Papers - NAKAJIMA Shotaro
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Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer.
Ryo Kanoda, Shotaro Nakajima, Hirokazu Okayama, Akinao Kaneta, Shun Chida, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Yuya Maruyama, Hiroya Suzuki, Kosaku Mimura, Motonobu Saito, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Scientific reports 15 ( 1 ) 19234 - 19234 2025.6
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Activation of the tumor cell-intrinsic STING pathway induced by Fusobacterium nucleatum is associated with poor prognosis in esophageal cancer patients
Shotaro Nakajima, Katsuharu Saito, Satoshi Fukai, Mei Sakuma, Akira Matsuishi, Ryo Kanoda, Yuya Maruyama, Hiroya Suzuki, Hirokazu Okayama, Motonobu Saito, Kosaku Mimura, Azuma Nirei, Tomohiro Kikuchi, Hiroyuki Hanayama, Zenichiro Saze, Tomoyuki Momma, Kyoko Nishiyama, Tatsuo Suzutani, Koji Kono
Esophagus 22 ( 2 ) 239 - 249 2025.2（ ISSN:1612-9059 ）
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The tumor cell-intrinsic cGAS-STING pathway is associated with the high density of CD8+ T cells after chemotherapy in esophageal squamous cell carcinoma.
Akira Matsuishi, Shotaro Nakajima, Akinao Kaneta, Katsuharu Saito, Satoshi Fukai, Mei Sakuma, Hideaki Tsumuraya, Hirokazu Okayama, Motonobu Saito, Kosaku Mimura, Azuma Nirei, Tomohiro Kikuchi, Hiroyuki Hanayama, Zenichiro Saze, Wataru Sakamoto, Tomoyuki Momma, Koji Kono
Esophagus : official journal of the Japan Esophageal Society 21 ( 2 ) 165 - 175 2024.2（ ISSN:1612-9059 ）
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Down-regulation of stimulator of interferon genes (STING) expression and CD8+ T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer.
Satoshi Fukai, Shotaro Nakajima, Motonobu Saito, Katsuharu Saito, Koji Kase, Hiroshi Nakano, Takahiro Sato, Mei Sakuma, Akinao Kaneta, Hirokazu Okayama, Kosaku Mimura, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Koji Kono
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26 ( 6 ) 878 - 890 2023.8（ ISSN:1436-3291 ）
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Lenvatinib suppress FGF19-FGFR4 signaling to enhance antitumor immune response in gastric cancer.
Yuya Maruyama, Motonobu Saito, Shotaro Nakajima, Katsuharu Saito, Hiroya Suzuki, Ryo Kanoda, Hirokazu Okayama, Hiroyuki Hanayama, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Akiteru Goto, Koji Kono
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 28 ( 3 ) 397 - 408 2025.2（ ISSN:1436-3291 ）
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High levels of tumor cell-intrinsic STING signaling are associated with increased infiltration of CD8(+) T cells in dMMR/MSI-H gastric cancer.
Kanoda R, Nakajima S, Fukai S, Saito M, Saito K, Suzuki H, Kikuchi T, Nirei A, Okayama H, Mimura K, Hanayama H, Sakamoto W, Momma T, Saze Z, Kono K
Scientific reports 14 ( 1 ) 20859 - 20859 2024.9
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胃癌におけるHER2シグナルを介した腫瘍微小環境の制御 HER2過剰発現の腫瘍内不均一性を呈する胃癌症例からの検討
中嶋正太郎, 深井 智司, 金田 晃尚, 圓谷 秀哲, 松石 彬, 岡山 洋和, 齋藤 元伸, 三村 耕作, 坂本 渉, 佐瀬 善一郎, 門馬 智之, 河野 浩二
癌と化学療法 51 ( 9 ) 903 - 905 2024.9
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[Regulation of the Tumor Microenvironment through HER2 Signaling-Insights from Gastric Cancer Cases with Heterogeneous HER2 Overexpression].
Shotaro Nakajima, Satoshi Fukai, Akinao Kaneta, Hideaki Tsumuraya, Akira Matsuishi, Hirokazu Okayama, Motonobu Saito, Kosaku Mimura, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Koji Kono
Gan to kagaku ryoho. Cancer & chemotherapy 51 ( 9 ) 903 - 905 2024.9（ ISSN:0385-0684 ）
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[Regulation of the Tumor Microenvironment through HER2 Signaling-Insights from Gastric Cancer Cases with Heterogeneous HER2 Overexpression].
Nakajima S, Fukai S, Kaneta A, Tsumuraya H, Matsuishi A, Okayama H, Saito M, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K
Gan to kagaku ryoho. Cancer & chemotherapy 51 ( 9 ) 903 - 905 2024.9（ ISSN:0385-0684 ）
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The impact of CLDN18.2 expression on effector cells mediating antibody-dependent cellular cytotoxicity in gastric cancer.
Matsuishi A, Nakajima S, Saito M, Saito K, Fukai S, Tsumuraya H, Kanoda R, Kikuchi T, Nirei A, Kaneta A, Okayama H, Mimura K, Hanayama H, Sakamoto W, Momma T, Saze Z, Kono K
Scientific reports 14 ( 1 ) 17916 - 17916 2024.8
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Tumor Infiltrating Effector Regulatory T Cells Express VEGF Receptor 2 in Patients With Colorectal Cancer.
Tsumuraya H, Mimura K, Nakajima S, Hanayama H, Matsuishi A, Okayama H, Fukai S, Ito M, Ashizawa M, Chida S, Onozawa H, Sakamoto W, Saito M, Saze Z, Momma T, Kono K
Anticancer research 44 ( 7 ) 2933 - 2941 2024.7
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Tumor Infiltrating Effector Regulatory T Cells Express VEGF Receptor 2 in Patients With Colorectal Cancer.
Hideaki Tsumuraya, Kosaku Mimura, Shotaro Nakajima, Hiroyuki Hanayama, Akira Matsuishi, Hirokazu Okayama, Satoshi Fukai, Misato Ito, Mai Ashizawa, Shun Chida, Hisashi Onozawa, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Koji Kono
Anticancer research 44 ( 7 ) 2933 - 2941 2024.7（ ISSN:0250-7005 ）
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α7 nicotinic acetylcholine receptor agonist attenuates allergen-induced immediate nasal response in murine model of allergic rhinitis.
Shuhei Yamashita, Kento Miura, Anna Matsuura, Norimasa Yamasaki, Naoto Uda, Sawako Ogata, Naohisa Hosomi, Shotaro Nakajima, Noriko Kitamura, Minoru Gotoh, Akio Mori, Osamu Kaminuma
The Journal of veterinary medical science 86 ( 7 ) 824 - 827 2024.6（ ISSN:0916-7250 ）
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食道癌の生物学 食道癌の腫瘍免疫微小環境
中嶋正太郎, 河野浩二
日本臨牀 食道癌2024ー基礎・臨床の最新動向ー 82 ( 3 ) 90 - 95 2024.5
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TIM-3 expression on dendritic cells in colorectal cancer
Mei Sakuma, Masanori Katagata, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Takahiro Sato, Satoshi Fukai, Hideaki Tsumuraya, Hisashi, Onozawa, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Koji Kono
Cancers 16 ( 10 ) 1888 - 1888 2024.5（ ISSN:2072-6694 ）
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TGFβ-Responsive Stromal Activation Occurs Early in Serrated Colorectal Carcinogenesis.
Hideaki Tsumuraya, Hirokazu Okayama, Masanori Katagata, Akira Matsuishi, Satoshi Fukai, Misato Ito, Wataru Sakamoto, Motonobu Saito, Tomoyuki Momma, Shotaro Nakajima, Kosaku Mimura, Koji Kono
International journal of molecular sciences 25 ( 9 ) 4626 - 4626 2024.4
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Biomarker-oriented chemo-immunotherapy for advanced gastric cancer.
Koji Kono, Shotaro Nakajima, Kosaku Mimura
International journal of clinical oncology 29 ( 7 ) 865 - 872 2024.4（ ISSN:1341-9625 ）
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Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer.
Kosaku Mimura, Takashi Ogata, Phuong H D Nguyen, Souvick Roy, Hassen Kared, Yate-Ching Yuan, Michael Fehlings, Yuya Yoshimoto, Daisaku Yoshida, Shotaro Nakajima, Hisashi Sato, Nozomu Machida, Takanobu Yamada, Yohei Watanabe, Tomoaki Tamaki, Hirohito Fujikawa, Yasuhiro Inokuchi, Suguru Hayase, Hiroyuki Hanayama, Zenichiro Saze, Hiroyuki Katoh, Fumiaki Takahashi, Takashi Oshima, Ajay Goel, Alessandra Nardin, Yoshiyuki Suzuki, Koji Kono
Journal for immunotherapy of cancer 12 ( 1 ) e008385 2024.1
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TIM-3 expression and M2 polarization of macrophages in the TGFβ-activated tumor microenvironment in colorectal cancer
Masanori Katagata, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Takahiro Sato, Mei Sakuma, Satoshi Fukai, Eisei Endo, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Koji Kono
Cancers 20 ( 15 ) 4943 2023.10（ ISSN:2072-6694 ）
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放射線治療による腫瘍細胞内cGAS-STING経路を介した食道扁平上皮癌微小環境の変化
中嶋正太郎, 三村耕作, 金田晃尚, 片方雅紀, 岡山洋和, 齋藤元伸, 佐瀬善一郎, 花山寛之, 多田武志, 門馬智之, 河野浩二
癌と化学療法 50 ( 10 ) 1099 - 1101 2023.10