Faculty Profiles - HASEGAWA Koki

Papers - HASEGAWA Koki

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Novel astatine (211At)-labelled prostate-specific membrane antigen ligand with a neopentyl-glycol structure: evaluation of stability, efficacy, and safety using a prostate cancer xenograft model.

Kei Yaginuma, Kazuhiro Takahashi, Seiji Hoshi, Taiki Joho, Saki Shimoyama, Naoko Hasegawa, Koki Hasegawa, Songji Zhao, Naoyuki Ukon, Syunta Makabe, Satoru Meguro, Akifumi Onagi, Kanako Matsuoka, Soichiro Ogawa, Motohide Uemura, Tomoki Yamashita, Hiroyuki Suzuki, Tomoya Uehara, Yoshiyuki Kojima

European journal of nuclear medicine and molecular imaging 2024.10（ ISSN:1619-7070 ）

Deep Learning-Driven Estimation of Centiloid Scales from Amyloid PET Images with 11C-PiB and 18F-Labeled Tracers in Alzheimer’s Disease

Tensho Yamao, Kenta Miwa, Yuta Kaneko, Noriyuki Takahashi, Noriaki Miyaji, Koki Hasegawa, Kei Wagatsuma, Yuto Kamitaka, Hiroshi Ito, Hiroshi Matsuda

Brain Sciences 14 ( 4 ) 406 - 406 2024.4（ ISSN:2076-3425 ）

Characterization of the expression of gastrin-releasing peptide and its receptor in the trigeminal and spinal somatosensory systems of Japanese macaque monkeys: Insight into humans.

Keiko Takanami, Takumi Oti, Yasuhisa Kobayashi, Koki Hasegawa, Takashi Ito, Naoaki Tsutsui, Yasumasa Ueda, Earl Carstens, Tatsuya Sakamoto, Hirotaka Sakamoto

The Journal of comparative neurology 530 ( 16 ) 2804 - 2819 2022.6（ ISSN:0021-9967 ）

Development of a phoswich detector composed of ZnS(Ag) and YAP(Ce) for astatine-211 imaging

Seiichi Yamamoto, Naoyuki Ukon, Kohshin Washiyama, Koki Hasegawa, Kei Kamada, Masao Yoshino, Akira Yoshikawa

Radiation Measurements 153 106734 - 106734 2022.3（ ISSN:1350-4487 ）

Discussion on Translational Research of Drug Product for Targeted Alpha Therapy-Part 8-Discussion on Targeted Alpha Therapy for Viral Infection

矢野恒夫, 淵上剛志, 高橋豊, 角永悠一郎, 長谷川功紀, 加藤弘樹, 渡部直史, 樺山一哉, 山村朝雄, 佐藤達彦, 佐藤達彦, 平林容子, 藤井博史, 米倉義晴, 深瀬浩一

Pharm Tech Japan 38 ( 13 ) 2022（ ISSN:0910-4739 ）

Discussion on Translational Research of Drug Product for Targeted Alpha Therapy-Part 7--Aiming for Practical Use of Targeted Alpha Therapy (TAT) based on Nanomedicine while Understanding an Abscopal treatment response and a Random walk approach deeply-

矢野恒夫, 角永悠一郎, 樺山一哉, 加藤弘樹, 高橋豊, 山村朝雄, 長谷川功紀, 佐藤達彦, 佐藤達彦, 淵上剛志, 渡部直史, 巽光朗, 平林容子, 藤井博史, 米倉義晴, 深瀬浩一

Pharm Tech Japan 38 ( 2 ) 281 - 289 2022（ ISSN:0910-4739 ）

アルファ線核医学治療のための薬剤開発の考察(その6)　標的分子・創薬化学の重要性(後編)

矢野恒夫, 長谷川功紀, 石井明子, 渡部直史, 巽光朗, 角永悠一郎, 樺山一哉, 深瀬浩一, 米倉義晴, 平林容子, 佐藤達彦, 藤井博史

PHARM TECH JAPAN 37 ( 14 ) 2483 - 2493 2021.11（ ISSN:0910-4739 ）

アルファ線核医学治療のための薬剤開発の考察(その6)　標的分子・創薬化学の重要性(前編)

矢野恒夫, 長谷川功紀, 石井明子, 渡部直史, 巽光朗, 角永悠一郎, 樺山一哉, 深瀬浩一, 米倉義晴, 平林容子, 佐藤達彦, 藤井博史

PHARM TECH JAPAN 37 ( 11 ) 1921 - 1930 2021.8（ ISSN:0910-4739 ）

アルファ線核医学治療のための薬剤開発の考察(その5)　IAEA Technical Meeting報告　α線核種並びにTAT薬剤の最新動向

矢野恒夫, 長谷川功紀, 山村朝雄, 渡部直史, 巽光朗, 佐藤達彦, 角永悠一郎, 樺山一哉, 深瀬浩一, 平林容子, 藤井博史, 米倉義晴

医薬品医療機器レギュラトリーサイエンス 52 ( 2 ) 85 - 106 2021.2（ ISSN:1884-6076 ）

Facile synthesis of 2-deoxy-2-[18 F]fluorosorbitol using sodium borohydride on aluminum oxide.

Koki Hasegawa, Kazuhiro Koshino, Takahiro Higuchi

Journal of labelled compounds & radiopharmaceuticals 64 ( 1 ) 40 - 46 2021.1（ ISSN:0362-4803 ）

Rationale for Translational Research on Targeted Alpha Therapy in Japan —Renaissance of Radiopharmaceuticals Utilizing Astatine-211 and Actinium-225—

Tsuneo Yano, Koki Hasegawa, Tatsuhiko Sato, Mitsuaki Tatsumi, Tadashi Watabe, Yuichiro Kadonaga, Kazuya Kabayama, Koichi Fukase, Akiko Hachisuka, Yoko Hirabayashi, Hirofumi Fujii, Yoshiharu Yonekura

RADIOISOTOPES 69 ( 10 ) 329 - 340 2020.10（ ISSN:1884-4111 ）

Enhancement of direct membrane penetration of arginine-rich peptides by polyproline II helix structure.

Takashi Ohgita, Yuki Takechi-Haraya, Keisuke Okada, Saki Matsui, Misaki Takeuchi, Chihiro Saito, Kazuchika Nishitsuji, Kenji Uchimura, Ryuji Kawano, Koki Hasegawa, Kumiko Sakai-Kato, Kenichi Akaji, Ken-Ichi Izutsu, Hiroyuki Saito

Biochimica et biophysica acta. Biomembranes 1862 ( 10 ) 183403 - 183403 2020.10（ ISSN:00052736 ）

Kiss1R Identification and Biodistribution Analysis Employing a Western Ligand Blot and Ligand-Derivative Stain with a FITC-Kisspeptin Derivative.

Koki Hasegawa, Rika Maedomari, Younosuke Sato, Kumiko Gotoh, Shinji Kudoh, Akihiro Kojima, Seiji Okada, Takaaki Ito

ChemMedChem 15 ( 18 ) 1699 - 1705 2020.9（ ISSN:18607179 ）

アルファ線核医学治療のための薬剤開発の考察(その4)　First-in-Human臨床に向けた要件

矢野恒夫, 長谷川功紀, 佐藤達彦, 巽光朗, 渡部直史, 藤井博史, 角永悠一郎, 樺山一哉, 深瀬浩一, 米倉義晴, 蜂須賀暁子, 平林容子

医薬品医療機器レギュラトリーサイエンス 51 ( 8 ) 364 - 377 2020.8（ ISSN:1884-6076 ）

アルファ線核医学治療のための薬剤開発の考察(その3)

矢野恒夫, 長谷川功紀, 角永悠一郎, 樺山一哉, 小田敬, 上野悟史, 蜂須賀暁子, 平林容子, 深瀬浩一

医薬品医療機器レギュラトリーサイエンス 50 ( 12 ) 749 - 763 2019.12（ ISSN:1884-6076 ）

国内未承認RI内用療法に関する海外動向ならびに国内導入に向けた臨床サイドから見たニーズ・問題点に関する調査研究

福島和人, 高野祥子, 長谷川功紀, 野上宗伸, 日向信之, 樋口隆弘

核医学 56 ( 1 ) 77 - 79 2019.6（ ISSN:0022-7854 ）

A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E.

Takashi Ohgita, Yuki Takechi-Haraya, Ryo Nadai, Mana Kotani, Yuki Tamura, Karin Nishikiori, Kazuchika Nishitsuji, Kenji Uchimura, Koki Hasegawa, Kumiko Sakai-Kato, Kenichi Akaji, Hiroyuki Saito

Biochimica et biophysica acta. Biomembranes 1861 ( 3 ) 541 - 549 2019.3（ ISSN:0005-2736 ）

アルファ線核医学治療のための薬剤開発の考察(その2)

矢野恒夫, 長谷川功紀, 佐藤達彦, 蜂須賀暁子, 深瀬浩一, 平林容子

医薬品医療機器レギュラトリーサイエンス 50 ( 3 ) 122 - 134 2019.3（ ISSN:1884-6076 ）

アルファ線核医学治療のための薬剤開発の考察(その1)

矢野恒夫, 長谷川功紀, 蜂須賀暁子, 深瀬浩一, 平林容子

医薬品医療機器レギュラトリーサイエンス 49 ( 10 ) 676 - 684 2018.10（ ISSN:1884-6076 ）

Relationship between the fluorescence intensity of rhodamine-labeled orexin A and the calcium responses in cortical neurons: An in vivo two-photon calcium imaging study.

Saori Ohtani, Satoshi Fujita, Koki Hasegawa, Hiromasa Tsuda, Morio Tonogi, Masayuki Kobayashi

Journal of pharmacological sciences 138 ( 1 ) 76 - 82 2018.9（ ISSN:1347-8613 ）

Expression of Draxin in Lung Carcinomas.

Younosuke Sato, Akira Matsuo, Shinji Kudoh, Liu Fang, Koki Hasegawa, Yohei Shinmyo, Takaaki Ito

Acta histochemica et cytochemica 51 ( 1 ) 53 - 62 2018.2（ ISSN:0044-5991 ）

Improved 68 Ga-labeling method using ethanol addition: Application to the α-helical peptide DOTA-FAMP.

Koki Hasegawa, Emi Kawachi, Yoshinari Uehara, Tsuyoshi Yoshida, Satoshi Imaizumi, Masahiro Ogawa, Shin-Ichiro Miura, Keijiro Saku

Journal of labelled compounds & radiopharmaceuticals 60 ( 1 ) 55 - 61 2017.1（ ISSN:0362-4803 ）

Somatostatin receptor staining in FFPE sections using a ligand derivative dye as an alternative to immunostaining.

Koki Hasegawa, Shinji Kudoh, Takaaki Ito

PloS one 12 ( 2 ) e0172030 - e0172030 2017（ ISSN:1932-6203 ）

Hybrid Light Imaging Using Cerenkov Luminescence and Liquid Scintillation for Preclinical Optical Imaging In Vivo.

Masako Shimamoto, Kumiko Gotoh, Koki Hasegawa, Akihiro Kojima

Molecular imaging and biology 18 ( 4 ) 500 - 9 2016.8（ ISSN:1536-1632 ）

Visualization and Quantitative Assessment of the Brain Distribution of Insulin through Nose-to-Brain Delivery Based on the Cell-Penetrating Peptide Noncovalent Strategy.

Noriyasu Kamei, Tomotaka Shingaki, Yousuke Kanayama, Misa Tanaka, Riyo Zochi, Koki Hasegawa, Yasuyoshi Watanabe, Mariko Takeda-Morishita

Molecular pharmaceutics 13 ( 3 ) 1004 - 11 2016.3（ ISSN:1543-8384 ）

Iodine-131 imaging using 284 keV photons with a small animal CZT-SPECT system dedicated to low-medium-energy photon detection.

Akihiro Kojima, Kumiko Gotoh, Masako Shimamoto, Koki Hasegawa, Seiji Okada

Annals of nuclear medicine 30 ( 2 ) 169 - 75 2016.2（ ISSN:0914-7187 ）

Notch1 controls cell chemoresistance in small cell lung carcinoma cells.

Wael Abdo Hassan, Ryoji Yoshida, Shinji Kudoh, Hiroki Kameyama, Koki Hasegawa, Kanako Niimori-Kita, Takaaki Ito

Thoracic cancer 7 ( 1 ) 123 - 8 2016.1（ ISSN:1759-7706 ）

Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer.

Kosuke Fujino, Yamato Motooka, Wael A Hassan, Mohamed O Ali Abdalla, Yonosuke Sato, Shinji Kudoh, Koki Hasegawa, Kanako Niimori-Kita, Hironori Kobayashi, Ichiro Kubota, Joeji Wakimoto, Makoto Suzuki, Takaaki Ito

The American journal of pathology 185 ( 12 ) 3164 - 77 2015.12（ ISSN:0002-9440 ）

Notch1 controls cell invasion and metastasis in small cell lung carcinoma cell lines.

Wael Abdo Hassan, Ryoji Yoshida, Shinji Kudoh, Koki Hasegawa, Kanako Niimori-Kita, Takaaki Ito

Lung cancer (Amsterdam, Netherlands) 86 ( 3 ) 304 - 10 2014.12（ ISSN:0169-5002 ）

Notch1 signaling controls cell proliferation, apoptosis and differentiation in lung carcinoma

Hassan Wael, Ryoji Yoshida, Shinji Kudoh, Kohki Hasegawa, Kanako Niimori-Kita, Takaaki Ito

Lung Cancer 85 ( 2 ) 131 - 140 2014.8（ ISSN:0169-5002 ）

Bromodeoxyuridine (BrdU)-label-retaining cells in mouse terminal bronchioles

Kameyama, H., Kudoh, S., Udaka, N., Kagayama, M., Hassan, W., Hasegawa, K., Niimori-Kita, K., Ito, T.

Histology and Histopathology 29 ( 5 ) 659 - 668 2014（ ISSN:0213-3911 ）

Identification of nuclear phosphoproteins as novel tobacco markers in mouse lung tissue following short-term exposure to tobacco smoke.

Kanako Niimori-Kita, Kiyoshi Ogino, Sayaka Mikami, Shinji Kudoh, Daikai Koizumi, Noritaka Kudoh, Fumiko Nakamura, Masahiro Misumi, Tadasuke Shimomura, Koki Hasegawa, Fumihiko Usui, Noriyuki Nagahara, Takaaki Ito

FEBS open bio 4 746 - 54 2014（ ISSN:2211-5463 ）

Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with 68Ga-DOTA-octreotide: a potential PET tracer for beta cell mass measurement.

Takeo Sako, Koki Hasegawa, Mie Nishimura, Yousuke Kanayama, Yasuhiro Wada, Emi Hayashinaka, Yilong Cui, Yosky Kataoka, Michio Senda, Yasuyoshi Watanabe

Biochemical and biophysical research communications 442 ( 1-2 ) 79 - 84 2013.12（ ISSN:0006-291X ）

64Cu-DOTA-trastuzumab PET imaging in patients with HER2-positive breast cancer.

Kenji Tamura, Hiroaki Kurihara, Kan Yonemori, Hitoshi Tsuda, Junko Suzuki, Yuzuru Kono, Natsuki Honda, Makoto Kodaira, Harukaze Yamamoto, Mayu Yunokawa, Chikako Shimizu, Koki Hasegawa, Yousuke Kanayama, Satoshi Nozaki, Takayuki Kinoshita, Yasuhiro Wada, Shusaku Tazawa, Kazuhiro Takahashi, Yasuyoshi Watanabe, Yasuhiro Fujiwara

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 54 ( 11 ) 1869 - 75 2013.11（ ISSN:0161-5505 ）

Comparison of 68Ga and 64Cu for Molecular Imging of Atherosclerosis using apo A-I mimetic Peptide FAMP

Eiji Yahiro, Yoshinari Uehara, Emi Kawachi, Koki Hasegawa, Setsuko Ando, Shin-ichiro Miura, Keijiro Saku

CIRCULATION 128 ( 22 ) 2013.11（ ISSN:0009-7322 ）

Detection of early stage atherosclerotic plaques using PET and CT fusion imaging targeting P-selectin in low density lipoprotein receptor-deficient mice

Ikuko Nakamura, Koki Hasegawa, Yasuhiro Wada, Tetsuaki Hirase, Koichi Node, Yasuyoshi Watanabe

Biochemical and Biophysical Research Communications 433 ( 1 ) 47 - 51 2013.3（ ISSN:0006-291X ）

Novel molecular imaging of atherosclerosis with Gallium-68-labeled Apolipoprotein A-I mimetic peptide and positron emission tomography

Emi Kawachi, Yoshinari Uehara, Koki Hasegawa, Eiji Yahiro, Setsuko Ando, Yasuhiro Wada, Tsuneo Yano, Hiroaki Nishikawa, Masashi Shiomi, Shin ichiro Miura, Yasuyoshi Watanabe, Keijiro Saku

Circulation Journal 77 ( 6 ) 1482 - 1489 2013（ ISSN:1346-9843 ）

Cu-64-DOTA-trastuzumab-PET imaging in patients with HER2-positive breast cancer

Kenji Tamura, Hiroaki Kurihara, Kan Yonemori, Kazuhiro Takahashi, Yasuhiro Wada, Koki Hasegawa, Fumiaki Koizumi, Hitoshi Tsuda, Makoto Kodaira, Mayu Yunokawa, Chikako Shimizu, Masashi Ando, Yasuyoshi Watanabe, Yasuhiro Fujiwara

JOURNAL OF CLINICAL ONCOLOGY 30 ( 15 ) 2012.5（ ISSN:0732-183X ）

The feasibility study of 64Cu-DOTA-trastuzumab PET imaging in patients with HER2-positive breast cancer

Yonemori, Kan, Tamura, Kenji, Kurihara, Hiroaki, Kono, Yuzuru, Arai, Yasuaki, Wada, Yasuhiro, Takahashi, Kazuhiro, Hasegawa, Koki, Watanabe, Yasuyoshi, Fujiwara, Yasuhiro

JOURNAL OF NUCLEAR MEDICINE 53 2012.5（ ISSN:0161-5505 ）

抗体医薬及び核酸医薬などバイオPET薬剤の安全性評価のための考察

矢野恒夫, 豊田浩士, 長谷川功紀, 野崎聡, 中村郁子, 片岡洋祐

医薬品医療機器レギュラトリーサイエンス 43 ( 2 ) 116 - 122 2012.2（ ISSN:1884-6076 ）

Novel System for the Molecular Imaging of Atherosclerotic Plaque with Ga-68-DOTA-ApoA-I Mimetic Peptide (-FAMP)

Eiji Yahiro, Yoshinari Uehara, Koki Hasegawa, Emi Kawachi, Tsuneo Yano, Yasuyoshi Watanabe, Shin-ichiro Miura, Keijiro Saku

CIRCULATION 124 ( 21 ) 2011.11（ ISSN:0009-7322 ）

理研CMISにおける64Cu-DOTA-Trastuzumab注射液の治験薬GMP製造への取り組み

田沢周作, 長谷川功紀, 高橋和弘, 矢野恒夫, 渡辺恭良

PHARM TECH JAPAN 27 ( 3 ) 431 - 440 2011.3（ ISSN:0910-4739 ）

Current Practice of producing Cu-64-DOTA-Trastuzumab Injections in RIKEN CMIS according to GMP for Investigational Products

Shusaku Tazawa, Koki Hasegawa, Yousuke Kanayama, Riyo Zochi, Yoko Morimoto, Kazutaka Hayashi, Akiko Tachibana, Kazuhiro Takahashi, Tsuneo Yano, Yasuyoshi Watanabe

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 54 S160 - S160 2011（ ISSN:0362-4803 ）

Noninvasive imaging of dendrimer-type N-glycan clusters: In vivo dynamics dependence on oligosaccharide structure

Katsunori Tanaka, Eric R.O. Siwu, Kaori Minami, Koki Hasegawa, Satoshi Nozaki, Yousuke Kanayama, Koichi Koyama, Weihsu C. Chen, James C. Paulson, Yasuyoshi Watanabe, Koichi Fukase

Angewandte Chemie - International Edition 49 ( 44 ) 8195 - 8200 2010.10（ ISSN:1433-7851 ）

Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography

Noriyasu Kamei, M. Morishita Mariko, Yousuke Kanayama, Koki Hasegawa, Mie Nishimura, Emi Hayashinaka, Yasuhiro Wada, Yasuyoshi Watanabe, Kozo Takayama

Journal of Controlled Release 146 ( 1 ) 16 - 22 2010.8（ ISSN:0168-3659 ）

抗体医薬におけるmolecular imaging

長谷川功紀, 渡辺恭良

腫瘍内科 6 ( 1 ) 86 - 92 2010.7（ ISSN:1881-6568 ）

First Positron Emission Tomography (PET) Imaging of Glycoproteins and Glycodendrimers by Efficient Chemical Labeling with [Ga-68]-DOTA

Katsunori Tanaka, Eric Richard Oktavianus Siwu, Kaori Minami, Koki Hasegawa, Yousuke Kanayama, Hiroshi Mizuma, Yasuhiro Wada, Yasuyoshi Watanabe, Koichi Fukase

GLYCOBIOLOGY 18 ( 11 ) 981 - 981 2008.11（ ISSN:0959-6658 ）

A submicrogram-scale protocol for biomolecule-based PET imaging by rapid 6π-azaelectrocyclization: Visualization of sialic acid dependent circulatory residence of glycoproteins

Katsunori Tanaka, Tatsuro Masuyama, Koki Hasegawa, Tsuyoshi Tahara, Hiroshi Mizuma, Yasuhiro Wada, Yasuyoshi Watanabe, Koichi Fukase

Angewandte Chemie - International Edition 47 ( 1 ) 102 - 105 2008（ ISSN:1433-7851 ）

Synthesis of an olefin-containing cyclic peptide using the solid-phase Horner-Emmons reaction

Jeong Kyu Bang, Koki Hasegawa, Toru Kawakami, Saburo Aimoto, Kenichi Akaji

Tetrahedron Letters 45 ( 1 ) 99 - 102 2004.1（ ISSN:0040-4039 ）

Preparation of phosphopeptide thioesters by Fmoc- and Fmoc(2-F)-solid phase synthesis

Koki Hasegawa, Yin Lin Sha, Jeong Kyu Bang, Toru Kawakami, Kenichi Akaji, Saburo Aimoto

Letters in Peptide Science 8 ( 3-5 ) 277 - 284 2001.5（ ISSN:0929-5666 ）

Polypeptide synthesis using an expressed peptide as a building block for condensation with a peptide thioester: Application to the synthesis of phosphorylated p21Max protein(1-101)

Toru Kawakami, Koki Hasegawa, Kenta Teruya, Kenichi Akaji, Masataka Horiuchi, Fuyuhiko Inagaki, Yasuyuki Kurihara, Seiichi Uesugi, Saburo Aimoto

Journal of Peptide Science 7 ( 9 ) 474 - 487 2001（ ISSN:1075-2617 ）

Polypeptide synthesis using an expressed peptide as a building block via the thioester method

Toru Kawakami, Koki Hasegawa, Kenta Teruya, Kenichi Akaji, Masataka Horiuchi, Fuyuhiko Inagaki, Yasuyuki Kurihara, Seiichi Uesugi, Saburo Aimoto

Tetrahedron Letters 41 ( 15 ) 2625 - 2628 2000.4（ ISSN:0040-4039 ）

Synthesis of a phosphorylated polypeptide by a thioester method

Toru Kawakami, Koki Hasegawa, Saburo Aimoto

Bulletin of the Chemical Society of Japan 73 ( 1 ) 197 - 203 2000.1（ ISSN:0009-2673 ）

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Papers - HASEGAWA Koki