeting of the Japanese Cancer Association
Phosphoproteomics analysis of nuclear protein kinase complexes associating with growth-related gene expression
The 77th Annual Meeting of the Japanese Cancer Association
Phosphoproteomics analysis of nuclear protein kinase complexes associating with growth-related gene expression
The 77th Annual Meeting of the Japanese Cancer Association
Protein Kinase Signaling System: Integrative studies of physiological approach and phosphoprotein analysis
ConBio 2017
Protein Kinase Signaling System: Integrative studies of physiological approach and phosphoprotein analysis
ConBio 2017
ゲノム編集細胞株を用いたCK2機能の解析
第39回日本分子生物学会年会
ゲノム編集細胞株を用いたCK2機能の解析
第39回日本分子生物学会年会
ゲノム編集細胞株を用いたCK2機能の解析
第39回日本分子生物学会年会
Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.
The 8th International Conference on Protein Kinase CK2
Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.
The 8th International Conference on Protein Kinase CK2
Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.
The 8th International Conference on Protein Kinase CK2
Function of protein kinase CK2 on cell cycle progression.
The 21st International Charles Heidelberger Symposium on Carcinogenesis,
Function of protein kinase CK2 on cell cycle progression.
The 21st International Charles Heidelberger Symposium on Carcinogenesis,
Function of protein kinase CK2 on cell cycle progression.
The 21st International Charles Heidelberger Symposium on Carcinogenesis,
Role of protein kinase CK2 on cell cycle progression
University of Washington and Kobe University International Joint Symposium
Role of protein kinase CK2 on cell cycle progression
University of Washington and Kobe University International Joint Symposium
Role of protein kinase CK2 on cell cycle progression
University of Washington and Kobe University International Joint Symposium
細胞周期進行と関連する核内CK2複合体解析
３７回日本分子生物学会年会 2014.11
細胞周期進行と関連する核内CK2複合体解析
３７回日本分子生物学会年会
細胞周期進行と関連する核内CK2複合体解析
３７回日本分子生物学会年会
Protein kinase CK2: its role in cell proliferation and cell cycle progression.
The 20th International Charles Heidelberger Symposium on Carcinogenesis
Protein kinase CK2: its role in cell proliferation and cell cycle progression.
The 20th International Charles Heidelberger Symposium on Carcinogenesis
Protein kinase CK2: its role in cell proliferation and cell cycle progression.
The 20th International Charles Heidelberger Symposium on Carcinogenesis
Proteomics analysis of CK2 interacting proteins during the progression of cell cycle
The 7th International Conference on Protein Kinase CK2
Important role of intramolecular phosphorylation for CK2 activity
The 7th International Conference on Protein Kinase CK2
Important role of intramolecular phosphorylation for CK2 activity
The 7th International Conference on Protein Kinase CK2
Proteomics analysis of CK2 interacting proteins during the progression of cell cycle
The 7th International Conference on Protein Kinase CK2
Important role of intramolecular phosphorylation for CK2 activity
The 7th International Conference on Protein Kinase CK2
Proteomics analysis of CK2 interacting proteins during the progression of cell cycle
The 7th International Conference on Protein Kinase CK2
Autophosphorylation of CK2 at the N-terminal region is required for its catalytic activity.
Cold Spring Harbor Laboratory Symposium“Protein Data Bank 40th"
Involvement of CK2 phosphorylation for its activity and nuclear localiztion during the cell cycle progression of normal human fibroblasts.
Keystone Symposia on “The Evolution of Protein Phosphorylation" 2011.1
Regulatory mechanisms involved in the activation of nuclear CK2
The 14th Meeting on Protein Phosphorylation and Cell Signaling
CK2 changes its cellular localization during the progression of cell cycle
Cold Spring Harbor Laboratory Meeting on Cell Cycle
Cell cycle-regulated phosphorylation and nuclear translocation of CK2.
5th International Conference on Protein Kinase CK2, Protien Kinase CK2 and Disease
Prognostic Biomarker of Cancer
福島県立医科大学 職務功績職員表彰
2008.9
日本女性科学者の会奨励賞
2008.6
乳癌予後予測と関連する核内集積分子についてのAI画像判定システムの構築
Cooperative Research with Industry-University research organizations and private agencies. Cooperative Research with Industry-University research organizations and private agencies. kyodo
IHC画像診断についてのAI技術導入は主観的要素を排除し客観的判定のもと、再現性と迅速性が期待される。特許出願中の「癌予後予測についての新たな手法の開発」と併せ技術的基盤を構築するために、AI専門家と共同研究実施を希望する。
Regulatory roles of protein kinases in cell growth
Cooperative Research with Industry-University research organizations and private agencies. form_gijutsu Cooperative Research with Industry-University research organizations and private agencies. kyodo
疾患メカニズム・疾患予後と関連するマーカー分子機能の研究
No Setting No Setting
内閣府 国・地⽅連携会議ネットワークを活⽤した男⼥共同参画推進事業
2013.8 - 2014.2
MEXT network for iPS cell research
2010.7 - 2015.8
科学技術政策の動向調査と提言（ライフサイエンス、医学分野）
2005.9 - 2007.3
SJWS
2010 - 2023.5
MEXT network for iPS cell research
2010.7 - Now
EPIMEWS
2010.3 - 2013.12
先端技術の広報活動
2008.10 - 2010.3
国・地方連携会議ネットワークを活用した男女共同参画推進事業（平成25年度） International contribution
内閣府 男女共同参画局 （共催）一般社団法人 日本女性科学者の会 （ こらっせ福島、福島市、福島県 ） 2013.2
