| Department of Neurophysiology |
|
 |
Introduction |
|
The Department was established in 1961 to cover
the field of neurophysiology. The first director
of the department was Dr. Susumu Tsukahara, who
had studies in a field close to medical/human
engineering and retired on 1987. Then Dr. Yukihiko
Kayama has directed the department. Now all members
are engaged in studying functions of the brain
mainly by electrophysiological experiments. We
have supreme techniques to record single neuronal
activity and to examine effects on neurons of
drugs applied micro-iontophoretically, especially
in unanesthetized, behaving animals. Results of
our very original studies have been published
in international journals.
Members of the Department are Yukihiko Kayama
(professor), Yoshimasa Koyama (associate professor),
Ei-ichi Jodo (lecturer), Yaeko Ninomiya (associate),
Kazumi Takahashi (associate), Nobuko Anzai (technologist),
and Seiko Minagawa (secretary). We have been consecutively
collaborating with Department of Psychiatry of
the University and Department of Urology of Kyoto
Prefectural University of Medicine. Also we have
had many collaborative studies with doctors in
Department of Anatomy of the University, Tokyo
Metropolitan Institute of Gerontology, Tokyo Metropolitan
Institute for Neuroscience, Osaka Bioscience Institute,
Shionogi Research Laboratories, Cleveland Clinic,
etc. Besides, many researchers/postgraduate students
have visited our laboratory to learn techniques
of experiments. |
|
Research |
|
We have two research groups.
One is sleep-physiology group supervised by Dr.
Yoshimasa Koyama. They record single neuronal
activity from brainstem cholinergic and monoaminergic
neurons, or from hypothalamic neurons, in animals
repeating sleep and wakefulness. They also have
experiments to study sleep mechanisms with behavioral
and/or pharmacological techniques. Recently, the
group enlarges area of the study to central mechanism
of micturition, since micturition center locates
in close vicinity of the cholinergic and monoaminergic
nuclei in the brainstem, and micturition system
interacts with sleep-wakefulness systems.
The other group, supervised by Dr. Ei-ichi Jodo,
is studying higher brain functions by recording
single neuronal activity especially in prefrontal
cortices. They have an unparalleled technique
to let rats learn a two-tone discrimination task;
with the technique they have succeeded in recording
an event-related potential P300 reliably in rats.
Their interest extends to pathophysiology of schizophrenia;
they record neuronal activity in rats doped with
phencyclidine or methamphetamine. |
|
Education |
|
| We teach all areas of neurophysiology to medical
students. For postgraduate students we offer every
support for their activity to be a researcher
in a field of neurophysiology. |
|
Publications |
|
Sleep physiology group
1. |
Discrete regions in the
laterodorsal tegmental area of the rat regulating
the urinary bladder and external urethral
sphincter. Y. Yamao, Y. Koyama, A. Kawauchi,
Y. Kayama and T. Miki, Brain Research vol.912,
pp.162-170, 2001. |
2. |
Postnatal development of
choline acetyltranferase activity in the
rat laterodorsal tegmental nucleus. Y. Ninomiya,
Y. Koyama and Y. Kayama, Neurosci. Lett.
vol.308, pp.138-140, 2001. |
3. |
State dependent response
of the locus coeruleus neurons to bladder
distention. N. Imada, Y. Koyama, A. Kawauchi,
H. Watanabe and Y. Kayama, J. Urol. vol.164,
pp.1740-1744, 2000. |
4. |
Firing of putative cholinergic
neurons and micturition center neurons in
the rat laterodorsal tegmentum during distention
and contraction of urinary bladder. Y. Koyama,
N. Imada, A. Kawauchi and Y. Kayama, Brain
Research vol.840, pp.45-55, 1999. |
5. |
Inhibition of
choline acetyltransferase activity by serum
albumine modified with octanoic acid and
other fatty acids. Y. Ninomiya and Y. Kayama,
Neurochem. Res. vol.23, pp.1303-1311, 1998. |
6. |
In vivo electrophysiological
distinction of histochemically identified
cholinergic neurons using extracellular
recording and labeling in rat laterodorsal
tegmental nucleus. Y. Koyama, T. Honda,
M. Kusakabe, Y. Kayama and Y. Sugiura, Neuroscience
vol.83, pp.1105-1112, 1998. |
7. |
Possible release of nitric
oxide from cholinergic axons in the thalamus
by stimulation of the rat laterodorsal tegmental
nucleus as measured with voltammetry. M.
Miyazaki, Y. Kayama, T. Kihara, K. Kawasaki,
E. Yamaguchi, Y. Wada and M. Ikeda, J. Chem.
Neuroanatomy vol.10, pp.203-207, 1996. |
8. |
Sensory responsiveness of
"broad-spike" neurons in the laterodorsal
tegmental nucleus, locus coeruleus and dorsal
raphe of awake rats: implications for cholinergic
and monoaminergic neuron-specific responses.
Y. Koyama, E. Jodo and Y. Kayama, Neuroscience
vol.63, pp.1021-1031, 1994. |
9. |
Regulation of regional blood
flow in the laterodorsal thalamus by ascending
cholinergic nerve fibers from the laterodorsal
tegmental nucleus. Y. Koyama, T. Toga, Y.
Kayama and A. Sato, Neurosci. Res. vol.20,
pp.79-84, 1994. |
10. |
Mutual interactions among
cholinergic, noradrenergic and serotonergic
neurons studied by ionophoresis of these
transmitters in rat brainstem nuclei. Y.
Koyama and Y. Kayama, Neuroscience vol.55,
pp.1117-1126, 1993. |
11. |
Firing of 'possibly' cholinergic
neurons in the rat laterodorsal tegmental
nucleus during sleep and wakefulness. Y.
Kayama, M. Ohta and E. Jodo, Brain Research
vol.569, pp.210-220, 1992. |
|
Higher brain function
group
| 1. |
Acute administration of phencyclidine
induces tonic activation of medial prefrontal
cortex neurons in freely moving rats. Y.
Suzuki, E. Jodo, S. Takeuchi, S. Niwa and
Y. Kayama, Neuroscience, in press. |
| 2. |
Selective responsiveness of medial prefrontal
cortex neurons to the meaningful stimulus
with a low probability of occurrence in
rats. E. Jodo, Y. Suzuki and Y. Kayama,
Brain Research vol.856, pp.68-74, 2000. |
| 3. |
ERP development in the rat in the course
of learning two-tone discrimination task.
S. Takeuchi, E. Jodo, Y. Suzuki, T. Matsuki,
K.-Y. Hoshino, S.-I. Niwa and Y. Kayama,
NeuroReport vol.11, pp.333-336, 2000. |
| 4. |
Effects of repeated administration of
methamphetamine on P3-like potentials in
rats. S. Takeuchi, E. Jodo, Y. Suzuki, T.
Matsuki, S.-I. Niwa and Y. Kayama, Intl.
J. Psychophysiol. vol.32, pp.183-192, 1999. |
| 5. |
P3b-like potential of rats recorded in
an active discrimination task. E. Jodo,
S. Takeuchi and Y. Kayama, Electroenceph.
Clin. Neurophysiol. vol.96, pp.555-560,
1995. |
| 6. |
Relation of a negative ERP component to
response inhibition in a Go/No-Go task.
E. Jodo and Y. Kayama, Electroenceph. Clin.
Neurophysiol. vol.82, pp.477-482, 1992. |
|
|
Detailed Information |
|
| |
|
To Contact Us |
|
| Yukihiko Kayama, M.D., y-kayama@fmu.ac.jp |
| |
|
