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Introduction |
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History
Department of Physiology opened in 1950 in parallel with the
establishment of Fukushima Medical School, based on Fukushima Women's
Medical Practitioner's training School founded in 1944. The department
was divided into two due to the establishment of Second Department of
Physiology in 1961 and renamed to First Department of Physiology. The
first, second and third professors were Shomatsu Yokoyama, Kosei Ishii
and Tsuyoshi Shimizu. Research field in our department was
traditionally autonomic function, but major subject of study changed
concomitant with the shift of the professor; autonomic regulations of
the gastrointestinal movement, autonomic control of the respiratory
system, autonomic regulation of cardiovascular function, in this order. |
Members
| Professor |
Akihiro Hazama, M.D. & Ph.D. |
| Assistant
professor |
Masao Yamasaki, Ph.D. |
| Assistant professor |
Shin-ichiro Katsuda, Ph.D. |
| Instructor |
Masao Miyake, M.S.
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| Chief
technician |
Haruyuki Wago |
| Chief
technician |
Toshiyasu Okouchi |
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Research |
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| In our laboratory, we engage in
education and training for students and studies on cardiovascular
physiology and space medicine e.g., mechanism of cerebral ischemic
response,functional and anatomical analysis of the aortic nerve due to
postnatal development, analysis of aortic pulse wave in the
atherosclerotic aorta and effect of microgravity on the baroreflex
system. We participated in the international cooperative studies,
NASA/NIH Neurolab Programs (STS-90) form 1993 to 1998 to study
development of the aortic baroreflex mechanisms under conditions of
microgravity. We spent for 5 years to prepare the experiment using
Space Shuttle. Experiment on baroreflex function was repeated 5 times
under simulated microgravity, e.g. parabolic flight using an aircraft
in 1998, premature rats were launched with Space Shuttle and bred under
microgravity environment for 16 days. We clarified that exposure of
premature rats to microgravity environment decreased aortic baroreflex
function, number of the unmyelinated fibers of the aortic nerve and
contractile response of the aortic wall to alpha-stimulant,
phenylephrine and suppressed growth of the smooth muscle fibers of the
aortic wall. |
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Education |
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| We give a lecture to medical students
on the following subjects; 1.General medicine of the human function (to
students in the 1st grade), 2. Physiology (to students in the 2nd and
3rd grade), 3. Medical English seminar (to students in the 2nd and 3rd
grades), 4. Seminar of preclinical medicine (to students in the 3rd
grade) and 5. Advanced course of preclinical medicine (to students in
the 4th grade). 1 & 2; Lectures on "General medicine of the human
function" and "Physiology" are allotted to the 1st and 2nd Department
of Physiology. Our department is assigned to the lecture on autonomic
functions, e.g., respiration, circulation, digestion & absorption,
endocrine, and so forth to learn from cell or tissue function to
integrative function of the whole body. 3 & 4; Tutorial system was
introduced to "Medical English seminar" and "Seminar of preclinical
medicine". Space Medicine and Physiology were mainly lectured to the
students. 5; several students select this course every year. This
course is designed to study physiology mainly through experiments under
the instruction of the educational staff according to a protocol
students planned. After the finish of the course, students make a
presentation on their work in our department, sometimes in an academic
society. |
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Publications |
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| 1. |
Katsuda, S., Hasegawa, M.,
Kusanagi, M. and Shimizu, T.: Alterations in harmonic components of
pressure pulse waves at different aortic regions due to progression of
atherosclerosis in Kurosawa and Kusanagi-Hypercholesterolemic (KHC)
rabbits. Japanese Journal of Applied Physiology, (2001) 31: 194-203. |
| 2. |
Katsuda, S., Waki, H.,
Nagayama, T., Yamasaki, M., O-ishi, H., Katahira, K. and Shimizu, T.:
Time-dependent change in baroreflex control capacity of arterial
pressure by pentobarbital anesthesia in rabbits. Experimental Animals,
(2000) 49: 111-118. |
| 3. |
Katsuda, S., Waseda, Y.,
Morimatsu, F., Taguchi, Y., Hasegawa, M., Ito, M., Takaichi, S.,
Yamada, R., Fukaya, O., Furukawa, Y. and Shimizu, T: Papain-hydrolyzed
pork meat reduces serum cholesterol level and premature atherosclerosis
in dietary-induced hypercholesterolemic rabbits. Journal of Nutritional
Science and Vitaminology, (2000) 46, 180-187. |
| 4. |
Katsuda, S., Hasegawa, M.,
Kusanagi, M. and Shimizu, T.: Comparison of pulse wave velocity at
different aortic regions in relation to extent and severity of
atherosclerosis between young and elder Kurosawa and
Kusanagi-hypercholesterolemic (KHC) rabbits. Clinical Science, (2000)
99, 393-404. |
| 5. |
Shimizu, T.: A model for
studying the baroreflex in microgravity and hypergravity. Journal of
gravitational physiology, (2000) 7: 51-54. |
| 6. |
Yamasaki, M. and Shimizu, T.:
Structural and functional characteristics of the aortic nerve in the
rabbit raised in head-down tilt posture. Journal of gravitational
physiology, (2000) 7: 165-166. |
| 7. |
Waki, H., Shimizu, T.,
Katahira, K., Nagayama, T., Yamasaki, M. and Katsuda, S.: Recording of
blood pressure, heart rate and aortic nerve activity during parabolic
flight in the rat via radio-telemetry,. Journal of gravitational
physiology, (2000) 7: 169-170. |
| 8. |
Katsuda, S., Shimizu, T.,
Yamasaki, M., Waki, H., Nagayama, T., O-ishi, H., Katahira, K., Wago,
H., Okouchi, T., Hasegawa, M., Miyamoto, Y., Miyake, M., Matsumoto, S.,
Kaneko, M., Nagaoka, S., Mukai, C., Izumi, T., Yanagawa, K. and Uemura,
M.: Mechanical tensile properties of the aortic wall in the premature
rat exposed to microgravity environment in the space flight for 16
days. Journal of gravitational physiology, (2000) 7: 157-158. |
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