| Department of
Bimolecular Science |
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Introduction |
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| This department has first opened in 1980 as
a Division of Environmental Pollution Research,
Central Research Laboratory at this University.
With the stream of recent progress on life sciences,
the department has been newly organized in 1995
to develop more advanced research on molecular
mechanisms of cellular signal transduction system.
Research on molecular basis advances in two related
areas in this laboratory: 1) stress signal transduction
associated with human diseases, and 2) epigenetics-controlled
gene expression. Department faculty members are
Dr. Yoshimi Homma, Professor; Dr. Masayuki Sekimata,
Lecturer; and Dr. Miwako K. Homma, Research Associate |
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Research |
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| Research in this laboratory is focused on understanding
the molecular basis of stress signal transduction
and regulation of gene expression. We are interested
in alteration of normal signal transduction pathways
and epigenetics by repeated or prolonged external
stimuli. At present, we are studying intracellular
signaling, initiated by various oxidative stresses.
We are also investigating DNA methylation in the
promoter of growth-associated genes in various
cells derived from chronic proliferating diseases. |
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Education |
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| The faculty in the department aims to train
medical school students and graduate students
in both the philosophy and practice of scientific
research. The department programs are developed
for undergraduate students, and lectures are on
the subjects of life science, biochemistry, molecular
biology, signal transduction associated with human
diseases and oncology. The faculty also takes
charge of the basic research experiments. For
the graduate school, we have a course of lectures
on biochemistry, molecular biology, and molecular
medicine, and a group seminar on advanced biotechnology.
This department also accepts graduate school students
and trains hands-on research experiments for a
thesis of Ph.D. |
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Publications |
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| 1. |
Kabuyama, Y., Homma, M.K.., Sekimata,
M. and Homma, Y. (2001) Wave length-specific
activation of MAP kinase family proteins
by monochromatic ultraviolet irradiation.
Photochem.Photobiol. 73:147-152. |
| 2. |
Satoh, K., Kikuchi, S., Sekimata, M.,
Homma, M.K., and Homma, Y. (2001) Involvement
of ErbB-2 in rheumatoid synovial cell growth.
Arthritis and Rheumatism 44: 260-265. |
| 3. |
Kushida, N., Kabuyama, N., Yamaguchi,
O., and Homma, Y. (2001) Essential role
for extracellular Ca2+ in JNK activation
by mechanical stretch in bladder smooth
muscle cells. Am. J. Physiol. 281:C1165-C1172 |
| 4. |
Sekimata, M., Takahashi, A., Murakami-Sekimata,
A., and Homma, Y. (2001) Involvement of
a novel zinc finger protein, MIZF, in transcriptional
repression by interacting with a methyl-CpG
binding protein, MBD2. J.Biol.Chem. 278:42632-2638 |
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Detailed Information |
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To Contact Us |
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| biomol@fmu.ac.jp |
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