論文 - 高木 基樹
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High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids.
Higa A, Takahashi N, Hiyama G, Tamura H, Hoshi H, Shimomura K, Watanabe S, Takagi M
Journal of visualized experiments : JoVE 2021 ( 172 ) 2021年6月（ ISSN:1940087X ）
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Takahashi N, Higa A, Hiyama G, Tamura H, Hoshi H, Dobashi Y, Katahira K, Ishihara H, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M
Oncology letters 21 ( 5 ) 406 2021年5月（ ISSN:1792-1074 ）
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An In Vitro System for Evaluating Molecular Targeted Drugs Using Lung Patient-Derived Tumor Organoids.
Takahashi N, Hoshi H, Higa A, Hiyama G, Tamura H, Ogawa M, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M
Cells 8 ( 5 ) 2019年5月
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Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer.
Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, Hirokawa T, Natsume T, Doi T.
Bioorg Med Chem. 26 ( 23-24 ) 6023 - 6034 2018年12月
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Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, Morisawa G, Yanagisawa Y, Ito E, Imai JI, Dobashi Y, Katahira K, Soeda S, Watanabe T, Fujimori K, Watanabe S, Takagi M
Oncology reports 40 ( 2 ) 635 - 646 2018年8月（ ISSN:1021-335X ）
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Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis.
Tsutsumi H, Katsuyama Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.
J Am Chem Soc. 140 ( 21 ) 6631 - 6639 2018年5月
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A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis.
Ito S, Ogawa K, Takeuchi K, Takagi M, Yoshida M, Hirokawa T, Hirayama S, Shin-ya K, Shimada I, Doi T, Goshima N, Natsume T, Nagata K.
The Journl of Biological Chemistry. 292 ( 49 ) 20076 - 20085 2017年12月
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ヒトiPS細胞由来心筋細胞と遺伝子発現解析を用いた薬物の催不整脈能の評価系(Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis)
Higa Arisa, Hoshi Hirotaka, Yanagisawa Yuka, Ito Emi, Morisawa Gaku, Imai Jun-ichi, Watanabe Shinya, Takagi Motoki
The Journal of Toxicological Sciences 42 ( 6 ) 755 - 761 2017年12月（ ISSN:0388-1350 ）
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Hoshi H, Hiyama G, Ishikawa K, Inageda K, Fujimoto J, Wakamatsu A, Togashi T, Kawamura Y, Takahashi N, Higa A, Goshima N, Semba K, Watanabe S, Takagi M
Oncology reports 37 ( 1 ) 66 - 76 2017年1月（ ISSN:1021-335X ）
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Streptomyces sp. RI-77から単離した改変ナフトキノン類JBIR-76とJBIR-77(JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77)
Motohashi Keiichiro, Izumikawa Miho, Kagaya Noritaka, Takagi Motoki, Shin-ya Kazuo
The Journal of Antibiotics 69 ( 9 ) 707 - 708 2016年9月（ ISSN:0021-8820 ）
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インピーダンス測定を用いて決定したヒト幹細胞由来心筋細胞の催不整脈薬に対する種々の応答(Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements)
Higa Arisa, Hoshi Hirotaka, Takagi Motoki
Fundamental Toxicological Sciences 3 ( 2 ) 47 - 53 2016年3月
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Involvement of the Baeyer-Villiger Monooxygenase IfnQ in the Biosynthesis of Isofuranonaphthoquinone Scaffold of JBIR-76 and -77.
Katsuyama Y, Sone K, Satou R, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.
Chembiochem 2016年
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Ishigami K., Kobayashi M., Takagi M., Shin-Ya K., Watanabe H.
Tetrahedron 71 ( 44 ) 8436 - 8443 2015年11月（ ISSN:00404020 ）
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新規チオビリダミド誘導体JBIR-140 チオビリダミド生合成のための遺伝子クラスターの異種発現(Novel thioviridamide derivative: JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis)
Izumikawa Miho, Kozone Ikuko, Hashimoto Junko, Kagaya Noritaka, Takagi Motoki, Koiwai Hanae, Komatsu Mamoru, Fujie Manabu, Satoh Noriyuki, Ikeda Haruo, Shin-ya Kazuo
The Journal of Antibiotics 68 ( 8 ) 533 - 536 2015年8月（ ISSN:0021-8820 ）
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Yoshida M., Sekioka N., Izumikawa M., Kozone I., Takagi M., Shin-ya K., Doi T.
Chemistry - A European Journal 21 ( 7 ) 3031 - 3041 2015年2月（ ISSN:09476539 ）
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Identification and Characterization of the Streptazone E Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.
Ohno S, Katsuyama Y, Tajima Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-ya K, Ohnishi Y.
Chembiochem 16 2385 - 2391 2015年
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Total synthesis and structure elucidation of JBIR-39: a linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues.
Yoshida M, Sekioka N, Izumikawa M, Kozone I, Takagi M, Shin-ya K, Doi T.
Chemistry 21 3031 - 3041 2015年
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Total synthesis and structure determination of JBIR-108-a 2-Hydroxy-2-(1-hydroxyethyl)-2,3-dihydro-3(2H)-furanone isolated from Streptomyces gramineus IR087Pi-4.
Fujiwara K, Tsukamoto H, Izumikawa M, Hosoya T, Kagaya N, Takagi M, Yamamura H, Hayakawa M, Shin-ya K, Doi T
J Org Chem. 80 114 - 132 2015年
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Pyrrolidine-containing peptides, JBIR-126, -148, and -149, from Streptomyces sp. NBRC 111228.
Izumikawa M, Kawahara T, Kagaya N, Yamamura H, Hayakawa M, Takagi M, Yoshida M, Doi T, Shin-ya K.
Tetrahedron Lett. 56 5333 - 5336 2015年
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Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23.
Muliandi A, Katsuyama Y, Sone K, Izumikawa M, Moriya T, Hashimoto J, Kozone I, Takagi M, Shin-ya K, Ohnishi Y
Chem Biol. 21 923 - 934 2015年