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Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders

Yuichi Suzuki, Shuntaro Itagaki, Maki Nodera, Kazuhide Suyama, Hirooki Yabe, Mitsuaki Hosoya

Author information

  • Yuichi Suzuki

    Department of Pediatrics, Fukushima Medical University School of Medicine

  • Shuntaro Itagaki

    Department of Neuropsychiatry, Fukushima Medical University School of Medicine

  • Maki Nodera

    Department of Pediatrics, Fukushima Medical University School of Medicine

  • Kazuhide Suyama

    Department of Pediatrics, Fukushima Medical University School of Medicine

  • Hirooki Yabe

    Department of Neuropsychiatry, Fukushima Medical University School of Medicine

  • Mitsuaki Hosoya

    Department of Pediatrics, Fukushima Medical University School of Medicine

Abstract

Background: This study investigated changes of lipid parameters in children with severe eating disorders during refeeding in order to explore the optimal timing for lipid preparation administration.


Methods: We prospectively assessed the physical conditions of patients with eating disorders after the start of nutrition therapy. The assessments were performed at admission and at 2 and 4 weeks. Lipid metabolism was assessed based on triglyceride (TG), total cholesterol (TC), and free carnitine (FC) levels, as well as acylcarnitine/free carnitine (AC/FC) ratio.


Results: A total of 18 patients were included. Of these, 12 and 6 received an oral diet (OD group) and total parenteral nutrition (TPN group), respectively. The mean body mass indexes at hospital admission were 12.8 kg/m2 in the OD group and 12.7 kg/m2 in the TPN group. At 2 weeks after the start of refeeding, TC, TG, and AC/FC levels were significantly lower in the TPN group than in the OD group. Other blood test results did not show any significant differences between the two groups.


Conclusions: Fat-free glucose-based nutrition promoted lipid metabolism over a 2-week period after the start of refeeding, suggesting that balanced energy and lipid intake are essential, even in TPN.

The cintent of reseach paper

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