Updated on 2023/12/07

写真a

 
KARIYA Yoshinobu
 
Organization
School of Medicine (Life Sciences and Social Medicine) Department of Biochemistry Associate Professor
Title
Associate Professor
Contact information
メールアドレス

Degree

  • 理学博士 ( 横浜市立大学 )

Research Interests

  • Cancer Invasion and Metastasis, Extracellular Matrix, Integrin, Osteopontin, Laminin, Glycosylation, Cell Migration, Cell Adhesion,

Research Areas

  • Life Science / Cell biology  / Cell Biology

  • Life Science / Functional biochemistry  / Functional Biochemistry

  • Life Science / Medical biochemistry

Education

  • Sophia University   Faculty of Science and Engineering

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    Country: Japan

Research History

  • 福島県立医科大学   准教授

    2013.4 - Now

  • 福島県立医科大学   講師

    2012.9 - 2013.3

  • 福島県立医科大学   学内講師

    2011.4 - 2012.8

  • 福島県立医科大学   助教

    2010.4 - 2011.3

  • 東北薬科大学・ポスドク

    2007 - 2010

  • Stanford University/Postdoc

    2005 - 2006

  • 横浜市立大学・ポスドク

    2003 - 2005

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Professional Memberships

  • 日本生化学会

  • 福島医学会

  • 日本癌学会

  • 日本結合組織学会

  • 日本がん転移学会

Committee Memberships

  • その他   組換えDNA実験安全委員  

       

Papers

  • Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3–Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit

    Yoshinobu Kariya, Jianguo Gu, Yukiko Kariya

    Biomolecules   13 ( 12 )   1752   2023.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : https://doi.org/10.3390/biom13121752

    Other Link : https://www.mdpi.com/2218-273X/13/12/1752

  • Osteopontin in Cancer: Mechanisms and Therapeutic Targets

    Yoshinobu Kariya, Yukiko Kariya

    Int. J. Transl. Med,   2   419 - 447   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/ijtm2030033

  • Phosphorylated osteopontin secreted from cancer cells induces cancer cell motility.

    Yoshinobu Kariya, Midori Oyama, Yukiko Kariya, Yasuhiro Hashimoto

    Biomolecules   11 ( 9 )   1323   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : https://doi.org/10.3390/biom11091323

  • αvβ3 integrin induces partial EMT independent of TGF-β signaling

    Yoshinobu Kariya, Midori Oyama, Takato Suzuki, Yukiko Kariya

    Comminications Biology   4 ( 1 )   490   2021.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : https://doi.org/10.1038/s42003-021-02003-6

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    Other Link : https://www.nature.com/articles/s42003-021-02003-6

  • Quantitative analysis of β1,6GlcNAc-branched N-glycans on β4 integrin in cutaneous squamous cell carcinoma.

    Yoshinobu Kariya, Midori Oyama, Mikio Ohtsuka, Nobuyuki Kikuchi, Yasuhiro Hashimoto, Toshiyuki Yamamoto

    Fukushima journal of medical science   66 ( 3 )   119 - 123   2020.12( ISSN:0016-2590

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.5387/fms.2020-12

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  • Ratio of Alpha 2-Macroglobulin Levels in Cerebrospinal Fluid and Serum: An Expression of Neuroinflammation in Acute Disseminated Encephalomyelitis.

    Yuichi Suzuki, Koichi Hashimoto, Kyoka Hoshi, Hiromi Ito, Yoshinobu Kariya, Kyohei Miyazaki, Masatoki Sato, Yukihiko Kawasaki, Mari Yoshida, Takashi Honda, Yasuhiro Hashimoto, Mitsuaki Hosoya

    Pediatric neurology   98   61 - 67   2019.9( ISSN:0887-8994

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.pediatrneurol.2019.04.020

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  • Molecular diagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid.

    Roxana Chiorean, Sorina Danescu, Oana Virtic, Mayson B. Mustafa, Adrian Baican, Annette Lischka, Takashi Hasimoto, Kim Yancey, Yoshinobu Kariya, Manuel Koch, Cassian Sitaru

    Orphanet journal of rare diseases   13 ( 1 )   111   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s13023-018-0855-x

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    Other Link : https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0855-x

  • β4-integrin/PI3K Signaling Promotes Tumor Progression through Galectin-3-N-glycan Complex.

    Yukiko Kariya, Midori Oyama, Yasuhiro Hashimoto, Jianguo Gu, Yoshinobu Kariya

    Molecular Cancer Research   16 ( 6 )   1024 - 1034   2018.6( ISSN:1541-7786

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1158/1541-7786.MCR-17-0365

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    Other Link : http://mcr.aacrjournals.org/content/16/6/921

  • Biological Role of Site-specific O-glycosylation in Cell Adhesion Activity and Phosphorylation of Osteopontin.

    Midori Oyama, Yoshinobu Kariya, Yukiko Kariya, Kana Matsumoto, Mayumi Kanno, Yoshiki Yamaguchi, Yasuhiro Hashimoto

    Biochemical Journal   475 ( 9 )   1583 - 1595   2018.5( ISSN:0264-6021

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1042/BCJ20170205

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    Other Link : http://www.usaco.co.jp/itemview/template44_6_25793.html

  • Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.

    Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe

    PLoS One   12 ( 10 )   e0186414   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0186414

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  • Roles of Integrin α6β4 Glycosylation in Cancer.

    Yoshinobu Kariya, Yukiko Kariya, Jianguo Gu

    Cancers   9 ( 7 )   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/cancers9070079

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    Other Link : http://www.mdpi.com/2072-6694/9/7/79

  • RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells.

    Yukiko Kariya, Takeo Tatsuta, Shigeki Sugawara, Yoshinobu Kariya, Kazuo Nitta, Masahiro Hosono

    International Journal of Oncology   49 ( 4 )   1334 - 42   2016.10( ISSN:1019-6439

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3892/ijo.2016.3656

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  • Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica.

    Yoshinobu Kariya, Yukiko Kariya, Toshie Saito, Shuhei Nishiyama, Takashi Honda, Keiko Tanaka, Mari Yoshida, Kazuo Fujihara, Yasuhiro Hashimoto

    BBA Clinical   3   126 - 34   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bbacli.2015.01.003

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    Other Link : https://www.sciencedirect.com/science/article/pii/S2214647415000045?via%3Dihub

  • In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver.

    Yuka Matsumoto, Toshie Saito, Kyoka Hoshi, Hiromi Ito, Yoshinobu Kariya, Masamichi Nagae, Yoshiki Yamaguchi, Yoshiaki Hagiwara, Noriaki Kinoshita, Ikuo Wada, Kiyoshi Saito, Takashi Honda, Yasuhiro Hashimoto

    Journal of Biochemistry   157 ( 4 )   211 - 6   2015.4( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvu071

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  • A Glycan Marker for Idiopathic Normal Pressure Hydrocephalus

    Kyoka Hoshi, Yuka Matsumoto, Toshie Saito, Hiromi Ito, Yoshinobu Kariya, Yoshiki Yamaguchi, Katsutoshi Furukawa, Hiroyuki Arai, Masakazu Miyajima, Hajime Arai, Hisashi Narimatsu, Kiyoshi Saito, Takashi Honda, Yasuhiro Hashimoto

    Glycoscience: Biology and Medicine   1 - 7   2014.11

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    Language:English   Publishing type:Research paper (other academic)  

  • Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties.

    Yoshinobu Kariya, Mayumi Kanno, Kana Matsumoto-Morita, Midori Konno, Yoshiki Yamaguchi, Yasuhiro Hashimoto

    Biochemical Journal   463 ( 1 )   93 - 102   2014.10( ISSN:0264-6021

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1042/BJ20140060

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    Other Link : http://www.biochemj.org/content/463/1/93.long

  • Lectin-dependent inhibition of antigen-antibody reaction: application for measuring α2,6-sialylated glycoforms of transferrin.

    Kyoka Hoshi, Yoshinobu Kariya, Kiyomitsu Nara, Hiromi Ito, Kana Matsumoto, Masamicihi Nagae, Yoshiki, Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Atsushi Kuno, Hisashi Narimatsu, Keiro Shirotani, and Yasuhiro Hashimoto

    Journal of Biochemistry   154 ( 3 )   229 - 32   2013.9( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvt065

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  • Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by N-Glycosylation.

    Yorinobu Kariya, Yukiko Kariya, Jianguo Gu

    Laminins: Structure, Biological Activity and Role in Disease.   29 - 51   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Potential roles of N-glycosylation in cell adhesion.

    Jianguo Gu, Tomoya Isaji, Qingsong Xu, Yoshinobu Kariya, Wei Gu, Tomohiko Fukuda, Yuguang Du

    Glycoconjugate Journal   29 ( 8-9 )   599 - 607   2012.12( ISSN:0282-0080

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s10719-012-9386-1

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  • Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration.

    Yoshinobu Kariya, Hiroki Sato, Naoko Katou, Yukiko Kariya, Kaoru Miyazaki

    PloS one   7 ( 5 )   e35546   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0035546

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    Other Link : http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035546

  • Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.

    Taizo Mori, Yoshinobu Kariya, Eriko Komiya, Shouichi Higashi, Yohei Miyagi, Kiyotoshi Sekiguchi, Kaoru Miyazaki

    Cancer Science   102 ( 5 )   1095 - 100   2011.5( ISSN:1347-9032

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/j.1349-7006.2011.01892.x

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  • Wnt/ß-catenin signaling down-regulates N-acetylglucosaminyltransferase III expression: the implications of two mutually exclusive pathways for regulation.

    Qingsong Xu, Ryota Akama, Tomoya Isaji, Yingying Lu, Hirokazu Hashimoto, Yoshinobu Kariya, Tomohiko Fukuda, Yuguang Du, Jianguo Gu

    Journal of Biological Chemistry   286 ( 6 )   4310 - 8   2011.2( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M110.182576

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  • N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes.

    Yoshinobu Kariya, Jianguo Gu

    PloS one   6 ( 11 )   e27084   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0027084

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    Other Link : http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027084

  • Laminin-3B11, a novel vascular-type laminin capable of inducing prominent lamellipodial protrusions in microvascular endothelial cells.

    Taizo Mori, Kota Ono, Yoshinobu Kariya, Takashi Ogawa, Shouichi Higashi, and Kaoru Miyazaki

    The Journal of biological chemistry   285 ( 45 )   35068 - 78   2010.11( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M110.146126

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  • Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility.

    Yoshinobu Kariya, Chihiro Kawamura, Toshiki Tabei and Jianguo Gu

    The Journal of biological chemistry   285 ( 5 )   3330 - 40   2010.1( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M109.038836

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    Other Link : http://www.jbc.org/content/285/5/3330.long

  • Functional roles of the bisecting GlcNAc in integrin-mediated cell adhesion.

    Tomoya Isaji, Yoshinobu Kariya, Qingsong Xu, Tomohiko Fukuda, Naoyuki Taniguchi, Jianguo Gu

    Methods in enzymology   480   445 - 59   2010( ISSN:0076-6879

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/S0076-6879(10)80019-9

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  • Roles of laminin-332 and alpha6beta4 integrin in tumor progression.

    Yoshinobu Kariya, Yukiko Kariya, Jianguo Gu

    Mini reviews in medicinal chemistry   9 ( 11 )   1284 - 91   2009.10( ISSN:1389-5575

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.2174/138955709789878114

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    Other Link : http://www.eurekaselect.com/85312/article

  • Importance of N-glycosylation on alpha5beta1 integrin for its biological functions.

    Jianguo Gu, Tomoya Isaji , Yuya Sato, Yoshinobu Kariya, Tomohiko Fukuda

    Biological & pharmaceutical bulletin   32 ( 5 )   780 - 5   2009.5( ISSN:0918-6158

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  • A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions.

    Jianguo Gu, Yuya Sato, Yoshinobu Kariya, Tomoya Isaji, Naoyuki Taniguchi and Tomohiko Fukuda

    Journal of proteome research   8 ( 2 )   431 - 5   2009.2( ISSN:1535-3893

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/pr800674g

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  • N-Glycosylation of laminin-332 regulates its biological functions. A novel function of the bisecting GlcNAc.

    Yoshinobu Kariya, Rika Kato, Satsuki Itoh, Tomohiko Fukuda, Yukinao Shibukawa, Noriko Sanzen, Kiyotoshi Sekiguchi, Yoshinao Wada, Nana Kawasaki, Jianguo Gu

    The Journal of biological chemistry   283 ( 48 )   33036 - 45   2008.11( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M804526200

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    Other Link : http://www.jbc.org/content/283/48/33036.long

  • N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex.

    Ryota Akama, Yuya Sato, Yoshinobu Kariya, Tomoya Isaji, Tomohiko Fukuda, LiangHao Lu, Naoyuki Taniguchi, Masayuki Ozawa and Jianguo Gu

    Proteomics   8 ( 16 )   3221 - 8   2008.8( ISSN:1615-9853

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/pmic.200800038

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  • Localization of laminin alpha3B chain in vascular and epithelial basement membranes of normal human tissues and its down-regulation in skin cancers.

    Yoshinobu Kariya, Taizo Mori, Chie Yasuda, Naoko Watanabe, Yoshie Kaneko, Yukiko Nakashima, Takashi Ogawa, Kaoru Miyazaki

    Journal of molecular histology   39 ( 4 )   435 - 46   2008.8( ISSN:1567-2379

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s10735-008-9183-0

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  • The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain.

    Takashi Ogawa, Yoshiaki Tsubota, Junko Hashimoto, Yoshinobu Kariya and Kaoru Miyazaki

    Molecular biology of the cell   18 ( 5 )   1621 - 33   2007.5( ISSN:1059-1524

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1091/mbc.E06-09-0806

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  • The beta3 chain short arm of laminin-332 (laminin-5) induces matrix assembly and cell adhesion activity of laminin-511 (laminin-10).

    Yukiko Nakashima, Yoshinobu Kariya and Kaoru Miyazaki

    Journal of cellular biochemistry   100 ( 3 )   545 - 56   2007.2( ISSN:0730-2312

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/jcb.21032

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  • Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions.

    Yanyang Zhao, Satsuki Itoh, Xiangehun Wang, Tomoya Isaji, Eiji Miyoshi, Yoshinobu Kariya, Kaoru Miyazaki, Nana Kawasaki, Naoyuki Taniguchi, Jianguo Gu

    The Journal of biological chemistry   281 ( 50 )   38343 - 50   2006.12( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M608764200

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  • Regulation of proliferation and chondrogenic differentiation of human mesenchymal stem cells by laminin-5 (laminin-332).

    Junko Hashimoto, Yoshinobu Kariya and Kaoru Miyazaki

    Stem cells (Dayton, Ohio)   24 ( 11 )   2346 - 54   2006.11( ISSN:1066-5099

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1634/stemcells.2005-0605

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  • Beta4 Integrin and EGF Coordinately Regulate Electric Field-mediated Directional Migration via Rac1.

    Christine E. Pullar, Brian S. Baier, Yoshinobu Kariya, Alan J. Russell, Basil A. J. Horst, M. Peter Marinkovich and R. Rivkah Isseroff

    Molecular biology of the cell   17 ( 11 )   4925 - 35   2006.11( ISSN:1059-1524

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1091/mbc.E06-05-0433

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  • N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration.

    Yanyang Zhao, Takatoshi Nakagawa, Satsuki Itoh, Kei-ichiro Inamori, Tomoya Isaji, Yoshinobu Kariya, Akihiro Kondo, Eiji Miyoshi, Kaoru Miyazaki, Nana Kawasaki, Naoyuki Taniguchi, Jianguo Gu

    The Journal of biological chemistry   281 ( 43 )   32122 - 30   2006.10( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M607274200

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  • Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells.

    Hyung Keun Lee, Joon H. Lee, Min Kim, Yoshinobu Kariya, Kaoru Miyazaki, and Eung Kweon Kim

    Investigative ophthalmology & visual science   47 ( 3 )   873 - 82   2006.3( ISSN:0146-0404

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1167/iovs.05-0826

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  • Regulation of cell adhesion and type VII collagen binding by the beta3 chain short arm of laminin-5: effect of its proteolytic cleavage.

    Yukiko Nakashima, Yoshinobu Kariya, Chie Yasuda, Kaoru Miyazaki

    Journal of biochemistry   138 ( 5 )   539 - 52   2005.11( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvi153

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  • Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4-5 domain of alpha3 chain.

    Yoshiaki Tsubota, Chie Yasuda, Yoshinobu Kariya, Takashi Ogawa, Tomomi Hirosaki, Hirot Mizushima, and Kaoru Miyazaki

    The Journal of biological chemistry   280 ( 15 )   14370 - 7   2005.4( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M413051200

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  • The basement membrane protein laminin-5 acts as a soluble cell motility factor.

    Yoshinobu Kariya and Kaoru Miyazaki

    Experimental cell research   297 ( 2 )   508 - 20   2004.7( ISSN:0014-4827

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.yexcr.2004.03.044

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  • Regulation of biological activity of laminin-5 by proteolytic processing of gamma2 chain.

    Takashi Ogawa, Yoshiaki Tsubota, Masato Maeda, Yosinobu Kariya and Kaoru Miyazaki

    Journal of cellular biochemistry   92 ( 4 )   701 - 14   2004.7( ISSN:0730-2312

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/jcb.20112

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  • Characterization of laminin 5B and NH2-terminal proteolytic fragment of its alpha3B chain: promotion of cellular adhesion, migration, and proliferation.

    Yoshinobu Kariya, Chie Yasuda, Yukiko Nakashima, Kumiko Ishida, Yoshiaki Tsubota and Kaoru Miyazaki

    The Journal of biological chemistry   279 ( 23 )   24774 - 84   2004.6( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M400670200

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  • Differential regulation of cellular adhesion and migration by recombinant laminin-5 forms with partial deletion or mutation within the G3 domain of alpha3 chain.

    Yoshinobu Kariya, Yoshiaki Tsubota, Tomomi Hirosaki, Hiroto Mizushima, Wilma Puzon-McLaughlin, Yoshikazu Takada, and Kaoru Miyazaki

    Journal of cellular biochemistry   88 ( 3 )   506 - 20   2003.2( ISSN:0730-2312

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/jcb.10350

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  • 癌細胞が分泌する蛋白質の機能に基づいた検索と同定

    安光英太郎、苅谷慶喜、宮崎香

    生物物理化学   47   127 - 130   2003

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  • Laminin-6 is activated by proteolytic processing and regulates cellular adhesion and migration differently from laminin-5.

    Tomomi Hirosaki, Yoshiaki Tsubota, Yoshinobu Kariya, Kayano Moriyama, Hiroto Mizushima, Kaoru Miyazaki

    The Journal of biological chemistry   277 ( 51 )   49287 - 95   2002.12( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M111096200

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  • Efficient expression system of human recombinant laminin-5.

    Yoshinobu Kariya, Kumiko Ishida, Yoshiaki Tsubota, Yukiko Nakashima, Tomomi Hirosaki, Takashi Ogawa and Kaoru Miyazaki

    Journal of biochemistry   132 ( 4 )   607 - 12   2002.10( ISSN:0021-924X

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  • Nucleotide sequence of phospholipase A(2) gene expressed in snake pancreas reveals the molecular evolution of toxic phospholipase A(2) genes.

    Takahiko J. Fujimi, Yoshinobu Kariya, Takahide Tsuchiya, Toru Tamiya

    Gene   292 ( 1-2 )   225 - 31   2002.6( ISSN:0378-1119

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Books

  • タンパク質実験ノート上巻第4版・動物細胞での遺伝子組み換えタンパク質の発現

    羊土社  2011.9 

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    Responsible for pages:181-190   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:苅谷慶喜   Publication place:  

  • FRAGRANCE JOURNAL・ラミニン332(ラミニン5)とインテグリンの皮膚における役割

    フレグランス社  2010.1 

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    Responsible for pages:25-31   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:苅谷慶喜、顧建国   Publication place:  

  • タンパク質実験ノート上巻第3版・動物細胞での遺伝子組み換えタンパク質の発現

    羊土社  2004 

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    Responsible for pages:188-194   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:苅谷慶喜   Publication place:  

  • 実験医学10月号・細胞外マトリックス分子による癌細胞機能調節-ラミニン5による接着と運動の制御

    羊土社  2003.10 

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    Responsible for pages:2064-2070   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:苅谷慶喜, 小川崇, 宮崎香   Publication place:  

  • 実験医学増刊・細胞外マトリックス分子による細胞の接着と運動の制御-ラミニン5を例として-

    羊土社  2002 

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    Responsible for pages:134-139   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:苅谷慶喜、坪田芳明、宮崎香   Publication place:  

  • 現代科学増刊・がん細胞が分泌するタンパク質の機能解析

    東京化学同人  2002 

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    Responsible for pages:113-120   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:安光英太郎、苅谷慶喜、宮崎香   Publication place:  

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Presentations

  • 抗癌薬ゲムシタビンが引き起こす膵癌悪性化のメカニズム

    第1回細胞接着研究会   2023.11  

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    Event date: 2023.11

  • β4インテグリンによるゲムシタビン耐性膵癌の悪性形質獲得機構

    第32回日本がん転移学会   2023.7  

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    Event date: 2023.7

  • 癌悪性化におけるリン酸化オステオポンチンの意義

    第8回マトリセルフォーラム  

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    Event date: 2022.9

  • 癌悪性化におけるβ4インテグリン上N型糖鎖の役割

    第14回東北糖鎖研究会  

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    Event date: 2020.8

  • 細胞接着分子による癌悪性化機構の解明

    令和元年度福島医学会学術奨励賞受賞記念講演  

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    Event date: 2020.1

  • αvβ3 integrin induces epithelial-mesenchymal transition (EMT) through TGF-β-independent pathway

    第78回日本癌学会学術総会  

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    Event date: 2019.9

  • リン酸化オステオポンチンによる癌細胞の浸潤・転移への影響

    第6回マトリセルフォーラム at 仙台  

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    Event date: 2019.8

  • インテグリンαvβ3は上皮-間葉転換を誘導する

    第5回マトリセルフォーラム at 三重  

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    Event date: 2018.9

  • インテグリンαvβ3は強力なEMT促進因子である

    第50回日本結合組織学会学術大会  

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    Event date: 2018.6

  • Effect of Site-specific O-glycosylation in Osteopontin on its Cell Adhesion Activity and Phosphorylation.

    International Osteopontin Conference  

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    Event date: 2017.11

  • Contribution of O-glycosylation and phosphorylation in osteopontin to its functional activities.

    International Osteopontin Conference  

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    Event date: 2017.11

  • Integrin αvβ3 drives epithelial–mesenchymal transition in lung adenocarcinoma cells

    第76回日本癌学会学術総会  

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    Event date: 2017.9

  • β4 integrin Signaling through Glycosylation Promotes Tumor Progression

    International Conference on Glycobiology  

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    Event date: 2017.9

  • β4 integrin Signaling Promotes Tumor Progression through Galectin-3–N-glycan Complex

    第75回日本癌学会学術総会 (口頭発表)at 横浜  

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    Event date: 2016.10

  • 部位特異的O-結合型糖鎖修飾がオステオポンチンの細胞接着活性に与える影響

    第89回日本生化学会大会 at 仙台  

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    Event date: 2016.9

  • β4インテグリンによる癌悪性化のメカニズム

    第3回マトリセルフォーラム at 東京  

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    Event date: 2016.9

  • Upregulation of C3 and alpha-2-Macroglobulin in cerebrospinal fluid of neuropsychiatric systemic lupus erythematosus

    18th Annual Meeting of American College of Rheumatology  

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    Event date: 2015.11

  • β4 integrin signaling through N-glycosylation promotes tumor progression

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    Event date: 2015.10

  • Modulation of osteopontin cell-adhesion activity by O-glycan deletion requires removal of multiple O-glycosylation sites

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    Event date: 2015.10

  • ラミニン332による癌の悪性進展メカニズム

    第37回水疱症研究会(招待講演)  

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    Event date: 2015.9

  • 糖鎖クラスター欠損によるオステオポンチンの細胞接着活性とリン酸化への影響

    第2回マトリセルフォーラム  

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    Event date: 2015.9

  • 糖鎖欠損によるオステオポンチンの細胞接着活性とリン酸化修飾への影響

    第47回日本結合組織学会  

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    Event date: 2015.5

  • 脳脊髄液中オステオポンチンの視神経脊髄炎病態への関与

    第47回結合組織学会  

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    Event date: 2015.5

  • O-結合型糖鎖を介したオステオポンチンの機能調節

    第1回 MatriCell フォーラム  

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    Event date: 2014.9

  • オステオポンチンのO-結合型糖鎖による細胞接着活性およびリン酸化への影響

    第46回日本結合組織学会学術大会・第61回マトリックス研究会大会合同学術集会  

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    Event date: 2014.6

  • オステオポンチン上O型糖鎖のリン酸化および細胞接着活性に及ぼす影響

    第86回生化学大会  

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    Event date: 2013.9

  • ラミニン332上のBisecting GlcNAc糖鎖はガレクチン3依存的ケラチノサイトの運動を抑制する

    第44回日本結合組織学会学術大会、第59回マトリックス研究会合同学術集会  

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    Event date: 2012.6

  • β4インテグリンの機能発現におけるN-結合型糖鎖の役割

    第84回日本生化学会大会  

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    Event date: 2011.9

  • N-glycosylation of β4 integrin controls the adhesion and motility of keratinocytes.

    The 31st Naito conference. Gene Expression and Regulation II: Metabolites, Stress Response, Microdomains, and beyond.  

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    Event date: 2011.9

  • β4インテグリンの機能発現におけるN-結合型糖鎖の役割

    第43回日本結合組織学会学術大会・第58回マトリックス研究会大会合同学術集会  

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    Event date: 2011.6

  • Wnt/beta-catenin signaling down-regulates N-acetylglucosaminyltransferase III expression: Implication of two mutually exclusive pathway for the regulation

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    Event date: 2010.12

  • β4インテグリンの機能発現におけるN-結合型糖鎖の役割

    第4回東北糖鎖研究会  

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    Event date: 2010.12

  • Bisecting GlcNAc Residues on Laminin-332 Downregulates Integrin-mediated Cell Motility and Intracellular Signaling

    The 25th International Carbohydrate Symposium (ICS2010). August 1-6, 2010, Chiba, Japan  

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    Event date: 2010.8

  • 糖転移酵素N-acetylglucosaminyltransferase III (GnT-III)による細胞運動阻害の新たな分子メカニズム:ガレクチン3を介したラミニン332 超分子複合体から

    第82回日本生化学会大会  

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    Event date: 2009.10

  • ラミニン332 (ラミニン5) のマトリックスプロテアーゼ誘導能とがんの浸潤性増殖

    第82回日本生化学会大会  

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    Event date: 2009.10

  • Expression of laminin alpha3B chain in vascular and epithelial basement membrane and its possible functions.

    Yokosuka Science FESTA2009  

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    Event date: 2009.6

  • N-glycosylation of laminin-332 affects its functional activities.

    Clinical and Translational Research on Cancer: Glycomics Applications.  

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    Event date: 2009.3

  • 新規ラミニンアイソフォームラミニン3B11(ラミニン6B)の発現と機能解析

    第31回日本分子生物学会年会・第81回日本生化学会大会合同大会  

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    Event date: 2008.12

  • Expression of laminin alpha3B chain in vascular and epithelial basement membrane and its possible functions.

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    Event date: 2008.5

  • N-glycosylation regulates function of laminin-332 (laminin-5)

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    Event date: 2008.5

  • 細胞間接着によるGnT-III発現の調節機構について

    第1回東北糖鎖研究会  

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    Event date: 2007.12

  • 組換型ヒトラミニン311(ラミニン6)の発現系の構築

    第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  

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    Event date: 2007.12

  • 細胞間接着によるGnT-III発現の調節機構について

    第30回分子生物学会年会/第80回日本生化学会大会合同大会  

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    Event date: 2007.12

  • ヒト皮膚がんにおけるラミニンbeta3 ・gamma2鎖の異常発現と腫瘍増殖におけるその意義

    第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  

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    Event date: 2007.12

  • The Effect of Topical Laminin 5 on Corneal Epithelial Wound Healing.

    2007 ARVO Annual Meeting  

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    Event date: 2007.5

  • ラミニン5点眼液の家兎角膜上皮創傷治癒への影響

    第111回日本眼科学会総会  

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    Event date: 2007.4

  • The short arm of laminin-5 gamma2 chain regulates cellular adhesion and migration by preventing phosphorylation of integrin beta4 chain

    20th IUBMB international congress of biochemistry and molecular biology and 11th FAOBMB congress  

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    Event date: 2006.6

  • The role of beta4 integrin in squamous cell carcinoma

    Gordon research conferences, Basement Membranes  

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    Event date: 2006.6

  • The short arm of laminin-5 gamma2 chain binds syndecan-1 and regulates cellular adhesion and migration by preventing phosphorylation of integrin beta4 chain

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    Event date: 2005.10

  • Wide distribution of laminin-5B in normal human tissues

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    Event date: 2005.10

  • ラミニンgamma2鎖短腕のインテグリンbeta4リン酸化抑制による細胞接着及び細胞運動の調節

    第37回日本結合組織学会学術大会  

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    Event date: 2005.5

  • The beta3 chain short arm of laminin-5 promotes to the deposition of laminins

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    Event date: 2004.10

  • Characterization of a new laminin-5 isoform, laminin-5B: strong promotion of cellular adhesion, migration and proliferation

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    Event date: 2004.10

  • Characterization of a new laminin isoform, laminin-5B

    Gordon research conferences, Basement Membranes  

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    Event date: 2004.6

  • Characterization of laminin-5B and N-terminal proteolytic fragment of its alpha3B chain

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    Event date: 2004.6

  • The basement membrane protein laminin-5 acts as a soluble cell motility factor

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    Event date: 2004.5

  • The basement membrane protein laminin-5 acts as a soluble cell motility factor

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    Event date: 2003.10

  • Role of beta 3 short arm in cell migration and matrix assembly of laminin-5

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    Event date: 2003.10

  • The basement membrane protein laminin-5 acts as a soluble cell motility factor

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    Event date: 2003.8

  • The basement membrane protein laminin-5 acts as a soluble cell motility factor

    The 5th Pan-Pacific Connective Tissue Societies Symposium  

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    Event date: 2003.6

  • PRODUCTION OF HUMAN RECOMBINANT LAMININ-5 IN HEK293 CELL LINE

    The 11th International basement membrane conferences  

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    Event date: 2003.3

  • PC12細胞の神経突起伸展におけるメタロプロテアーゼとNGF受容体p75の作用

    第75回日本生化学会大会  

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    Event date: 2002.10

  • 細胞の形態と運動性に対するラミニン5と他の細胞外マトリックス蛋白質との協調作用

    第55回 日本細胞生物学会大会  

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    Event date: 2002.5

  • DIFFERENTIAL REGULATION OF CELL ADHESION AND MIGRATION BY alpha3-G3 DOMAIN OF LAMININ-5

    The 10th International basement membrane conferences  

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    Event date: 2001.9

  • ラミニン5 の細胞接着活性と細胞運動活性の発現におけるG3 ドメインの役割

    第54回 日本細胞生物学会大会  

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    Event date: 2001.5

  • Classification of sea snakes in genus Laticauda by nucleotide sequences encoding short chain neurotoxins

    12th World Congress on Animal, Plant and microbial Toxins, International Society on Toxinology  

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    Event date: 1997.9

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Industrial property rights

  • 糖鎖アイソフォーム検出方法及び糖鎖アイソフォーム検出装置

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    Property type:Patent

    Application no:特願2012-178722  Date applied:2012.8

  • ラミニン5を利用した間葉系幹細胞の培養技術

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    Property type:Patent

    Application no:特願2007-532157  Date applied:2006.8

    Patent/Registration no:特許第5001155号  Date registered:2012.5  Date issued:2012.5

  • ラミニン5B

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    Property type:Patent

    Application no:特許2005-506790  Date applied:2004.5

    Patent/Registration no:特許第4798560号  Date registered:2011.8  Date issued:2011.8

Awards

  • 令和元年度福島医学会学術奨励賞

    2020.1  

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    Country:Japan

  • 平成23年度日本結合組織学会大高賞

    2011.6  

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    Country:Japan

  • 第10回インテリジェント・コスモス奨励賞

    2011.5  

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    Country:Japan

  • Journal of Biochemistry/OUP ポスター賞

    2009.10  

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    Country:Japan

  • 第77回 日本組織培養学会学会奨励賞

    2004.5  

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    Country:Japan