ONO Yuko

写真a

Title

Postdoctoral Researcher

Date of Birth

1982

Research Fields, Keywords

Airway management, trauma, sepsis, pharmacology, toll like receptor, skeltel muscle myogenesis

Mail Address

E-mail address

Laboratory Phone number

81-078-382-6521

Laboratory Fax number

+81-078-341-5254

Homepage URL

http://orcid.org/0000-0002-5953-3042

Profile

I am currently serving as a staff physician and an assistant professor at the Emergency Department, Kobe University Hospital. I am also conducting the laboratory work, as a postdoctoral researcher at Department of Bioregulation and Pharmacological Medicine, at Fukushima Medical University. My time is divided between researches (both clinical and laboratory); clinical practice; and teaching.

My clinical background is emergency medicine, intensive care medicine, and anesthesiology. My major clinical research interests are: emergency airway management; trauma; emergency surgery; perioperative medicine; and sepsis. My clinical research work have featured in a series of publications [Scand J Trauma Resusc Emerg Med. 2016;24:106, and J Anesth. 2016;30:644-52].

As for the basic research, in order to elucidate the etiology of ICU acquired weakness associated with severe sepsis, I am currently working on mouse sepsis model and established myoblast cell lines. My laboratory research work have featured in a series of publication [Sci Rep. 2020 ;10:694, PLoS One. 2017;12:e0182040, and J Pharmacol Sci. 2017;133:276-279].

As a board certified acute care physician and a board certified anesthesiologist, I carry out my clinical service at the Emergency Department, Kobe University Hospital. I am also involved in ICU inpatients and clinical supervisory role of junior and senior residents.

The majority of my teaching activities take place at Kobe University Hospital. I regularly give 5th year medical school students lectures and practice on endotracheal intubation using simulators. I also teach paramedical students.

Integrating these multifaceted activities of clinical and basic science research, clinical service, and teaching, I am striving to develop my academic career as a physician-scientist with expertise in airway management, trauma, and sepsis.

Current Affiliation Organization 【 display / non-display

  • Concurrently ,  Office for Gender Equality Support, Fukushima Medical University, member

  • Duty ,  School of Medicine (Life Sciences and Social Medicine) ,  Department of Pharmacology ,  Postdoctoral Researcher

Graduating School 【 display / non-display

  • Fukushima Medical University ,  Faculty of Medicine ,  School of Medicine ,  Graduated ,  JAPAN ,  2007.03

  • Asaka High School ,  general education curriculum ,  general education curriculum ,  Graduated ,  JAPAN ,  2001.03

Graduate School 【 display / non-display

  • Fukushima Medical University ,  Graduate School, Division of Medicine ,  Molecular Pharmacology (No. 603) ,  Doctor's Course ,  Completed ,  JAPAN ,  2018.03

Degree 【 display / non-display

  • Fukushima Medical University -  M.D.(No. 3605) ,  2007.03

  • Fukushima Medical University -  Ph.D. in Medicine (No. 603) ,  2018.03

Career 【 display / non-display

  • 2007.04
    -
    2009.03

    Fukushima Medical University Hospital, Junior Resident

  • 2009.04
    -
    2009.10

    Fukushima Medical University Hospital,Emergency and Critical Care Medicine, Senior Resident

  • 2009.11
    -
    2010.03

    Shodokai Southern Tohoku Hospital Department of Anesthesiology and Emergency Medicine, Attending physician.

  • 2010.04
    -
    2012.03

    Fukushima Medical University Hospital,Emergency and Critical Care Medicine, Senior Resident

  • 2012.04
    -
    2014.03

    Ohta General Hospital Foundation, Ohta Nishinouchi Hospital,Department of Anesthesiology, Attending anesthesiologist

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Academic Society Affiliations 【 display / non-display

  • 2008.10
    -
    Now

    Japanese Association for Acute Medicine (No. o1702) ,  JAPAN

  • 2009.05
    -
    2018.12

    Japanese Society for Emergency Medicine ,  JAPAN

  • 2009.05
    -
    Now

    Japanese Society of Intensive Care Medicine (No. 5431) ,  JAPAN

  • 2009.05
    -
    Now

    Japanese Society of Anesthesiologists (No. 00015541) ,  JAPAN

  • 2010.11
    -
    2018.10

    Japanese society of aeromedical survices ,  JAPAN

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Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • General Pharmacology

  • Anesthesiology/Resuscitation Studies

  • Emergency Medicine

  • epidemiology

  • molecular biology

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Qualification acquired 【 display / non-display

  • Japanese Society of Anesthesiologists Board certification (No.10455) ,  2016.04

  • Japanese Association for Acute Medicine Board certification (No.4767) ,  2013.01

  • Qualified anesthesiologist,Ministry of Health, Labour and Welfare, Japan (No.26656) ,  2012.12

  • Japanese Society of Anesthesiologists qualified anesthesiologist (No.10455) ,  2013.01

  • Japanese Association for Medical Simulation, certified Difficult Airway Management (DAM) instructor (DAM0093) ,  2015.06

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Current state of research and teaching activities 【 display / non-display

  • 1. Endotracheal intubation practice using Simulators; Fukushima Medical University, Fukushima, Japan; 3rd year M.D program students; 2 hours sessions per week for 12 months.
    2. Physiological and pharmacological practice (Teaching assistant); Fukushima Medical University, Fukushima, Japan; 1st year M.D program students; 4 hours sessions per week for 2 months.

 

Research Career 【 display / non-display

  • Airway management

    Project Year: 2011.04  -  Now 

    My featuring works related to this topic are:

    1. Ono Y*, Tanigawa K, Kakamu T, Shinohara K, Iseki K. Out-of-hospital endotracheal intubation experience, confidence and confidence-associated factors among Northern Japanese emergency life-saving technicians: a population-based cross-sectional study. BMJ Open. 2018;8:e021858.
    2. Ono Y*, Kakamu T, Kikuchi H, Mori Y, Watanabe Y, Shinohara K. Expert-Performed Endotracheal Intubation-Related Complications in Trauma Patients: Incidence, Possible Risk Factors, and Outcomes in the Prehospital Setting and Emergency Department. Emerg Med Int. 2018;2018:5649476.
    3. Ono Y*, Tanigawa K, Shinohara K, Yano T, Sorimachi K, Inokuchi R, Shimada J. Human and equipment resources for difficult airway management, airway education programs, and capnometry use in Japanese emergency departments: a nationwide cross-sectional study. Int J Emerg Med. 2017;10:28.
    4. Ono Y*, Shinohara K, Tanigawa K. Reappraising the role of supraglottic airway devices for difficult airway management in critical care and emergency medicine. J Jpn Soc Intensive Care Med 2017;24:535-41 (In Japanese) .
    5. Ono Y*, Shinohara K, Goto A, Yano T, Sato L, Miyazaki H, Shimada J, Tase C. Are prehospital airway management resources compatible with difficult airway algorithms? A nationwide cross-sectional study of helicopter emergency medical services in Japan. J Anesth. 2016;30:205-14.
    6. Ono Y*, Tanigawa K, Shinohara K, Yano T, Sorimachi K, Sato L, Inokuchi R, Shimada J, Tase C. Difficult airway management resources and capnography use in Japanese intensive care units: a nationwide cross-sectional study. J Anesth. 2016;30:644-52.
    7. Ono Y*, Sugiyama T, Chida Y, Sato T, Kikuchi H, Suzuki D, Ikeda M, Tanigawa K, Shinohara K. Association between off-hour presentation and endotracheal-intubation-related adverse events in trauma patients with a predicted difficult airway: A historical cohort study at a community emergency department in Japan.Scand J Trauma Resusc Emerg Med. 2016;24:106.
    8. Ono Y*, Kikuchi H, Hashimoto K, Sasaki T, Ishii J, Tase C, Shinohara K. Emergency endotracheal intubation-related adverse events in bronchial asthma exacerbation: can anesthesiologists attenuate the risk? J Anesth. 2015;29:678-685.
    9. Ono Y*, Yokoyama H, Matsumoto A, Kumada Y, Shinohara K, Tase C. Surgical airways for trauma patients in an emergency surgical setting: 11 years' experience at a teaching hospital in Japan. J Anesth. 2013; 27: 832-7.

    endotracheal intubation

  • Other fields of Emergency Medicine

    Project Year: 2013.04  -  Now 

    My featuring works related to this topic are:

    1. Ono Y*, Ishida T, Iwasaki Y, Kawakami Y, Inokuchi R, Tase C, Shinohara K. The off-hour effect on trauma patients requiring subspecialty intervention at a community hospital in Japan: a retrospective cohort study. Scand J Trauma Resusc Emerg Med. 2015;23:20.
    2. Ono Y*, Yokoyama H, Matsumoto A, Kumada Y, Shinohara K, Tase C. Is preoperative period associated with severity and unexpected death of injured patients needing emergency trauma surgery? J Anesth. 2014; 28:381-9.
    3. Ono Y*, Satou M, Ikegami Y, Shimada J, Hasegawa A, Tsukada Y, Nemoto C, Shinohara K, Tase C. Activation intervals for a helicopter emergency medical service in Japan. Air Med J. 2013; 32: 346-9.
    4. Ono Y*, Ikegami Y, Shimada J, Hasegawa A, Tsukada Y, Shinohara K, Tase C. Helicopter emergency medical services (doctor-helicopters) in Fukushima provide appropriate field triage for trauma patients. (in Japanese) JJAAM. 2013; 24: 12-8

    Emergency Operation, Helicopter Emergency Medical Survive, Trauma

  • Sepsis/ICU acquired weakness/Myogenesis

    Project Year: 2013.10  -  Now 

    My featuring works related to this topic are:

    1. Ono Y*, Sakamoto K. Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α. PLoS One. 2017;12:e0182040.
    2. Tanaka S, Ono Y*, Sakamoto K. DCEBIO facilitates myogenic differentiation via intermediate conductance Ca2+ activated K+ channel activation in C2C12 myoblasts. J Pharmacol Sci. 2017;133:276-279.

    Sepsis/ICU acquired weakness/Myogenesis

  • Case Report/Letter

    Project Year: 2010.04  -  Now 

    My featuring works related to this topic are:

    1. Ono Y*, Kunii M, Miura T, Shinohara K. "Cannot ventilate, cannot intubate" situation after penetration of the tongue root through to the epipharynx by a surfboard: a case report. J Med Case Rep. 2017;11:121.
    2. Ono Y*, Ono N, Shinohara K. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Rep Emerg Med. 2017;2017:3968045.
    3. Ono Y*, Shimada J, Shinohara K. Possible additional role for nasal jet oxygen insufflation. J Anesth. 2017;31:797.
    4. Sorimachi K, Ono Y *(corresponding author), Kobayashi H, Watanabe K, Shinohara K, Otani K. Airway management in a patient with nuchal, interspinous, and flavum ligament rupture by a sickle: a case report. J Med Case Rep. 2016;10:172.
    5. Hamaya R, Ono Y *(corresponding author), Chida Y, Inokuchi R, Kikuchi K, Tameda T, Tase C, Shinohara K. Polytetrafluoroethylene fume-induced pulmonary edema: a case report and review of the literature. J Med Case Rep. 2015;9:111.
    6. Ono Y*, Okubo Y, Hashimoto K, Inokuchi R, Odajima H, Tase C, Shinohara K. Massive subcutaneous emphysema, bilateral pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum after multiple direct laryngoscopies: an autopsy case report. J Anesth. 2015 ;29:622-6.
    7. Ono Y*, Abe Y, Shinohara K. Identification of a displaced glottis using vocalization. J Anesth. 2015;29:320.
    8. Ono Y*, Ikegami Y, Tasaki K, Abe M, Tase C. Case of scrub typhus complicated by severe disseminated intravascular coagulation and death. Emerg Med Australas. 2012; 24: 577-80.

    Case Report/Letter

Papers 【 display / non-display

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Books 【 display / non-display

  • ICUとCCU

    大野 雄康, 斎藤 雅史, 藤浪 好寿, 井上 茂亮, 小谷 穣治 (Part:ICU-acquired weaknessの病態生理-敗血症中心に-)

    東京: 医学図書出版; ,  2020.06

  • Airway management case files for emergency lifesaving technicians

    Asai T, Ueshima H (Part:Out-of-Hospital Cardiac Arrest Due to Suffocation: Rethink the airway-related complication in patients with difficult airway (in Japanese).) (Page:p. 98-102)

    Chugaiigaku. Co ,  2019.06

    Ono Y. Out-of-Hospital Cardiac Arrest Due to Suffocation: Rethink the airway-related complication in patients with difficult airway (in Japanese). In: Asai T, Ueshima H. Airway management case files for emergency lifesaving technicians. Chugaiigaku. Co, Tokyo, Japan. 2019. p. 98-102. ,  Tokyo

  • Airway management case files for emergency lifesaving technicians

    Asai T, Ueshima H (Part:Out-of-Hospital Cardiac Arrest in Patients with High Cervical-level Spinal Cord Injuries: What Is the Suitable Laryngoscope In Case With Restricted Neck Movements? ) (Page:p. 98-102)

    Chugaiigaku. Co ,  2019.06

    3. Ono Y. Out-of-Hospital Cardiac Arrest in Patients with High Cervical-level Spinal Cord Injuries: What Is the Suitable Laryngoscope In Case With Restricted Neck Movements? In: Asai T, Ueshima H. Airway management case files for emergency lifesaving technicians. Chugaiigaku. Co, Tokyo, Japan. 2019. p.103-106. ,  Tokyo

  • Cardiopulmonary resuscitation

    (Part:Bradycardia) (Page:173-183)

    Kokuseido Co ,  2011.12

    Choichiro Tase, Yukihiro Ikegami, Yuko Ono*. ,  Tokyo, Japan

Academic Awards Received 【 display / non-display

  • Award for best presentation The 66th Annual Meeting of the Japanese Society of Anesthesiologists, Kobe, Japan.

    2019.05.30 ,  JAPAN

  • Award for best presentation,The 23rd Annual Meeting of the Japanese Society of Intensive Care Medicine, Tohoku Branch

    2014.06.28 ,  JAPAN

  • Best paper award, Japanese Association for Medical Simulation 2021

    2021.03.11 ,  JAPAN

  • Award for best presentation,The 24th Annual Meeting of Japan Society of Critical Care for Endotoxemia, Fukuoka, Japan

    2020.02.01 ,  JAPAN

  • Award for best presentation

    2020.02

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Joint Research activities 【 display / non-display

  • Drug Exploration for Sepsis-Induced Skeletal Muscle Atrophy

    Assistance  

    Project Year:2018.07 - 2019.06 

    Investigator(s): Yuko Ono*  ,  Member: Kenju Shimomura, Yuko Maejima

  • Nuclear Factor-kappa B Signaling Inhibition for Sepsis-induced Skeletal Muscle Atrophy

    Assistance  

    Project Year:2018.04 - 2022.03 

    Investigator(s): Yuko Ono* 

    The main purposes of this project are to find novel pharmacological intervention to prevent sepsis induced skeletal muscle atrophy. To achieve this goal, we have established in vitro and in vivo models of sepsis induced skeletal muscle atrophy. Using these models, we seek to determine whether pharmacological inhibition of TLR4/NF-κB signal (1) prevents skeletal muscle degradation; (2) histologically ameliorates skeletal muscle atrophy; and (3) functionally improve skeletal muscle contraction.

  • Identification of the mechanism of sepsis induced muscle wasting and potential pharmacological treatment

    Assistance  

    Project Year:2015.04 - 2018.03 

    Investigator(s): Yuko Ono* 

    We found lipopolysaccharide inhibit muscle differentiation on mouse myoblast (C2C12).
    The main object of this project are to determine this molecular mechanism in C2C12 differentiation, and find the useful drug.

Preferred joint research theme 【 display / non-display

  • sepsis induced skeletal muscle atrophy and its novel therapy

    Cooperative Research with Industry-University research organizations and private agencies.  Technical consultation, Commisioned research, Joint research, Others

 

Charge of on-campus class subject 【 display / non-display

  • Prehospital Medicine (October 17, 2018)

  • Endotracheal intubation practice using a simulator

  • Physiology and Pharmacology student practice:Glucose Metabolism

  • Pharmacology advanced student practice. January 12, 2018- February 21, 2018

  • Physiology and Pharmacology student practice:Adverse Drug Event

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Other educational activity and Special note 【 display / non-display

  • Yuko Ono. Clinical Study (Basic). One hour seminar. Ohta General Hospital Foundation, Ohta Nishinouchi Hospital, Koriyama, Japan. November 16, 2018

    2018.11
     
     

  • Clinical Pathological Conference (CPC)

    2018.09
     
     

  • How to use a rigid video laryngoscope; Fukushima Fire Academy, Fukushima, Japan. lecture and hands on sessions.

    2018.07
    -
    2018.11

  • Clinical Pathological Conference January 24, 2018

    2018.01
     
     

  • Objective Structured Clinical Examination (OSCE), Emergency Medicine Skill Station, examiner.

    2017.12
     
     

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Academic Activity 【 display / non-display

  • Japanese Association for Acute Medicine (No. o1702)

    Member

    2008.10
    -
    Now

  • Japanese Society of Anesthesiologists (No. 00015541)

    Member

    2009.05
    -
    Now

  • Japanese Society of Intensive Care Medicine (No. 5431)

    Member

    2009.05
    -
    Now

  • Japanese Society for Emergency Medicine

    Member

    2009.05
    -
    Now

  • Fukushima medical association

    Member

    2012.01
    -
    Now

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