Organization
Research Facility Attached to the School of Medicine Department of Molecular Genetics Assistant Professor
Title
Assistant Professor
Contact information
Homepage
External link
IGUCHI Yoshio
Degree
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PhD ( 2009.3 Nagoya University )
Research Interests
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Experimental Psychology
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Flavor aversion conditioning
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Locus ceruleus
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Oxidative stress
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Instrumental learning
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Associative learning
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Drug-addicted
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Habit
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Striatum
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Comparative psychology
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Basal ganglia
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Chemogenetics
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Motivation
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Nucleus accumbens
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Resilience
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Pavlovian conditioning
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Noradrenaline
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Dopamine
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Operant conditioning
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Rodents
Research Areas
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Life Science / Neuroscience-general
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Humanities & Social Sciences / Experimental psychology
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Life Science / Psychiatry
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Life Science / Neuroscience-general / 行動神経科学, 精神薬理学
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Humanities & Social Sciences / Experimental psychology / 学習心理学, 比較心理学, 行動心理学
Education
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Nagoya Univerisity Graduate School of Environmental Studies Socio-environmental Studies
- 2007.3
Country： Japan
Research History
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Institute of Biomedical Sciences, Fukushima Medical University School of Medicine Department of Molecular Genetics Senior Lecturer
2025.1 - Now
Country：Japan
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Institute of Biomedical Sciences, Fukushima Medical University School of Medicine Department of Molecular Genetics Assistant Professor
2017.4 - 2024.12
Country：Japan
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Nagoya University Graduate School of Environmental Studies, Department of Social and Human Environment
2007.3
Professional Memberships
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日本神経科学学会
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日本動物心理学会
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日本心理学会
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Society for Neuroscience
Papers
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Iguchi, Y, Benton, R, Kobayashi, K
Neuroscience Research 214 56 - 61 2024.11（ ISSN:0168-0102 ）
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Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Hisashi Doi, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi
Communications Biology 7 ( 1 ) 547 2024.5
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Matsushita, N, Nishizawa, K, Kato, S, Iguchi, Y, Fukabori, R, Takeuchi, K, Miyasaka, Y, Mashimo, T, Kobayashi, K
Journal of Neuroscience Methods 381 109707 - 109707 2022.11（ ISSN:0165-0270 ）
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Osanai M, Miwa H, Tamura A, Kikuta S, Iguchi Y, Yanagawa Y, Kobayashi K, Katayama N, Tanaka T, Mushiake H
Advances in experimental medicine and biology 1293 471 - 479 2021.1（ ISSN:0065-2598 ）
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Fukabori R, Iguchi Y, Kato S, Takahashi K, Eifuku S, Tsuji S, Hazama A, Uchigashima M, Watanabe M, Mizuma H, Cui Y, Onoe H, Hikishima K,..., Nishijo T, Momiyama T, Benton R, Kobayashi K
The Journal of Neuroscience 40 ( 43 ) 8367 - 8385 2020.10
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Sakayori, N, Katakura, M, Hamazaki, K, Higuchi, O, Fujii, K, Fukabori, R, Iguchi, Y, Setogawa, S, Takao, K, Miyazawa, T, Arita, M, Kobayashi, K
Communications Biology 3 ( 1 ) 473 2020.8
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Sustaining temporal attention prevents habit expression during operant learning in rats
Lin, Z, Nishikawa, H, Iguchi, Y, Iwanami, A, Kikuchi, M, Toda, S.
Scientific Reports 10 ( 1 ) 2020.6
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Kikuta, S., Iguchi, Y., Kakizaki, T., Kobayashi, K., Yanagawa, Y., Takada, M., & Osanai, M.
Frontiers in Cellular Neuroscience-Cellular Neurophysiology 13 ( 547 ) 1 - 9 2019.12
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Arakawa, H., & Iguchi, Y.
Neuroscience Research in press 2018.10
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Iguchi Y, Lin Z, Nishikawa H, Minabe Y, Toda S
Scientific reports 7 43307 2017.2
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【Neuroanatomy Across Scales】Tracing of specific neural pathways in the rat brain using lentiviral vectors for retrograde gene transfer(タイトル和訳中)
Akama Saaya, Iguchi Yoshio, Kato Shigeki, Kobayashi Kazuto
Anatomical Science International 100 ( 4 ) 413 - 419 2025.9（ ISSN:1447-6959 ）
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Akama, S., Iguchi, Y., Kato, S., Kobayashi, K.
Anatomical Science International 2025.7（ ISSN:14476959 ）
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【Cell type census approaches to understanding structural and functional organization of neural circuits】A chemogenetic technology using insect Ionotropic Receptors to stimulate target cell populations in the mammalian brain(タイトル和訳中)
Iguchi Yoshio, Benton Richard, Kobayashi Kazuto
Neuroscience Research 214 56 - 61 2025.5（ ISSN:0168-0102 ）
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A reinforcement schedule with two types of temporal information
Hata Y, Matsui H, Iguchi Y, Samejima K, Sawa S
MethodsX 13 102831 2024.6
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昆虫におい受容体を用いた哺乳類脳神経細胞のリモート活性化技術における嗅物質の脳移行性の改善
井口善生, 小林和人
2024.5
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A new chemogenetic system using Ionotropic Receptors from the fruit fly Drosophila melanogaster
Yoshio Iguchi, Richard Benton, Kazuto Kobayashi
Springer Nature Research Communities, Behind the Paper (Published in Neuroscience) 2024.5
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Y Iguchi, K Kobayashi
Mendeley Data 2024.4
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Iguchi Y, Fukabori R, Kato S, Takahashi K, Eifuku S, Maejima Y, Shimomura K, Mzuma H, Mawatari A, Doi H, Cui Y, Onoe H, Hikishima K, Osanai M, Nishijo T, Momiyama T, Benton R, Kobayashi K
bioRxiv 2023.9
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Natsuki Matsushita, Kayo Nishizawa, Shigeki Kato, Yoshio Iguchi, Ryoji Fukabori, Kosei Takeuchi, Yoshiki Miyasaka, Tomoji Mashimo, Kazuto Kobayashi
bioRxiv 2022.4
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昆虫のにおい受容体を用いたほ乳類脳神経細胞の新たな活動操作技術の開発と，その応用による嫌悪性記憶の想起を制御する脳神経回路の同定
深堀良二, 井口善生, 小林和人
福島県立医科大学 2020年 NEWS 2020.11
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Fukabori, R, Iguchi, Y, Kato, S, Takahashi, K, Eifuku, S, Tsuji, S, Hazama, A, Uchigashima, M, Watanabe, M, Mizuma, H, Cui, Y, Onoe, H, Hikishima, K, Yasoshima, Y, Osanai, M, Inagaki, R, Fukunaga, K, Nishijo, T, Momiyama, T, Benton, R, Kobayashi, K
bioRxiv 2019.11
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オペラント条件づけ 基礎理論を学ぶ
井口 善生
臨床心理学 18 ( 1 ) 7 - 11 2018.1（ ISSN:1345-9171 ）
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動物心理学研究における還元・比較・発生:―研究遍歴をめぐる対談をふまえて―
辻 敬一郎, 井口 善生
動心研究 67 ( 2 ) 73 - 78 2017（ ISSN:0916-8419 ）
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Reconsidering animal models of major depressive disorder in the elderly
Toda, S., Iguchi, Y., Lin, Z., Nishikawa, H., Nagasawa, T., Watanabe, H., & Minabe, Y.
Frontiers in Aging Neuroscience 8 ( 188 ) 1 - 6 2016.8
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Pre-stress performance in an instrumental training predicts post-stress behavioral alterations in chronically stressed rats
Iguchi, Y., Kosugi, S., Lin, Z., Nishikawa, H., Minabe, Y., & Toda, S.
Frontiers in Behavioral Neuroscience 9 ( 119 ) 1 - 13 2015.5
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Repeated exposure of adult rats to transient oxidative stress induces various long-lasting alterations in cognitive and behavioral functions
Iguchi, Y., Kosugi, S., Nishikawa, H., Lin, Z., Minabe, Y., & Toda, S.
PLoS ONE 9 ( 12 ) 2014.12
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Role of incentive learning in reduction of instrumental performance in rats (Rattus norvegicus) by irrelevant drive state
Iguchi, Y.
The Japanese Journal of Animal Psychology 2014.1
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Effects of extended context discrimination training and context extinction on transfer of context dependency of conditioned flavor aversion.
Iguchi, Y., Fukumoto, K., Sawa, K., & Ishii, K.
Behavioural Processes 2014.1（ ISSN:0376-6357 ）
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Iguchi, Y., Sawa, K., & Ishii, K.
International Journal of Comparative Psychology 23 121 - 144 2010
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Instrumental outcome devaluation with representation-mediated conditioning.
Iguchi Y., & Ishii, K.
Behavioural Processes 81 95 - 104 2009.5（ ISSN:0376-6357 ）
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Conditioned taste aversion is enhanced when the unconditioned stimulus is presented in a different context
Ishii, K., Iguchi, Y., Fukumoto, K., & Nakayasu, T.
Learning and Motivation 39 257 - 264 2008
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IGUCHI, Y.
The Japanese Journal of Animal Psychology 58 ( 1 ) 61 - 68 2008（ ISSN:0916-8419|1880-9022 ）
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Reduction of instrumental discrimination performance by post-conditioning devaluation of discriminative stimulus: the effects of novelty in reinforcing outcome and extended training.
Iguchi, Y., & Ishii, K.
Behavioural Processes 73 49 - 61 2006.7（ ISSN:0376-6357 ）
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Context dependency of conditioned aversions to familiar and novel fluids
Ishii, K. Iguchi, Y., & Sawa, K.
Learning and Motivation 37 113 - 130 2006
Books
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井口善生, 木村新伍, 小林和人（第4章 神経回路ダイナミクス 第3節）
株式会社エヌ・ティー・エス 2026.1 （ ISBN:9784860439118 ）
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動物心理学入門 : 動物行動研究から探るヒトのこころの世界 小川園子・富原一哉・岡田隆(編)
井口善生（7-2 なぜ依存するの？（7章 動物のこころの不調から探る―なぜ悩み，病むのか？））
有斐閣 2023.7 （ ISBN:9784641174887 ）
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Optogenetics. Advances in Experimental Medicine and Biology, vol 1293
Osanai, M, Miwa, H, Tamura, A, Kikuta, S, Iguchi, Y, Yanagawa, Y, Kobayashi, K, Katayama, N, Tanaka, Y, Mushiake, H（Multimodal functional analysis platform: 1. Ultrathin fluorescence endoscope imaging system enables flexible functional brain imaging）
Springer, Singapore 2021.1
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あの人はどうしてそうしてしまうの？身近な7つの扉から入る心理学の世界
羽成隆司・河野和明
ポラーノ出版 2018.4 （ ISBN:4908765111 ）
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行動生物学辞典
上田恵介・菊水健史他（S-R連合，S-S連合，過剰学習，葛藤他17語）
東京化学同人 2013.11 （ ISBN:9784807908370 ）
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心理学へのファーストステップ (テーマ4 学ぶ)
羽成隆司・河野和明（テーマ4 まなぶ）
おうふう 2008.5 （ ISBN:4892429317 ）
Presentations
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2024年度積水化学・自然に学ぶ研究助成 オンライン技術交流会 2024.11
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Dopaminergic circuit mechanisms originated in the ventral tegmental area in the regulation of motivation for goal-directed behavior
The 46th annual Meeting of the Japan Neuroscience Society Simposium 1S04a (Shedding new light on the implications of dopamine in normal brain functions and diseases) (co-organizer with Dr. Louis-Eric Trudeau) 2023.8
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Dopamine 2022 2022.5
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A neuro-mereology starting from the striatum to understand the neural processes supporting trial-and-error-based memory acquisition and habit formation
The 99th Annual Meeting of the Physiological Society of Japan 2022.3
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味覚連合記憶の想起における青斑核ノルアドレナリン細胞の役割―ハエ嗅覚器由来のイオンチャネルを利用した新規神経活動活性化ツールによる検討―
生理研研究会2020・行動の多様性を支える神経基盤とその動作様式の解明 2020.12
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Enhanced retrieval of learned emotional memory by chemogenetic activation of locus coeruleus noradrenergic neurons
Symposium: Diverse Physiological and Pathophysiological Roles in Noradrenergic Neurons (organized by Shigenobu Toda & Takashi Minamimoto). The 49th Annual Meeting of JSNP 2019.10
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報酬獲得のための意欲の管理プロセスにおける辺縁系ドーパミントーンの役割
次世代を担う若手のための創薬・医療薬理シンポジウム2025 2025.8
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Role of D2 receptor-positive ventral tegmental area dopamine neurons in effort-related motivation for food-seeking
Dopamine2022
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Toward a mereological understanding of brain functions starting from the striatum to support trial-and-error-based memory acquisition and habit formation
The 99th Annual Meeting of the Physiological Society of Japan
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Cortico-basal ganglia loop circuits shifting during the learning acquisition process and functions of striatal projection pathways
The 95th Annual Meeting of the Japanese Pharmacological Society
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The 95th Annual Meeting of the Japanese Pharmacological Society 2022.3
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The role of locus coeruleus noradrenergic neurons in the recall of taste-association memories: investigation using a novel neuronal activation system based on anion channels derived from Drosophila Melanogaster
NIPS
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Enhanced retrieval of learned emotional memory by chemogenetic activation of locus coeruleus noradrenergic neurons.
Symposium: Diverse Physiological and Pathophysiological Roles in Noradrenergic Neurons; The 19th Annual Meeting of JSNP
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オペラント行動の制御における線条体ニューロンの役割―意思決定の変調としての依存症理解への示唆―（シンポジウム，「依存症抑止に向けた文理横断的挑戦」）
平成30年度アルコール・薬物依存関連学会合同学術総会
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The link between individual differences in the decision-making style and vulnerability to psychiatric disorders
The link between individual differences in the decision-making style and vulnerability to psychiatric disorders
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意思決定スタイルの個性創発と適応破たんとしての精神疾患発症脆弱性の統合的理解（文部科学省科学研究費補助金新学術領域研究 多様な「個性」を創発する脳システムの統合的理解 第2回領域会議）
文部科学省科学研究費補助金新学術領域研究 多様な「個性」を創発する脳システムの統合的理解 第2回領域会議
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Coordinated expression of learned motor behavior through striatofugal pathways (Symposium: Advances in Behavioral Neuroscience in Japan and Diversity of DAergic Regulation)
International Behavioral Neuroscience Society 26th Annual Meeting
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ストレスと意思決定の関係を分析する―ラットのオペラント学習を用いた検討
第6回東北脳科学ウインタースクール
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道具的学習の連合理論―習慣形成とその異常の機序解明に向けて―（シンポジウム「連合学習理論の展開と臨床との接点」）
日本認知・行動療法学会第42回大会
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「医学」から見た心理学界（シンポジウム「隣接領域から見た心理学界―心理学のここが不満―）
日本心理学会第79回大会
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側坐核シナプス外GABAA受容体：大うつ病動物モデルにおける治療標的性の検討.
第20回海馬と高次脳機能学会
Research Projects
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Elucidation of the dopaminergic system in the motivation management for goal-directed behavior
Grant number：24K06623 2024.4 - 2027.3
Grant-in-Aid for Scientific Research (C)
Y Iguchi
Authorship：Principal investigator
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
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Grant number：19K03381 2019.4 - 2022.3
Grant-in-Aid for Scientific Research (C)
Iguchi Yoshio
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
We investigated the role of D2R-positive ventral tegmental area dopamine neurons in the motivational control of goal-directed behavior. We established a system to specifically and reversibly manipulate the activity of target neurons using chemogenetic technologies and a behavioral experiment to estimate intrinsic variables involved in the motivation of appetitive operant behavior in rats.
By a series of systematic experiments combining histochemical, biochemical, and behavioral methods, we found that D2R-positive ventral tegmental area dopamine neurons play an essential role in the maintenance of motivation associated with increased reward prices through projections to the nucleus accumbens core. -
Grant number：17H05955 2017.4 - 2019.3
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Grant amount：\5200000 （ Direct Cost: \4000000 、 Indirect Cost：\1200000 ）
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Neural basis for mode shift in instrumental decision-making and its deficit in psychiatric disorder
Grant number：16K04429 2016.4 - 2019.3
Grant-in-Aid for Scientific Research (C)
Iguchi Yoshio
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
By the time we started this study, we had a working hypothesis: noradrenergic projection from the locus coeruleus (LC) to the anterior cingulate cortex is a switch for a mode of decision-making (goal-directed/habit) shift; this behavioral function is realized through the regulation of the functional balance between the medial and lateral parts of the dorsal striatum. In this study, we developed three basic technologies necessary to test this hypothesis: (i) techniques to manipulate the in vivo activity of the LC neurons; (ii)techniques to inhibit the in vivo activity of the catecholaminergic neurons of rodents; (iii) an evaluation system for decision control modes in rodents. These projects have progressed smoothly, and we will be able to conduct experiments in behavioral neuroscience by integrating these basic technologies.
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Technology for pathway-selective manipulation and control of neural circuit
Grant number：26112002 2014.7 - 2019.3
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Kobayashi Kazuto, Kato Shigeki, Fukabori Ryoji, Nishizawa Kayo, Iguchi Yoshio, Setogawa Susumu
Grant amount：\137280000 （ Direct Cost: \105600000 、 Indirect Cost：\31680000 ）
Here we applied our new strategy to manipulate specific neural types and pathways and to characterize dynamic changes of the neural circuit and aimed to elucidate the mechanisms underlying the development and transition of neural circuit during learning processes and the functional compensation of the circuit against neural injury. To achieve this purpose, our planned group focused on the development of the technology for the neural circuit control, in particular, through the application of optogenetic and chemogenetic approaches with viral vector system. In addition, we investigated the roles of specific cell types or neural pathways constituting the cortico-basal ganglia-thalamic network in behavioral acquisition, performance, and switching, and challenged to identify the brain regions in which the activity changes during the learning processes to elucidate the mechanisms underlying the functional shift of neural circuit.
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2013.4 - 2015.3
Yoshio Iguchi
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2011.4 - 2013.3
Yoshio Iguchi
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2011.4 - 2012.3
Yoshio Iguchi
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2007.10 - 2009.3
Yoshio Iguchi
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Spatial forward- and backward-blocking in fish (goldfish and carps)
2007
Yoshio Iguchi