Highlighted Publications
Chiba H, Ichikawa-Tomikawa N, Imura T, Sugimoto K. The region-selective
regulation of endothelial claudin-5 expression and signaling in brain health
and disorders. J Cell Physiol. 2021
Sugimoto K, Chiba H. The claudin-transcription factor signaling pathway.
Tissue Barriers. 2021
Kojima M, Sugimoto K, Kobayashi M, Ichikawa-Tomikawa N, Kashiwagi K, Watanabe
T, Soeda S, Fujimori K, Chiba H. Aberrant Claudin-6-Adhesion Signaling
Promotes Endometrial Cancer Progression via Estrogen Receptor α. Mol Cancer
Res. 2021
Watanabe M, Higashi T, Ozeki K, Higashi AY, Sugimoto K, Mine H, Takagi
H, Ozaki Y, Muto S, Okabe N, Matsumura Y, Hasegawa T, Shio Y, Suzuki H,
Chiba H. CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.
Sci Rep. 2021
Yamashita R, Tanaka M, Chiba H, Sugimoto K. Bacterial Myocarditis in a
Patient with Cancer. JMA J. 2021
Rahman A, Kobayashi M, Sugimoto K, Endo Y, Kojima M, Furukawa S, Watanabe
T, Soeda S, Hashimoto Y, Fujimori K, Chiba H. Reduced Claudin-12 Expression
Predicts Poor Prognosis in Cervical Cancer. Int J Mol Sci. 2021
Yamazaki M, Sugimoto K, Mabuchi Y, Yamashita R, Ichikawa-Tomikawa N, Kaneko
T, Akazawa C, Hasegawa H, Imura T, Chiba H. Soluble JAM-C Ectodomain Serves
as the Niche for Adipose-Derived Stromal/Stem Cells. Biomedicines. 2021
Sugimoto K, Ichikawa-Tomikawa N, Nishiura K, Kunii Y, Sano Y, Shimizu F,
Kakita A, Kanda T, Imura T, Chiba H. Serotonin/5-HT1A Signaling in the
Neurovascular Unit Regulates Endothelial CLDN5 Expression. Int J Mol Sci.
2020
Kojima M, Sugimoto K, Tanaka M, Endo Y, Kato H, Honda T, Furukawa S, Nishiyama
H, Watanabe T, Soeda S, Fujimori K, Chiba H. Prognostic Significance of
Aberrant Claudin-6 Expression in Endometrial Cancer. Cancers. 2020
Higashi T, Chiba H. Molecular organization, regulation and function of
tricellular junctions. Biochim Biophys Acta Biomembr. 2020
Sugimoto K, Ichikawa-Tomikawa N, Kashiwagi K, Endo C, Tanaka S, Sawada
N, Watabe T, Higashi T, Chiba H. Cell adhesion signals regulate the nuclear
receptor activity. Proc Natl Acad Sci USA . 2019
Okai K, Ichikawa-Tomikawa N, Saito AC, Watabe T, Sugimoto K, Fujita D,
Ono C, Fukuhara T, Matsuura Y, Ohira H, Chiba H. A novel occludin-targeting
monoclonal antibody prevents hepatitis C virus infection in vitro. Oncotarget. 2018
Kashiwagi K, Yanagida M, Matsui D, Tanaka M, Sugimoto K, Chen H, Ichikawa-Tomikawa
N, S. Marubashi, H. Suzuki, H. Chiba. Expression of liver X receptors in
normal and refractory carcinoma tissues of the human lung and pancreas. Histol Histopathol. 2017
Nishiura K, Ichikawa-Tomikawa N, Sugimoto K, Kunii Y, Kashiwagi K, Tanaka
M, Yokoyama Y, Hino M, Sugimot T, Yabe H, Takahashi H, Kakita A, Imura
T, Chiba H. PKA activation and endothelial claudin-5 breakdown in the schizophrenic
prefrontal cortex. Oncotarget. 2017
Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi
C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H. Liver X receptor reduces
proliferation of human oral cancer cells by promoting cholesterol efflux
via up-regulation of ABCA1 expression. Oncotarget. 2015
Tanaka M, Ichikawa-Tomikawa N, Shishito N, Nishiura K, Miura T, Hozumi
A, Chiba H, Yoshida S, Ohtake T, Sugino T. Co-expression of S100A14 and
S100A16 correlates with a poor prognosis in human breast cancer and promotes
cancer cell invasion. BMC Cancer. 2015
Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T,
Sawada N, Chiba H. The tight-junction protein claudin-6 induces epithelial
differentiation from mouse F9 and embryonic stem cells. PLoS One. 2013
Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N,
Tsukamoto T, Sawada N. Claudin-4-targeted therapy using Clostridium perfringens
enterotoxin for prostate cancer. Prostate. 2011
[Review article] Ichikawa-Tomikawa N, Sugimoto K, Satohisa S, Nishiura K, Chiba H. Possible
involvement of tight junctions, extracellular matrix and nuclear receptors
in epithelial differentiation. J Biomed Biotechnol. 2011
Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto
Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H.
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent
Ca2+ absorption between enterocytes. Mol Biol Cell. 2008
[Review article] Chiba H, Osanai M, Murata M, Kojima T, Sawada N. Transmembrane proteins
of tight junctions. Biochim Biophys Acta. 2008
Chiba H, Sakai N, Murata M, Osanai M, Ninomiya T, Kojima T, Sawada N. The
nuclear receptor hepatocyte nuclear factor 4 acts as a morphogen to induce
the formation of microvilli. J Cell Biol. 2006
Satohisa S, Chiba H, Osanai M, Ohno S, Kojima T, Saito T, Sawada N. Behavior
of tight-junction, adherens-junction and cell polarity proteins during
HNF-4α-induced epithelial polarization. Exp Cell Res. 2005
Chiba H, Chambon P, Metzger D. 2000. F9 embryonal carcinoma cells engineered
for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible
gene expression.Exp Cell Res. 260:334–339. doi:10.1006/excr.2000.5022.
Kubota H, Chiba H, Takakuwa Y, Osanai M, Tobioka H, Kohama G, Mori M, Sawada
N. Retinoid X receptor alpha and retinoic acid receptor gamma mediate expression
of genes encoding tight-junction proteins and barrier function in F9 cells
during visceral endodermal differentiation.Exp Cell Res. 2000
Chiba H, Clifford J, Metzger D, Chambon P. Distinct retinoid X receptor-retinoic
acid receptor heterodimers are differentially involved in the control of
expression of retinoid target genes in F9 embryonal carcinoma cells. Mol Cell Biol. 1997
Chiba H, Clifford J, Metzger D, Chambon P. Specific and redundant functions
of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation,
proliferation, and apoptosis of F9 embryonal carcinoma cells. J Cell Biol. 1997