{"id":809,"date":"2010-10-15T02:51:52","date_gmt":"2010-10-14T17:51:52","guid":{"rendered":"http:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/?p=809"},"modified":"2018-04-16T03:17:03","modified_gmt":"2018-04-15T18:17:03","slug":"%e7%b1%b3%e5%9b%bd%e3%80%80%e7%a7%91%e5%ad%a6%e9%9b%91%e8%aa%8c-%e3%80%8cthe-journal-of-biological-chemistry%e3%80%8d2011%e5%b9%b41%e6%9c%88%e5%8f%b7","status":"publish","type":"post","link":"https:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/research\/%e7%b1%b3%e5%9b%bd%e3%80%80%e7%a7%91%e5%ad%a6%e9%9b%91%e8%aa%8c-%e3%80%8cthe-journal-of-biological-chemistry%e3%80%8d2011%e5%b9%b41%e6%9c%88%e5%8f%b7.html","title":{"rendered":"\u7c73\u56fd\u3000\u79d1\u5b66\u96d1\u8a8c \u300cThe Journal of Biological Chemistry\u300d2011\u5e741\u6708\u53f7"},"content":{"rendered":"<div class=\"profile\">\n<img data-src=\"http:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wordpress\/wp-content\/uploads\/2018\/04\/10001_hashimoto.jpg\" class=\"img-fitter\" alt=\"\"><\/p>\n<dl>\n<dt><a href=\"http:\/\/www.fmu.ac.jp\/kenkyu\/Profiles\/15\/0001435\/profile.html\" target=\"_blank\">\u6a4b\u672c\u3000\u5eb7\u5f18<\/a><\/dt>\n<dd>\u798f\u5cf6\u770c\u7acb\u533b\u79d1\u5927\u5b66 \u533b\u5b66\u90e8 \u751f\u5316\u5b66\u8b1b\u5ea7 \u6559\u6388<\/dd>\n<\/dl>\n<\/div>\n<p><!--\/.profile--><\/p>\n<div class=\"profile\">\n<img data-src=\"http:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wordpress\/wp-content\/uploads\/2018\/04\/10001_honda.jpg\" class=\"img-fitter\" alt=\"\"><\/p>\n<dl>\n<dt><a href=\"http:\/\/www.fmu.ac.jp\/kenkyu\/Profiles\/5\/0000435\/profile.html\" target=\"_blank\">\u672c\u591a\u3000\u305f\u304b\u3057<\/a><\/dt>\n<dd>\u798f\u5cf6\u770c\u7acb\u533b\u79d1\u5927\u5b66 \u770b\u8b77\u5b66\u90e8 \u751f\u547d\u79d1\u5b66\u90e8\u9580\u3000\u5f62\u614b\u30fb\u6a5f\u80fd\u5b66 \uff08\u89e3\u5256\u5b66\u30fb\u751f\u7406\u5b66\u30fb\u75c5\u7406\u5b66\uff09 \u6559\u6388<\/dd>\n<\/dl>\n<\/div>\n<p><!--\/.profile--><\/p>\n<h4 class=\"h4_title2\"><span class=\"h5_title\">\uff0d\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u95a2\u9023\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u84c4\u7a4d\u6a5f\u69cb\u306b\u65b0\u305f\u306a\u53ef\u80fd\u6027\uff0d<\/span><\/p>\n<p>  (\u72ec)\u7406\u5316\u5b66\u7814\u7a76\u6240\u3068\u672c\u5b66\u6559\u6388\u3089\u306e\u5171\u540c\u7814\u7a76\u30c1\u30fc\u30e0\u306b\u304a\u3044\u3066<br \/>\n\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u7279\u7570\u7684\u306a\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u898b\u3057\u3001<br \/>\n    \u305d\u306e\u7814\u7a76\u7d50\u679c\u304c\u7c73\u56fd\u79d1\u5b66\u96d1\u8a8c\u300cJ. Biol. Chem.\u300d\u306b\u63b2\u8f09\u3055\u308c\u307e\u3059\u3002<\/h4>\n<p><strong><span class=\"green\">\u25cf<\/span> \u30d2\u30c8\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea770\uff08APP770\uff09\u3092\u767a\u73fe<br \/>\n<span class=\"green\">\u25cf<\/span> \u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306eAPP770\u304b\u3089\uff12\u7a2e\u985e\u306e\u795e\u7d4c\u6bd2\u6027\u30da\u30d7\u30c1\u30c9\uff08A\u03b240\/42\uff09\u3092\u7523\u751f<br \/>\n<span class=\"green\">\u25cf<\/span> \u30d2\u30c8\u8133\u810a\u9ac4\u6db2\u4e2d\u306b\u5206\u6ccc\u3055\u308c\u308bAPP770\u5207\u65ad\u7523\u7269\u306f\u3001\u8133\u75be\u60a3\u30de\u30fc\u30ab\u30fc\u5019\u88dc<\/strong><\/p>\n<p><a href=\"http:\/\/www.riken.go.jp\/\" target=\"_blank\">\u72ec\u7acb\u884c\u653f\u6cd5\u4eba \u7406\u5316\u5b66\u7814\u7a76\u6240<\/a>\uff08\u91ce\u4f9d\u826f\u6cbb\u7406\u4e8b\u9577\uff09\u30fb<a href=\"http:\/\/www.riken.go.jp\/r-world\/research\/results\/2010\/101021\/index.html\" target=\"_blank\">\u57fa\u5e79\u7814\u7a76\u6240<\/a>\uff08\u7389\u5c3e\u7693\u5e73\u6240\u9577\uff09<a href=\"http:\/\/www.riken.go.jp\/r-world\/research\/lab\/frontier-rs\/sys-gly\/index.html\" target=\"_blank\">\u30b7\u30b9\u30c6\u30e0\u7cd6\u9396\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/a>\uff08\u8c37\u53e3\u76f4\u4e4b\u30b0\u30eb\u30fc\u30d7\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\uff09<a href=\"http:\/\/www.riken.go.jp\/r-world\/research\/lab\/frontier-rs\/sys-gly\/dise\/index.html\" target=\"_blank\">\u75be\u60a3\u7cd6\u9396\u7814\u7a76\u30c1\u30fc\u30e0<\/a>\u306e\u5317\u722a\u3057\u306e\u3076\u526f\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u3001\u7acb\u7530\u7531\u91cc\u5b50\u30c6\u30af\u30cb\u30ab\u30eb\u30b9\u30bf\u30c3\u30d5\u3089\u3068<a href=\"http:\/\/www.riken.go.jp\/r-world\/research\/lab\/nokagaku\/index.html\" target=\"_blank\">\u8133\u79d1\u5b66\u7dcf\u5408\u7814\u7a76\u30bb\u30f3\u30bf\u30fc<\/a>\u306e\u897f\u9053\u9686\u81e3\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u304a\u3088\u3073<span class=\"red\">\u672c\u5b66\u306e\u6a4b\u672c\u5eb7\u5f18\u6559\u6388\u3001\u672c\u591a\u305f\u304b\u3057\u6559\u6388\u3089<\/span>\u306f\u3001\u30d2\u30c8\u306e\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u3001\u795e\u7d4c\u7d30\u80de\uff08\u30cb\u30e5\u30fc\u30ed\u30f3\uff09\u3068\u7570\u306a\u308b\u30e6\u30cb\u30fc\u30af\u306a\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff08APP\uff09\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u767a\u898b\u3057\u3001\u3053\u306eAPP\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u6df1\u3044\u95a2\u308f\u308a\u3092\u6301\u3064\u8001\u4eba\u6591\u306e\u4e3b\u6210\u5206\u3067\u3042\u308b\u795e\u7d4c\u6bd2\u6027\u30da\u30d7\u30c1\u30c9\uff08A\u03b2\uff09<a href=\"#hosoku\">\u203b1<\/a>\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u5e73\u621022\u5e7410\u670821\u65e5\u3001\u6587\u90e8\u79d1\u5b66\u7701\u306b<\/span><span class=\"text80par\">\u3066\u516c\u5f0f\u767a\u8868\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>  \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u3001\u6700\u3082\u4ee3\u8868\u7684\u306a\u8001\u4eba\u6027\u8a8d\u77e5\u75c7\u75be\u60a3\u3067\u3001\u8133\u5b9f\u8cea\u306bA\u03b2\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u304c\u539f\u56e0\u3067\u767a\u75c7\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n  \u4e00\u65b9\u3067\u3001\u5b9f\u306b9\u5272\u8fd1\u3044\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3067\u3001\u8133\u8840\u7ba1\u58c1\u306b\u3082A\u03b2\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n  A\u03b2\u306f\u3001APP\u304c2\u7a2e\u985e\u306e\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3067\u5207\u65ad\u3055\u308c\u3066\u751f\u3058\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u8133\u5b9f\u8cea\u306b\u84c4\u7a4d\u3059\u308bA\u03b2\u306f\u3001\u4e3b\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u767a\u73fe\u3059\u308bAPP\uff08APP695\uff09\u304b\u3089\u751f\u3058\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8133\u8840\u7ba1\u58c1\u306b\u84c4\u7a4d\u3059\u308bA\u03b2\u306e\u7531\u6765\u306f\u4e0d\u660e\u306e\u307e\u307e\u3067\u3057\u305f\u3002 <\/p>\n<p>  \u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001<span class=\"red\">\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u3068\u7570\u306a\u308bAPP\uff08APP770\uff09\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b<\/span>\u3057\u307e\u3057\u305f\u3002<br \/>\n  APP770\u3082A\u03b2\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u3001\u3053\u306eA\u03b2\u304c\u8133\u8840\u7ba1\u58c1\u306b\u84c4\u7a4d\u3057\u5f97\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n  \u3055\u3089\u306b\u3001A\u03b2\u306e\u751f\u6210\u904e\u7a0b\u3067APP\u5207\u65ad\u7523\u7269\u3068\u3057\u3066\u751f\u3058\u3001<span class=\"red\">\u8840\u6e05\u3084\u30d2\u30c8\u8133\u810a\u9ac4\u6db2\u306b\u5206\u6ccc\u3055\u308c\u308bsAPP\u03b2\u3082\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u578b\u3068\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u578b\u304c\u5b58\u5728\u3057\u3001\u76f8\u4e92\u8b58\u5225\u304c\u53ef\u80fd<\/span>\u3067\u3042\u308b\u3053\u3068\u3082\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>  \u8840\u7ba1\u5185\u76ae\u7d30\u80de\u578bAPP770\u7531\u6765\u306esAPP770\u03b2\u306f\u3001\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u4f55\u3089\u304b\u306e\u969c\u5bb3\u3092\u53d7\u3051\u3066\u91cf\u7684\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u305f\u3081\u3001\u4eca\u5f8c\u3001<span class=\"red\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u8133\u8840\u7ba1\u6027\u8a8d\u77e5\u75c7\u306a\u3069\u306e\u8a8d\u77e5\u969c\u5bb3\u306e\u65b0\u305f\u306a\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85<\/span>\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>  \u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u7c73\u56fd\u306e\u79d1\u5b66\u96d1\u8a8c<a href=\"http:\/\/www.jbc.org\/\" target=\"_blank\">\u300eJ. Biol. Chem. \u300f<\/a> (The Journal of Biological Chemistry) 2011\u5e741\u6708\u53f7\u306b\u63b2\u8f09\u3055\u308c\u308b\u306b\u5148\u7acb\u3061\u3001<a href=\"http:\/\/www.jbc.org\/content\/early\/2010\/10\/15\/jbc.M110.144626.abstract?sid=11595fb6-2805-491f-8a57-cf190333de56\" target=\"_blank\">\u30aa\u30f3\u30e9\u30a4\u30f3\u7248 \uff0810\u670815\u65e5\u4ed8 \uff1a \u65e5\u672c\u6642\u959310\u670816\u65e5\uff09<\/a> \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br \/><\/span><\/p>\n<p class=\"text_box1\">&nbsp;<\/p>\n<h4 class=\"h4_title\"><span class=\"green2\">\u25cf<\/span> \u7814\u7a76\u6210\u679c\u306e\u6982\u8981<\/h4>\n<h5 class=\"h5_title\">\u3010 1\uff0e\u80cc\u666f \u3011<\/h5>\n<p class=\"text_box1\"><span class=\"text80par\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u3001\u6700\u3082\u5178\u578b\u7684\u306a\u8001\u4eba\u6027\u8a8d\u77e5\u75c7\u3067\u3001\u8133\u5b9f\u8cea\u3078\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u30da\u30d7\u30c1\u30c9\uff08A\u03b2\uff09\u3068\u795e\u7d4c\u539f\u7e4a\u7dad\u5909\u5316<a href=\"#hosoku\">\u203b2<\/a>\u306e\u84c4\u7a4d\u304c\u4e3b\u306a\u75c5\u7406\u7684\u7279\u5fb4\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n  \u75c5\u6c17\u304c\u9032\u884c\u3059\u308b\u3068\u795e\u7d4c\u7d30\u80de\u306e\u8131\u843d\u306b\u3088\u308a\u8133\u304c\u840e\u7e2e\u3059\u308b\u3053\u3068\u3067\u3001\u8a8d\u77e5\u969c\u5bb3\u304c\u73fe\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3067\u306f\u3001A\u03b2\u306e\u8133\u5b9f\u8cea\u3078\u306e\u84c4\u7a4d\u904e\u7a0b\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4e3b\u305f\u308b\u539f\u56e0\u3067\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4e00\u65b9\u3067\u3001\u5b9f\u306b9\u5272\u8fd1\u3044\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u8133\u306e\u75c5\u7406\u6240\u898b\u306b\u304a\u3044\u3066\u3001\u8133\u8840\u7ba1\u58c1\u306b\u3082A\u03b2\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\uff08\u8133\u30a2\u30df\u30ed\u30a4\u30c9\u30fb\u30a2\u30f3\u30ae\u30aa\u30d1\u30c1\u30fc\uff09\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n  \u3053\u306e\u8133\u30a2\u30df\u30ed\u30a4\u30c9\u30fb\u30a2\u30f3\u30ae\u30aa\u30d1\u30c1\u30fc\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u306e\u76f8\u95a2\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u307b\u304b\u3001\u8133\u5185\u51fa\u8840\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u3082\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>A\u03b2\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff08APP\uff09\u304c2\u7a2e\u985e\u306e\u9175\u7d20\u3067\u5207\u65ad\u3055\u308c\u308b\u30b9\u30c6\u30c3\u30d7\u3092\u7d4c\u3066\u751f\u3058\u307e\u3059\u3002<br \/>\n\u307e\u305a\u3001BACE1\u30d7\u30ed\u30c6\u30a2\u30fc<a href=\"#hosoku\">\u203b3<\/a> \u306b\u3088\u3063\u3066\u03b2\u90e8\u4f4d\u3067\u5207\u65ad\u3055\u308c\u3001\u6b21\u306b\u30d7\u30ec\u30bb\u30cb\u30ea\u30f3\u8907\u5408\u4f53<a href=\"#hosoku\">\u203b4<\/a> \u306b\u3088\u3063\u3066\u03b3\u90e8\u4f4d\u3067\u5207\u65ad\u3055\u308c\u307e\u3059<a href=\"#picture1\">\uff08\u56f31\uff09<\/a>\u3002\u307e\u305f\u3001APP\u306b\u306f\u3001\u305d\u306e\u751f\u5408\u6210\u904e\u7a0b\u3067\u751f\u3058\u308bAPP695\u3001APP751\u3001APP770\u3068\u3044\u30463\u7a2e\u985e\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u304a\u308a\u3001\u3053\u306e\u3046\u3061\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u306f\u3001APP695\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059<a href=\"#picture2\">\uff08\u56f32\uff09<\/a>\u3002<br \/>\n\u8133\u5b9f\u8cea\u306b\u84c4\u7a4d\u3059\u308bA\u03b2\u306f\u3001\u4e3b\u3068\u3057\u3066\u30cb\u30e5\u30fc\u30ed\u30f3\u578bAPP695\u7531\u6765\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8840\u7ba1\u58c1\u306b\u84c4\u7a4d\u3059\u308bA\u03b2\u306e\u7531\u6765\u306f\u4e0d\u660e\u306e\u307e\u307e\u3067\u3057\u305f\u3002<br \/>\n<\/span><\/p>\n<h5 class=\"h5_title\">\u3010 2\uff0e\u7814\u7a76\u624b\u6cd5\u3068\u6210\u679c \u3011<\/h5>\n<p class=\"text_box1\"><span class=\"text80par\">\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u81ea\u4f53\u306bAPP\u306e\u4ee3\u8b1d\u6a5f\u69cb\u304c\u5b58\u5728\u3059\u308b\u306e\u3067\u306a\u3044\u304b\u3068\u8003\u3048\u3001\u30d2\u30c8\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002<br \/>\n\u305d\u306e\u7d50\u679c\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u578bAPP695\u3068\u306f\u7570\u306a\u308b\u30d0\u30ea\u30a2\u30f3\u30c8\u3067\u3042\u308bAPP770\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u8133\u8840\u7ba1\u5185\u76ae\u578bAPP770\u306f\u3001\u03b2\u90e8\u4f4d\u3068\u03b3\u90e8\u4f4d\u3067\u5207\u65ad\u3055\u308c\u3001A\u03b2\u30da\u30d7\u30c1\u30c940\u304a\u3088\u307342\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u3082\u898b\u51fa\u3057\u307e\u3057\u305f<a href=\"#picture1\">\uff08\u56f31\uff09<\/a>\u3002\u3055\u3089\u306b\u3001APP770\u306b\u306f\u3001O\u578b\u7cd6\u9396\u304c\u7d50\u5408\u3057\u3066\u3044\u308b\u30bf\u30a4\u30d7\u3068\u7d50\u5408\u3057\u3066\u3044\u306a\u3044\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u3001O\u578b\u7cd6\u9396\u3092\u6301\u3064\u30bf\u30a4\u30d7\u3060\u3051\u304cA\u03b2\u7523\u751f\u7d4c\u8def\u3092\u305f\u3069\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u3001APP770\u7279\u7570\u7684\u306a\u6297\u4f53\u3092\u7528\u3044\u3066\u30d2\u30c8\u8133\u5207\u7247\u306e\u514d\u75ab\u67d3\u8272\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u8133\u8840\u7ba1\u5185\u76ae\u90e8\u5206\u304c\u67d3\u8272\u3055\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u3001\u5b9f\u969b\u306b\u30d2\u30c8\u306e\u8133\u8840\u7ba1\u306bAPP770\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001A\u03b2\u751f\u6210\u904e\u7a0b\u3067APP\u5207\u65ad\u7523\u7269\u3068\u3057\u3066\u751f\u3058\u3001\u8133\u810a\u9ac4\u6db2\u3084\u8840\u6e05\u4e2d\u306b\u5206\u6ccc\u3059\u308bsAPP\u03b2\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001APP770\u306eBACE1\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u5207\u65ad\u7523\u7269\u3067\u3042\u308bsAPP770\u03b2\u3092\u898b\u51fa\u3059\u3053\u3068\u306b\u3082\u6210\u529f\u3057\u307e\u3057\u305f\u3002A\u03b2\u306fAPP770\u7531\u6765\u3001APP695\u7531\u6765\u3068\u3082\u306b\u5171\u901a\u306e\u69cb\u9020\u3092\u3082\u3064\u305f\u3081\u3001\u3069\u3061\u3089\u306e\u7531\u6765\u3067\u3042\u308b\u304b\u898b\u5206\u3051\u308b\u3053\u3068\u304c\u4e0d\u53ef\u80fd\u3067\u3059\u3002\u3057\u304b\u3057\u3001sAPP770\u03b2\u306f\u3001APP770\u306b\u56fa\u6709\u306e\u69cb\u9020\u3092\u3082\u3064\u305f\u3081\u3001\u8133\u810a\u9ac4\u6db2\u3084\u8840\u6e05\u4e2d\u306esAPP\u03b2\u304c\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u7531\u6765\u304b\u8133\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u7531\u6765\u304b\u3092\u5224\u5225\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n<\/span><\/p>\n<h5 class=\"h5_title\">\u3010 3\uff0e\u4eca\u5f8c\u306e\u671f\u5f85 \u3011<\/h5>\n<p class=\"text_box1\"><span class=\"text80par\">\u4eca\u56de\u3001\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u30cb\u30e5\u30fc\u30ed\u30f3\u578bAPP695\u3068\u306f\u7570\u306a\u308bAPP770\u3092\u767a\u73fe\u3059\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u898b\u51fa\u3057\u3001\u3055\u3089\u306bAPP770\u7531\u6765\u306eBACE1\u5207\u65ad\u7523\u7269\u3067\u3042\u308bsAPP770\u03b2\u304c\u30d2\u30c8\u8133\u810a\u9ac4\u6db2\u3084\u8840\u6e05\u4e2d\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304b\u304b\u308b\u7d4c\u6e08\u30b3\u30b9\u30c8\u306f2010\u5e74\u306e\u6642\u70b9\u3067\u3001\u4e16\u754c\u306eGDP\u306e1\uff05\u3092\u5360\u3081\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u8a8d\u77e5\u75c7\u5bfe\u7b56\u306e\u91cd\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n\u8a8d\u77e5\u75c7\u306e\u81e8\u5e8a\u75c7\u72b6\u3092\u53cd\u6620\u3059\u308b\u8a3a\u65ad\u85ac\u306e\u958b\u767a\u306f\u8a8d\u77e5\u75c7\u5bfe\u7b56\u306e\u4e2d\u3067\u3082\u91cd\u8981\u306a\u8ab2\u984c\u306e1\u3064\u3067\u3059\u3002\u8133\u810a\u9ac4\u6db2\u3084\u8840\u6e05\u4e2d\u306esAPP770\u03b2\u306f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u4f55\u3089\u304b\u306e\u969c\u5bb3\u3092\u53d7\u3051\u3066\u91cf\u7684\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u305f\u3081\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u8133\u8840\u7ba1\u6027\u8a8d\u77e5\u75c7\u306a\u3069\u306e\u8a8d\u77e5\u969c\u5bb3\u306e\u65e9\u671f\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u306b\u306a\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u304a\u308a\u3001\u73fe\u5728sAPP770\u03b2\u3092\u5b9a\u91cf\u3059\u308b\u305f\u3081\u306e<a name=\"picture1\" id=\"picture1\"><\/a>\u30b5\u30f3\u30c9\u30a4\u30c3\u30c1ELISA\u30b7\u30b9\u30c6\u30e0\u3092\u65e5\u672c\u514d\u75ab\u751f\u7269\u7814\u7a76\u6240\u3068\u5171\u540c\u3067\u958b\u767a\u3057\u3066\u3044\u307e\u3059<a href=\"#picture3\">\uff08\u56f33\uff09<\/a>\u3002<br \/>\n<img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wordpress\/wp-content\/uploads\/2018\/04\/10001_1.gif\" alt=\"\" width=\"400\" height=\"359\" class=\"aligncenter size-full wp-image-816\" \/><br \/>\n<img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wordpress\/wp-content\/uploads\/2018\/04\/10001_2.gif\" alt=\"\" width=\"435\" height=\"251\" class=\"aligncenter size-full wp-image-817\" \/><br \/>\n<img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/www.fmu.ac.jp\/univ\/kenkyuseika\/wordpress\/wp-content\/uploads\/2018\/04\/10001_3.gif\" alt=\"\" width=\"560\" height=\"394\" class=\"aligncenter size-full wp-image-818\" \/><br \/>\n<a name=\"hosoku\" id=\"hosoku\"><\/a><\/p>\n<h5 class=\"h5_title\">\uff1c\u88dc\u8db3\u8aac\u660e\uff1e<\/h5>\n<p class=\"text_box1\"><span class=\"text80par\"><br \/>\n\u203b1\u3000<span class=\"red\">A\u03b2\uff08\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\uff09<\/span><br \/>\n\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea(APP)\u304b\u3089\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08\u30da\u30d7\u30c1\u30c9\u7d50\u5408\u52a0\u6c34\u5206\u89e3\u9175\u7d20\uff09\u3067\u5207\u65ad\u3055\u308c\u3066\u7523\u751f\u3055\u308c\u308b\u30da\u30d7\u30c1\u30c9\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u8133\u306b\u84c4\u7a4d\u304c\u8a8d\u3081\u3089\u308c\u3001\u3053\u306e\u84c4\u7a4d\u904e\u7a0b\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u539f\u56e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u300240\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u306eA\u03b240\u306b\u6bd4\u3079\u300142\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u306eA\u03b242\u306f\u3001\u3088\u308a\u51dd\u96c6\u3057\u3084\u3059\u304f\u6bd2\u6027\u304c\u9ad8\u3044\u3002<\/p>\n<p>\u203b2\u3000<span class=\"red\">\u795e\u7d4c\u539f\u7e4a\u7dad\u5909\u5316<\/span><br \/>\n\u3000\u30ea\u30f3\u9178\u5316\u3055\u308c\u305f\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7e4a\u7dad\u69cb\u9020\u3092\u3068\u3063\u3066\u795e\u7d4c\u7d30\u80de\u5185\u306b\u84c4\u7a4d\u3057\u305f\u3082\u306e\u3002<\/p>\n<p>\u203b3\u3000<span class=\"red\">BACE1\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc<\/span><br \/>\nAPP\u306e\u03b2\u90e8\u4f4d\u3067\u306e\u5207\u65ad\u3092\u884c\u3046\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3002<\/p>\n<p>\u203b4\u3000<span class=\"red\">\u30d7\u30ec\u30bb\u30cb\u30ea\u30f3\u8907\u5408\u4f53<\/span><br \/>\nAPP\u3092\u03b3\u90e8\u4f4d\u3067\u5207\u65ad\u3059\u308b\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u672c\u4f53\u3067\u3042\u308a\u3001\u30d7\u30ec\u30bb\u30cb\u30ea\u30f3\u30683\u7a2e\u985e\u306e\u88dc\u52a9\u56e0\u5b50\u3067\u3042\u308b\u30cb\u30ab\u30b9\u30c8\u30ea\u30f3\u3001APH-1\u3001PEN-2\u306e\u8907\u5408\u4f53\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u308b\u3002<br \/>\n<\/span><\/p>\n<h4 class=\"h4_title\"><span class=\"green2\">\u25cf<\/span> \u304a\u554f\u3044\u5408\u308f\u305b\u5148<\/h4>\n<p class=\"text_box1\"><span class=\"text80par\">\u798f\u5cf6\u770c\u7acb\u533b\u79d1\u5927\u5b66\u3000\u533b\u5b66\u90e8\u3000\u751f\u5316\u5b66\u8b1b\u5ea7<br \/>\n\t  \u6559\u6388\u3000\u6a4b\u672c\u5eb7\u5f18<br \/>\n\t  \u3012960-1295\u3000\u798f\u5cf6\u5e02\u5149\u304c\u4e18\uff11\u756a\u5730\u3000\u3000\u7814\u7a76\u5ba4\u96fb\u8a71\uff1a 024-547-1143\u3000\uff08FAX\u3000024-548-8641\uff09<\/span><span class=\"text80par\"><br \/>\n          <span class=\"green\">\u25cf<\/span> \u533b\u5b66\u90e8\u751f\u5316\u5b66\u8b1b\u5ea7\u306e\u3054\u7d39\u4ecb <a href=\"http:\/\/www.fmu.ac.jp\/cms\/biochem1\/index_html\" target=\"_blank\">http:\/\/www.fmu.ac.jp\/cms\/biochem1\/index_html<\/a><br \/>\n\t  <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6a4b\u672c\u3000\u5eb7\u5f18 \u798f\u5cf6\u770c\u7acb\u533b\u79d1\u5927\u5b66 \u533b\u5b66\u90e8 \u751f\u5316\u5b66\u8b1b\u5ea7 \u6559\u6388 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