論文 - 町田 豪
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Roles of MASP-1 and MASP-3 in the development of retinal degeneration in a murine model of dry age-related macular degeneration
Tomoko Omori, Takeshi Machida, Yumi Ishida, Tetstuju Sekiryu, and Hideharu Sekine
Frontiers in Immunology 16 1566018 2025年
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"Factor D" in "Alternative Pathway / Amplification Loop Basics"
Hideharu Sekine, Takeshi Machida, and Teizo Fujita
Immunological Reviews 313 15 - 24 2023年
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重症筋無力症の病態：補体の役割と活性化のメカニズム
町田豪, 関根英治
脳神経内科 98 809 - 815 2023年
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The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation
Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Ikuo Wada, Teizo Fujita, and Hideharu Sekine
Frontiers in Immunology 13 907023 2022年
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補体の多面性：自然免疫・獲得免疫と補体
町田豪, 関根英治
日本臨牀 80 1728 - 1734 2022年
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A novel complement inhibitor sMAP-FH targeting both the lectin and alternative complement pathways
Mika Takasumi, Tomoko Omori, Takeshi Machida, Yumi Ishida, Manabu Hayashi, Toshiyuki Suzuki, Yoshimi Homma, Yuichi Endo, Minoru Takahashi, Hiromasa Ohira, Teizo Fujita, Hideharu Sekine
The FASEB Journal 34 6598 - 6612 2020年
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Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway
Manabu Hayashi, Takeshi Machida, Yumi Ishida, Yusuke Ogata, Tomoko Omori, Mika Takasumi, Yuichi Endo, Toshiyuki Suzuki, Masayuki Sekimata, Yoshimi Homma, Masahito Ikawa, Hiromasa Ohira, Teizo Fujita, and Hideharu Sekine
The Journal of Immunology 203 ( 6 ) 1411 - 1416 2019年（ ISSN:0022-1767 ）
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Response to Comment on “Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway”
Takeshi Machida, Manabu Hayashi, Teizo Fujita, and Hideharu Sekine
The Journal of Immunology 203 ( 12 ) 3091 - 3092 2019年
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Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice
Takeshi Machida, Natsumi Sakamoto, Yumi Ishida, Minoru Takahashi, Teizo Fujita, and Hideharu Sekine
Frontiers in Immunology 9 1191 2018年
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Chloroplastic NADPH-dependent thioredoxin reductase from Chlorella vulgaris alleviates environmental stresses in yeast with 2-Cys peroxiredoxin
Takeshi Machida, Akiko Ishibashi, Ai Kirino, Jun-ichi Sato, Shinji Kawasaki, Youichi Niimura, Ken-ichi Honjoh, Takahisa Miyamoto
PLoS ONE 7 ( 9 ) e45988 2012年
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Expression pattern of a chloroplast NADPH-dependent thioredoxin reductase in Chlorella vulgaris and its interaction with 2-Cys peroxiredoxin.
Takeshi Machida, Eri Kato, Akiko Ishibashi, Jun-ichi Sato, Shinji Kawasaki, Youichi Niimura, Ken-ichi Honjoh, Takahisa Miyamoto
Bioscience, Biotechnology, and Biochemistry 73 695 - 701 2009年
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Isolation of cDNAs for hardening-induced genes from Chlorella vulgaris by suppression subtractive hybridization.
Takeshi Machida, Hisako Murase, Eri Kato, Ken-ichi Honjoh, Kiyoshi Matsumoto, Takahisa Miyamoto, Masayoshi Iio
Plant Science 175 238 - 246 2008年
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C5a stimulation induces caspase-1 activation and mature IL-1β production in human peripheral blood mononuclear cells
Yuya Fujita, Haruki Matsumoto, Kenji Inada, Michio Onizawa, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Takeshi Machida, Kiyoshi Migita
Immunological Medicine 47 68 - 75 2024年6月
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Complement activation products in tears of dry eye and meibomian gland dysfunction
Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato, Akihito Kasai, Ryo Mukai, Tomoko Omori, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu
Scientific Reports 14 43 2024年1月
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Tear fluid and complement activation products in tears after ocular surgery.
Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato, Akihito Kasai, Tomoko Omori, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu
BMC Ophthalmology 23 329 2023年7月
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Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration
Yutaka Kato, Yasuharu Oguchi, Tomoko Omori, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Yumi Ishida, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu
Ophthalmology Science 2 100167 2022年
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Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis
Haruki Matsumoto, Yuya Fujita, Michio Onizawa, Kenji Saitoh, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Takeshi Machida, Hiroshi Watanabe, Kiyoshi Migita
Frontiers in Immunology 13 978435 2022年
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Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine and Tetsuju Sekiryu
Scientific Reports 11 ( 1 ) 8464 2021年
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Evidence for activation of lectin and classical pathway complement components in aqueous humor of neovascular age-related macular degeneration
Tomoko Omori, Yasuharu Oguchi, Takeshi Machida, Yutaka Kato, Yumi Ishida, Akira Ojima, Kanako Itagaki, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Yukinori Sugano, Masashi Ogasawara, Hideharu Sekine, and Tetsuju Sekiryu
Ophthalmic Research 63 252 - 258 2020年
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Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities
Yasuharu Oguchi, Tetsuju Sekiryu, Tomoko Omori, Yutaka Kato, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine
Experimental Eye Research 195 108025 2020年
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Complement activation products and cytokines in pachychoroid neovasculopathy and neovascular age-related macular degeneration
Yutaka Kato, Yasuharu Oguchi, Tomoko Omori, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, and Tetsuju Sekiryu
Investigative Ophthalmology & Visual Science 61 39 2020年
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Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia
Junya Hata, Takeshi Machida, Kanako Matsuoka, Seiji Hoshi, Hidenori Akaihata, Hiroyuki Hiraki, Toshiyuki Suzuki, Soichiro Ogawa, Masao Kataoka, Nobuhiro Haga, Kei Ishibashi, Yoshimi Homma, Hideharu Sekine, Yoshiyuki Kojima
Scientific Reports 9 20357 2019年
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Freezing tolerance of Lactuca sativa and induction of CBF and GolS genes during cold treatment
Ken-ichi Honjoh, Hitomi Okano, Aya Kawabata, Masaru Kurosawa, Taiki Kimura, Takeshi Machida, Yoshimitsu Masuda and Takahisa Miyamoto
Journal of Faculty of Agriculture, Kyushu University 63 249 - 257 2018年
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Autoimmune disease mouse model exhibits pulmonary arterial hypertension
Koichi Sugimoto, Kazuhiko Nakazato, Akihiko Sato, Satoshi Suzuki, Akiomi Yoshihisa, Takeshi Machida, Shu-ichi Saito, Hideharu Sekine, Yasuchika Takeishi
PLoS ONE 12 e0184990 2017年
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全身性エリテマトーデスの病態理解の進歩〜SLEにおける補体活性化経路の役割〜
関根英治、大森智子、坂本夏美、町田豪
福島医学雑誌 67 ( 3 ) 113 - 122 2017年
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IL-13-dependent biomarkers with liver inflammatory differentiation after pneumococcal sepsis during rapid inflammatory phase 国際共著
Natsuo Yamamoto, Kiwamu Nakamura, Kazuaki Arai, Charles Dela Cruz, Takeshi Machida, Yuhko Suzuki, Yasunori Ogura, Yoshinobu Abe, Hideharu Sekine, Ken Iseki, Philip Askenase, and Keiji Kanemitsu
European Journal of Immunology 46 ( Supple 1 ) 321 2016年
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IFN-γ-receptor-1 is required for intrafollicular localization of marginal zone B cells in the spleens of lupus-prone MRL+/+ mice 国際共著
Takeshi Machida, Tomoko Omori, Natsumi Sakamoto, Xian Zhang, Gary S. Gilkeson, and Hideharu Sekine
European Journal of Immunology 46 ( Supple 1 ) 935 2016年
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Essential role of mannose-binding lectin-associated serine proteases-1/3 (MASP-1/3) in the development of lupus-like glomerulonephritis in MRL/lpr mice
Natsumi Sakamoto, Takeshi Machida, Minoru Takahashi, Teizo Fujita, and Hideharu Sekine
Immunobiology 221 1166 2016年
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酵母の凍結ストレス耐性改善へのアプローチ
本城賢一, 町田豪, 菅向志郎, 宮本敬久
低温生物工学会誌 61 13 - 17 2015年
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補体異常値を示す疾患とそのメカニズム
関根英治、大森智子、町田豪
補体 52 ( 2 ) 14 - 26 2015年
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A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice 国際共著
Takeshi Machida, Natsumi Sakamoto, Gary S. Gilkeson, Hideharu Sekine
Arthritis & Rheumatology 66 S857 - S858 2014年
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Role of complement in a murine model of peanut-induced anaphylaxis
Toshihisa Kodama, Hideharu Sekine, Yuichi Endo, Minoru Takahashi, Daisuke Iwaki, Takeshi Machida, Kazuko Kanno, Yumi Ishida, and Teizo Fujita
Immunobiology 218 ( 6 ) 844 - 850 2013年
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Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells
Takeshi Machida, Natsumi Sakamoto, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, and Hideharu Sekine
Frontiers in Immunology 2013年
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Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice 国際共著
Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xian Zhang, Christopher M. Reilly, Gary S. Gilkeson, and Hideharu Sekine
Frontiers in Immunology 2013年
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Circulating myeloid-derived suppressor cells are increased and correlate to immune suppression, inflammation, and hypoproteinemia in patients with cancer
Shinji Ohki, Masahiko Shibata, Kenji Gonda, Takeshi Machida, Tatsuo Shimura, Izumi Nakamura, Toru Ohtake, Yoshihisa Koyama, Shinichi Suzuki, Hitoshi Ohto, and Seiichi Takenoshita
Oncology Reports 28 453 - 458 2012年
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IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity 国際共著
Hideharu Sekine, Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xiang Zhang, Christopher M. Reily, Gary S. Gilkeson
Arthritis & Rheumatology 64 S619-620 2012年
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Interferon regulatory factor-4 deficient lupus-prone MRL/lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs 国際共著
Hideharu Sekine, Takeshi Machida, Eiji Suzuki, Ting Ting Hsieh Kinser, Efrain Martinez Avila, Phil Ruiz, Christopher M. Reily, Gary Gilkeson
Arthritis & Rheumatology 63 S213 2011年
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Enhancement of menadione stress tolerance in yeast by accumulation of hypotaurine and taurine.
Ken-ichi Honjoh, Kanae Matsuura, Takeshi Machida, Koutarou Nishi, Miki Nakao, Tomoki Yano, Takahisa, Miyamoto, Masayoshi Iio
Amino Acids 38 1173 - 1183 2010年
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Chloroplastic glucose 6-phosphate dehydrogenase from Chlorella vulgaris alleviates freezing and menadione-induced oxidative stresses in Saccharomyces cerevisiae.
Takeshi Machida, Naoto Ohashi, Ayano Mimura, Ken-ichi Honjoh, Masayoshi Iio, Takahisa Miyamoto
Journal of Faculty of Agriculture, Kyushu University 55 29 - 38 2010年
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Trehalose 6-phosphate synthase and trehalose 6-phosphate phosphatase from Nicotiana tabacum function in trehalose biosynthesis and environmental stress tolerance of yeast
Takeshi Machida, Ken-ichi Honjoh, Ayuko Aso, Maiko Yamamoto, Masayoshi Iio, Takahisa Miyamoto
Journal of Faculty of Agriculture, Kyushu University 55 261 - 268 2010年
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IRF-4-deficient lupus-prone MRL/lpr mice lack serum Ig/auto-Abs and Th17 cells but develop non-immune complex-mediated diffuse proliferative glomerulonephritis and dermatitis/ear necrosis 国際共著
Hideharu Sekine, Takeshi Machida, Eiji Suzuki, Efrain Martinez Avila, Phil Ruiz, Christopher M. Reily, Gary S. Gilkeson
Arthritis & Rheumatism 62 S435 2010年
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Expression of a gene encoding a functional glycosyl hydrolase, trehalase, from Nicotiana tabacum in Saccharomyces cerevisiae.
Takeshi Machida, Ken-ichi Honjoh, Hideyuki Shimizu, Maiko Yamamoto, Masayoshi Iio, Takahisa Miyamoto
Journal of Faculty of Agriculture, Kyushu University 54 297 - 303 2009年
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Influence of cold hardening on chlorophyll and carotenoid in Chlorella vulgaris.
Yuta Watanabe, Naotaka Yamada, Takeshi Machida, Ken-ichi Honjoh, Eiichi Kuwano
Journal of Faculty of Agriculture, Kyushu University 54 195 - 200 2009年
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Molecular characterization of low-temperature-inducible NTR-C in Chlorella vulgaris.
Takeshi Machida, Eri Kato, Akiko Ishibashi, Naoto Ohashi, Ken-ichi Honjoh, Takahisa Miyamoto
Oxford University Press Nucleic Acids Symposium Series 51 463 - 464 2007年
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Improvement of Freezing and Oxidative-Stress Tolerance in Saccharomyces cerevisiae by Taurine
Ken-ichi Honjoh, Takeshi Machida, Koutarou Nishi, Kanae Matsuura, Kevin Webby Soli, Takatoshi Sakai, Hiroya Ishikawa, Kiyoshi Matsumoto, Takahisa Miyamoto, Masayoshi Iio
Food Science and Technology Research 13 145 - 154 2007年
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Molecular cloning and characterization of a cDNA for low-temperature-inducible cytosolic glucose 6-phosphate dehydrogenase gene from Chlorella vulgaris and expression of the gene in Saccharomyces cerevisiae
Ken-ichi Honjoh, Takeshi Machida, Takahiro Hagisako, Koushirou Suga, Madoka Yonekura, Hideyuki Shimizu, Naoto Ohashi, Takahisa Miyamoto, Masayoshi Iio, Shoji Hatano
Plant Science 172 649 - 658 2007年
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タウリン蓄積による耐凍性付与の試み
本城賢一、西孝太郎、町田豪、宮本敬久、飯尾雅嘉
低温生物工学会誌 53 47 - 51 2007年