研究者詳細 - 中嶋　正太郎

論文 - 中嶋　正太郎

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The tumor cell-intrinsic cGAS-STING pathway is associated with the high density of CD8(+) T cells after chemotherapy in esophageal squamous cell carcinoma.

Matsuishi A, Nakajima S, Kaneta A, Saito K, Fukai S, Sakuma M, Tsumuraya H, Okayama H, Saito M, Mimura K, Nirei A, Kikuchi T, Hanayama H, Saze Z, Sakamoto W, Momma T, Kono K

Esophagus : official journal of the Japan Esophageal Society 21 ( 2 ) 165 - 175 2024年2月（ ISSN:1612-9059 ）

Down-regulation of stimulator of interferon genes (STING) expression and CD8(+) T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer.

Fukai S, Nakajima S, Saito M, Saito K, Kase K, Nakano H, Sato T, Sakuma M, Kaneta A, Okayama H, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26 ( 6 ) 878 - 890 2023年8月（ ISSN:1436-3291 ）

High levels of tumor cell-intrinsic STING signaling are associated with increased infiltration of CD8(+) T cells in dMMR/MSI-H gastric cancer.

Kanoda R, Nakajima S, Fukai S, Saito M, Saito K, Suzuki H, Kikuchi T, Nirei A, Okayama H, Mimura K, Hanayama H, Sakamoto W, Momma T, Saze Z, Kono K

Scientific reports 14 ( 1 ) 20859 2024年9月

The impact of CLDN18.2 expression on effector cells mediating antibody-dependent cellular cytotoxicity in gastric cancer.

Matsuishi A, Nakajima S, Saito M, Saito K, Fukai S, Tsumuraya H, Kanoda R, Kikuchi T, Nirei A, Kaneta A, Okayama H, Mimura K, Hanayama H, Sakamoto W, Momma T, Saze Z, Kono K

Scientific reports 14 ( 1 ) 17916 2024年8月

Tumor Infiltrating Effector Regulatory T Cells Express VEGF Receptor 2 in Patients With Colorectal Cancer.

Tsumuraya H, Mimura K, Nakajima S, Hanayama H, Matsuishi A, Okayama H, Fukai S, Ito M, Ashizawa M, Chida S, Onozawa H, Sakamoto W, Saito M, Saze Z, Momma T, Kono K

Anticancer research 44 ( 7 ) 2933 - 2941 2024年7月

α7 nicotinic acetylcholine receptor agonist attenuates allergen-induced immediate nasal response in murine model of allergic rhinitis.

Yamashita S, Miura K, Matsuura A, Yamasaki N, Uda N, Ogata S, Hosomi N, Nakajima S, Kitamura N, Gotoh M, Mori A, Kaminuma O

The Journal of veterinary medical science 86 ( 7 ) 824 - 827 2024年6月（ ISSN:0916-7250 ）

食道癌の腫瘍免疫微小環境

中嶋正太郎, 河野浩二

日本臨牀食道癌2024ー基礎・臨床の最新動向ー 82 ( 3 ) 90 - 95 2024年5月

TIM-3 Expression on Dendritic Cells in Colorectal Cancer.

Sakuma M, Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Fukai S, Tsumuraya H, Onozawa H, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

Cancers 16 ( 10 ) 1888 - 1888 2024年5月（ ISSN:2072-6694 ）

TGFβ-Responsive Stromal Activation Occurs Early in Serrated Colorectal Carcinogenesis.

Tsumuraya H, Okayama H, Katagata M, Matsuishi A, Fukai S, Ito M, Sakamoto W, Saito M, Momma T, Nakajima S, Mimura K, Kono K

International journal of molecular sciences 25 ( 9 ) 4626 - 4626 2024年4月

Biomarker-oriented chemo-immunotherapy for advanced gastric cancer.

Kono K, Nakajima S, Mimura K

International journal of clinical oncology 29 ( 7 ) 865 - 872 2024年4月（ ISSN:1341-9625 ）

Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer.

Mimura K, Ogata T, Nguyen PHD, Roy S, Kared H, Yuan YC, Fehlings M, Yoshimoto Y, Yoshida D, Nakajima S, Sato H, Machida N, Yamada T, Watanabe Y, Tamaki T, Fujikawa H, Inokuchi Y, Hayase S, Hanayama H, Saze Z, Katoh H, Takahashi F, Oshima T, Goel A, Nardin A, Suzuki Y, Kono K

Journal for immunotherapy of cancer 12 ( 1 ) e008385 2024年1月

TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer.

Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

Cancers 20 ( 15 ) 4943 2023年10月（ ISSN:2072-6694 ）

放射線治療による腫瘍細胞内cGAS-STING経路を介した食道扁平上皮癌微小環境の変化

中嶋正太郎, 三村耕作, 金田晃尚, 片方雅紀, 岡山洋和, 齋藤元伸, 佐瀬善一郎, 花山寛之, 多田武志, 門馬智之, 河野浩二

癌と化学療法 50 ( 10 ) 1099 - 1101 2023年10月

[Remodeling of the Tumor Microenvironment by Radiotherapy through the cGAS-STING Pathway in Esophageal Squamous Cell Carcinoma].

Nakajima S, Mimura K, Kaneta A, Katagata M, Okayama H, Saito M, Saze Z, Hanayama H, Tada T, Momma T, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 50 ( 10 ) 1099 - 1101 2023年10月（ ISSN:0385-0684 ）

放射線治療による腫瘍細胞内cGAS-STING経路を介した食道扁平上皮癌微小環境の変化

中嶋正太郎, 三村耕作, 金田晃尚, 片方雅紀, 岡山洋和, 齋藤元伸, 佐瀬善一郎, 花山寛之, 多田武志, 門馬智之, 河野浩二

癌と化学療法 50 ( 10 ) 1099 - 1101 2023年10月（ ISSN:0385-0684 ）

cGAS‒STING 経路を標的とした大腸癌の新規治療戦略の可能性

中嶋正太郎, 金田晃尚, 河野浩二

癌と化学療法 50 ( 9 ) 950 - 954 2023年9月（ ISSN:0385-0684 ）

[The Potential of a Novel Therapeutic Strategy for Colorectal Cancer Targeting the cGAS-STING Pathway].

Nakajima S, Kaneta A, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 50 ( 9 ) 950 - 954 2023年9月（ ISSN:0385-0684 ）

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer.

Mimura K, Ogata T, Yoshimoto Y, Yoshida D, Nakajima S, Sato H, Machida N, Yamada T, Watanabe Y, Tamaki T, Fujikawa H, Inokuchi Y, Hayase S, Hanayama H, Saze Z, Katoh H, Takahashi F, Oshima T, Suzuki Y, Kono K

Communications medicine 3 ( 1 ) 111 - 111 2023年8月

Down-regulation of stimulator of interferon genes (STING) expression and CD8(+) T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer.

Fukai S, Nakajima S, Saito M, Saito K, Kase K, Nakano H, Sato T, Sakuma M, Kaneta A, Okayama H, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K

Gastric cancer 26 ( 6 ) 878 - 890 2023年8月

A Potential Biomarker of Dynamic Change in Peripheral CD45RA(-)CD27(+)CD127(+) Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma.

Sakuma M, Mimura K, Nakajima S, Kaneta A, Kikuchi T, Nirei A, Tada T, Hanayama H, Okayama H, Sakamoto W, Saito M, Momma T, Saze Z, Kono K

Cancers 15 ( 14 ) 3641 2023年7月（ ISSN:2072-6694 ）

The Impact of Tumor Cell-Intrinsic Expression of Cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) on the Infiltration of CD8(+) T Cells and Clinical Outcomes in Mismatch Repair Proficient/Microsatellite Stable Colorectal Cancer.

Nakajima S, Kaneta A, Okayama H, Saito K, Kikuchi T, Endo E, Matsumoto T, Fukai S, Sakuma M, Sato T, Mimura K, Saito M, Saze Z, Sakamoto W, Onozawa H, Momma T, Kono K

Cancers 15 ( 10 ) 2826 2023年5月（ ISSN:2072-6694 ）

Radiation-Induced Remodeling of the Tumor Microenvironment Through Tumor Cell-Intrinsic Expression of cGAS-STING in Esophageal Squamous Cell Carcinoma.

Nakajima S, Mimura K, Kaneta A, Saito K, Katagata M, Okayama H, Saito M, Saze Z, Watanabe Y, Hanayama H, Tada T, Sakamoto W, Momma T, Ohira H, Kono K

International journal of radiation oncology, biology, physics 115 ( 4 ) 957 - 971 2023年3月（ ISSN:0360-3016 ）

M2 tumor-associated macrophages resist to oxidative stress through heme oxygenase-1 in the colorectal cancer tumor microenvironment.

Ito M, Mimura K, Nakajima S, Okayama H, Saito K, Nakajima T, Kikuchi T, Onozawa H, Fujita S, Sakamoto W, Saito M, Momma T, Saze Z, Kono K

Cancer immunology, immunotherapy : CII 72 ( 7 ) 2233 - 2244 2023年3月（ ISSN:0340-7004 ）

ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer.

Sato T, Saito M, Nakajima S, Saito K, Katagata M, Fukai S, Okayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26 ( 3 ) 379 - 392 2023年2月（ ISSN:1436-3291 ）

用語解説

中嶋正太郎

分子細胞免疫学原著第10版アバス-リックマン-ピレ 535 - 564 2023年1月

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer.

Cancer medicine 3 ( 1 ) 111 2023年

TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer.

Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

Cancers 15 ( 20 ) 4943 2023年

cGAS-STING経路を標的とした大腸癌の新規治療戦力の可能性

中嶋正太郎, 金田晃尚, 河野浩二

癌と化学療法 50 ( 9 ) 950 - 954 2023年

Radiation-Induced Remodeling of the Tumor Microenvironment Through Tumor Cell-Intrinsic Expression of cGAS-STING in Esophageal Squamous Cell Carcinoma.

Nakajima S, Mimura K, Kaneta A, Saito K, Katagata M, Okayama H, Saito M, Saze Z, Watanabe Y, Hanayama H, Tada T, Sakamoto W, Momma T, Ohira H, Kono K

International journal of radiation oncology, biology, physics 115 ( 4 ) 957 - 971 2022年11月（ ISSN:0360-3016 ）

[Expression of the cGAS-STING Pathway in dMMR/MSI-H in Colorectal Cancer].

Kaneta A, Nakajima S, Mimura K, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 49 ( 10 ) 1130 - 1132 2022年10月（ ISSN:0385-0684 ）

dMMR/MSI-H大腸癌におけるcGAS-STING経路の発現

金田晃尚，中嶋正太郎，三村耕作，河野浩二

癌と化学療法 49 ( 10 ) 1130 - 1132 2022年10月

Immune escape mechanism behind resistance to anti-PD-1 therapy in gastrointestinal tract metastasis in malignant melanoma patients with multiple metastases

Ito M, Mimura K, Nakajima S, Saito K, Min AKT, Okayama H, Saito M, Momma T, Saze Z, Ohtsuka M, Yamamoto T, Kono K.

Cancer Immunol Immunother. 71 ( 9 ) 2293 - 2300 2022年9月

Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR/MSI colorectal cancer.

Kaneta A, Nakajima S, Okayama H, Matsumoto T, Saito K, Kikuchi T, Endo E, Ito M, Mimura K, Kanke Y, Saito M, Saze Z, Fujita S, Sakamoto W, Onozawa H, Momma T, Ohki S, Kono K

Cancer immunology, immunotherapy : CII 71 ( 11 ) 2765 - 2776 2022年4月（ ISSN:0340-7004 ）

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K

British journal of cancer 126 ( 6 ) 917 - 926 2022年4月（ ISSN:0007-0920 ）

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K

Br J Cancer 126 ( 6 ) 917 - 926 2022年4月

Immune escape mechanism behind resistance to anti-PD-1 therapy in gastrointestinal tract metastasis in malignant melanoma patients with multiple metastases.

Ito M, Mimura K, Nakajima S, Saito K, Min AKT, Okayama H, Saito M, Momma T, Saze Z, Ohtsuka M, Yamamoto T, Kono K

Cancer immunology, immunotherapy : CII 71 ( 9 ) 2293 - 2300 2022年1月（ ISSN:0340-7004 ）

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K

Br J Cancer 2021年12月

Immunotherapy Targeting Tumor-Associated Carbohydrate Antigens in Deficient Mismatch Repair Colorectal Cancer

Matsumoto T, Okayama H, Nakano H, Ito M, Nakajima S, Saito M, Saze Z, Momma T, Mimura K, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 48 ( 10 ) 1275 - 1277 2021年10月（ ISSN:03850684 ）

ミスマッチ修復機構欠損大腸癌における糖鎖抗原を標的とした免疫療法の可能性

松本拓朗, 岡山洋和, 仲野宏, 伊藤美郷, 中嶋正太郎, 齋藤元伸, 佐瀬善一郎, 門馬智之, 三村耕作, 河野浩二

癌と化学療法 48 ( 10 ) 1275 - 1277 2021年10月（ ISSN:0385-0684 ）

The Expression of Immune Checkpoint Receptors and Ligands in the Colorectal Cancer Tumor Microenvironment.

Neupane P, Mimura K, Nakajima S, Okayama H, Ito M, Thar Min AK, Saito K, Onozawa H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Kono K

Anticancer research 41 ( 10 ) 4895 - 4905 2021年10月（ ISSN:0250-7005 ）

The effects of T-DXd on the expression of HLA class I and chemokines CXCL9/10/11 in HER2-overexpressing gastric cancer cells.

Nakajima S, Mimura K, Matsumoto T, Thar Min AK, Ito M, Nakano H, Neupane P, Kanke Y, Okayama H, Saito M, Momma T, Watanabe Y, Hanayama H, Hayase S, Saze Z, Kono K

Scientific reports 11 ( 1 ) 16891 - 16891 2021年8月

Chemoradiation induces upregulation of immunogenic cell death-related molecules together with increased expression of PD-L1 and galectin-9 in gastric cancer.

Petersen SH, Kua LF, Nakajima S, Yong WP, Kono K.

Scientific Reports 11 ( 1 ) 12264 - 12264 2021年6月

Stromal expression of cancer-associated fibroblast-related molecules, versican and lumican, is strongly associated with worse relapse-free and overall survival times in patients with esophageal squamous cell carcinoma.

Yamauchi N, Kanke Y, Saito K, Okayama H, Yamada S, Nakajima S, Endo E, Kase K, Yamada L, Nakano H, Matsumoto T, Hanayama H, Watanabe Y, Hayase S, Saito M, Saze Z, Mimura K, Momma T, Oki S, Hashimoto Y, Kono K

Oncology letters 21 ( 6 ) 445 - 445 2021年6月（ ISSN:1792-1074 ）

Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma.

Nakajima S, Mimura K, Saito K, Thar Min AK, Endo E, Yamada L, Kase K, Yamauchi N, Matsumoto T, Nakano H, Kanke Y, Okayama H, Saito M, Neupane P, Saze Z, Watanabe Y, Hanayama H, Hayase S, Kaneta A, Momma T, Ohki S, Ohira H, Kono K

Molecular cancer research : MCR 19 ( 6 ) 1085 - 1095 2021年6月（ ISSN:1541-7786 ）

ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation.

Kase K, Saito M, Nakajima S, Takayanagi D, Saito K, Yamada L, Ashizawa M, Nakano H, Hanayama H, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Shiraishi K, Kohno T, Kono K

Carcinogenesis 42 ( 1 ) 21 - 30 2021年2月（ ISSN:0143-3334 ）

Therapeutic potential of anti-VEGF receptor 2 therapy targeting for M2-tumor-associated macrophages in colorectal cancer.

Min AKT, Mimura K, Nakajima S, Okayama H, Saito K, Sakamoto W, Fujita S, Endo H, Saito M, Saze Z, Momma T, Ohki S, Kono K

Cancer immunology, immunotherapy : CII 70 ( 2 ) 289 - 298 2021年2月（ ISSN:0340-7004 ）

PD-L1 overexpression in EBV-positive gastric cancer is caused by unique genomic or epigenomic mechanisms.

Nakano H, Saito M, Nakajima S, Saito K, Nakayama Y, Kase K, Yamada L, Kanke Y, Hanayama H, Onozawa H, Okayama H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Goto A, Kono K

Scientific reports 11 ( 1 ) 1982 - 1982 2021年1月

Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer.

Yamada L, Saito M, Thar Min AK, Saito K, Ashizawa M, Kase K, Nakajima S, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 24 ( 1 ) 60 - 71 2021年1月（ ISSN:1436-3291 ）

ARID1A欠損胃癌における合成致死に基づいたEZH2阻害剤の選択的感受性(Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer)

Yamada Leo, Saito Motonobu, Aung Kyi Thar Min , Saito Katsuharu, Ashizawa Mai, Kase Koji, Nakajima Shotaro, Onozawa Hisashi, Okayama Hirokazu, Endo Hisahito, Fujita Shotaro, Sakamoto Wataru, Saze Zenichiro, Momma Tomoyuki, Mimura Kosaku, Ohki Shinji, Kono Koji

Gastric Cancer 24 ( 1 ) 60 - 71 2021年1月（ ISSN:1436-3291 ）

Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice.

Nakajima S, Manita S, Yu G, Ishimaru K, Kono K, Kitamura K, Nakao A

Allergy 75 ( 12 ) 3275 - 3279 2020年12月（ ISSN:0105-4538 ）

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer.

Matsumoto T, Okayama H, Nakajima S, Saito K, Nakano H, Endo E, Kase K, Ito M, Yamauchi N, Yamada L, Kanke Y, Onozawa H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

International journal of molecular sciences 21 ( 23 ) 9081 - 9081 2020年11月（ ISSN:16616596 ）

A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Colorectal Cancer.

Endo E, Okayama H, Saito K, Nakajima S, Yamada L, Ujiie D, Kase K, Fujita S, Endo H, Sakamoto W, Saito M, Saze Z, Momma T, Ohki S, Mimura K, Kono K

Molecular cancer research : MCR 18 ( 9 ) 1402 - 1413 2020年9月（ ISSN:1541-7786 ）

Current status of immune checkpoint inhibitors for gastric cancer.

Kono K, Nakajima S, Mimura K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 23 ( 4 ) 565 - 578 2020年7月（ ISSN:1436-3291 ）

Current status of immune checkpoint inhibitors for gastric cancer(和訳中)

Kono Koji, Nakajima Shotaro, Mimura Kosaku

Gastric Cancer 23 ( 4 ) 565 - 578 2020年7月（ ISSN:1436-3291 ）

cutting-edge medicineがん診療の副作用マネジメント　複合がん免疫療法の発展を目指して

中嶋正太郎, 河野浩二

Precision Medicine 3 ( 4 ) 299 - 302 2020年4月（ ISSN:2434-3625 ）

巻頭グラビア複合がん免疫療法の発展を目指して

中嶋正太郎, 河野浩二

プレシジョンメディシン 2020年4月号 ( 4 ) 1 - 4 2020年3月

Changes in the mental health status of adolescents following the Fukushima Daiichi nuclear accident and related factors: Fukushima Health Management Survey.

Hayashi F, Sanpei M, Ohira T, Nakano H, Okazaki K, Yasumura S, Nakajima S, Yabe H, Suzuki Y, Kamiya K, Fukushima Health Management Survey Group

Journal of affective disorders 260 432 - 439 2020年1月（ ISSN:0165-0327 ）

第10 章腫瘍免疫学と移植免疫学がん細胞と正常非自己細胞に対する免疫応答

中尾篤人，井上修，氏家大輔，内田萌菜，柏木麻里子，香山尚子，河合利尚，木村元子，河野浩二，佐藤卓哉，竹田潔，中嶋正太郎，中野信浩，中山俊憲，中山勝文，廣瀬晃一，穂積勝人，村上正晃，村上悠二，八木良二，松嶋綱治，山田幸宏

基礎免疫学原著第6 版免疫系の機能とその異常 185 - 205 2020年

The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock.

Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A

International journal of molecular sciences 20 ( 24 ) 2019年12月（ ISSN:16616596 ）

Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.

Nakajima S, Ishimaru K, Kobayashi A, Yu G, Nakamura Y, Oh-Oka K, Suzuki-Inoue K, Kono K, Nakao A

Scientific reports 9 ( 1 ) 18423 2019年12月

The frequency of Th17 cells in the small intestine exhibits a day-night variation dependent on circadian clock activity.

Ha Pham Thu Le, Yuki Nakamura, Kyoko Oh-Oka, Kayoko Ishimaru, Shotaro Nakajima, Atsuhito Nakao

Biochemical and biophysical research communications 490 ( 2 ) 290 - 295 2017年8月

Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor.

Kyoko Oh-Oka, Yuko Kojima, Koichiro Uchida, Kimiko Yoda, Kayoko Ishimaru, Shotaro Nakajima, Jun Hemmi, Hiroshi Kano, Yoshiaki Fujii-Kuriyama, Ryohei Katoh, Hiroyuki Ito, Atsuhito Nakao

Cellular and molecular gastroenterology and hepatology 4 ( 1 ) 135 - 151 2017年7月

Upregulation of thioredoxin-1 in activated human NK cells confers increased tolerance to oxidative stress.

Mimura K, Kua LF, Shimasaki N, Shiraishi K, Nakajima S, Siang LK, Shabbir A, So J, Yong WP, Kono K

Cancer immunology, immunotherapy : CII 66 ( 5 ) 605 - 613 2017年5月（ ISSN:0340-7004 ）

Selective deletion of adipocytes, but not preadipocytes, by TNF-α through C/EBP- and PPARγ-mediated suppression of NF-κB.

Minori Tamai, Tsuyoshi Shimada, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Yasuhiro Tagawa, Shuhei Takahashi, Shotaro Nakajima, Jian Yao, Masanori Kitamura

Laboratory investigation; a journal of technical methods and pathology 97 ( 2 ) 228 - 228 2017年2月

Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility.

Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K

Journal of gastroenterology 51 ( 12 ) 1101 - 1111 2016年12月（ ISSN:0944-1174 ）

Accumulation of CD11c+CD163+ Adipose Tissue Macrophages through Upregulation of Intracellular 11β-HSD1 in Human Obesity.

Nakajima S, Koh V, Kua LF, So J, Davide L, Lim KS, Petersen SH, Yong WP, Shabbir A, Kono K

Journal of immunology (Baltimore, Md. : 1950) 197 ( 9 ) 3735 - 3745 2016年11月（ ISSN:0022-1767 ）

eIF2α-independent inhibition of TNF-α-Triggered NF-κB activation by salubrinal

Nakajima S., Chi Y., Gao K., Kono K., Yao J.

Biological and Pharmaceutical Bulletin 38 ( 9 ) 1368 - 1374 2015年9月（ ISSN:09186158 ）

Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels - pivotal roles in hemichannel-mediated cell injury.

Yuan Chi, Kun Gao, Kai Li, Shotaro Nakajima, Satoru Kira, Masayuki Takeda, Jian Yao

Journal of cell science 127 ( Pt 7 ) 1487 - 99 2014年4月

Acidic stress-ER stress axis for blunted activation of NF-kappa B in mesothelial cells exposed to peritoneal dialysis fluid (vol 27, pg 4053, 2012)

Hisashi Johno, Ryouji Ogata, Shotaro Nakajima, Nobuhiko Hiramatsu, Tetsuro Kobayashi, Hideaki Hara, Masanori Kitamura

NEPHROLOGY DIALYSIS TRANSPLANTATION 29 ( 2 ) 470 - 470 2014年2月（ ISSN:0931-0509 ）

Bidirectional regulation of NF-κB by reactive oxygen species: a role of unfolded protein response.

Nakajima S, Kitamura M

Free Radic Bio Med 65 162 - 174 2013年12月（ ISSN:0891-5849 ）

Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.

Hui Zhang, Shotaro Nakajima, Hironori Kato, Liubao Gu, Tatsuya Yoshitomi, Kaoru Nagai, Hideyuki Shinmori, Susumu Kokubo, Masanori Kitamura

British journal of pharmacology 170 ( 4 ) 822 - 34 2013年10月

Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.

Liubao Gu, Hisashi Johno, Shotaro Nakajima, Tatsuya Yoshitomi, Shuhei Takahashi, Masanori Kitamura

Toxicological sciences : an official journal of the Society of Toxicology 134 ( 2 ) 345 - 54 2013年8月

Pleiotropic Potential of Dehydroxymethylepoxyquinomicin for NF-kappa B Suppression via Reactive Oxygen Species and Unfolded Protein Response

Shotaro Nakajima, Hironori Kato, Liubao Gu, Shuhei Takahashi, Hisashi Johno, Kazuo Umezawa, Masanori Kitamura

JOURNAL OF IMMUNOLOGY 190 ( 12 ) 6559 - 6569 2013年6月（ ISSN:0022-1767 ）

Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential.

Liubao Gu, Hisashi Johno, Shotaro Nakajima, Hironori Kato, Shuhei Takahashi, Ryohei Katoh, Masanori Kitamura

Laboratory investigation; a journal of technical methods and pathology 93 ( 4 ) 450 - 61 2013年4月

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<中嶋 正太郎>

論文 - 中嶋 正太郎

<中嶋　正太郎>

論文 - 中嶋　正太郎