Publication原著論文

Publication

*はCorresponding author、#はEqual first authorを示す。全ての原著論文は査読あり。

  1. Inoue N*., Saito T., Wada I. Noncanonical phagocytosis-like SEAL establishes mammalian fertilization. Cell Rep 44(4):115463. 2025
  2. Inoue N*., Wada I. Deletion of the initial methionine codon of the Tmem95 gene causes subfertility, but not complete infertility, in male mice. Biol Reprod 106(3):378-381. 2022
  3. Inoue N*. Gamete Fusion Assay in Mice. Bio Protoc 11(22):e4233. 2021
  4. Inoue N*., Satouh Y., Wada I. IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation. Mol Reprod Dev 88(7):479-481. 2021
  5. Inoue N*., Hagihara Y., Wada I. Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion. eLife 10:e66313. 2021
  6. Ono R*., Masuya M., Inoue N., Shinmei M., Ishii S., Maegawa Y., Maharjan B., Katayama N., Nosaka T*. Tet1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models. PLoS One 16(3):e0248425 2021
  7. Inoue N*., Saito T., Wada I. Unveiling a novel function of CD9 in surface compartmentalization of oocytes. Development 147(15):dev189985. 2020
  8. Saito T., Wada I., Inoue N*. Sperm IZUMO1-dependent gamete fusion influences male fertility in mice. Int J Mol Sci 20(19). pii:E4809. 2019
  9. Saito T., Wada I., Inoue N*. Alternative splicing of the Izumo1 gene ensures triggering gamete fusion in mice. Sci Rep 9(1):3151. 2019
  10. Inoue N*., Wada I. Monitoring dimeric status of IZUMO1 during the acrosome reaction in living spermatozoon. Cell Cycle 17(11):1279-1285. 2018
  11. Ikezawa M., Tajika Y., Ueno H., Murakami T., Inoue N., Yorifuji H*. Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung. Dev Dyn 247(5):754-762. 2018
  12. Ishikawa T., Kitaura Y*., Kadota Y., Morishita Y., Ota M., Yamanaka F., Xu M., Ikawa M., Inoue N., Kawano F., Nakai N., Murakami T., Miura S., Hatazawa Y., Kamei Y., Shimomura Y*. Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. Sci Rep 7:39825. 2017
  13. Ohto U*., Ishida H., Krayukhina E., Uchiyama S., Inoue N., Shimizu T*. Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature 534(7608):566-569. 2016
  14. Inoue N*., Hagihara Y., Wright D., Suzuki T., Wada I. Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice. Nat Commun 6:8858. 2015
  15. Miyazaki N., Kiyose N., Akazawa Y., Takashima M., Hagihara Y., Inoue N., Matsuda T., Ogawa R., Inoue S., Ito Y*. Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing. J Biochem 158(3):205-215. 2015
  16. Matsuo T., Hattori T., Asaba A., Inoue N., Kanomata N., Kikusui T., Kobayakawa R*., Kobayakawa K*. Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice. Proc Natl Acad Sci U S A 112(3):E311-320. 2015
  17. Inoue N., Hamada D., Kamikubo H., Hirata K., Kataoka M., Yamamoto M., Ikawa M., Okabe M., Hagihara Y*. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. Development 140(15):3221-3229. 2013
  18. Fujihara Y., Kaseda K., Inoue N., Ikawa M., Okabe M*. Production of mouse pups from germline transmission-failed knockout chimeras. Transgenic Res 22(1):195-200. 2013
  19. Satouh Y#., Inoue N#., Ikawa M., Okabe M*. Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1. J Cell Sci 125(Pt 21):4985-4990. 2012
  20. Fujihara Y., Satouh Y., Inoue N., Isotani A., Ikawa M., Okabe M*. SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development 139(19):3583-3589. 2012
  21. Inoue N*., Nishikawa T., Ikawa M., Okabe M. Tetraspanin-interacting protein IGSF8 is dispensable for mouse fertility. Fertil Steril 98(2):465-470. 2012
  22. Inoue N., Satouh Y., Ikawa M., Okabe M*., Yanagimachi R*. Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs. Proc Natl Acad Sci U S A 108(50):20008-20011. 2011
  23. Ikawa M*., Tokuhiro K., Yamaguchi R., Benham A., Tamura T., Wada I., Satouh Y., Inoue N., Okabe M. Calsperin is a testis-specific chaperone required for sperm fertility. J Biol Chem 286(7): 5639-5646. 2011
  24. Oshiumi H*., Miyashita M., Inoue N., Okabe M., Matsumoto M., Seya T. The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. Cell Host Microbe 8(6):496-509. 2010
  25. Inoue N., Kasahara T., Ikawa M., Okabe M*. Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. PLoS One 5(4):e10301. 2010
  26. Fujihara Y., Murakami M., Inoue N., Satouh Y., Kaseda K., Ikawa M., Okabe M*. Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse. J Cell Sci 123(Pt 9):1531-1536. 2010
  27. Inoue N., Ikawa M., Okabe M*. Putative sperm fusion protein IZUMO and the role of N-glycosylation. Biochem Biophys Res Commun 377(3):910-914. 2008
  28. Hayasaka S., Terada Y*., Inoue N., Okabe M., Yaegashi N., Okamura K. Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients. Fertil Steril 88(1):214-216. 2007
  29. Sakurai F., Kawabata K., Koizumi N., Inoue N., Okabe M., Yamaguchi T., Hayakawa T., Mizuguchi H*. Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice. Gene Ther 13(14):1118-1126. 2006
  30. Shingai M#., Inoue N#., Okuno T., Okabe M., Akazawa T., Miyamoto Y., Ayata M., Honda K., Kurita-Taniguchi M., Matsumoto M., Ogura H., Taniguchi T., Seya T*. Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection. J Immunol 175(5):3252-3261. 2005
  31. Inoue N., Ikawa M., Isotani A., Okabe M*. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 434(7030):234-238. 2005
  32. Matsumura M., Hasuwa H., Inoue N., Ikawa M., Okabe M*. Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain. Biochem Biophys Res Commun 321(2):275-279. 2004
  33. Kimura Y#., Inoue N#., Fukui A., Oshiumi H., Matsumoto M., Nonaka M., Kuratani S., Fujita T., Nonaka M., Seya T*. A short consensus repeat-containing complement regulatory protein of lamprey that participates in cleavage of lamprey complement 3. J Immunol 173(2):1118-1128. 2004
  34. Inoue N., Ikawa M., Nakanishi T., Matsumoto M., Nomura M., Seya T., Okabe M*. Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm. Mol Cell Biol 23(7):2614-2622. 2003
  35. Yamamoto T., Nishiguchi M., Inoue N., Goto H., Kudawara I., Ueda T., Yoshikawa H., Tanigaki Y., Nishizawa Y*. Inhibition of murine osteosarcoma cell proliferation by glucocorticoid. Anticancer Res 22(6C):4151-4156. 2002
  36. Yamamoto K., Inoue N., Masuda R., Fujimori A., Saito T., Imajoh-Ohmi S., Shinkai H., Sakiyama H*. Cloning of hamster type XVII collagen cDNA, and pathogenesis of anti-type XVII collagen antibody and complement in hamster bullous pemphigoid. J Invest Dermatol 118(3):485-492. 2002
  37. Sakiyama H*., Nonaka T., Masuda R., Inoue N., Kuboki Y., Iijima M., Hirabayasi Y., Takahagi M., Yoshida K., Kuriiwa K., Yoshida M., Imajoh-Ohmi S. Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP). Cell Tissue Res 309(2):269-279. 2002
  38. Nomura M., Kurita-Taniguchi M., Kondo K., Inoue N., Matsumoto M., Yamanishi K., Okabe M., Seya T*. Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: identification of a CMV-responsive element in the CD46 promoter region. Eur J Immunol 32(10):2954-2964. 2002
  39. Tsujimura A., Nunoue K., Inoue N., Shida K., Kurita-Taniguchi M., Matsumoto M., Nomura M., Takeya T., Seya T*. Three soluble form messages of murine CD46 are produced through alternative mRNA splicing. J Biochem 130(6):841-848. 2001
  40. Sakiyama H*., Masuda R., Inoue N., Yamamoto K., Kuriiwa K., Nakagawa K., Yoshida K. Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers. J Bone Miner Metab 19(4):220-227. 2001
  41. Inoue N., Fukui A, Nomura M., Matsumoto M., Nishizawa Y., Toyoshima K., Seya T*. A novel chicken membrane-associated complement regulatory protein: molecular cloning and functional characterization. J Immunol 166(1):424-431. 2001
  42. Fukui A., Inoue N., Matsumoto M., Nomura M., Yamada K., Matsuda Y., Toyoshima K., Seya T*. Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns. J Biol Chem 276(50):47143-47149. 2001
  43. Takada Y., Sakiyama H*., Kuriiwa K., Masuda R., Inoue N., Nakagawa K., Itano N., Saito T., Yamada T., Kimata K. Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases. Cell Tissue Res 298(2):317-325. 1999
  44. Inoue N., Saito T., Masuda R., Suzuki Y., Ohtomi M., Sakiyama H*. Selective complement C1s deficiency caused by homozygous four-base deletion in the C1s gene. Hum Genet 103(4):415-418. 1998