研究業績|nishitalab

研究業績

原著論文

2022

Saji T, Nishita M, Ikeda K, Endo M, Okada Y, Minami Y. c-Src-mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells. J Biol Chem. 2022

Okamoto D, Yamauchi N, Takiguchi G, Nishita M, Kakeji Y, Minami Y, Kamizaki K. Autonomous and intercellular chemokine signaling elicited from mesenchymal stem cells regulates migration of undifferentiated gastric cancer cells. Genes Cells. 27:368-375, 2022

Sonoda D, Kamizaki K, Matsuo Y, Aruga K, Mikubo M, Yamashita K, Nishita M, Minami Y, Satoh Y. Characterization of morphological alterations in micropapillary adenocarcinoma of the lung using an established cell line. Oncol Rep. 47(1):19. 2022.

2021

Avincsal MO, Kamizaki K, Jimbo N, Shinomiya H, Nibu KI, Nishita M, Minami Y. Oncogenic E6 and/or E7 proteins drive proliferation and invasion of human papilloma virus‑positive head and neck squamous cell cancer through upregulation of Ror2 expression. Oncol Rep. 46(1):148. 2021.

Alcantara MC, Suzuki K, Acebedo AR, Sakamoto Y, Nishita M, Minami Y, Kikuchi A, Yamada G. Stage-dependent function of Wnt5a during male external genitalia development. Congenit Anom (Kyoto). 2021 Jul 13.

2020

Ikeda, T., *Nishita, M., Hoshi, K., Honda, T., Kakeji, Y., and *Minami, Y. Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1. Cancer Sci. 111: 1254-1265, 2020.

Yamazoe, T., *Nagai, T., Umeda, S., Sugaya, Y., and *Mizuno, K. Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling. J Biol Chem 295: 14723-14736, 2020.

Irie, K., Nagai, T., and Mizuno, K. Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. J Biol Chem 295: 3017-3028, 2020.

2019

Miao, W., Sakai, K., Sato, H., Imamura, R.,Jangphattananont, N., Takagi, J., Nishita, M., Minami, Y., and Matsumoto, K. Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer. Cancer Sci. 110:3340-3349. 2019.

Suzuki Y, Hashimoto K, Hoshi K, Ito H, Kariya Y, Miyazaki K, Sato M, Kawasaki Y, Yoshida M, Honda T, Hashimoto Y, Hosoya M, Ratio of Alpha2-Macroglobulin Levels in Cerebrospinal Fluid and Serum: An Expression ofNeuroinflammation in Acute Disseminated Encephalomyelitis. Pediatr Neurol. 98:61-67. 2019.

Weissenbock, M., Latham, R., Nishita, M., Wolff, L. I., Ho, H. H., Minami, Y., andHartmann, C. Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compoundmutants. Genes Cells 24: 307-317, 2019.

Aoki, T., *Nishita, M., Sonoda, J., Ikeda, T., Kakeji, Y., and *Minami, Y. Intraflagellartransport 20 promotes collective cancer cell invasion by regulating polarizedorganization of Golgi-associated microtubules. Cancer Sci. 110:1306-1316. 2019.

2018

#Nagai T., #Mukoyama S., Kagiwada H., Goshima N., Mizuno K. Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation. J. Cell Sci. 131: jcs219527. 2018.

Takahashi K., Nagai T. Chiba S., Nakayama K. and Mizuno K. Glucose deprivation induces primary cilium formation through mTORC1 inactivation. J. Cell Sci. 131: jcs208769. 2018.

Saji, T., *Nishita, M., Ogawa, H., Doi, T., Sakai, Y., Maniwa, Y., and *Minami, Y. Critical role of the Ror-family of receptor tyrosine kinasesin invasion and proliferation of malignant pleural mesothelioma cells. Genes Cells 23: 606-613, 2018.

Kishimoto, K., Tamura, M., Nishita, M., Minami, Y., Yamaoka, A.,Abe, T., Shigeta, M., and Morimoto, M. Synchronized mesenchymal cellpolarization and differentiation shape the formation of the murine trachea andesophagus. Nat. Commun. 9: 2816, 2018.

Yukiko Kariya, Midori Oyama, Yasuhiro Hashimoto, Jianguo Gu, Yoshinobu Kariya*: β4-integrin/PI3K Signaling Promotes Tumor Progression throughGalectin-3-N-glycan Complex. Mol. Cancer Res. 16(6), 1024-1034, 2018 (*corresponding author)

Midori Oyama, Yoshinobu Kariya*, Yukiko Kariya, Kana Matsumoto, Mayumi Kanno,Yoshiki Yamaguchi, Yasuhiro Hashimoto: Biological Role of Site-specific O-glycosylation in Cell Adhesion Activityand Phosphorylation of Osteopontin. Biochem J. 9;475(9):1583-1595. 2018(*corresponding author)

Roxana Chiorean, Sorina Danescu, OanaVirtic, Mayson B. Mustafa, Adrian Baican, Annette Lischka, Takashi Hasimoto,Kim Yancey, Yoshinobu Kariya, Manuel Koch, Cassian Sitaru: Moleculardiagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid. Orphanet Journal of Rare Diseases, 13(1), 111, 2018.

Murakami Y, Matsumoto Y, Hoshi K, Ito H, Fuwa TJ, Yamaguchi Y, Nakajima M, Miyajima M, Arai H, Nollet K, Kato N, Nishikata R, Kuroda N, Honda T, Sakuma J, Saito K and Hashimoto Y, Rapid increase of “brain-type” transferrin incerebrospinal fluid after shunt surgery for idiopathic normal pressurehydrocephalus: a prognosis marker for cognitive recovery. J Biochem.164:205-213. 2018.

Murakami Y, Takahashi K, Hoshi K, Ito H, Kanno M,Saito K, Nollet K, Yamaguchi Y, Miyajima M, Arai H, Hashimoto Y, and Mima T,Spontaneous intracranial hypotension is diagnosed by a combination oflipocalin-type prostaglandin D synthase and brain-type transferrin incerebrospinal fluid. BBA General Subjects 1862:1835-1842. 2018.

2017

Nagai T. and Mizuno K. Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation. PLoS One, 12, e0183030. 2017.

Abe S., Nagai T. Masukawa M., Okumoto K., Homma Y., Fujiki Y., Mizuno K. Localization of NDR2 to peroxisomes and its role in ciliogenesis. J. Biol Chem., 292, 4089-4098. 2017.

Takahashi K., Okabe H., Kanno SI., Nagai T. and Mizuno K. A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1. Biochem. Biophys. Res. Commun., 482, 686-692. 2017.

Takahashi, D.,Suzuki, H., Kakei, Y., Yamakoshi, K., *Minami, Y., Komori, T., and *Nishita, M. Expression of Ror2 Associated with Fibrosis of the Submandibular Gland. Cell Struct. Funct. 42: 159-167, 2017.

Uehara,S., Udagawa, N., Mukai, H., Ishihara, A., Maeda, K., Yamashita, T., Murakami,K., Nishita, M., Nakamura, T., Kato, S., Minami, Y., Takahashi, N.,and Kobayashi, Y. Protein kinase N3 promotes bone resorption by osteoclasts inresponse to Wnt5a-Ror2 signaling. Sci. Signal. 10, 2017.

*Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi,T., Hashimoto, R., Otani, H., Pazour, G.J., Hsu, V.W., and *Minami, Y. Ror2 signaling regulates Golgi structure and transportthrough IFT20 for tumor invasiveness. Sci. Rep. 7: 1, 2017.

Iijima J, Kobayashi S, Kitazume S, Kizuka Y, Fujinawa R, Korekane H, Shibata T, SaitohSI, Akashi-Takamura S, Miyake K, Miyoshi E, Taniguchi N. Core fucose iscritical for CD14-dependent Toll-like receptor 4 signaling. Glycobiology 27:1006-1015, 2017.

Asano T, Ito H, KariyaY, Hoshi K, Yoshihara A, Ugawa Y, Sekine H, Hirohata S, Yamaguchi Y,Sato S, Kobayashi H, Migita K, Ohira H, Hashimoto Y, Watanabe H, Evaluation ofblood-brain barrier function by quotient alpha2 macroglobulin and itsrelationship with interleukin-6 and complement component 3 levels inneuropsychiatric systemic lupus erythematosus. PLoS One 12:e0186414. 2017.

Hoshi K, MatsumotoY, Ito H, Saito K, Honda T, Yamaguchi Y, Hashimoto Y, A uniqueglycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic markerfor neurological diseases. Biochim Biophys Acta 1861:2473-2478. 2017.

2016

Konotop G., Bausch E., Nagai T., Turchinovich A., Becker N., Benner A., Boutros M., Mizuno K., Krämer A. and Raab MS. Pharmacological inhibition of centrosome clustering by Slingshot-mediated cofilin activation and actin cortex destabilization. Cancer Res., 76, 6690-6700. 2016.

Diaz-Horta, O.,Abad, C., Sennaroglu, L., Foster II, J., DeSmidt, A., Bademci, G.,Tokgoz-Yilmaz, S., Duman, D., Cengiz, F. B., Grati, M., Fitoz, S., Liu, X.,Farooq, A., Imtiaz, F., Currall, B., Morton, C., Nishita, M., Minami,Y., Lu, Z., Walz, K., and Tekin, M. ROR1 is essential for properinnervation of auditory hair cells and hearing in humans and mice. Proc.Natl. Acad. Sci. U.S.A. 113: 5993-5998, 2016.

Qi, X., Okinaka,Y., *Nishita, M., and *Minami, Y. Essential role of Wnt5a-Ror1/Ror2 signaling in metanephricmesenchyme and ureteric bud formation. Genes Cells 21: 325-334, 2016.

#Takiguchi, G., #Nishita, M., Kurita, K.,Kakeji, Y., and Minami, Y. Wnt5a-Ror2 signaling in mesenchymal stem cellspromotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis. Cancer Sci. 107:290-297, 2016.

Yukiko Kariya, Takeo Tatsuta, Shigeki Sugawara, Yoshinobu Kariya, Kazuo Nitta, Masahiro Hosono: RNase activity ofsialic acid-binding lectin from bullfrog eggs drives antitumor effect via theactivation of p38MAPK to caspase3/7 signaling pathway in human breast cancercells. Int. J. Oncol. 49(4), 1334-1342, 2016

Ito H, HoshiK, Osuka F, Gotoh M, Saito T, Hojo H, Suzuki R, Ohira H, Honda T, HashimotoY, Lectin inhibits antigen-antibody reaction in a glycoform-specific manner:Application for detecting α2,6sialylated-carcinoembryonic antigen. Proteomics 16:3081-3084. 2016.

Yoshihara A, FukatsuM, Hoshi K, Ito H, Nollet K, Yamaguchi Y, Ishii R, Tokuda T,Miyajima M, Arai H, Kato T, Furukawa K, Arai H, Kikuchi A, Takeda A, Ugawa Y, Hashimoto Y, Subgroup differences in "brain-type" transferrin andalpha-synuclein in Parkinson's disease and multiple system. J Biochem. 160:87-91. 2016.

Ito H, Kaji H, Togayachi A, Azadi P, Ishihara M, Geyer R, Galuska C, Geyer H, Kakehi K, Kinoshita M, Karlsson NG, Jin C, Kato K, Yagi H, Kondo S, Kawasaki N, Hashii N, Kolarich D, Stavenhagen K, Packer NH, Thaysen-Andersen M, Nakano M, Taniguchi N, Kurimoto A, Wada Y, Tajiri M, Yang P, Cao W, Li H, Rudd PM, Narimatsu H, Comparison of analytical methods for profiling N- and O-linkedglycans from cultured cell lines HUPO Human Disease Glycomics/Proteome Initiative Multi-institutional Study. Glycoconj J. 33: 405-415. 2016.

2015

Yoshinobu Kariya*, Yukiko Kariya, Toshie Saito, Shuhei Nishiyama, TakashiHonda, Keiko Tanaka, Mari Yoshida, Kazuo Fujihara, Yasuhiro Hashimoto: Increased cerebrospinal fluid osteopontin levels and its involvement inmacrophage infiltration in neuromyelitis optica. BBA Clinical. 3, 126-134, 2015 (*corresponding author)

MatsumotoY, Saito T, Hoshi K, Ito H, Kariya Y, Nagae M, YamaguchiY, Hagiwara Y, Kinoshita N, Wada I, Saito K, Honda T, Hashimoto Y., In situ visualization of a glycoform of transferrin: localization of α2,6-sialylatedtransferrin in the liver. J Biochem.157:211-216. 2015.

2014

#Oda T., #Chiba S., #Nagai T., Mizuno K. Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis. Genes Cells., 19, 927-940 (2014)

NarimatsuY, Kuno A, Ito H, Kaji H, Kaneko S, Usui J, Yamagata K, Narimatsu H, Ig Anephropathy caused by unusual polymerization of IgA1 with aberrantN-glycosylation in a patient with monoclonal immunoglobulin deposition disease. PLoS One 9:e91079. 2014.

Homma, Y., Kanno,S., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K. Insulin receptor substrate-4 binds to Slingshot-1 phosphatase andpromotes cofilin dephosphorylation. J. Biol. Chem. 289: 26302-26313, 2014.

#*Nishita, M., #Qiao, S., Miyamoto, M., Okinaka, Y., Yamada, M., Hashimoto, R., Iijima, K., Otani, H., Hartmann, C., Nishinakamura, R., and *Minami, Y. Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephricmesenchyme during ureteric budding. Mol. Cell. Biol. 34: 3096-3105, 2014.

Mori, K., Kitazawa, R., Kondo, T., Mori, M.,Hamada, Y., Nishita, M., Minami, Y., Haraguchi, R., and Kitazawa, S. Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene. PLoS ONE 9:e102797, 2014.

Doi, R., Endo, M., Yamakoshi, K., Yamanashi, Y., Nishita, M., Fukada, S. I., and Minami, Y. Critical role of Frizzled1 in age-relatedalterations of Wnt/ß-catenin signal inmyogenic cells during differentiation. Genes Cells 19:287-296, 2014.

Yoshinobu Kariya*, Mayumi Kanno, Kana Matsumoto-Morita, Midori Konno, Yoshiki Yamaguchi, Yasuhiro Hashimoto*: Osteopontin O-glycosylation contributes to its phosphorylation and celladhesion properties. Biochem. J. 463 (1), 93-102, 2014 (*corresponding author)