Updated on 2024/03/06

写真a

 
UEMURA Takefumi
 
Organization
School of Medicine (Life Sciences and Social Medicine) Department of Anatomy and Histology Associate Professor
Title
Associate Professor

Degree

  • 博士(医学) ( 2009.3   群馬大学 )

Research Interests

  • membrane traffic, knockout mouse

Research Areas

  • Life Science / Anatomy  / General Anatomy(includes Histology/Embryology)

  • Life Science / Cell biology  / Cell Biology

Education

  • 群馬大学大学院   医学系研究科   医科学専攻

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    Country: Japan

Research History

  • Fukushima Medical University   School of Medicine (Life Sciences and Social Medicine) Department of Anatomy and Histology   Associate Professor

    2018.7 - Now

  • Fukushima Medical University   School of Medicine (Life Sciences and Social Medicine) Department of Anatomy and Histology   Associate Professor

    2017.2 - 2018.6

Professional Memberships

  • 日本癌学会

  • 日本細胞生物学会

  • 日本解剖学会

Papers

  • Endosomal protein expression of γ1-adaptin is associated with tumor growth activity and relapse-free survival in breast cancer

    Nobuhiro Hoshi, Takefumi Uemura, Kazunoshin Tachibana, Sadahiko Abe, Yuko Murakami-Nishimagi, Maiko Okano, Masaru Noda, Katsuharu Saito, Koji Kono, Tohru Ohtake, Satoshi Waguri

    Breast Cancer   31 ( 2 )   305 - 316   2024.1

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    Language:English  

  • STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

    Kuchitsu Y, Mukai K, Uematsu R, Takaada Y, Shinojima A, Shindo R, Shoji T, Hamano S, Ogawa E, Sato R, Miyake K, Kato A, Kawaguchi Y, Nishitani-Isa M, Izawa K, Nishikomori R, Yasumi T, Suzuki T, Dohmae N, Uemura T, Barber GN, Arai H, Waguri S, Taguchi T

    Nature Cell Biology   25 ( 3 )   453 - 466   2023.3

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    Language:English  

  • The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.

    Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M.

    Nature Communications   13 ( 1 )   7857   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth

    Uemura T, Suzuki T, Dohmae N, Waguri S

    Oncogenesis   10   80   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Homeostatic regulation of STING by retrograde membrane traffic to the ER

    Kojiro Mukai, Emari Ogawa, Rei Uematsu, Yoshihiko Kuchitsu, Fumika Kiku, Takefumi Uemura, Satoshi Waguri, Takehiro Suzuki, Naoshi Dohmae, Hiroyuki Arai, Anthony K. Shum, Tomohiko Taguchi

    Nature Communications   12   61   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Emerging roles of Golgi/endosome-localizing monomeric clathrin adaptors GGAs

    Uemura T, Waguri S

    Anatomical Science International   95 ( 1 )   12 - 21   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s12565-019-00505-2

  • Intracellular localization of GGA accessory protein p56 in cell lines and central nervous system neurons

    Uemura T, Sawada N, Sakaba T, Kametaka S, Yamamoto M, Waguri S

    Biomed Res   39 ( 4 )   179 - 187   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • LC3-positive puncta increase in skeletal muscle of patient-derived xenograft mice

    Hiromich Annoh, Yuu Dobashi, Naoki Tamura, Takefumi Uemura, Satoshi Waguri

    Jpn J Phys Fitness Sports Med   67 ( 1 )   99 - 105   2018.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth

    Takefumi Uemura, Satoshi Kametaka, Satoshi Waguri

    Scientific Reports   8   1368   2018.1

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  • ジペプチダーゼ1発現が癌細胞の増殖および酸化ストレス耐性に及ぼす影響

    永井千晴、植村武文、和栗聡

    福島医学雑誌   67 ( 3 )   139 - 148   2017.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.

    Muona M, Ishimura R, Laari A, Ichimura Y, Linnankivi T, Keski-Filppula R, Herva R, Rantala H, Paetau A, Pöyhönen M, Obata M, Uemura T*, Karhu T, Bizen N, Takebayashi H, McKee S, Parker MJ, Akawi N, McRae J, Hurles ME; DDD Study, Kuismin O, Kurki MI, Anttonen AK, Tanaka K, Palotie A, Waguri S, Lehesjoki AE, Komatsu M.

    Am J Hum Genet   99 ( 3 )   683 - 694   2016.9

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    Language:English   Publishing type:Research paper (other academic)  

  • p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

    Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T*, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M.

    Nature Communications   7   12030   2016.6

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    Language:English   Publishing type:Research paper (other academic)  

  • Activation of STING requires palmitoylation at the Golgi.

    Mukai K, Konno H, Akiba T, Uemura T*, Waguri S, Kobayashi T, Barber GN, Arai H, Taguchi T.

    Nature Communications   7   11932   2016.6

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    Language:English   Publishing type:Research paper (other academic)  

  • Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1.

    Hirano S, Uemura T*, Annoh H, Fujita N, Waguri S, Itoh T, Fukuda M

    Autophagy   12   312 - 326   2016.2

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    Language:English   Publishing type:Research paper (other academic)  

  • Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.

    Eino A, Kageyama S, Uemura T*, Annoh H, Saito T, Narita I, Waguri S, Komatsu M

    Journal of Cell Science.   128   4453 - 4461   2015.12

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    Language:English   Publishing type:Research paper (other academic)  

  • Proteasome dysfunction activates autophagy and the keap1-nrf2 pathway.

    Kageyama S, Sou YS, Uemura T*, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M.

    J Biol Chem.   289 ( 36 )   24944 - 24955   2014.9

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    Language:English   Publishing type:Research paper (other academic)  

  • A Cluster of Thin Tubular Structures Mediates Transformation of the Endoplasmic Reticulum to Autophagic Isolation Membrane

    Takefumi Uemura*, Masaya Yamamoto, Ai Kametaka, Yu-shin Sou, Atsuko Yabashi, Akane Yamada, Hiromichi Annoh, Satoshi Kametaka, Masaaki Komatsu, and Satoshi Waguri

    Mol Cell Biol.   34 ( 9 )   1695 - 1706   2014.5

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  • Electron Microscopic Analyses of Autophagy-Related Organelles in Mammalian Cells

    49 ( 2 )   118 - 123   2014

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • オートファジー隔離膜近傍細管集合体の観察に用いるアルデヒド-オスミウム混合固定液の至適温度について

    矢橋あつ子, 植村武文*, 和栗聡

    医学生物学電子顕微鏡技術学会誌   28 ( 1 )   2014

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi.

    D'Angelo G, Uemura T*, Chuang C, Polishchuk E, Santoro M, Ohvo-Rekilä H, Sato T, Di Tullio G, Varriale A, D'Auria S, Daniele T, Capuani F, Johannes L, Mattjus P, Monti M, Pucci P, Williams R, Burke J, Platt F, Harada A, De Matteis, MA.

    Nature   501 ( 7465 )   116 - 120   2013.9

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  • Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity

    Ishibashi, Koutaro; Uemura, Takefumi*; Waguri, Satoshi*; Fukuda, Mitsunori.

    Mol. Biol. Cell   23 ( 16 )   3193 - 3202   2012.8

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  • OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.

    Itoh,Takashi; Kanno,Eiko; Uemura,Takefumi*; Waguri,Satoshi*; Fukuda,Mitsunori.

    The Journal of Cell Biology.   192 ( 5 )   839 - 853   2011.3

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  • Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis.

    Misaki,Ryo; Morimatsu,Miki; Uemura,Takefumi*; Waguri,Satoshi*; Miyoshi,Eiji; Taniguchi,Naoyuki; Matsuda,Michiyuki; Taguchi,Tomohiko.

    The Journal of Cell Biology.   191 ( 1 )   23 - 29   2010.9

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  • p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.

    Uemura T*, Sato T, Aoki T, Yamamoto A, Okada T, Hirai R, Harada R, Mori K, Tagaya M, Harada A.

    Mol Cell Biol.   29 ( 7 )   1869 - 1881   2009.1

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  • Neuron-specific and inducible recombination by Cre recombinase in the mouse.

    Hashimoto Y, Muramatsu K, Uemura T*, Harada R, Sato T, Okamoto K, Harada A.

    Neuroreport.   19 ( 6 )   621 - 624   2008.4

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  • Neuron-specific recombination by Cre recombinase inserted into the murine tau locus.

    Muramatsu K, Hashimoto Y, Uemura T*, Kunii M, Harada R, Sato T, Morikawa A, Harada A.

    Biochem Biophys Res Commun.   370 ( 3 )   419 - 423   2008.3

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  • Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.

    Arasaki K, Uemura T*, Tani K, Tagaya M.

    Biochem Biophys Res Commun.   359 ( 3 )   811 - 816   2007.8

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  • 14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice.

    Fujio K, Sato M, Uemura T*, Sato T, Sato-Harada R, Harada A.

    Neuroreport.   18 ( 10 )   1049 - 1052   2007.7

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Presentations

  • Clathrin adaptors AP-1 and GGA2 regulate cell surface expression of EGFR for cell growth

    第82回日本癌学会学術総会   2023.9  

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    Event date: 2023.9

  • クラスリンアダプターAP-1複合体によるEGFR発現調節機構

    第128回日本解剖学会総会・全国学術集会   2023.3  

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    Event date: 2023.3

  • クラスリンアダプターAP-1複合体はEGFR発現を調節する

    第68回日本解剖学会東北・北海道連合支部学術集会  

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    Event date: 2022.9

  • 膜交通によるEGFRの寿命調節機構

    日本顕微鏡学会第78回学術講演会  

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    Event date: 2022.5

  • Roles of recycling endosome-localized clathrin adaptors AP-1 and GGA2 in regulation of cell surface expression of EGFR for cell growth

    第127回日本解剖学会総会  

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    Event date: 2022.3

  • Recycling endosome-localized clathrin adaptors AP-1 and GGA2 regulate cell surface expression of EGFR for cell growth

    第80回日本癌学会学術総会  

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    Event date: 2021.10

  • Endosome-localized clathrin adaptors AP-1 and GGA2 regulate cell surface expression of EGFR for cell growth

    第126回日本解剖学会・第98回日本生理学会合同大会  

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    Event date: 2021.3

  • Clathrin adaptor complex-1 regulates the endosomal sorting of EGFR and cell growth

    第124回日本解剖学会総会全国学術集会  

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    Event date: 2019.3

  • メンブレントラフィックの機能・形態

    第124回日本解剖学会総会全国学術集会  

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    Event date: 2019.3

  • Clathrin adaptor complex-dependent sorting of EGFR at endosomes

    第77回日本癌学会学術総会  

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    Event date: 2018.9

  • ゴルジ‐エンドソーム局在型クラスリンアダプターによるEGFRの新規寿命調節機構

    日本解剖学会 第64回 東北・北海道連合支部学術集会  

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    Event date: 2018.9

  • GGA2 supports cell growth by sustaining EGFR expression in cancer cells

    Joint Annual Meeting of 70th JSCB and 51st JSDB  

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    Event date: 2018.6

  • ゴルジ‐エンドソーム局在型クラスリンアダプターによるEGFRの新規寿命調節機構

    第123回日本解剖学会総会全国学術集会  

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    Event date: 2018.3

  • Golgi/endosome-localized clathrin adaptor protein GGA2 sustains cell growth by preventing EGFR degradation

    第76回日本癌学会学術総会  

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    Event date: 2017.9

  • Involvement of Golgi/endosome-localized clathrin adaptor proteins GGAs in EGFR degradation

    第69回日本細胞生物学会大会  

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    Event date: 2017.6

  • ゴルジ‐エンドソーム局在型クラスリンアダプターGGA2は上皮成長因子受容体(EGFR)の安定化を介して腫瘍増殖を促進する

    第122回日本解剖学会総会全国学術集会  

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    Event date: 2017.3

  • 上皮成長因子受容体の分解と細胞増殖におけるGGA分子の機能

    第74回日本癌学会学術総会  

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    Event date: 2015.10

  • 上皮成長因子受容体の恒常的分解と細胞増殖に関与するGGA分子の解析

    日本解剖学会 第60回東北・北海道連合支部学術集会  

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    Event date: 2014.9

  • Tissue and cellular distribution of the clathrin adaptor accessory protein p56 in mouse tissues

    XXIII International Symposium on morphological Science 2013  

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    Event date: 2013.9

  • 上皮成長因子受容体の細胞内分解に関与するゴルジ‐エンドソーム局在型クラスリンアダプター分子の解析

    第65回日本細胞生物学会大会  

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    Event date: 2013.6

  • 上皮成長因子受容体の細胞内分解に関与するゴルジ‐エンドソーム局在型クラスリン アダプター分子の解析

    第117回日本解剖学会総会・全国学術集会  

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    Event date: 2012.3

  • 上皮成長因子受容体の細胞内分解に関与するゴルジ‐エンドソーム局在型クラスリンアダプター分子の解析

    日本解剖学会第57回 東北・北海道連合支部学術集会  

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    Event date: 2011.9

  • Tissue and cellular distribution of p56, an accessory protein for clathrin adaptors

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    Event date: 2011.3

  • クラスリンアダプターのアクセリー蛋白質であるp56の発現分布解析

    第115回日本解剖学会総会・全国学術集会  

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    Event date: 2010.3

  • 小胞体局在SNARE, p31は小胞体の形態を調節する

    日本解剖学会第55回東北 北海道連合支部学術集会  

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    Event date: 2009.9

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Awards

  • 日本解剖学会奨励賞

    2019.3  

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    Country:Japan