研究者詳細 - 高木　基樹

論文 - 高木　基樹

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High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids.

Higa A, Takahashi N, Hiyama G, Tamura H, Hoshi H, Shimomura K, Watanabe S, Takagi M

Journal of visualized experiments : JoVE 2021 ( 172 ) 2021年6月（ ISSN:1940087X ）

Construction of <i>in vitro</i> patient-derived tumor models to evaluate anticancer agents and cancer immunotherapy.

Takahashi N, Higa A, Hiyama G, Tamura H, Hoshi H, Dobashi Y, Katahira K, Ishihara H, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M

Oncology letters 21 ( 5 ) 406 2021年5月（ ISSN:1792-1074 ）

An In Vitro System for Evaluating Molecular Targeted Drugs Using Lung Patient-Derived Tumor Organoids.

Takahashi N, Hoshi H, Higa A, Hiyama G, Tamura H, Ogawa M, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M

Cells 8 ( 5 ) 2019年5月

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer.

Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, Hirokawa T, Natsume T, Doi T.

Bioorg Med Chem. 26 ( 23-24 ) 6023 - 6034 2018年12月

Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues.

Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, Morisawa G, Yanagisawa Y, Ito E, Imai JI, Dobashi Y, Katahira K, Soeda S, Watanabe T, Fujimori K, Watanabe S, Takagi M

Oncology reports 40 ( 2 ) 635 - 646 2018年8月（ ISSN:1021-335X ）

Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis.

Tsutsumi H, Katsuyama Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

J Am Chem Soc. 140 ( 21 ) 6631 - 6639 2018年5月

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis.

Ito S, Ogawa K, Takeuchi K, Takagi M, Yoshida M, Hirokawa T, Hirayama S, Shin-ya K, Shimada I, Doi T, Goshima N, Natsume T, Nagata K.

The Journl of Biological Chemistry. 292 ( 49 ) 20076 - 20085 2017年12月

ヒトiPS細胞由来心筋細胞と遺伝子発現解析を用いた薬物の催不整脈能の評価系(Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis)

Higa Arisa, Hoshi Hirotaka, Yanagisawa Yuka, Ito Emi, Morisawa Gaku, Imai Jun-ichi, Watanabe Shinya, Takagi Motoki

The Journal of Toxicological Sciences 42 ( 6 ) 755 - 761 2017年12月（ ISSN:0388-1350 ）

Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation.

Hoshi H, Hiyama G, Ishikawa K, Inageda K, Fujimoto J, Wakamatsu A, Togashi T, Kawamura Y, Takahashi N, Higa A, Goshima N, Semba K, Watanabe S, Takagi M

Oncology reports 37 ( 1 ) 66 - 76 2017年1月（ ISSN:1021-335X ）

Streptomyces sp. RI-77から単離した改変ナフトキノン類JBIR-76とJBIR-77(JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77)

Motohashi Keiichiro, Izumikawa Miho, Kagaya Noritaka, Takagi Motoki, Shin-ya Kazuo

The Journal of Antibiotics 69 ( 9 ) 707 - 708 2016年9月（ ISSN:0021-8820 ）

インピーダンス測定を用いて決定したヒト幹細胞由来心筋細胞の催不整脈薬に対する種々の応答(Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements)

Higa Arisa, Hoshi Hirotaka, Takagi Motoki

Fundamental Toxicological Sciences 3 ( 2 ) 47 - 53 2016年3月

Involvement of the Baeyer-Villiger Monooxygenase IfnQ in the Biosynthesis of Isofuranonaphthoquinone Scaffold of JBIR-76 and -77.

Katsuyama Y, Sone K, Satou R, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

Chembiochem 2016年

Synthesis of marine oxylipin topsentolide A<inf>1</inf>and its stereoisomers, and determination of the absolute configuration of the natural product

Ishigami K., Kobayashi M., Takagi M., Shin-Ya K., Watanabe H.

Tetrahedron 71 ( 44 ) 8436 - 8443 2015年11月（ ISSN:00404020 ）

新規チオビリダミド誘導体JBIR-140　チオビリダミド生合成のための遺伝子クラスターの異種発現(Novel thioviridamide derivative: JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis)

Izumikawa Miho, Kozone Ikuko, Hashimoto Junko, Kagaya Noritaka, Takagi Motoki, Koiwai Hanae, Komatsu Mamoru, Fujie Manabu, Satoh Noriyuki, Ikeda Haruo, Shin-ya Kazuo

The Journal of Antibiotics 68 ( 8 ) 533 - 536 2015年8月（ ISSN:0021-8820 ）

Total synthesis and structure elucidation of JBIR-39: A linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues

Yoshida M., Sekioka N., Izumikawa M., Kozone I., Takagi M., Shin-ya K., Doi T.

Chemistry - A European Journal 21 ( 7 ) 3031 - 3041 2015年2月（ ISSN:09476539 ）

Identification and Characterization of the Streptazone E Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.

Ohno S, Katsuyama Y, Tajima Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-ya K, Ohnishi Y.

Chembiochem 16 2385 - 2391 2015年

Total synthesis and structure elucidation of JBIR-39: a linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues.

Yoshida M, Sekioka N, Izumikawa M, Kozone I, Takagi M, Shin-ya K, Doi T.

Chemistry 21 3031 - 3041 2015年

Total synthesis and structure determination of JBIR-108-a 2-Hydroxy-2-(1-hydroxyethyl)-2,3-dihydro-3(2H)-furanone isolated from Streptomyces gramineus IR087Pi-4.

Fujiwara K, Tsukamoto H, Izumikawa M, Hosoya T, Kagaya N, Takagi M, Yamamura H, Hayakawa M, Shin-ya K, Doi T

J Org Chem. 80 114 - 132 2015年

Pyrrolidine-containing peptides, JBIR-126, -148, and -149, from Streptomyces sp. NBRC 111228.

Izumikawa M, Kawahara T, Kagaya N, Yamamura H, Hayakawa M, Takagi M, Yoshida M, Doi T, Shin-ya K.

Tetrahedron Lett. 56 5333 - 5336 2015年

Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23.

Muliandi A, Katsuyama Y, Sone K, Izumikawa M, Moriya T, Hashimoto J, Kozone I, Takagi M, Shin-ya K, Ohnishi Y

Chem Biol. 21 923 - 934 2015年

海洋由来の放線菌が産生する二次代謝産物の新規薬剤探索ライブラリーの構築

高木　基樹、新家　一男

バイオサイエンスとインダストリー 72 ( 2 ) 208 - 212 2014年5月

Actinoplanes missouriensisからの新規プレニル化インドール誘導体3-hydroxy-6-dimethylallylindolin-2-oneの単離、構造決定および生合成(Isolation, structural elucidation and biosynthesis of 3-hydroxy-6-dimethylallylindolin-2-one, a novel prenylated indole derivative from Actinoplanes missouriensis)

Satou Ryutaro, Izumikawa Miho, Katsuyama Yohei, Matsui Misato, Takagi Motoki, Shin-ya Kazuo, Ohnishi Yasuo

The Journal of Antibiotics 67 ( 3 ) 231 - 236 2014年3月（ ISSN:0021-8820 ）

Total synthesis and characterization of thielocin B1 as a protein–protein interaction inhibitor of PAC3 homodimer.

Doi T, Yoshida M, Ohsawa K, Shin-ya K, Takagi M, Uekusa Y, Yamaguchi T, Kato K, Hirokawa T, Natsume T.

Chem Sci. 5 1860 - 1868 2014年

Isolation, structural elucidation and biosynthesis of 3-hydroxy-6-dimethylallylindolin-2-one, a novel prenylated indole derivative from Actinoplanes missouriensis.

Satou R, Izumikawa M, Katsuyama Y, Matsui M, Takagi M, Shin-ya K, Ohnishi Y.

J Antibiot. 67 231 - 236 2014年

Synthesis of heptaoxazole macrocyclic analogues of telomestatin and evaluation of their telomerase inhibitory activities

Shibata K., Yoshida M., Takahashi T., Takagi M., Shin-Ya K., Doi T.

Bulletin of the Chemical Society of Japan 86 ( 12 ) 1453 - 1465 2013年12月（ ISSN:00092673 ）

Spectomycin B1 as a novel sumoylation inhibitor that directly binds to SUMO E2

Hirohama M., Kumar A., Fukuda I., Matsuoka S., Igarashi Y., Saitoh H., Takagi M., Shin-Ya K., Honda K., Kondoh Y., Saito T., Nakao Y., Osada H., Zhang K., Yoshida M., Ito A.

ACS Chemical Biology 8 ( 12 ) 2635 - 2642 2013年12月（ ISSN:15548929 ）

Isaria種NBRC 104353由来の新規ピリドンアルカロイドJBIR-130、JBIR-131、JBIR-132(New pyridone alkaloids JBIR-130, JBIR-131 and JBIR-132 from Isaria sp. NBRC 104353)

Hosoya Takahiro, Takagi Motoki, Shin-ya Kazuo

The Journal of Antibiotics 66 ( 4 ) 235 - 238 2013年4月（ ISSN:0021-8820 ）

Total Synthesis of Destruxin E and its Derivatives

YOSHIDA Masahito, ISHIDA Yoshitaka, TAKEUCHI Hisayuki, NAKAGAWA Hiroshi, YASHIRODA Yoko, YOSHIDA Minoru, TAKAGI Motoki, SHIN-YA Kazuo, DOI Takayuki

Peptide science : proceedings of the ... Japanese Peptide Symposium 2012 95 - 96 2013年3月（ ISSN:13447661 ）

Synthesis of hepta-oxazole macrocyclic analogues of telomestatin and evaluation of their telomerase inhibitory activities.

Shibata K, Yoshida M, Takahashi T, Takagi M, Shin-ya K, Doi T.

Bull. Chem. Soc. Jpn 86 1453 - 1465 2013年

Spectomycin B1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E2.

Hirohama M, Kumar A, Fukuda I, Matsuoka S, Igarashi Y, Saitoh H, Takagi M, Shin-ya K, Honda K, Kondoh Y, Saito T, Nakao Y, Osada H, Zhang KY, Yoshida M, Ito A.

ACS Chem Biol. 8 2635 - 2642 2013年

JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047.

Izumikawa M, Kawahara T, Hwang JH, Takagi M, Shin-ya K.

Biosci Biotechnol Biochem. 77 663 - 665 2013年

Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites.

Komatsu M, Komatsu K, Koiwai H, Yamada Y, Kozone I, Izumikawa M, Hashimoto J, Takagi M, Omura S, Shin-ya K, Cane DE, Ikeda H.

ACS Synth Biol. 2 384 - 396 2013年

Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.

Fuse S, Inaba K, Takagi M, Tanaka M, Hirokawa T, Johmoto K, Uekusa H, Shin-ya K, Takahashi T, Doi T.

Eur J Med Chem. 66 180 - 184 2013年

A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis.

Maruyama C, Toyoda J, Kato Y, Izumikawa M, Takagi M, Shin-ya K, Katano H, Utagawa T, Hamano Y.

Nat Chem Biol 8 ( 9 ) 791 - 797 2012年9月

Construction of a natural product library containing secondary metabolites produced by actinomycetes.

Takagi M, Shin-ya K.

J Antibiot. 65 443 - 447 2012年

Tyrosyl-DNA Phosphodiesterase 1 Inhibitor from an Anamorphic Fungus.

Takagi M, Ueda JY, Hwang JH, Hashimoto J, Izumikawa M, Murakami H, Sekido Y and Shin-ya K.

J Nat Prod 75 764 - 767 2012年

JBIR-124: a novel antioxidative agent from a marine sponge-derived fungus Penicillium citrinum SpI080624G1f01.

Kawahara T, Takagi M and Shin-ya K

J Antibiot 65 45 - 47 2012年

A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil.

Izumikawa M, Hosoya T, Takagi M and Shin-ya K

J Antibiot 65 41 - 43 2012年

JBIR-94 and JBIR-125, Antioxidative Phenolic Compounds from Streptomyces sp. R56-07.

Kawahara T, Izumikawa M, Otoguro M, Yamamura H, Hayakawa M, Takagi M and Shin-ya K

J Nat Prod 75 107 - 110 2012年

JBIR-78 and JBIR-95: Phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56.

Izumikawa M, Takagi M and Shin-ya K

J Nat Prod 75 280 - 284 2012年

Trichostatin Analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.

Hosoya T, Hirokawa T, Takagi M and Shin-ya K

J Nat Prod 75 285 - 289 2012年

Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.

Ohnuki S, Kobayashi T, Ogawa H, Kozone I, Ueda JY, Takagi M, Shin-Ya K, Hirata D, Nogami S and Ohya Y

FEMS Yeast Res 12 293 - 304 2012年

Actinobacteria Associated with the Marine Sponges Cinachyra sp., Petrosia sp., and Ulosa sp. and Their Culturability.

Khan ST, Takagi M and Shin-ya K

Microbes Environ 27 99 - 104 2012年

Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36.

Kawahara T, Takagi M and Shin-ya K

J Antibiot 65 147 - 150 2012年

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

Takahashi M, Takemoto Y, Shimazu T, Kawasaki H, Tachibana M, Shinkai Y, Takagi M, Shin-ya K, Igarashi Y, Ito A and Yoshida M.

J Antibiot. 65 263 - 265 2012年

JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells.

Kawahara T, Hosoya T, Tsukamoto M, Okabe S, Yamamura H, Hayakawa M, Seimiya H, Takagi M* and Shin-ya K.

J Antibiot. 65 373 - 375 2012年

JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75.

Kawahara T, Nagai A, Takagi M, Shin-ya K.

J Antibiot. 65 535 - 538 2012年

Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74.

Kawahara T, Izumikawa M, Takagi M, Shin-ya K.

Org Lett. 14 4434 - 4437 2012年

A new furaquinocin derivative, JBIR-136, from Streptomyces sp. 4963H2.

Kawahara T, Nagai A, Takagi M, Shin-ya K.

J Antibiot. 65 579 - 581 2012年

JBIR-129 and -139, Cytotoxic 34-membered polyol macrolides of microbial origin.

Kawahara T, Hwang JH, Izumikawa M, Hashimoto J, Takagi M, Shin-ya K.

J Nat Prod. 75 1814−1818 2012年

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