Papers - SEKINE Hideharu
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Polymorphisms of the FCN2 Gene 3'UTR Region and Their Clinical Associations in Preterm Newborns
Świerzko Anna S, Jarych Dariusz, Gajek Gabriela, Chojnacka Karolina, Kobiela Paulina, Kufelnicka-Babout Maja, Michalski Mateusz, Sobczuk Katarzyna, Szala-Poździej Agnieszka, Matsushita Misao, Mazela Jan, Domżalska-Popadiuk Iwona, Kilpatrick David C, Kalinka Jarosław, Sekine Hideharu, Cedzyński Maciej
Frontiers in Immunology 12 741140 2021.10
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Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease
Tanaka Keiichiro, Oguchi Yasuharu, Omori Tomoko, Ishida Yumi, Shintake Hiroaki, Tomita Ryutaro, Kasai Akihito, Ogasawara Masashi, Sugano Yukinori, Itagaki Kanako, Ojima Akira, Machida Takeshi, Sekine Hideharu, Sekiryu Tetsuju
Scientific Reports 11 ( 1 ) 8464 2021.4
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Complement Activation Products and Cytokines in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular Degeneration
Kato Y, Oguchi Y, Omori T, Shintake H, Tomita R, Kasai A, Ogasawara M, Sugano Y, Itagaki K, Ojima A, Machida T, Sekine H, Sekiryu T.
Invest Ophthalmol Vis Sci 61 ( 13 ) 39 2020.11
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Narratives of resilience in medical students following the 3/11 triple disaster: Using thematic analysis to examine paths to recovery.
Kaye-Kauderer H, Rodriguez A, Levine J, Takeguchi Y, Machida M, Feingold J, Sekine H, Katz C, Yanagisawa R
Psychiatry research 292 113348 2020.10（ ISSN:0165-1781 ）
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Association between serum ficolin-1 level and disease progression in primary biliary cholangitis
Hayashi M, Abe K, Fujita M, Takahashi A, Sekine H, Ohira H.
PLoS One 15 ( 9 ) e0238300 2020.9
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Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities
Oguchi Y, Sekiryu T, Omori T, Kato Y, Ogasawara M, Sugano Y, Itagaki K, Ojima A, Machida T, Sekine H
Exp Eye Res 195 2020.6
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Evidence for activation of lectin and classical pathway complement components in aqueous humor of neovascular age-related macular degeneration
Tomoko Omori, Yasuharu Oguchi, Takeshi Machida, Yutaka Kato, Yumi Ishida, Akira Ojima, Kanako Itagaki, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Yukinori Sugano, Masashi Ogasawara, Hideharu Sekine, and Tetsuju Sekiryu
Ophthalmic Research 63 ( 3 ) 252 - 258 2020.5
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A novel complement inhibitor sMAP-FH targeting both the lectin and alternative complement pathways
Takasumi M, Omori T, Machida T, Ishida Y, Hayashi M, Suzuki T, Homma Y, Endo Y, Takahashi M, Ohira H, Fujita T, Sekine H
The FASEB Journal 34 ( 5 ) 6598 - 6612 2020.3
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感染症と補体・凝固線溶系
関根英治
Thrombosis Medicine 10 274 - 280 2020
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Post-Traumatic Growth and Resilience Among Medical Students After the March 2011 Disaster in Fukushima, Japan.
Kaye-Kauderer HP, Levine J, Takeguchi Y, Machida M, Sekine H, Taku K, Yanagisawa R, Katz C
The Psychiatric quarterly 90 ( 3 ) 507 - 518 2019.9（ ISSN:0033-2720 ）
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Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia
Junya Hata, Takeshi Machida, Kanako Matsuoka, Seiji Hoshi, Hidenori Akaihata, Hiroyuki Hiraki, Toshiyuki Suzuki, Soichiro Ogawa, Masao Kataoka, Nobuhiro Haga, Kei Ishibashi, Yoshimi Homma, Hideharu Sekine, Yoshiyuki Kojima
Scientific Reports 9 20357 2019
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Response to Comment on “Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway”
Takeshi Machida, Manabu Hayashi, Teizo Fujita, and Hideharu Sekine
The Journal of Immunology 203 ( 12 ) 3091 - 3092 2019
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Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway
Manabu Hayashi, Takeshi Machida, Yumi Ishida, Yusuke Ogata, Tomoko Omori, Mika Takasumi, Yuichi Endo, Toshiyuki Suzuki, Masayuki Sekimata, Yoshimi Homma, Masahito Ikawa, Hiromasa Ohira, Teizo Fujita, and Hideharu Sekine
The Journal of Immunology 203 ( 6 ) 1411 - 1416 2019（ ISSN:0022-1767 ）
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Furuya MY, Asano T, Sumichika Y, Sato S, Kobayashi H, Watanabe H, Suzuki E, Kozuru H, Yatsuhashi H, Koga T, Ohira H, Sekine H, Kawakami A, Migita K
Arthritis research & therapy 20 ( 1 ) 196 2018.8（ ISSN:1478-6354 ）
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Taku K, Prioleau PG, Anderson DS, Takeguchi Y, Sekine H, Maeda M, Yabe H, Yanagisawa RT, Katz CL
The Psychiatric quarterly 2018.8（ ISSN:0033-2720 ）
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Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice
Machida T, Sakamoto N, Ishida Y, Takahashi M, Fujita T, Sekine H
Frontiers in Immunology 9 1191 2018.5
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「補体」シリーズ<第6回> 補体と全身性エリテマトーデス(SLE)
関根 英治
Schneller ( 106 ) 13 - 17 2018.4
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Fukushima Triple Disaster and the Road to Recovery: a Qualitative Exploration of Resilience in Internally Displaced Residents.
Mann CL, Gillezeau CN, Massazza A, Lyons DJ, Tanaka K, Yonekura K, Sekine H, Yanagisawa R, Katz CL
The Psychiatric quarterly 89 ( 2 ) 383 - 397 2018.1（ ISSN:0033-2720 ）
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全身性エリテマトーデスの病態理解の進歩 SLEにおける補体活性化経路の役割
関根 英治, 大森 智子, 坂本 夏美, 町田 豪
福島医学雑誌 67 ( 3 ) 113 - 122 2017.12（ ISSN:0016-2582 ）
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Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.
Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM
Journal of immunology (Baltimore, Md. : 1950) 199 ( 5 ) 1835 - 1845 2017.9（ ISSN:0022-1767 ）
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Evaluation of blood-brain barrier function by quotient alpha2macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus
Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe
PlosOne 12 ( 10 ) e0186414 2017
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Autoimmune disease mouse model exhibits pulmonary arterial hypertension.
Sugimoto K, Nakazato K, Sato A, Suzuki S, Yoshihisa A, Machida T, Saitoh SI, Sekine H, Takeishi Y
PloS one 12 ( 9 ) e0184990 2017
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Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.
Asano T, Ito H, Kariya Y, Hoshi K, Yoshihara A, Ugawa Y, Sekine H, Hirohata S, Yamaguchi Y, Sato S, Kobayashi H, Migita K, Ohira H, Hashimoto Y, Watanabe H
PloS one 12 ( 10 ) e0186414 2017
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Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing.
Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM
Journal of immunology (Baltimore, Md. : 1950) 197 ( 9 ) 3680 - 3694 2016.11（ ISSN:0022-1767 ）
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Hashimoto T., Tsuruta D., Yasukochi A., Imanishi H., Sekine H., Fujita T., Wanibuchi H., Gi M., Kárpáti S., Sitaru C., Zone J., Endo D., Abe S., Nishino T., Koji T., Ishii N.
Acta Dermato-Venereologica 96 ( 6 ) 748 - 753 2016.9（ ISSN:00015555 ）
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【補体関連疾患の新局面】 膠原病への補体の関与と抗補体療法の可能性
関根 英治
医学のあゆみ 257 ( 8 ) 854 - 860 2016.5（ ISSN:0039-2359 ）
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Post-traumatic stress and growth among medical student volunteers after the March 2011 disaster in Fukushima, Japan: Implications for student involvement with future disasters
David Anderson, Phoebe Prioleau, Kanako Taku, Yu Naruse, Hideharu Sekine, Masaharu Maeda, Hirooki Yabe, Craig Katz, Robert Yanagisawa
Psychia Quart 87 ( 2 ) 241 - 251 2016
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補体異常値を示す疾患とそのメカニズム
関根英治、大森智子、町田豪
補体 52 ( 2 ) 14 - 26 2015.12
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補体異常値を示す疾患とそのメカニズム
関根 英治, 大森 智子, 町田 豪
補体 52 ( 2 ) 14 - 26 2015.12（ ISSN:2188-8205 ）
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補体異常値を示す疾患とそのメカニズム
関根英治、大森智子、町田豪
補体 52 ( 2 ) 14 - 26 2015.12
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補体異常値を示す疾患とそのメカニズム
関根英治、大森智子、町田豪
補体 52 ( 2 ) 14 - 26 2015
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遺伝性血管性浮腫(HAE)ガイドライン 改訂2014年版
堀内 孝彦, 大澤 勲, 岡田 秀親, 塚本 浩, 中尾 実樹, 木下 タロウ, 高橋 実, 野中 勝, 松下 操, 関根 英治, 山本 哲郎, 若宮 伸隆, 藤田 禎三, 瀬谷 司, 井上 徳光, 大井 洋之, 一般社団法人日本補体学会HAEガイドライン作成委員会
補体 51 ( 2 ) 24 - 30 2014.12（ ISSN:2188-8205 ）
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Lessons learned from mice deficient in lectin complement pathway molecules.
Genster N, Takahashi M, Sekine H, Endo Y, Garred P, Fujita T
Molecular immunology 61 ( 2 ) 59 - 68 2014.10（ ISSN:0161-5890 ）
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Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".
Takahashi M, Sekine H, Fujita T
Journal of immunology (Baltimore, Md. : 1950) 192 ( 12 ) 5448 - 9 2014.6（ ISSN:0022-1767 ）
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Takahashi M., Sekine H., Fujita T.
Journal of Immunology 192 ( 12 ) 5448 - 5449 2014.6（ ISSN:00221767 ）
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Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Teizo Fujita
J Immunol 192 ( 12 ) 5448 - 5449 2014
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Lessons learned from mice deficient in lectin complement pathway molecules.
Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita
Mol Immunol 61 ( 2 ) 59 - 68 2014
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Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Teizo Fujita
J Immunol 192 ( 12 ) 5448 - 5449 2014
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Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Teizo Fujita
J Immunol 192 ( 12 ) 5448 - 5449 2014
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Lessons learned from mice deficient in lectin complement pathway molecules.
Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita
Mol Immunol 61 ( 2 ) 59 - 68 2014
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Lessons learned from mice deficient in lectin complement pathway molecules.
Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita
Mol Immunol 61 ( 2 ) 59 - 68 2014
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Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Teizo Fujita
J Immunol 192 ( 12 ) 5448 - 5449 2014
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Lessons learned from mice deficient in lectin complement pathway molecules.
Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita
Mol Immunol 61 ( 2 ) 59 - 68 2014
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Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita
J Immunol 190 2477 2013.6
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補体の異常値と疾患
関根 英治, 町田 豪, 坂本 夏美, 高橋 実
福島医学雑誌 63 ( 2 ) 93 - 107 2013.6（ ISSN:0016-2582 ）
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Role of complement in a murine model of peanut-induced anaphylaxis.
Kodama T, Sekine H, Takahashi M, Iwaki D, Machida T, Kanno K, Ishida Y, Endo Y, Fujita T
Immunobiology 218 ( 6 ) 844 - 50 2013.6（ ISSN:0171-2985 ）
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Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita
J Immunol 190 2477 2013.6
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The role of MASP-1/3 in complement activation
Sekine H, Takahashi M, Iwaki D, Fujita T
Adv Exp Med Biol 735 41 - 53 2013
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補体の異常値と疾患
関根英治、町田豪、坂本夏美、高橋実
福島医学雑誌 63 ( 2 ) 93 - 107 2013
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補体の異常値と疾患
関根英治、町田豪、坂本夏美、高橋実
福島医学雑誌 63 ( 2 ) 93 - 107 2013
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Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita
J Immunol 190 2477 2013
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Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".
Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita
J Immunol 190 2477 2013
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The role of MASP-1/3 in complement activation.
Sekine H, Takahashi M, Iwaki D, Fujita T
Advances in experimental medicine and biology 735 41 - 53 2013（ ISSN:0065-2598 ）
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補体の異常値と疾患
関根英治、町田豪、坂本夏美、高橋実
福島医学雑誌 63 ( 2 ) 93 - 107 2013
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The dual role of complement in the progression of renal disease in NZB/W F1 mice and alternative pathway inhibition
Sekine H, Ruiz P, Gilkeson GS, Tomlinson S
Mol Immunol 49 317 - 323 2011.10
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The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice
Sekine H, Kinser TT, Qiao F, Martinez E, Paulling E, Ruiz P, Gilkeson GS, Tomlinson S
Arthritis Rheum 63 1076 - 1085 2011.4
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Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching"
Sekine H, Ferreira RC, Pan-Hammarström Q, Hammarström L, Gilkeson GS, Behrens TW
J Immunol 182 4495 - 4496 2009.4
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Role for Msh5 in the regulation of Ig class switch recombination
Sekine H, Ferreira RC, Pan-Hammarstrom Q, Graham RR, Ziemba B, de Vries SS, Liu J, Hippen K, Koeuth T, Ortmann W, Iwahori A, Elliott MK, Offer S, Skon C, Du L, Novitzke J, Lee AT, Zhao N, Tompkins JD, Altshuler D, Gregersen PK, Cunningham-Rundles C, Harris RS, Her C, Nelson DL, Hammarstrom L, Gilkeson GS, Behrens TW
Proc Natl Acad Sci USA 104 7193 - 7198 2007.4
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Role of MHC-linked genes in autoantigen selection and renal disease in a murine model of systemic lupus erythematosus
Sekine H, Graham KL, Zhao S, Elliott MK, Ruiz P, Utz PJ, Gilkeson GS
J Immunol 177 7423 - 7434 2006.11
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Enrichment of Anti-Glomerular Antigen Antibody-Producing Cells in the Kidneys of MRL/MpJ-Faslpr Mice
Sekine H, Watanabe H, Gilkeson GS
J Immunol 172 3913 - 3921 2004.3
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An ancient lectin-dependent complement system in an ascidian: novel lectin isolated from the plasma of the solitary ascidian, Halocynthia roretzi
Sekine H, Kenjo A, Azumi K, Ohi G, Takahashi M, Kasukawa R, Ichikawa N, Nakata M, Mizuochi T, Matsushita M, Endo Y, Fujita T
J Immunol 167 4504 - 4510 2001.10
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Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice
Sekine H, Reilly CM, Molano ID, Garnier G, Circolo A, Ruiz P, Holers VM, Boackle SA, Gilkeson GS
J Immunol 166 6444 - 6451 2001.5