生体分子プロファイリング部門
活動内容
患者さんの組織や血液の中で発現、または存在している遺伝子、タンパク質、抗体等を網羅的に調べ、それらの相違による疾患の鑑別診断や薬剤の効果・副作用予測のためのバイオマーカーを探します。
また、他部門で加工・創出される生体材料および世界中で入手可能な市販の生体由来材料も網羅的に調べて評価します。
スタッフ
| 渡辺 慎哉 | 教授 |
| 今井 順一 | 准教授 |
| 伊藤 恵美 | 講師 |
| 酒井 夕佳 | 助教 |
| 森澤 学 | 助教 |
主な論文・学会発表等
研究員の過去の主な業績をリストアップしています
論文
- Saito, M., Kato, Y., Ito, E., Fujimoto, J., Ishikawa, K., Doi, A., Kumazawa, K., Matsui, A., Takebe, S., Ishida, T., Azuma, S., Mochizuki, H., Kawamura, Y., Yanagisawa, Y., Honma, R., Imai, J., Ohbayashi, H., Goshima, N., Semba, K., Watanabe, S. Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene. FEBS Lett, 586, 1708-1714 (2012)
- Miyamoto, K., Iwadate, M., Yanagisawa, Y., Ito, E., Imai, J., Yamamoto, M., Sawada, N., Saito, M., Suzuki, S., Nakamura, I., Ohki, S., Saze, Z., Kogure, M., Gotoh, M., Omicronbara, K., Ohira, H., Tasaki, K., Abe, M., Goshima, N., Watanabe, S., Waguri, S., Takenoshita, S. Cathepsin L is highly expressed in gastrointestinal stromal tumors. Int J Oncol, 39, 1109-1115 (2011)
- Katao, K., Honma, R., Kato, S., Watanabe, S., Imai, J. Influence of platinum nanoparticles orally administered to rats evaluated by systemic gene expression profiling. Exp Anim, 60, 33-45 (2011)
- Wakamatsu, A., Imai, J., Watanabe, S., Isogai, T. Alternative splicing of genes during neuronal differentiation of NT2 pluripotential human embryonal carcinoma cells. FEBS Lett, 584, 4041-4047 (2010)
- Ueda, K., Ito, E., Karayama, M., Ohsaki, E., Nakano, K., Watanabe, S. KSHV-infected PEL cell lines exhibit a distinct gene expression profile. Biochem Biophys Res Commun, 394, 482-487 (2010)
- Momose, H., Imai, J., Hamaguchi, I., Kawamura, M., Mizukami, T., Naito, S., Masumi, A., Maeyama, J., Takizawa, K., Kuramitsu, M., Nomura, N., Watanabe, S., Yamaguchi, K. Induction of indistinguishable gene expression patterns in rats by Vero cell-derived and mouse brain-derived Japanese encephalitis vaccines. Jpn J Infect Dis, 63, 25-30 (2010)
- Yamaguchi, N., Ito, T., Azuma, S., Ito, E., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J., Watanabe, S., Semba, K., Inoue, J. Constitutive activation of nuclear factor-kappaB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines. Cancer Sci, 100, 1668-1674 (2009)
- Goshima, N., Kawamura, Y., Fukumoto, A., Miura, A., Honma, R., Satoh, R., Wakamatsu, A., Yamamoto, J., Kimura, K., Nishikawa, T., Andoh, T., Iida, Y., Ishikawa, K., Ito, E., Kagawa, N., Kaminaga, C., Kanehori, K., Kawakami, B., Kenmochi, K., Kimura, R., Kobayashi, M., Kuroita, T., Kuwayama, H., Maruyama, Y., Matsuo, K., Minami, K., Mitsubori, M., Mori, M., Morishita, R., Murase, A., Nishikawa, A., Nishikawa, S., Okamoto, T., Sakagami, N., Sakamoto, Y., Sasaki, Y., Seki, T., Sono, S., Sugiyama, A., Sumiya, T., Takayama, T., Takayama, Y., Takeda, H., Togashi, T., Yahata, K., Yamada, H., Yanagisawa, Y., Endo, Y., Imamoto, F., Kisu, Y., Tanaka, S., Isogai, T., Imai, J., Watanabe, S., Nomura, N. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nat Methods, 5, 1011-1017 (2008)
- Hamaguchi, I., Imai, J., Momose, H., Kawamura, M., Mizukami, T., Naito, S., Maeyama, J., Masumi, A., Kuramitsu, M., Takizawa, K., Kato, H., Mizutani, T., Horiuchi, Y., Nomura, N., Watanabe, S., Yamaguchi, K. Application of quantitative gene expression analysis for pertussis vaccine safety control. Vaccine, 26, 4686-4696 (2008)
- Mizukami, T., Imai, J., Hamaguchi, I., Kawamura, M., Momose, H., Naito, S., Maeyama, J., Masumi, A., Kuramitsu, M., Takizawa, K., Nomura, N., Watanabe, S., Yamaguchi, K. Application of DNA microarray technology to influenza A/Vietnam/1194/2004 (H5N1) vaccine safety evaluation. Vaccine, 26, 2270-2283 (2008)