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Cytokine profiles in an extremely preterm infant with congenital syphilis

Eisuke Fukama, Tomoaki Nomura, Daisuke Hatanaka, Michiko Kusakari, Hidehiro Takahashi, Toshihiko Nakamura, Naoto Takahashi

Author information

  • Eisuke Fukama

    Department of Neonatology, Japanese Red Cross Musashino Hospital

  • Tomoaki Nomura

    Department of Neonatology, Japanese Red Cross Musashino Hospital

  • Daisuke Hatanaka

    Department of Neonatology, Japanese Red Cross Musashino Hospital

  • Michiko Kusakari

    Department of Neonatology, Japanese Red Cross Musashino Hospital

  • Hidehiro Takahashi

    Department of Neonatology, Japanese Red Cross Musashino Hospital

  • Toshihiko Nakamura

    Department of Neonatology, Japanese Red Cross Musashino Hospital

  • Naoto Takahashi

    Department of Pediatrics, Tokyo University School of Medicine

Abstract

We report the cytokine profiles of an infant with congenital syphilis as a first case. This female infant was born by vaginal delivery at a gestational age of 27 weeks during her mother’s treatment for syphilis. Elevation of T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supports immunological mechanisms of Th-1, was similar to that in cases of syphilis in adults. IL-6 and granulocyte colony-stimulating factor (G-CSF), the synergistic effects of which cause the leukemoid reaction, were also elevated. The levels of interferon-γ and IL-17 in cerebral spinal fluid, which are elevated in neurosyphilis in adults, were slightly elevated.

The cintent of reseach paper

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