Updated on 2023/04/26

写真a

 
HINO Mizuki
 
Organization
School of Medicine (Clinical Medicine) Department of Neuropsychiatry Fellow
Title
Fellow

Research History

  • Fukushima Medical University   School of Medicine (Clinical Medicine) Department of Neuropsychiatry   Fellow

    2019.4 - Now

Papers

  • Real-Time Prediction of Medical Demand and Mental Health Status in Ukraine under Russian Invasion Using Tweet Analysis.

    Fujii S, Kunii Y, Nonaka S, Hamaie Y, Hino M, Egawa S, Kuriyama S, Tomita H

    The Tohoku journal of experimental medicine   259 ( 3 )   177 - 188   2023.2( ISSN:0040-8727

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    Language:English  

    DOI : 10.1620/tjem.2022.J111

    PubMed

  • Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model.

    Iwakura Y, Kawahara-Miki R, Kida S, Sotoyama H, Gabdulkhaev R, Takahashi H, Kunii Y, Hino M, Nagaoka A, Izumi R, Shishido R, Someya T, Yabe H, Kakita A, Nawa H

    Neurochemical research   47 ( 9 )   2715 - 2727   2022.4( ISSN:0364-3190

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s11064-022-03599-9

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  • Tubulin/microtubules as novel clozapine targets(和訳中)

    Hino Mizuki, Kondo Takeshi, Kunii Yasuto, Matsumoto Junya, Wada Akira, Niwa Shin-ichi, Setou Mitsutoshi, Yabe Hirooki

    Neuropsychopharmacology Reports   42 ( 1 )   32 - 41   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Tubulin/microtubules as novel clozapine targets.

    Hino M, Kondo T, Kunii Y, Matsumoto J, Wada A, Niwa SI, Setou M, Yabe H

    Neuropsychopharmacology reports   42 ( 1 )   32 - 41   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/npr2.12221

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  • Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain.

    Izumi R, Hino M, Nagaoka A, Shishido R, Kakita A, Hoshino M, Kunii Y, Yabe H

    Neuroscience research   175   73 - 81   2022.2( ISSN:0168-0102

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.neures.2021.09.004

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  • 【Constructive Understanding of Multi-scale Dynamism of Neuropsychiatric Disorders】Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain(和訳中)

    Izumi Ryuta, Hino Mizuki, Nagaoka Atsuko, Shishido Risa, Kakita Akiyoshi, Hoshino Mikio, Kunii Yasuto, Yabe Hirooki

    Neuroscience Research   175   73 - 81   2022.2( ISSN:0168-0102

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  • High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice.

    Hirai S, Miwa H, Tanaka T, Toriumi K, Kunii Y, Shimbo H, Sakamoto T, Hino M, Izumi R, Nagaoka A, Yabe H, Nakamachi T, Shioda S, Dan T, Miyata T, Nishito Y, Suzuki K, Miyashita M, Tomoda T, Hikida T, Horiuchi J, Itokawa M, Arai M, Okado H

    Science advances   7 ( 46 )   eabl6077   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1126/sciadv.abl6077

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  • Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia.

    Kunii Y, Matsumoto J, Izumi R, Nagaoka A, Hino M, Shishido R, Sainouchi M, Akatsu H, Hashizume Y, Kakita A, Yabe H

    International journal of molecular sciences   22 ( 15 )   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/ijms22158280

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  • Detailed Postmortem Profiling of Inflammatory Mediators Expression Revealed Post-inflammatory Alternation in the Superior Temporal Gyrus of Schizophrenia.

    Izumi R, Hino M, Wada A, Nagaoka A, Kawamura T, Mori T, Sainouchi M, Kakita A, Kasai K, Kunii Y, Yabe H

    Frontiers in psychiatry   12   653821   2021( ISSN:1664-0640

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3389/fpsyt.2021.653821

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  • Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity.

    Komatsu H, Takeuchi H, Kikuchi Y, Ono C, Yu Z, Iizuka K, Takano Y, Kakuto Y, Funakoshi S, Ono T, Ito J, Kunii Y, Hino M, Nagaoka A, Iwasaki Y, Yamamori H, Yasuda Y, Fujimoto M, Azechi H, Kudo N, Hashimoto R, Yabe H, Yoshida M, Saito Y, Kakita A, Fuse N, Kawashima R, Taki Y, Tomita H

    Schizophrenia bulletin   46 ( 6 )   1619 - 1628   2020.4( ISSN:0586-7614

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/schbul/sbaa049

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  • ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism.

    Nagaoka A, Kunii Y, Hino M, Izumi R, Nagashima C, Takeshima A, Sainouchi M, Nawa H, Kakita A, Yabe H

    Journal of psychiatric research   123   119 - 127   2020.4( ISSN:0022-3956

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.jpsychires.2020.02.001

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  • Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder.

    Kunii Y, Hino M, Matsumoto J, Nagaoka A, Nawa H, Kakita A, Akatsu H, Hashizume Y, Yabe H

    Scientific reports   9 ( 1 )   14877   2019.10

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    DOI : 10.1038/s41598-019-51456-7

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  • Minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric post-mortem brain studies(和訳中)

    Ono Chiaki T., Yu Zhiqian, Kikuchi Yoshie, Kunii Yasuto, Hino Mizuki, Matsumoto Junya, Nagaoka Atsuko, Ito Junko, Iwasaki Yasushi, Hagihara Hideo, Miyakawa Tsuyoshi, Yoshida Mari, Saito Yuko, Niwa Shin-ichi, Yabe Hirooki, Kakita Akiyoshi, Tomita Hiroaki

    Psychiatry and Clinical Neurosciences   73 ( 9-10 )   566 - 573   2019.10( ISSN:1323-1316

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  • Investigation of betaine as a novel psychotherapeutic for schizophrenia.

    Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y, Fujita Y, Tan Y, Hisano Y, Shimamoto-Mitsuyama C, Nozaki Y, Esaki K, Nagaoka A, Matsumoto J, Hino M, Mataga N, Hayashi-Takagi A, Hashimoto K, Kunii Y, Kakita A, Yabe H, Yoshikawa T

    EBioMedicine   45   432 - 446   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.ebiom.2019.05.062

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  • 統合失調症患者における脳内コンドロイチン硫酸鎖の変化

    湯川 尊行, 岩倉 百合子, 武井 延之, 斎藤 摩美, 渡部 雄一郎, 豊岡 和彦, 五十嵐 道弘, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 入谷 修司, 丹羽 真一, 竹内 亮子, 高橋 均, 柿田 明美, 染矢 俊幸, 那波 宏之

    精神神経学雑誌   ( 2019特別号 )   S410 - S410   2019.6( ISSN:0033-2658

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  • 統合失調症患者の脳内ゲノムにおけるコピー数変異の評価

    坂井 美和子, 渡部 雄一郎, 染矢 俊幸, 荒木 一明, 澁谷 雅子, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 橋本 健志, 菱本 明豊, 北村 登, 入谷 修司, 白川 治, 前田 潔, 宮下 哲典, 丹羽 真一, 高橋 均, 柿田 明美, 桑野 良三, 那波 宏之

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6( ISSN:0033-2658

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  • A minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric postmortem brain studies.

    Ono CT, Yu Z, Kikuchi Y, Kunii Y, Hino M, Matsumoto J, Nagaoka A, Ito J, Iwasaki Y, Hagihara H, Miyakawa T, Yoshida M, Saito Y, Niwa SI, Yabe H, Kakita A, Tomita H

    Psychiatry and clinical neurosciences   73 ( 9 )   566 - 573   2019.5( ISSN:1323-1316

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/pcn.12863

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  • Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia.

    Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa SI, Takeuchi R, Takahashi H, Kakita A, Someya T, Nawa H

    Psychiatry research   270   940 - 946   2018.12( ISSN:0165-1781

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.psychres.2018.10.062

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  • 脳からみた精神科臨床-精神科ブレインバンクへの期待- 精神科臨床と死後脳とを結ぶ研究とは

    國井 泰人, 長岡 敦子, 日野 瑞城, 松本 純弥, 丹羽 真一, 矢部 博興

    精神神経学雑誌   ( 2018特別号 )   S326 - S326   2018.6( ISSN:0033-2658

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  • DNA methylation of ANKK1 and response to aripiprazole in patients with acute schizophrenia: A preliminary study.

    Miura I, Kunii Y, Hino M, Hoshino H, Matsumoto J, Kanno-Nozaki K, Horikoshi S, Kaneko H, Bundo M, Iwamoto K, Yabe H

    Journal of psychiatric research   100   84 - 87   2018.5( ISSN:0022-3956

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    DOI : 10.1016/j.jpsychires.2018.02.018

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  • Influences of the T102C polymorphism in the 5-HT2A receptor gene on the five-factor model of Positive and Negative Syndrome Scale and treatment response to aripiprazole in patients with acute schizophrenia.

    Kanno-Nozaki K, Miura I, Kaneko H, Horikoshi S, Ota T, Nozaki M, Ejiri H, Yahiro M, Watanabe K, Hino M, Yabe H

    Psychiatry research   265   244 - 245   2018.5( ISSN:0165-1781

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.psychres.2018.05.020

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  • 【精神科臨床と脳病理-精神科ブレインバンクへの期待】 生前登録制度に基づく精神疾患ブレインバンクの実践 当事者と研究者が協働する研究体制とは

    國井 泰人, 松本 純弥, 長岡 敦子, 日野 瑞城, 丹羽 真一, 矢部 博興

    精神神経学雑誌   120 ( 4 )   269 - 276   2018.4( ISSN:0033-2658

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  • Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia.

    Matsumoto J, Nagaoka A, Kunii Y, Miura I, Hino M, Niwa SI, Nawa H, Takahashi H, Kakita A, Yabe H

    Psychiatry research   264   116 - 118   2018.3( ISSN:0165-1781

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.psychres.2018.03.029

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  • <i>COMT</i> Val 108/158 Met polymorphism and treatment response to aripiprazole in patients with acute schizophrenia.

    Kaneko H, Miura I, Kanno-Nozaki K, Horikoshi S, Hino M, Yabe H

    Neuropsychiatric disease and treatment   14   1657 - 1663   2018( ISSN:1176-6328

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.2147/NDT.S164647

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  • Our Practice in Organizing Psychiatric Brain Bank : With Particular Emphasis on "Pre-Registered Donation System"

    120 ( 4 )   269 - 276   2018( ISSN:0033-2658

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  • A Consideration of Molecular Basis of the Auditory Hallucination : Through a Case of the Patient with Colon Cancer Who Showed Transient Verval Hallucination Just After the Administration of Anti-EGFR Antibody or Anti-VEGF Antibody

    59 ( 12 )   1141 - 1145   2017.12( ISSN:0488-1281

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  • 幻聴体験の分子メカニズムを考える 抗EGFR抗体,抗VEGF抗体の投与後に一過性の対話性幻聴を呈した1例

    長岡 敦子, 國井 泰人, 松本 純弥, 日野 瑞城, 矢部 博興

    精神医学   59 ( 12 )   1141 - 1145   2017.12( ISSN:0488-1281

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex.

    Nishiura K, Ichikawa-Tomikawa N, Sugimoto K, Kunii Y, Kashiwagi K, Tanaka M, Yokoyama Y, Hino M, Sugino T, Yabe H, Takahashi H, Kakita A, Imura T, Chiba H

    Oncotarget   8 ( 55 )   93382 - 93391   2017.11

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.18632/oncotarget.21850

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  • 分子標的剤副作用例と死後脳研究に基づく、統合失調症における幻聴体験の分子メカニズムの考察

    長岡 敦子, 國井 泰人, 松本 純弥, 日野 瑞城, 矢部 博興, 宮川 哲平, 飯田 聡, 山崎 繁

    福島医学雑誌   67 ( 2 )   101 - 102   2017.8( ISSN:0016-2582

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  • High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

    Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H

    Neuron   94 ( 6 )   1085 - 1100.e6   2017.6( ISSN:0896-6273

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.neuron.2017.05.017

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  • 精神科臨床と脳病理-精神科ブレインバンクへの期待- 生前登録制度に基づく精神疾患ブレインバンクの実践 当事者と研究者が協働する研究体制とは

    國井 泰人, 松本 純弥, 長岡 敦子, 日野 瑞城, 丹羽 真一, 矢部 博興

    精神神経学雑誌   ( 2017特別号 )   S410 - S410   2017.6( ISSN:0033-2658

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.

    Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H

    Scientific reports   7   45050   2017.3

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/srep45050

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  • Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.

    Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S

    Journal of proteomics   158   31 - 42   2017.3( ISSN:1874-3919

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    DOI : 10.1016/j.jprot.2017.02.009

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  • Prominent increased calcineurin immunoreactivity in the superior temporal gyrus in schizophrenia: A postmortem study.

    Wada A, Kunii Y, Matsumoto J, Hino M, Yang Q, Niwa SI, Yabe H

    Psychiatry research   247   79 - 83   2017.1( ISSN:0165-1781

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.psychres.2016.11.018

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  • Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.

    Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa S, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H

    Journal of psychiatric research   82   100 - 108   2016.11( ISSN:0022-3956

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.jpsychires.2016.07.018

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  • Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor, tacrolimus, for leukemia.

    Wada A, Kunii Y, Matsumoto J, Hino M, Nagaoka A, Niwa S, Yabe H

    Neuropsychiatric disease and treatment   12   1645 - 1650   2016( ISSN:1176-6328

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.2147/NDT.S106371

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  • 統合失調症患者の前頭葉におけるタンパク質プロファイリングと変動する分子ネットワークの同定

    平山 未央, 國井 泰人, 松本 純弥, 和田 明, 日野 瑞城, 矢部 博興, 丹羽 真一, 近藤 豪, 瀬藤 光利, 大槻 純男

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [2LBA087] - [2LBA087]   2015.12

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  • Influence of -141C Ins/Del Polymorphism in DRD2 Gene on Clinical Symptoms and Plasma Homovanillic Acid Levels in the Treatment of Schizophrenia With Aripiprazole.

    Miura I, Kanno-Nozaki K, Hino M, Horikoshi S, Ota T, Mashiko H, Niwa S, Yabe H

    Journal of clinical psychopharmacology   35 ( 3 )   333 - 4   2015.6( ISSN:0271-0749

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1097/JCP.0000000000000330

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  • Assessment of copy number variations in the brain genome of schizophrenia patients.

    Sakai M, Watanabe Y, Someya T, Araki K, Shibuya M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Hashimoto T, Hishimoto A, Kitamura N, Iritani S, Shirakawa O, Maeda K, Miyashita A, Niwa S, Takahashi H, Kakita A, Kuwano R, Nawa H

    Molecular cytogenetics   8   46   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s13039-015-0144-5

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  • Elevated postmortem striatal t-DARPP expression in schizophrenia and associations with DRD2/ANKK1 polymorphism.

    Kunii Y, Miura I, Matsumoto J, Hino M, Wada A, Niwa S, Nawa H, Sakai M, Someya T, Takahashi H, Kakita A, Yabe H

    Progress in neuro-psychopharmacology & biological psychiatry   53   123 - 8   2014.8( ISSN:0278-5846

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.pnpbp.2014.03.014

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  • 生前の精神症状情報を利用した精神疾患死後脳研究の展開

    松本 純弥, 國井 泰人, 和田 明, 日野 瑞城, 池本 桂子, 瀬藤 光利, 丹羽 真一

    福島医学雑誌   63 ( 3 )   173 - 174   2013.9( ISSN:0016-2582

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  • X irradiation changes dendritic spine morphology and density through reduction of cytoskeletal proteins in mature neurons.

    Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-jahdari WS, Chakravarti A, Shirao T, Nakano T

    Radiation research   179 ( 6 )   630 - 636   2013.6( ISSN:0033-7587

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1667/RR3098.1

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  • Increased ratio of calcineurin immunoreactive neurons in the caudate nucleus of patients with schizophrenia.

    Wada A, Kunii Y, Ikemoto K, Yang Q, Hino M, Matsumoto J, Niwa S

    Progress in neuro-psychopharmacology & biological psychiatry   37 ( 1 )   8 - 14   2012.4( ISSN:0278-5846

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.pnpbp.2012.01.005

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  • VAMP2 marks quiescent satellite cells and myotubes, but not activated myoblasts.

    Tajika Y, Takahashi M, Hino M, Murakami T, Yorifuji H

    Acta histochemica et cytochemica   43 ( 4 )   107 - 114   2010.8( ISSN:1347-5800|0044-5991

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1267/ahc.10010

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    J-GLOBAL

  • Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain.

    Katayama T, Watanabe M, Tanaka H, Hino M, Miyakawa T, Ohki T, Ye LH, Xie C, Yoshiyama S, Nakamura A, Ishikawa R, Tanokura M, Oiwa K, Kohama K

    American journal of physiology. Heart and circulatory physiology   298 ( 2 )   H505 - 14   2010.2( ISSN:0363-6135

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    DOI : 10.1152/ajpheart.00577.2009

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  • Utilization of myosin and actin bundles for the transport of molecular cargo.

    Takatsuki H, Rice KM, Asano S, Day BS, Hino M, Oiwa K, Ishikawa R, Hiratsuka Y, Uyeda TQ, Kohama K, Blough ER

    Small (Weinheim an der Bergstrasse, Germany)   6 ( 3 )   452 - 457   2010.2( ISSN:1613-6829|1613-6810

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/smll.200901369

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    J-GLOBAL

  • Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.

    Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, Yokota Y, Fukamoto K, Mutou Y, Kobayashi Y, Yorifuji H

    Journal of electron microscopy   59 ( 6 )   495 - 501   2010( ISSN:1477-9986|0022-0744

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  • Erratum

    Gerashchenko BI, Hino M, Hosoya H

    Cytometry   41 ( 2 )   150   2000.10( ISSN:0196-4763

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