{"id":832,"date":"2009-12-28T08:17:50","date_gmt":"2009-12-27T23:17:50","guid":{"rendered":"http:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/?p=832"},"modified":"2018-04-16T08:38:02","modified_gmt":"2018-04-15T23:38:02","slug":"09001","status":"publish","type":"post","link":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/research\/09001.html","title":{"rendered":"\u7c73\u56fd\u3000\u5b9f\u9a13\u533b\u5b66\u96d1\u8a8c \u300cThe Journal of Experimental Medicine\u300d"},"content":{"rendered":"<p>\n\u516c\u7acb\u5927\u5b66\u6cd5\u4eba\u798f\u5cf6\u770c\u7acb\u533b\u79d1\u5927\u5b66\u533b\u5b66\u90e8\u3000<a href=\"http:\/\/www.fmu.ac.jp\/cms\/immunol\/index_html\" target=\"_blank\">\u514d\u75ab\u5b66\u8b1b\u5ea7<\/a>\u3000\uff08\u6559\u6388\u30fb\u85e4\u7530\u798e\u4e09\uff09\u3000\u306e\u9ad8\u6a4b\u5b9f\u52a9\u6559\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u9818\u57df\u3067\u8840\u4e2d\u306b\u5b58\u5728\u3059\u308b\u88dc\u4f53\u6d3b\u6027\u5316\u9175\u7d20\u300cMASP-1\u300d \u306e\u65b0\u305f\u306a\u6a5f\u80fd\u306e\u89e3\u660e\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>MASP\u3068\u306f\u3001\u5f53\u8b1b\u5ea7\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u3001\u8840\u6e05\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308b\u30de\u30f3\u30ce\u30fc\u30b9\u7d50\u5408\u30ec\u30af\u30c1\u30f3(MBL) \u3084\u30d5\u30a3\u30b3\u30ea\u30f3\u306b\u7d50\u5408\u3057\u3066\u88dc\u4f53\u3092\u6d3b\u6027\u5316\u3059\u308b\u91cd\u8981\u306a\u9175\u7d20\u3067\u3059\u3002\u3053\u306e\u88dc\u4f53\u6d3b\u6027\u5316\u7d4c\u8def\u3092\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u3068\u547c\u3073\u3001\u81ea\u7136\u514d\u75ab\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\nMASP\u306b\u306f\u3001MASP-1\u306e\u4ed6\u306bMASP-2\u3068MASP-3\u304c\u3042\u308a\u3001MASP-2\u304c\u88dc\u4f53\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u306e\u4e3b\u305f\u308b\u6d3b\u6027\u5316\u9175\u7d20\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001MASP-1\/-3\u306e\u751f\u4f53\u3067\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306f\u307b\u3068\u3093\u3069\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\n\u4eca\u56de\u3001\u9ad8\u6a4b\u3089\u306fMASP-1\/-3\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u89e3\u6790\u306b\u3088\u308a\u3001MASP-1\u304c\u7b2c\u4e8c\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u9175\u7d20\u3067\u3042\u308b\uff24\u56e0\u5b50\u306e\u524d\u99c6\u4f53\u3092\u6d3b\u6027\u578b\u306b\u8ee2\u63db\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u3053\u306e\u6210\u679c\u306f\u514d\u75ab\u5b66\u306e\u9818\u57df\u306b\u65b0\u6982\u5ff5\u3092\u63d0\u5531\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u7c73\u56fd\u306e\u5b9f\u9a13\u533b\u5b66\u96d1\u8a8c <a href=\"http:\/\/jem.rupress.org\/\" target=\"_blank\"> (The Journal of Experimental Medicine)<\/a> \u306e2009\u5e7412\u670828\u65e5\u767a\u8868\u306e <a href=\"http:\/\/jem.rupress.org\/cgi\/content\/abstract\/jem.20090633v1?maxtoshow=&#038;HITS=10&#038;hits=10&#038;RESULTFORMAT=1&#038;author1=Takahashi&#038;andorexacttitle=and&#038;andorexacttitleabs=and&#038;andorexactfulltext=and&#038;searchid=1&#038;FIRSTINDEX=0&#038;sortspec=relevance&#038;resourcetype=HWCIT\" target=\"_blank\">\u96fb\u5b50\u7248 <\/a>\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u518a\u5b50\u7248\u306f\uff11\u6708\u53f7\u306b\u3066\u63b2\u8f09\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002<br \/>\n\u306a\u304a\u3001\u672c\u7814\u7a76\u306f <a href=\"http:\/\/www.fmu.ac.jp\/cms\/biomol\/index_html\" target=\"_blank\">\u672c\u5b66\u9644\u5c5e\u751f\u4f53\u60c5\u5831\u4f1d\u9054\u7814\u7a76\u6240 \u751f\u4f53\u7269\u8cea\u7814\u7a76\u90e8\u9580<\/a> \u3068\u306e\u5171\u540c\u7814\u7a76\u3068\u3057\u3066\u884c\u308f\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306f\u3001T\u7d30\u80de\u3084B\u7d30\u80de\u306e\u62c5\u5f53\u3059\u308b\u7372\u5f97\u514d\u75ab\u306b\u5148\u3060\u3063\u3066\u767a\u52d5\u3055\u308c\u308b\u521d\u671f\u751f\u4f53\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002<br \/>\n\u88dc\u4f53\u3082\u305d\u306e\u91cd\u8981\u306a\u8981\u7d20\u3067\u3001\u75c5\u539f\u4f53\u304c\u4fb5\u5165\u3059\u308b\u3068\u53e4\u5178\u7d4c\u8def\u3001\u7b2c\u4e8c\u7d4c\u8def\u3001\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u306e\uff13\u3064\u306e\u7570\u306a\u308b\u30ab\u30b9\u30b1\u30fc\u30c9\u3067\u88dc\u4f53\u7b2c3\u6210\u5206(C3) \u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002C3\u4ee5\u964d\u306fC5~C9\u304c\u50cd\u304f\u5171\u901a\u306e\u53cd\u5fdc\u3067\u3001\u7d50\u679c\u3068\u3057\u3066\u75c5\u539f\u4f53\u306e\u7d30\u80de\u819c\u306b\u7a74\u3092\u958b\u3051\u3001\u307e\u305f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u8caa\u98df\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u751f\u4f53\u9632\u5fa1\u306b\u50cd\u304d\u307e\u3059\u3002\u88dc\u4f53\u6210\u5206\u306f\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u9175\u7d20\u3092\u542b\u307f\u3001\u4e0d\u6d3b\u6027\u306a\u9175\u7d20\u524d\u99c6\u4f53\u306e\u5f62\u3067\u8840\u4e2d\u306b\u5206\u6ccc\u3055\u308c\u307e\u3059\u304c\u3001D\u56e0\u5b50\u306f\u4f8b\u5916\u7684\u306b\u8102\u80aa\u7d44\u7e54\u3067\u6d3b\u6027\u5316\u3092\u53d7\u3051\u5206\u6ccc\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<br \/>\n\u4eca\u56de\u306e\u7814\u7a76\u306fMASP-1\/-3\u304c\u306a\u3044\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u7b2c\u4e8c\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u8d77\u3053\u3089\u305a\u3001\u305d\u306e\u539f\u56e0\u3068\u3057\u3066D\u56e0\u5b50\u304cN\u672b\u7aef\u5074\u306b5\u3064\u306e\u30a2\u30df\u30ce\u9178\u3092\u4ed8\u52a0\u3057\u305f\u524d\u99c6\u4f53\u306e\u307e\u307e\u5faa\u74b0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306bMASP-1\u304c\u305d\u306e\uff15\u3064\u306e\u30a2\u30df\u30ce\u9178\u3092\u5207\u308a\u96e2\u3057\u3001\uff24\u56e0\u5b50\u3092\u6d3b\u6027\u578b\u306b\u3059\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n\u9ad8\u6a4b\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u65e2\u306bMASP-1\u306fMASP-2\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3057\u3001\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u306e\u5373\u6642\u7684\u306a\u53cd\u5fdc\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u304a\u308a\u3001\uff11\u5206\u5b50\u304c\uff12\u3064\u306e\u88dc\u4f53\u30ab\u30b9\u30b1\u30fc\u30c9\u306b\u50cd\u304f\u8981\u306e\u9175\u7d20\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u672c\u7814\u7a76\u306e\u610f\u7fa9\u306f\u5927\u304d\u3044\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br \/>\n\u7279\u306b\u88dc\u4f53\u306f\u751f\u4f53\u9632\u5fa1\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308b\u4e00\u65b9\u3001\u69d8\u3005\u306a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002MASP-1\u306f\u305d\u306e\u3088\u3046\u306a\u75be\u60a3\u3092\u6cbb\u7642\u3059\u308b\u4e0a\u3067\u3001\u65b0\u305f\u306a\u6a19\u7684\u5206\u5b50\u3068\u3057\u3066\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<h5 class=\"h5_title\">\u3010\u63b2\u8f09\u8ad6\u6587\u540d \u304a\u3088\u3073 \u63b2\u8f09\u96d1\u8a8c\u3011<\/h5>\n<p>\u201cEssential role of Mannose-binding lectin-assocaited serine protease-1 in activation of the complement factor D\u201d<br \/>\u3000<br \/>\n  \uff08MASP-1\u306f\u88dc\u4f53D\u56e0\u5b50\u3092\u6d3b\u6027\u5316\u3059\u308b\u5fc5\u9808\u306e\u56e0\u5b50\u3067\u3042\u308b\uff09<\/p>\n<p>\u300cThe Journal of Experimental Medicine\u300d (\u5b9f\u9a13\u533b\u5b66\u96d1\u8a8c)\u3000<a href=\"http:\/\/jem.rupress.org\/\" target=\"_blank\">\u30db\u30fc\u30e0\u30da\u30fc\u30b8 \uff08\u82f1\u6587\uff09<\/a><br \/>\n<span class=\"green\"><br \/>\n\u25cf<\/span> \u96fb\u5b50\u7248\u306f <a href=\"http:\/\/jem.rupress.org\/cgi\/content\/abstract\/jem.20090633v1?maxtoshow=&#038;HITS=10&#038;hits=10&#038;RESULTFORMAT=1&#038;author1=Takahashi&#038;andorexacttitle=and&#038;andorexacttitleabs=and&#038;andorexactfulltext=and&#038;searchid=1&#038;FIRSTINDEX=0&#038;sortspec=relevance&#038;resourcetype=HWCIT\" target=\"_blank\">\u3053\u3061\u3089<\/a> \uff08\u8981\u7d04\u30da\u30fc\u30b8\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u516c\u7acb\u5927\u5b66\u6cd5\u4eba\u798f\u5cf6\u770c\u7acb\u533b\u79d1\u5927\u5b66\u533b\u5b66\u90e8\u3000\u514d\u75ab\u5b66\u8b1b\u5ea7\u3000\uff08\u6559\u6388\u30fb\u85e4\u7530\u798e\u4e09\uff09\u3000\u306e\u9ad8\u6a4b\u5b9f\u52a9\u6559\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u9818\u57df\u3067\u8840\u4e2d\u306b\u5b58\u5728\u3059\u308b\u88dc\u4f53\u6d3b\u6027\u5316\u9175\u7d20\u300cMASP-1\u300d \u306e\u65b0\u305f\u306a\u6a5f\u80fd\u306e\u89e3\u660e\u306b\u6210\u529f\u3057\u307e\u3057\u305f&#8230;<\/p>\n","protected":false},"author":1,"featured_media":833,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,4,26],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/posts\/832"}],"collection":[{"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/comments?post=832"}],"version-history":[{"count":7,"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/posts\/832\/revisions"}],"predecessor-version":[{"id":844,"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/posts\/832\/revisions\/844"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/media\/833"}],"wp:attachment":[{"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/media?parent=832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/categories?post=832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wp-json\/wp\/v2\/tags?post=832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}