Lab Staff Research Resource Publication
Novel insight into the molecular mechanism of sperm-egg fuion via IZUMO1.  Inoue N
J Plant Res (2017) 130, 475-478 
Chaos Analysis of ER-Network Dynamics in Microscopy Imaging
in "A Handbook on Applications of Chaos Theory" (Taylor & Francis), 253-270,
Tuan Pham and Ikuo Wada, 2016
「見えないものを見る」 和田郁夫 医学のあゆみ、251/ 12, 1162-1165, 2014
The Mechanism of Sperm-Egg Fusion in Mouse. Inoue Naokazu.
Sexual Reproduction in Animal and Plants 393-400. 2014
「精子と卵子の膜融合」井上直和, 宮戸健二. 細胞工学 33, 386-392. 2014
「哺乳類における受精の分子メカニズム」 伊藤千鶴、伊藤昌彦、井上直和、年森清隆、宮戸健二
哺乳類における受精の分子メカニズム  239-261  澤田均編 「動植物の受精学」  化学同人  2014 
「細胞がものを食べる仕組み」(バイオイメージング 画像で見る驚異の世界) 初沢清隆、櫻井千恵、和田郁夫
生物の科学 遺伝 65(3)68-73、2011
「ファイゴサイトーシスにおけるSNAREタンパク質の関与」 初沢清隆
生体の化学、61(3), 2010
「ファイゴサイトーシスの分子機構」 初沢清隆
「生細胞蛍光イメージングー阪大・北大 顕微鏡コースブック」 木村宏・和田郁夫、10、11、19章、共立出版、2007
「FRAPとFCSを用いた拡散解析」 大橋功治、和田郁夫
染色・バイオイメージング実験ハンドブック(羊土社)pp222-227, 2006
pdfファイルの請求は、 までごどうぞ。
ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing α-mannosidase-like protein 3 (EDEM3).
Yu S, Ito S, Wada I, Hosokawa N (2018) J Biol Chem . doi: 10.1074/jbc.RA118.003129

Monitoring dimeric status of IZUMO1 during the acrosome reaction in living spermatozoon.
Inoue N and Wada I (2018) Cell Cycle in press

IPhosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages.
Sakurai C, Itakura M, Kinoshita D, Arai S, Hashimoto H, Wada I, Hatsuzawa K (2018) Mol Biol Cell, DOI: 10.1091/mbc.E17-08-0523  

Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung. (2018) Ikezawa M., Tajika Y., Ueno H., Murakami T., Inoue N., Yorifuji H.  (2018) Dev Dyn 247(5):754-762.

Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition
Ishikawa T., Kitaura Y*., Kadota Y., Morishita Y., Ota M., Yamanaka F., Xu M., Ikawa M., Inoue N., Kawano F., Nakai N., Murakami T., Miura S., Hatazawa Y., Kamei Y., Shimomura Y. (2017) Sci Rep 7, 39825.

Yeast cells as an assay system for in vivo O-GlcNAc modification.
Nakanishi H, Li F, Han B, Arai S, Gao X-D.  Biochimica et Biophysica Acta (2017) 1861:1159-1167. 
Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation. 
Fujimori T, Suno R, Iemura SI, Natsume T, Wada I, Hosokawa N,  Genes to cells (2017) 22(8) 684-698.

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Saito T, Bokhove M, Croci R,  Letarte M, Sanctis D, Jovine L.
Cell Reports (2017) 19(9)1917-1928.

Antibacterial effects of the artificial surface of nanoimprinted moth-eye film.
Minoura K, Yamada M, Mizoguchi T, Kaneko T, Nishiyama K, Ozminsky M, Koshizuka T, Wada I, Suzutani T.  PLoS One (2017) 12(9) e0185366.

Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum
Hayashi Y, Nemoto-Sasaki Y, Matsumoto N, Tanikawa T, Oka S, Tanaka Y, Arai S, Wada I, Sugiura T, Yamashita A.  J Biol Chem (2017) 292(3) 1122-1141.

Application of a silver coating on plastic biliary stents to prevent biofilm formation: an experimental study using electron microscopy.
Akane Yamabe, Atsushi Irisawa, Ikuo Wada, Goro Shibukawa, Koki Hoshi, Mariko Fujisawa, Ryo Igarashi, Ai Sato, Takumi Maki. Endoscopy international open (2016) 4(10) E1090-E1095

Generation of airway epithelial cells with native characteristics from mouse induced pluripotent stem cells
Yoshie S, Imaizumi M, Nakamura R, Otsuki K, Ikeda M, Nomoto Y, Wada I, Omori K. Cell Tissue Res 364/ 2, 319-330, 2016

M1 macrophage infiltrations and histological changes in the liver after portal vein embolization using fibrinogen and OK432 in the rat.
Sato T, Marubashi S, Kenjo A, Tsuchiya T, Kimura T, Sato N, Watanabe J, Tasaki K, Hashimoto Y, Wada I, Gotoh M. Cell Immunol. 303, 66-71, 2016

Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.
Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T
Nature, doi:10.1038/nature18596

Regeneration of tracheal epithelium using mouse induced pluripotent stem cells.
Ikeda M, Imaizumi M, Yoshie S, Otsuki K, Miyake M, Hazama, Wada I, Omori K Acta Otolaryngol 136/ 4, 373-378, 2016

Potential of laryngeal muscle regeneration using induced pluripotent stem cell-derived skeletal muscle cells.Dirja BT, Yoshie S, Ikeda M, Imaizumi M, Nakamura R, Otsuki K, Nomoto Y, Wada I, Hazama A, Omori K. 136/ 4, 391-396

Association of the SEL1L Protein Transmembrane Domain with HRD1 Ubiquitin Ligase regulates ERAD-L
Hosokawa N and Wada I,
FEBS Journal, 283(1) 157-172, 2016

Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice.
Inoue K, Hagihara Y, Wright D, Suzuki T, Wada I
Nature Communications, 6:8858, 2015 doi: 10.1038/ncomms9858

Visualization of mouse induced pluripotent stem cells for evaluation of tracheal regeneration.
Yoshie S1, Ikeda M, Imaizumi M, Otsuki K, Nomoto Y, Wada I, Omori K.
Acta Otolaryngol, 135, 395-401, 2015

Characterization of Russell bodies accumulating the mutant antithrombin that derived from endoplasmic reticulum.
Kimura K, Kawaguchi K, Ueda Y, Arai S, Morita M, Imanaka T, Wada, I.
Biol. Pharm. Bull. 38 (6), 852-861, 2015

In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver.
Matsumoto Y, Saito T, Hoshi K, Ito H, Kariya Y, Nagae M, Yamaguchi Y, Hagiwara Y, Kinoshita N, Wada I, Saito K, Honda T, Hashimoto Y.
J Biochem 257, 211-216, 2015

Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice .
Matsuo, T., Hattori, T., Asaba, A., Inoue, N., Kanomata, N., Kikusui, T., Kobayakawa, R., Kobayakawa, K.  Matsuo, T., Hattori, T., Asaba, A., Inoue, N., Kanomata, N., Kikusui, T., Kobayakawa, R., Kobayakawa, K. 
Proc Natl Acad Sci U S A  112(3) 311-320  2015

Structural change of N-glycan exposes hydrophobic surface of human transferrin.
Nagae M, Morita-Matsumoto K, Arai S, Wada I, Matsumoto Y, Saito K, Hashimoto Y, Yamaguchi Y.
Glycobiology, 24/ 8, 693-902, 2014

Constitutive expression of a COOH-terminal leucine mutant of lysosome-associated membrane protein-1 causes its exclusive localization in low density intracellular vesicles.
Akasaki K, Shiotsu K, Michihara A, Ide N, Wada I
J Biochem. 156/ 1, 39-49, 2014

Effective embryoid body formation from induced pluripotent stem cells for regeneration of respiratory epithelium.
Otsuki K, Imaizumi M, Nomoto Y, Nomoto M, Wada I, Miyake M, Omori K.
Laryngoscope, 121/ 1, E8-14, 2014

Genetic basis of cell-cell fusion mechanisms 
Aguilar AP, Baylies MK, Fleissner A, Helming L, Inoue N, Podbilewicz B, Wang H, Wong M
Trends Genet.  29(7): 427-437  2013    

Production of mouse pups from germline transmission-failed knockout chimeras 
Fujihara Y, Kaseda K, Inoue N, Ikawa M, Okabe M.
Transgenic Res  22(1), 195-200  2013 

Evaluation of the use of induced pluripotent stem cells (iPSCs) for the regeneration of tracheal cartilage.
Imaizumi M, Nomoto Y, Sato Y, Sugino T, Miyake M, Wada I, Nakamura T, Omori K.
Cell Transplant. 22(2):341-53. 2013

Stepwise Assembly of Fibrinogen Is Assisted by the Endoplasmic Reticulum Lectin-Chaperone System in HepG2 Cells
Tamura T, Arai S, Nagaya H, Mizuguchi J, Wada I
PLoS ONE 8(9)e745802013

Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion
Inoue N, Hamada D,Kamikubo H, Hirata K, Kataoka M, Yamamoto M, Ikawa M, Okabe M Hagihara Y. Development (2013) 140:3221-3229

nsulin receptor activation through its accumulation in lipid rafts by mild electrical stress. (2013) 
J Cell Physiol 228(2):439-46.
Morino-Koga S1, Yano S, Kondo T, Shimauchi Y, Matsuyama S, Okamoto Y, Suico MA, Koga T, Sato T, Shuto T, Arima H, Wada I, Araki E, Kai H.

Regenerative process of tracheal epithelium using a collagen vitrigel sponge scaffold.
Tani A, Tada Y, Takezawa T, Wada I, Imaizumi M, Nomoto Y, Nomoto M, Omori K.
Laryngoscope. 2013 123(6):1469-1473.

Potential for respiratory epithelium regeneration from induced pluripotent stem cells.
Otsuki K, Imaizumi M, Nomoto Y, Wada I, Miyake M, Sugino T, Omori K. Ann Otol Rhinol Laryngol. 2013 Jan;122(1):25-32.

Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.
Endo Y, Takahashi M, Iwaki D, Ishida Y, Nakazawa N, Kodama T, Matsuzaka T, Kanno K, Liu Y, Tsuchiya K, Kawamura I, Ikawa M, Waguri S, Wada I, Matsushita M, Schwaeble WJ, Fujita T.
J Immunol. (2012) Dec 15;189(12):5860-5866

SNAP-23 regulates phagosome formation and maturation in macrophages
Sakurai C, Hashimoto H, Nakanishi H, Arai S, Wada Y, Sun-Wada GH, Wada I, Hatsuzawa K
Mol Biol Cell (2012) 23 4849-4863

Development of cysteine-free fluorescent proteins for the oxidative environment
Suzuki T, Arai S, Takeuchi M, Sakurai C, Ebana H, Higashi T, Hashimoto H, Hatsuzawa K, Wada I
PLoS ONE 7(5)e37551 2012

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein Sato T, Sako Y, Sho M, Momohara M, Chosa K, Taura M, Nishitoh H, Okiyoneda T, Kokame K, Kaneko M, Miyata M, Suico MA, Shuto T, Koga T, Morino-Koga S, Wada I, Kai H
Mol Cell 47(1) 99-110, 2012

Autofluorescence of the cells in human subretinal fluid
Sekiryu T, Oguchi Y, Arai S, Wada I, Iida T
Invest Ophthalmol Vis Sci. 2011 52(11):8534-8541

SEL1L critically determines the stability of the HRD1-SEL1L ERAD complex to optimize the degradation kinetics of ERAD substrates
Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N
J Biol Chem 286(19): 16929-16939, 2011

Inhibition of Rab1 GTPase and endoplasmic reticulum-to-Golgi trafficking underlies statin's toxicity in rat skeletal myofibers.
Sakamoto K, Wada I, Kimura J
J Pharmacol Exp Ther. 338(1):62-69 2011

Calsperin is a testis specific chaperone required for sperm fertility

Ikawa M, Tkuhiro K, Yamaguchi R, Tamura T, Wada I, Tatouh Y, Inoue N, Okabe M
J Biol Chem 286(7):5639-5646, 2011

Involvement of membrane type 1-matrix metalloproteinase (MT1-MMP) in RAGE activation signaling pathways.
Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y
J Cell Physiol. 226(6):1554-1563 2011

The ALG-2 binding site in Sec31A influences the retention kinetics of Sec31A at the endoplasmic reticulum exit sites as revealed by live-cell time-lapse imaging.
Shibata H, Inuzuka T, Yoshida H, Sugiura H, Wada I, Maki M.
Biosci Biotechnol Biochem. 23;74(9):1819-1826, 2010

COOH-Terminal Isoleucine of Lysosome-Associated Membrane Protein-1 (LAMP-1) Is Optimal for Its Efficient Targeting to Dense Secondary Lysosomes.
Akasaki K, Suenobu M, Mukaida M, Michihara A, Wada I.
J Biochem. 2010 Dec;148(6):669-679.

Potential of induced pluripotent stem cells for the regeneration of the tracheal wall.
Imaizumi M, Nomoto Y, Sugino T, Miyake M, Wada I, Nakamura T, Omori K.
Ann Otol Rhinol Laryngol. 2010 Oct;119(10):697-703.

A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells.
Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Wada I, Nakamura T, Omori K.Biomaterials.31(18):4855-4863, 2010

EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans Hosokawa N, Tremblay LO, Sleno B, Kamiya Y, Wada I, Nagata K, Kato K, Herscovics A
Glycobiology, ;20(5):567-575,2010

Bioengineered trachea with fibroblasts in a rabbit model.
Okano W, Nomoto Y, Wada I, Kobayashi K, Miyake M, Nakamura T, Omori K.
Ann Otol Rhinol Laryngol. 118(11):796-804, 2009

Sec22b Is a Negative Regulator of Phagocytosis in Macrophages
Hatsuzawa K, Hashimoto H, Hashimoto H, Arai S, Tamura T, Higa-Nishiyama A, Wada I
Mol Biol Cell, 20(20)4435-4443, 2009

Involvement of Na+/Ca2+ exchanger in migration and contraction of cultured rat tendon fibroblasts
Sakamoto K, Owada Y, Shikama Y, Wada I, Waguri S, Iwamoto T, Kimura J.
J Physiol 587(22):5345-5359, 2009

The Rab GTPase Ypt11 functions in bud-directed transport of the Golgi by linking Myo2 to the
coatomer subunit Ret2.

Arai S, Noda Y, Kainuma S, Wada I, Yoda K
Current Biology 18(13), 987-991, 2008

Human XTP3-B forms an ER quality-control scaffold with the Hrd1-Sel1l ubiquitin ligase complex and BiP.
Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K
J Biol Chem 283(30), 20914-20924, 2008

Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulumNEWS "Traffic control in the ER"
Nagaya H, Tamura T, Higa-Nishiyama A, Ohashi T, Takeuchi M, Hashimoto H, Hatsuzawa K, Kinjo M, Okada T, Wada I
J Cell Biol 180(1), 129-143, 2008

Regeneration of the trachea using a bioengineered scaffold with adipose-derived stem cells.
Suzuki T, Kobayashi K, Tada Y, Suzuki Y, Wada I, Nakamura T, Omori K.
Ann Otol Rhinol Laryngol. 117(6):453-463, 2008

Effect of fibroblasts on epithelial regeneration on the surface of a bioengineered trachea.
Nomoto Y, Kobayashi K, Tada Y, Wada I, Nakamura T, Omori K.
Ann Otol Rhinol Laryngol. 117(1):59-64, 2008

Carboxyl-Terminal Disulfide Bond of Acid Sphingomyelinase Is Critical for Its Secretion and Enzymatic Function
Lee C-Yin, Tamura T, Rabah N, Lee D-Y, Ruel I, Hafiane A, Iatan I, Nyholt D, Laporte F, Lazure C, Wada I, Krimbou L, Genest J
Biochemistry 2007 46(51), 14969-14978

Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis.
Takahashi T, Wada I, Ohtsuka Y, Munakata M, Homma Y, Kuroki Y.
Respirology 12(5):642-53, 2007

Meltrin beta/ADAM19 Mediates Ectodomain Shedding of Neuregulin beta1 in the Golgi Apparatus:
Fluorescence Correlation Spectroscopic Observation of the Dynamics of Ectodomain Shedding in Living Cells
Yokozeki T, Wakatsuki S, Hatsuzawa K, Black RA, Wada I, Sehara-Fujisawa A
Genes to Cells, 12(3): 329-343, 2007

Involvement of Syntaxin 18, an Endoplasmic Reticulum (ER)-localized SNARE Protein, in ER-mediated Phagocytosis
Hatsuzawa K, Tamura T, Hashimoto H, Hashimoto H, Yokoya S, Miura M, Nagaya H, Wada I
Mol Biol Cell 17(9) 3964-3977, 2006

Tissue engineering for regeneration of the tracheal epithelium.
Nomoto Y, Suzuki T, Tada Y, Kobayashi K, Miyake M, Hazama A, Wada I, Kanemaru S, Nakamura T, Omori K.
Ann Otol Rhinol Laryngol.115(7):501-506, 2006

Calreticulin negatively regulates the cell surface expression of CFTR
Harada K, Okiyoneda T, Hashimoto Y, Ueno K, Nakamura K, Yamahira K, Sugahara T, Shuto T,
Wada I, Suico MA, Kai M
J Biol Chem, 281(18) 12841-12848, 2006

EDEM3, a soluble EDEM homolog, enhances glycoprotein ERAD and mannose trimming
Hirao K, Natsuka Y, Tamura T, Wada I, Morito M, Natsuka S, Romero P, Sleno B, Tremblay LO,
Herscovics A, Nagata K, Hosokawa N
J. Biol. Chem. 281(14)9650-9658, 2006

EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin.
Hosokawa N, Wada I, Natsuka Y, Nagata K
Genes to Cells 11 465-476, 2006

Involvement of a novel Q-SNARE, D12, in quality control of endomembrane system.
Joo-Okumura A, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I,
J Biol Chem 281(7), 4495-4506, 2006

CK2 phosphorylation of translation initiation factor eIF5 potentiates cell cycle progression
Kato-Homma M, Wada I, Suzuki T, Yamaki J, Krebs EG, Homma Y
Proc Natl Acad Sci U S A, 102(43), 15688-15693, 2005

Reticulon 3 is involved in membrane trafficking between the endoplasmic
reticulum and Golgi.
Wakana Y, Koyama S, Nakajima K, Hatsuzawa K, Nagahama M, Tani K, Hauri HP,
Melancon P, Tagaya M.
Biochem Biophys Res Commun. 334 (4) 1198-1205, 2005

Human M-Ficolin Is a Secretory Protein That Activates the Lectin Complement Pathway
Liu Y, Endo Y, Iwaki D, Nakata M, Matsushita M, Wada I, Inoue K, Munakata M, Fujita T
J Immunol 175(5):3150-3156, 2005.

Uninephrectomy induces progressive glomerulosclerosis and apoptosis in anti-Thy1 glomerulonephritis.
Sakai N, Iseki K, Suzuki S, Mori T, Hagino S, Zhang Y, Yokoya S, Suzuki J, Isome M, Wada I, Homma Y, Suzuki H.
Pathol Int. 55(1):19-26, 2005

WAVE/Scars in Platelets
Oda A, Miki H, Wada I, Yamaguchi H, Yamazaki D, Suetsugu S, Nakajima M, Nakayama A, Okawa K, Miyazaki H, Matsuno K, Ochs HD, Machesky LM, Fujita H, Takenawa T
Blood 105(8): 3141-3148, 2005

Direct detection of caspase-3 activation in single live cells by cross-correlation analysis
Saito K, Wada I, Tamura M, Kinjo M
Biochem. Biophys.Res.Com.324(2) 849-854, 2004

NVL2 Is a Nucleolar AAA-ATPase that Interacts with Ribosomal Protein L5
through Its Nucleolar Localization Sequence.
Nagahama M, Hara Y, Seki A, Yamazoe T, Kawate Y, Shinohara T, Hatsuzawa K,
Tani K, Tagaya M.
Mol. Biol. Cell. 15 (12) 5712-5723, 2004

Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi
Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Magashima M, Tani K, Yamamoto A, Tohyama M, Tagaya M
EMBO J, 23(6):1267-78、2004

Regulation of immature protein dynamics in the endoplasmic reticulum
Kamada A, Nagaya H, Tamura T, Kinjo M, Jin H-Y, Yamashita T, Jimbow K, Kanoh H, Wada I
J Biol Chem, 279(20), 21533-21542, 2004

Determinants of liposome fusion mediated by synaptic SNARE proteins
Schuette CG, Hatsuzawa K, MargittaiM, Stein A, Riedel D, Kuster P, Konig M, Seidel C, Jahn R
Proc.Nat.Acad.Sci.U.S.A. 101 (9) 2858-2863, 2004

F508CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression
Okiyoneda T, Harada K, Takeya M, Yamahira K, Wada I, Shuto T, Soten MAS, Kai H
Mol Bio Cell 15(2) 263-574, 2004

Accumulation of Hsp70/Hsc70 molecular chaperone regulator BAG-1 on COPI-coated structures in gastric epitherial cells
Takamura A, Adachi M, Wada I, Takayama S, Imai K
Int J Oncol 23(5) 1301-1308, 2003

cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrie endothelial cells via protein kinase A-dependent and -independent pathways
Ishizaki T, Chiba H., Kojima T., Fujibe M, Soma T, Miyajima H, Nagasawa K, Wada I, Sawada N
Exp Cell Res 290(2) 275-288, 2003

Spatiotemporal dynamics of the COPI vesicle machinery
Elsner M, Hashimoto H, Simpson JC, Cassel D, Nilsson T, Weiss M.
EMBO reports 4, 10, 1000-1004, 2003

Anomalous protein diffusion in living cells as seen by fluorescence correlation spectroscopy.
Weiss M, Hashimoto H, Nilsson T.
Biophys J, 84, 4043-4052, 2003

The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.
Hatsuzawa K, Lang T, Fasshauer D, Bruns D, Jahn R.
J Biol Chem. 278, 31159-31166, 2003

Gaf-1b is an alternative splice variant of Gaf-1/Rip11
Kawase K, Shibata M, Kawashima H, Hatsuzawa K, Nagahama M, Tagaya M, Tani K.
Biochem. Biophys. Res. Commun. 303, 1042-1046, 2003

Mapping of functional domains of gamma-SNAP
Tani K, Shibata M, Kawase K, Kawashima H, Hatsuzawa K, Nagahama M, Tagaya M.
J Biol Chem. 278, 13531-13538, 2003

Enhancement of Endoplasmic Reticulum (ER) Degradation of Misfolded NullHongKong {alpha}1-Antitrypsin by Human ER Mannosidase I.
Hosokawa N, Tremblay LO, You Z, Herscovics A, Wada I, Nagata K.
J. Biol. Chem. 278;26287-26294, 2003
EDEM as an Acceptor of Terminally Misfolded Glycoproteins Released from Calnexin.
Oda Y, Hosokawa N, Wada I, Nagata K.
Science 299(5611):1394-1397, 2003
CrkL Directs ASAP1 to Peripheral Focal Adhesions.
Oda A, Wada I, Miura K, Okawa K, Kadoya T, Kato T, Nishihara H, Maeda M, Tanaka S, Nagashima K, Nishitani C, Matsuno K, Ishino M, Machesky L, Fujita H, Randazzo P.
J. Biol. Chem. 278(8):6456-6460, 2003

SVIP is a novel VCP/p97-interacting protein whose expression causes cell vaculation.
Nagahama M, Suzuki M, Hamada Y, Hatsuzawa K, Tani K, Yamamoto A and Tagaya M.
Mol. Biol. Cell. 14(1); 262-273, 2003

Calnexin Delta 185-520 partially reverses the misprocessing of the Delta F508 cystic fibrosis transmembrane conductance regulator.
Okiyoneda T, Wada I, Jono H, Shuto T, Yoshitake K, Nakano N, Nagayama S, Harada K, Isohama Y, Miyata T, Kai H.FEBS Lett 526(1-3):87-92, 2002
N-linked oligosaccharide chains of Sendai virus fusion protein determine the interaction with endoplasmic reticulum molecular chaperones.
Tamura T, Yamashita H, Segawa H, Taira H.
FEBS Lett. 513; 153-158, 2002
Tyrosinase and tyrosinase-related protein 1 require rab7 for their intracellular transport.
Hirosaki K, Yamashita T, Wada I, Jin H-Y, Jimbow K.
J. Inv. Dermatol. 119(2), 475-480, 2002 
Progression of the stacked Golgi compartments in the yeast Saccharomyces cerevisiae by overproduction of GDP-mannose transporter.
Hashimoto H, Abe M, Hirata A, Noda Y, Adachi H, Yoda K.
Yeast 19, 1413-1424, 2002.

A critical role for the carboxy terminal region of the proprotein convertase, PACE4A, in the regulation of its autocatalytic activation coupled with secretion
Taniguchi T, Kuroda R, Sakurai K, Nagahama M, Wada I, Tsuji A, Matsuda K .
Biochem. Biophys. Res. Com. 290(2), 878-884, 2002

Diacylglycerol kinase δ suppresses ER-to-Golgi traffic through its SAM and PH domains.
Nagaya H, Wada I, Jia Y-J, Kanoh H.
Mol. Biol. Cell, 13(1), 302-316, 2002

Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility.
Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M.
Dev. Biol. 240, 254-261, 2001

Extracellular toll-Like receptor 2 region containing serine 40 -isoleucine 64 but not cysteine 30 -serine 39 is critical for the recognition of Staphylococcus aureus peptidoglycan.
Mitsuzawa H, Wada I, Sano H, Iwaki D, Murakami S, Himi T, Matsushima N, Kuroki Y.
J. Biol. Chem. 276(44), 41350-41356, 2001

Nitric oxide-induced apoptosis in pancreatic -cells is mediated by the endoplasmic reticulum stress pathway
Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, Akira S, Araki E, Mori M.
Proc.Natl.Acad.Sci.U.S.A.,98, 10845-10850, 2001

Oculocutaneous albinism types 1 and 3 are ER retention diseases: mutation of tyrosinase or tyrp1 can affect the processing of both mutant and wild-type proteins.
Toyofuku K, Wada I, Valencia JC, Kushimoto T, Ferrans VJ, Hearing VJ.
FASEB J., 15, 2149-2161, 2001.

Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER
Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T.
FEBS Lett, 508, 201-209, 2001.
Identification of a novel melanogenesis marker, J1 which recognizes luminal membrane of "prelysosomes" common to biogenesis process of melanosomes and lysosomes
Shinoda K, Wada I, Jin HY,.Jimbow K
Cell Structure and Function, 26, 169-177, 2001.

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation
Hosokawa N, Wada I, Hasegawa K, Yorihuzi T, Tremblay L, Herscovics A, Nagata K.
EMBO Report, 2, 415-422, 2001.

The molecular basis of oculocutaneous albinism type 1 (OCA1): sorting failure and degradation of mutant tyrosinases results in a lack of pigmentation.
Toyofuku K, Wada I, Spritz RA, Hearing VJ
Biochem J, 35, 259-269, 2001.
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