Updated on 2023/08/28

写真a

 
ISHIOKA Ken
 
Organization
School of Medicine (Life Sciences and Social Medicine) Department of Microbiology Associate Professor
Title
Associate Professor
Contact information
メールアドレス

Degree

  • Ph. D ( 1997.3   Osaka University )

  • 修士 ( 弘前大学 )

Research Interests

  • Herpes simplex virus,Cytomegalovirus, Innate Immunity, gut microbiota

Research Areas

  • Life Science / Virology  / Virology

  • Life Science / Molecular biology  / Molecular Biology

Education

  • Osaka University   Graduate School, Division of Medicine

    - 1997

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    Country: Japan

  • Hirosaki University   Graduate School, Division of Natural Science

    - 1992

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    Country: Japan

  • Hirosaki University   Faculty of Science

    - 1990

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    Country: Japan

Research History

  • Fukushima Medical University   Associate Professor

    2017.2 - Now

  • 福島県立医科大学 微生物学講座

    1998.7 - Now

  • 株式会社 海洋バイオテクノロジー研究所 博士研究員

    1997.7 - 1998.6

Professional Memberships

  • 日本細菌学会東北支部会

  • 日本分子生物学会

  • 日本ウイルス学会

Papers

  • Characterization of a thiourea derivative that targets viral transactivators of cytomegalovirus and herpes simplex virus type 1.

    Kondo H, Koshizuka T, Majima R, Takahashi K, Ishioka K, Suzutani T, Inoue N

    Antiviral research   196   105207   2021.12( ISSN:0166-3542

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.antiviral.2021.105207

    PubMed

  • Characteristics of Helicase-primase Inhibitor Amenamevir-resistant Herpes Simplex Virus.

    Sato Y, Suenaga T, Kobayashi M, Miyazaki N, Suzuki T, Ishioka K, Suzutani T

    Antimicrobial agents and chemotherapy   AAC0049421   2021.7( ISSN:0066-4804

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1128/AAC.00494-21

    PubMed

  • Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture.

    Kanno R, Koshizuka T, Miyazaki N, Kobayashi T, Ishioka K, Ozaki C, Chiba H, Suzutani T

    Foods (Basel, Switzerland)   10 ( 2 )   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/foods10020291

    PubMed

  • Draft Genome Sequence of the Lactococcus lactis 11/19-B1 Strain, Isolated from Kiwifruit.

    Ishioka K, Nishiyama K, Suzutani T

    Microbiology resource announcements   9 ( 36 )   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1128/MRA.00793-20

    PubMed

  • Rapid repair of human disease-specific single-nucleotide variants by One-SHOT genome editing.

    Yokouchi Y, Suzuki S, Ohtsuki N, Yamamoto K, Noguchi S, Soejima Y, Goto M, Ishioka K, Nakamura I, Suzuki S, Takenoshita S, Era T

    Scientific reports   10 ( 1 )   13927   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/s41598-020-70401-7

    PubMed

  • 血液透析下の慢性腎臓病患者におけるスクロフェリックオキシヒドロキシドの消化管マイクロバイオームおよび尿毒症毒素への影響(Effect of sucroferric oxyhydroxide on gastrointestinal microbiome and uremic toxins in patients with chronic kidney disease undergoing hemodialysis)

    Iguchi Akira, Yamamoto Suguru, Oda Akira, Tanaka Kenichi, Kazama Junichiro James, Saeki Takako, Yamazaki Hajime, Ishioka Ken, Suzutani Tatsuo, Narita Ichiei

    Clinical and Experimental Nephrology   24 ( 8 )   725 - 733   2020.8( ISSN:1342-1751

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    Language:English  

  • Effect of sucroferric oxyhydroxide on gastrointestinal microbiome and uremic toxins in patients with chronic kidney disease undergoing hemodialysis.

    Iguchi A, Yamamoto S, Oda A, Tanaka K, Kazama JJ, Saeki T, Yamazaki H, Ishioka K, Suzutani T, Narita I

    Clinical and experimental nephrology   2020.4( ISSN:1342-1751

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s10157-020-01892-x

    PubMed

  • Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial.

    Uemura M, Hayashi F, Ishioka K, Ihara K, Yasuda K, Okazaki K, Omata J, Suzutani T, Hirakawa Y, Chiang C, Aoyama A, Ohira T

    European journal of nutrition   2018.12( ISSN:1436-6207

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s00394-018-1873-0

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  • A Double-Blind Controlled Study to Evaluate the Effects of Yogurt Enriched with <i>Lactococcus lactis</i> 11/19-B1 and <i>Bifidobacterium lactis</i> on Serum Low-Density Lipoprotein Level and Antigen-Specific Interferon-γ Releasing Ability.

    Nishiyama K, Kobayashi T, Sato Y, Watanabe Y, Kikuchi R, Kanno R, Koshizuka T, Miyazaki N, Ishioka K, Suzutani T

    Nutrients   10 ( 11 )   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/nu10111778

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  • Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases.

    Koshizuka T, Kobayashi T, Ishioka K, Suzutani T

    Scientific reports   8 ( 1 )   4447   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/s41598-018-22682-2

    PubMed

  • Modification of the HCMV-specific IFN-γ release test (QuantiFERON-CMV) and a novel proposal for its application.

    Kobayashi T, Sato JI, Ikuta K, Kanno R, Nishiyama K, Koshizuka T, Ishioka K, Suzutani T

    Fukushima journal of medical science   63 ( 2 )   64 - 74   2017.8( ISSN:0016-2590

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.5387/fms.2017-01

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  • HCMV特異的IFN-γ放出試験(QuantiFERON-CMV)の改変とその適用に関する新しい提案(Modification of the HCMV-specific IFN-γ release test(QuantiFERON-CMV) and a novel proposal for its application)

    Kobayashi Takahiro, Sato Jun-ichi, Ikuta Kazufumi, Kanno Ryoko, Nishiyama Kyoko, Koshizuka Tetsuo, Ishioka Ken, Suzutani Tatsuo

    Fukushima Journal of Medical Science   63 ( 2 )   64 - 74   2017.8( ISSN:0016-2590

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Involvement of herpes simplex virus type 1 UL13 protein kinase in induction of SOCS genes, the negative regulators of cytokine signaling.

    Sato Y, Koshizuka T, Ishibashi K, Hashimoto K, Ishioka K, Ikuta K, Yokota SI, Fujii N, Suzutani T

    Microbiology and immunology   61 ( 5 )   159 - 167   2017.5( ISSN:0385-5600

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/1348-0421.12483

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  • サイトカインシグナル伝達の負の制御因子であるSOCS遺伝子の誘導における単純ヘルペスウイルス1型UL13プロテインキナーゼの関与(Involvement of herpes simplex virus type 1 UL13 protein kinase in induction of SOCS genes, the negative regulators of cytokine signaling)

    Sato Yuka, Koshizuka Tetsuo, Ishibashi Kei, Hashimoto Koichi, Ishioka Ken, Ikuta Kazufumi, Yokota Shin-ichi, Fujii Nobuhiro, Suzutani Tatsuo

    Microbiology and Immunology   61 ( 5 )   159 - 167   2017.5( ISSN:0385-5600

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Protection from lethal herpes simplex virus type 1 infection by vaccination with a UL41-deficient recombinant strain.

    Koshizuka T, Ishioka K, Kobayashi T, Ikuta K, Suzutani T

    Fukushima journal of medical science   62 ( 1 )   36 - 42   2016.6( ISSN:0016-2590

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.5387/fms.2015-24

    PubMed

  • Protection from lethal herpes simplex virus type 1 infection by vaccination with a UL41-deficient recombinant strain.

    Koshizuka T, Ishioka K, Kobayashi T, Ikuta K, Suzutani T.

    Fukushima J Med Sci.   2016.3

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    Language:English   Publishing type:Research paper (other academic)  

  • Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation.

    Ishioka K, Ikuta K, Sato Y, Kaneko H, Sorimachi K, Fukushima E, Saijo M, Suzutani T.

    Microbiol Immunol   57 ( 6 )   426 - 436   2013.6

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  • 単純ヘルペスウイルス1型ビリオンに由来するUS11は1型インターフェロンによる蛋白質キナーゼRリン酸化を阻害する(Herpes simplex virus type 1 virion-derived US11 inhibits type 1 intterferon-induced protein kinase R phosphorylation)

    Ishioka Ken, Ikuta Kazufumi, Sato Yuka, Kaneko Hisatoshi, Sorimachi Kotaro, Fukushima Eiko, Saijo Masayuki, Suzutani Tatsuo

    Microbiology and Immunology   57 ( 6 )   426 - 436   2013.6( ISSN:0385-5600

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation.

    Ishioka K, Ikuta K, Sato Y, Kaneko H, Sorimachi K, Fukushima E, Saijo M, Suzutani T

    Microbiology and immunology   57 ( 6 )   426 - 36   2013.6( ISSN:0385-5600

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/1348-0421.12048

    PubMed

  • A novel real-time PCR method for determination and quantification of each cytomegalovirus glycoprotein H subtype in clinical samples.

    Ikuta K, Ishioka K, Sato Y, Imamura T, Asano K, Koyano S, Inoue N, Suzutani T.

    J Clin Microbiol.   50   499 - 501   2012

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  • The quantitative detection of herpes simplex virus, varicella zoster virus, and cytomegalovirus DNAs in recipient corneal buttons.

    Kaneko H, Higaki S, Fukuda M, Shimomura Y, Ishioka K, Fukushima E, Sato Y, Suzutani T.

    Cornea.   29   1436 - 1439   2010

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  • DSCG reduces RSV-induced illness in RSV-infected mice.

    Hashimoto K, Mori S, Hashimoto Y, Kaneko H, Ishibashi K, Ishioka K, Kawasaki Y, Peebles RS Jr, Munakata M, Hosoya M, Suzutani T.

    J Med Virol.   81 ( 2 )   354 - 361   2009

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  • An improved rapid quantitative detection and identification method for a wide range of fungi.

    Soeta N, Terashima M, Gotoh M, Mori S, Nishiyama K, Ishioka K, Kaneko H, Suzutani T.

    J Med Microbiol.   58   1037 - 1044   2009

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  • RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules.

    Hashimoto K, Ishibashi K, Ishioka K, Zhao D, Sato M, Ohara S, Abe Y, Kawasaki Y, Sato Y, Yokota S, Fujii N, Peebles RS Jr, Hosoya M, Suzutani T.

    Virology.   391   162 - 170   2009

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  • Discrimination of herpes simplex virus type 2 strains by nucleotide sequence variations.

    Kaneko H, Kawana T, Ishioka K, Fukushima E, Suzutani T.

    J Clin Microbiol.   46   780 - 784   2008

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  • Evaluation of mixed infection cases with both herpes simplex virus types 1 and 2.

    Kaneko H, Kawana T, Ishioka K, Ohno S, Aoki K, Suzutani T.

    J Med Virol.   80   883 - 887   2008

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  • Identification of a highly conserved region in the human cytomegalovirus glycoprotein H gene and design of molecular diagnostic methods targeting the region.

    Fukushima E, Ishibashi K, Kaneko H, Nishimura H, Inoue N, Tokumoto T, Tanabe K, Ishioka K, Ogawa H, Suzutani T.

    J Virol Methods.   151   55 - 60   2008

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  • HSVの遺伝子とその産物

    錫谷達夫、石岡賢

    日本臨床   64 ( suppl 3 )   127 - 132   2006.3

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir.

    Suzutani T, Ishioka K, De Clercq E, Ishibashi K, Kaneko H, Kira T, Hashimoto K, Ogasawara M, Ohtani K, Wakamiya N, Saijo M.

    Antimicrob Agents Chemother.   47   1707 - 1713   2003

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  • Isolation and characterization of NMSO3-resistant mutants of respiratory syncytial virus.

    Kimura K, Ishioka K, Hashimoto K, Mori S, Suzutani T, Bowlin TL, Shigeta S.

    Antiviral Res.   65   1207 - 1211   2003

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  • Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning.

    Ken Ishioka, Atsushi Fukuoh, Hiroshi Iwasaki, Atsuo Nakata and Hideo Shinagawa.

    Genes to Cells   3   209 - 220   1998

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  • Roles of the recG gene product of Escherichia coli in recombination repair: Effects of the &#8710;recG mutation on cell division and chromosome partition.

    Ken Ishioka, Hiroshi Iwasaki and Hideo Shinagawa.

    Genes Genet. Syst.   72   91 - 99   1997

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  • ATP-dependent resolution of R-loops at the ColE1 replication origin by Escherichia coli RecG protein, a Holliday junction-specific helicase.

    Atsushi Fukuoh, Hiroshi Iwasaki, Ken Ishioka and Hideo Shinagawa.

    EMBO J.   16   203 - 209   1997

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  • Molecular analysis of the Pseudomonas aeruginosa genes, ruvA, ruvB and ruvC, involved in processing of homologous recombination intermediates.

    Takashi Hishida, Hiroshi Iwasaki, Ken Ishioka and Hideo Shinagawa.

    Gene   182   63 - 70   1996

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Presentations

  • 単純ヘルペスウイルスI型のナンセンス変異による US9膜貫通領域欠損タンパクが感染細胞内で発現しない機構

    日本分子生物学会年会  

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    Event date: 2016.12

  • 単純ヘルペスウイルスI型のナンセンス変異による US9膜貫通領域欠損タンパクが感染細胞内で発現しない機構

    日本分子生物学会年会  

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    Event date: 2016.12

  • ヒトサイトメガロウイルス(HCMV) 臨床分離株の細胞指向性を 決定する因子の同定

    乳酸菌研究会  

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    Event date: 2016.7

  • ヒトサイトメガロウイルス(HCMV) 臨床分離株の細胞指向性を 決定する因子の同定

    乳酸菌研究会  

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    Event date: 2016.7

  • 味噌によるマウス腸内細菌叢の変化についての解析

    日本細菌学会東北支部総会  

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    Event date: 2013.8

  • 味噌によるマウス腸内細菌叢の変化についての解析

    日本細菌学会東北支部総会  

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    Event date: 2013.8

  • HSV-1ウイルス粒子に含まれるUS11タンパクはIFN感受性を決める要因の1つである

    細菌学会東北支部総会  

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    Event date: 2011.8

  • HSV-1 チミジンキナーゼ変異株(VRTK-)がIFN感受性となるメカニズム

    ヘルペス研究会  

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    Event date: 2010

  • 二本鎖RNA依存性PKRの活性化を阻害するHSV-1US11タンパクと結合するRNAライブラリーの構築

    第57回日本ウイルス学会  

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    Event date: 2009

  • HSV-1に対するアシクロビルとインターフェロンが相乗効果を示す機構について

    第56回日本ウイルス学会  

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    Event date: 2008

  • HSV-1チミジンキナーゼ変異株のIFN感受性にUS11は関与する

    第55回日本ウイルス学会  

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    Event date: 2007.10

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