論文 - 大河原 浩
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Blockade of renin-angiotensin system attenuates advanced glycation end products-mediated signaling pathways
KAMIOKA, Masashi*; ISHIBASHI, Toshiyuki*; SUGIMOTO, Koichi*; UEKITA, Hironori*; NAGAI, Ryoji; SAKAMOTO, Nobuo*; ANDO, Katsuya*; OHKAWARA, Hiroshi*; TERAMOTO, Tamio; MARUYAMA, Yukio; TAKEISHI, Yasuchika*
Journal of Atherosclerosis and Thrombosis 17 ( 6 ) 590 - 600 2010年
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Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo
OHKAWARA, Hiroshi*; ISHIBASHI, Toshiyuki*; SAITOH, Shu-ichi*; INOUE, Nobutaka; SUGIMOTO, Koichi*; KAMIOKA, Masashi*; UEKITA, Hironori*; KANESHIRO, Takashi*; ANDO, Katsuya*; TAKUWA, Yoh; MARUYAMA, Yukio; TAKEISHI, Yasuchika*
Cardiovascular Research 88 ( 3 ) 492 - 501 2010年
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Hematopoietic stem cell transplantation in the Department of Hematology, Fukushima Medical University
OGAWA, Kazuei*; NOJI, Hideyoshi*; FURUKAWA, Miki*; HARADA-SHIRADO, Kayo*; MASHIMO, Yumiko*; TAKAHASHI, Hiroshi*; MATSUMOTO, Hayato*; KIMURA, Satoshi*; SHICHISHIMA-NAKAMURA, Akiko*; OHKAWARA, Hiroshi*; IKEDA, Kazuhiko*; OHTO, Hitoshi; TAKEISHI, Yasuchika*
Fukushima Journal of Medical Science 56 ( 2 ) 107 - 114 2010年
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A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation
OGAWA, Kazuei*; IKEDA, Kazuhiko*; FURUKAWA, Miki*; HARADA-SHIRADO, Kayo*; MASHIMO, Yumiko*; TAKAHASHI, Hiroshi*; MATSUMOTO, Hayato*; KIMURA, Satoshi*; SHICHISHINA-NAKAMURA, Akiko*; OHKAWARA, Hiroshi*; HASHIMOTO, Yuko; ASAHI, Koichi; NOJI, Hideyoshi*; OHTO, Hitoshi; TAKEISHI, Yasuchika*
Fukushima Journal of Medical Science 56 ( 2 ) 151 - 156 2010年
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Bone marrow-derived progenitor cells prevent thrombin-induced increase in lung vascular permeability
ZHAO, Yidan; OHKAWARA, Hiroshi*; VOGEL, Stephen; MALIK, Asrar; ZHAO, You-Yang Y. D. Zhao and H. Ohkawara contributed equally to this study.
American Journal of Physiology Lung Cellular and Molecular Physiology 298 ( 1 ) L36-L44 2010年
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Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells
SAKAMOTO, Nobuo*; ISHIBASHI, Toshiyuki*; SUGIMOTO, Koichi*; SAWAMURA, Tatsuya; SAKAMOTO, Takayuki*; INOUE, Nobutaka; SAITOH, Shu-ichi*; KAMIOKA, Masashi*; UEKITA, Hironori*; OHKAWARA, Hiroshi*; SUZUKI, Koji; TERAMOTO, Tamio; MARUYAMA, Yukio; TAKEISHI, Yasuchika*
Journal of Cellular Physiology 220 ( 3 ) 706 - 715 2009年
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LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells
SUGIMOTO, Koichi*; ISHIBASHI, Toshiyuki*; SAWAMURA, Tatsuya; INOUE, Nobutaka; KAMIOKA, Masashi*; UEKITA, Hironori*; OHKAWARA, Hiroshi*; SAKAMOTO, Takayuki*; SAKAMOTO, Nobuo*; OKAMOTO, Yasuo; TAKUWA, Yoh; KAKINO, Akemi; FUJITA, Yoshiki; TANAKA, Takashi; TERAMOTO, Tamio; MARUYAMA, Yukio; TAKEISHI, Yasuchika*
Cardiovascular Research 84 ( 1 ) 127 - 136 2009年
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Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction
SAITOH, Shu-ichi*; MATSUMOTO, Ken*; KAMIOKA, Masashi*; OHKAWARA, Hiroshi*; KANESHIRO, Takashi*; ISHIBASHI, Toshiyuki*; MARUYAMA, Yukio*
Coronary Artery Disease 20 ( 6 ) 400 - 408 2009年
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RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits
OHKAWARA, Hiroshi*; ISHIBASHI, Toshiyuki*; SHIOMI, Masashi; UEKITA, Hironori*; KAMIOKA, Masashi*; TAKUWA, Yoh; TERAMOTO, Tamio; MARUYAMA, Yukio; TAKEISHI, Yasuchika*
Journal of Atherosclerosis and Thrombosis 16 ( 6 ) 846 - 856 2009年
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Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling
ZHAO, Yidan; OHKAWARA, Hiroshi*; REHMAN, Jalees; WARY, Kishore; VOGEL, Stephen; MINSHALL, Richard; ZHAO, You-Yang; MALIK, Asrar
Circulation Research 105 ( 77 ) 696 - 704 2009年
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RhoA-dependent PAI-1 gene expression induced in endothelial cells by monocyte adhesion mediates geranylgeranyl transferase I and Ca2+ signaling
SAKAMOTO, Takayuki*; ISHIBASHI, Toshiyuki*; SUGIMOTO, Koichi*; SAKAMOTO, Nobuo*; OHKAWARA, Hiroshi*; NIINUMA, Miki*; NAGATA, Kenji*; KAMIOKA, Masashi*; SUGIMOTO, Naotoshi; WATANABE, Atai; KURABAYASHI, Masahiko; TAKUWA, Yoh; MARUYAMA, Yukio*
Atherosclerosis 193 ( 1 ) 44 - 54 2007年4月
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Low serum ferritin levels as a clue to colonic cancer detection in two patients with coronary artery disease: a case report.
Yaoita H, Ohkawara H, Uekita H, Mitsugi M, Tajima H, Kaneko H, Hoshino Y, Otani S, Gotoh M, Maruyama Y.
Fukushima J Med Sci. 51 ( 2 ) 95 - 104 2005年12月
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Endogenous NO blockade enhances tissue factor expression via increased Ca2+ influx through MCP-1 in endothelial cells by monocyte adhesion.
Sakamoto T, Ishibashi T, Sakamoto N, Sugimoto K, Egashira K, Ohkawara H, Nagata K, Yokoyama K, Kamioka M, Ichiki T, Sugimoto N, Kurabayashi M, Suzuki K, Takuwa Y, Maruyama Y.
Arterioscler Thromb Vasc Biol. 25 ( 9 ) 2005 - 2011 2005年9月
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Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells.
Ohkawara H, Ishibashi T, Sakamoto T, Sugimoto K, Nagata K, Yokoyama K, Sakamoto N, Kamioka M, Matsuoka I, Fukuhara S, Sugimoto N, Takuwa Y, Maruyama Y.
J Biol Chem. 280 ( 11 ) 10182 - 10188 2005年3月
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Integral role of RhoA activation in monocyte adhesion-triggered tissue factor expression in endothelial cells.
Ishibashi T, Sakamoto T, Ohkawara H, Nagata K, Sugimoto K, Sakurada S, Sugimoto N, Watanabe A, Yokoyama K, Sakamoto N, Kurabayashi M, Takuwa Y, Maruyama Y.
Arterioscler Thromb Vasc Biol. 23 ( 4 ) 681 - 687 2003年4月
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Rho/Rho-kinase is involved in the synthesis of tissue factor in human monocytes
Nagata K, Ishibashi T, Sakamoto T, Ohkawara H, Shindo J, Yokoyama K, Sugimoto K, Sakurada S, Takuwa Y, Nakamura S, Teramoto T, Maruyama Y.
Atherosclerosis. 163 ( 1 ) 39 - 47 2002年7月
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Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.
Ishibashi T, Nagata K, Ohkawara H, Sakamoto T, Yokoyama K, Shindo J, Sugimoto K, Sakurada S, Takuwa Y, Teramoto T, Maruyama Y.
Biochim Biophys Acta. 1590 ( 1-3 ) 123 - 130 2002年6月
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HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells.
Yokoyama K, Ishibashi T, Ohkawara H, Kimura J, Matsuoka I, Sakamoto T, Nagata K, Sugimoto K, Sakurada S, Maruyama Y.
Circulation. 105 ( 8 ) 962 - 967 2002年2月