Abstract/References

Clinical course and background of nasopharyngeal antibiotic-resistant bacteria carriers among preschool children hospitalized for lower respiratory tract infection

Aya Takeyama, Kenta Suzuki, Masaki Ito, Masatoki Sato, Koichi Hashimoto, Masahiko Katayose, Mitsuaki Hosoya

Author information
  • Aya Takeyama

    Department of Pediatrics, Public Soma General Hospital

  • Kenta Suzuki

    Department of Pediatrics, School of Medicine, Fukushima Medical University

  • Masaki Ito

    Department of Pediatrics, Public Soma General Hospital

  • Masatoki Sato

    Department of Pediatrics, School of Medicine, Fukushima Medical University

  • Koichi Hashimoto

    Department of Pediatrics, School of Medicine, Fukushima Medical University

  • Masahiko Katayose

    Nanohana Kids Clinic

  • Mitsuaki Hosoya

    Department of Pediatrics, School of Medicine, Fukushima Medical University

Abstract

AbstractWe investigated the nasopharyngeal microbiota in preschool patients hospitalized with lower respiratory tract infection to clarify the relationships between culturable nasopharyngeal bacteria and prognosis. From 2016 to 2018, nasopharyngeal culture was performed on inpatients under 6 years of age with a lower respiratory tract infection. Among the 1,056 study patients, 1,046 provided nasopharyngeal samples that yielded positive cultures, yielding 1,676 isolated strains. Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, were isolated in 25%, 27%, and 31% of the samples, respectively, and were the major causes of respiratory tract infection in these children. The only factor associated with the isolation of antibiotic-resistant strains from the nasopharynx was daycare attendance, which did not affect clinical severity, such as duration of fever and hospitalization. This study demonstrated that resistant bacteria in the nasopharynx did not affect the severity of lower respiratory tract infection and supports the use of narrow-spectrum antimicrobial agents in accordance with published guidelines when initiating therapy for pediatric patients with community-acquired pneumonia.

The cintent of reseach paper

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