研究者詳細 - 藤原　一男

論文 - 藤原　一男

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Dynamic changes in patient admission and their disabilities in multiple sclerosis and neuromyelitis optica: a Japanese nationwide administrative data study.

Matsumoto Y, Tarasawa K, Misu T, Namatame C, Takai Y, Kuroda K, Fujihara K, Fushimi K, Fujimori K, Aoki M.

Mult Scler Relat Disord. 81 105349 2024年1月

Myelin oligodendrocyte glycoprotein antibody-associated disorders: an overview.

Misu T, Matsumoto Y, Kaneko K, Takahashi T, Takai Y, Ono H, Namatame C, Nishiyama S, Fujimori J, Kuroda H, Nakashima I, Fujihara K, Aoki M.

Clin Exp Neuroimmunol. 2023年12月

Microfibrillar-associated protein 4 as potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: pathological and clinical aspects.

Samadzadeh S, Olesen MN, Wirenfeldt M, Möller S, Misu T, Soelberg K, Frederiksen JL, Heegaard S, Mariotto S, Fujihara K, Ruprecht K, Andersen TL, Marignier R, Lillevang ST, Flanagan EP, Pittock SJ, Kim HJ, Bennett JL, Friedeman Paul F, Sorensen GL, Weinshenker BG, Lassmann H, Asgari N.

Mult Scler. 29 ( 14 ) 1721 - 1735 2023年10月

Diagnostic implications of MOG-IgG detection in sera and cerebrospinal fluids.

Matsumoto Y, Kaneko K, Takahashi T, Takai Y, Namatame C, Kuroda H, Misu T, Fujihara K, Aoki M.

Brain. 146 ( 9 ) 3938 - 3948 2023年9月

Epidemiology of MOGAD: A review of prevalence and incidence worldwide.

Hor JY, Fujihara K.

Front Neurol. 15 ( 14 ) 1260358 2023年9月

Serum neurofilament light chain levels at attack predict post-attack disability worsening and are mitigated by inebilizumab: analysis of four potential biomarkers in neuromyelitis optica spectrum disorder.

Aktas O, Hartung HP, Smith MA, Rees WA, Fujihara K, Paul F, Marignier R, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Cutter G, She D, Gunsior M, Cimbora D, Katz E, Cree BAC, N-MOmentum study investigators.

J Neurol Neurosurg Psychiatry. 94 ( 9 ) 757 - 768 2023年9月

Efficacy and safety of inebilizumab in Asian participants with neuromyelitis optica spectrum disorder: Subgroup analyses of the N-MOmentum study.

Fujihara K, Kim HJ, Saida T, Misu T, Nagano Y, Totsuka N, Iizuka M, Kido S, Terata R, Okumura K, Hirota S, Cree BAC.

Mult Scler Relat Disord. 79 104938 2023年8月

Differential diagnosis of suspected multiple sclerosis: an updated consensus approach.

Solomon AJ, Arrambide G, Brownlee WJ, Flanagan EP, Amato MP, Amezcua L, Banwell BL, Barkhof F, Corboy JR, Correale J, Fujihara K, Graves J, Harnegie MP, Hemmer B, Lechner-Scott J, Marrie RA, Newsome SD, Rocca MA, Royal W, Waubant EL, Yamout B, Cohen JA.

Lancet Neurol. 22 ( 8 ) 750 - 768 2023年8月

Associations between neuromyelitis optica spectrum disorder, Sjogren's ¨ syndrome, and conditions with electrolyte disturbances.

Akaishi T, Tarasawa K, Matsumoto Y, Sandhya P, Misu T, Fushimie K, Takahashi T, Fujimori J, Ishii T, Fujimori K, Yaegashi N, Nakashima I, Fujihara K, Aoki M.

J Neurol Sci. 452 120742 2023年7月

Time-Dependent Analysis of Sicca Symptoms and Anti-Ro/SSA and Anti-La/SSB Antibodies in Patients with AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder.

Akaishi T, Takahashi T, Misu T, Fujihara K, Nakashima I, Aoki M.

Tohoku J Exp Med. 260 ( 3 ) 215 - 221 2023年7月

Pathology of MOGAD: a comparison with MS and AQP4 antibody-positive NMOSD.

Takai Y, Misu T, Fujihara K, Aoki M.

Front Neurol. 21 ( 14 ) 1209749 2023年7月

Clinical use of dimethyl fumarate in multiple sclerosis treatment: an update to include China, using a modified Delphi method.

Gold R, Barnett M, Chan A, Feng H, Fujihara K, Giovannoni G, Motalban X, Shi FD, Tintore M, Xue Q, Yang C, Zhou H.

Ther Adv Neurol Disord. 14 ( 16 ) 2023年7月

Long-term safety and effectiveness of eculizumab in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: a 2-year interim analysis of post-marketing surveillance in Japan.

Nakashima I, Nakahara J, Yokote H, Manabe Y, Okamura K, Hasegawa K, Fujihara K.

Ther Adv Neurol Disord. 16 2023年6月

Attack adjudication in neuromyelitis optica spectrum disorder: substantiation of criteria by magnetic resonance imaging and biomarkers in N-Momentum.

Weinshenker BG, Wingerchuk DM, Green AJ, Bennett JL, Kim HJ, Pittock SJ, Fujihara K, Paul F, Cutter G, Marignier R, Aktas O, Hartung HP, She D, Smith M, Rees W, Patterson K, Cimbora D, Katz E, Cree BAC, N-MOmentum study investigator.

Mult Scler. 29 ( 8 ) 945 - 955 2023年6月

International Delphi Consensus on the Management of AQP4-IgG+ NMOSD: Recommendations for Eculizumab, Inebilizumab, and Satralizumab.

Paul F, Marignier R, Palace J, Arrambide G, Asgari N, Bennett JL, Cree BAC, De Seze J, Fujihara K, Kim HJ, Hornby R, Huda S, Kissani N, Kleiter I, Kuwabara S, Lana-Peixoto MA, Law L, Leite IS, Pandit L, Pittock SJ, Quan C, Ramanathan S, Rotstein D, Saiz A, Sato DK, Vaknin-Dembinsky A.

Neurol Neuroimmunol Neuroinflamm. 10 ( 4 ) e200124 - e200124 2023年5月

White blood cell count profiles in the acute phase of AQP4-IgG seropositive NMOSD and MOG-IgG-associated disease.

Akaishi T, Misu T, Fujihara K, Nakaya K, Nakaya N, Nakamura T, Kogure M, Hatanaka R, Itabashi F, Kanno I, Kaneko K, Takahashi T, Fujimori J, Takai Y, Nishiyama S, Ishii T, Aoki M, Nakashima I, Hozawa A.

Sci Rep. 13 ( 1 ) 6481 - 6481 2023年4月

Diagnosis of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD): International MOGAD Panel Proposed Criteria.

Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan E, Ramanathan S, Waters P, Tenembaum S, MD, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock S, Fujihara K, Palace J.

Lancet Neurol. 22 ( 3 ) 268 - 282 2023年3月

SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab.

Bennett JL, Fujihara K, Kim HJ, Marignier R, O’Connor KC, Sergott RC, Traboulsee A, Wiendl H, Wuerfel J, Zamvil SS, Anania VG, Buffels R, Künzel T, Lekkerkerker AN, Lennon-Chrimes S, Pittock SJ.

Front Neurol. 17 ( 14 ) 1114667 2023年2月

Contrast-enhanced double inversion recovery sequence for patients with multiple sclerosis: feasibility of subtraction images between pre- and post-contrast images.

Tomura N, Saginoya T, Sanpei T, Konno T, Fujihara K.

Acta Radiol 64 ( 2 ) 719 - 724 2023年2月

A novel association of osmotic demyelination in Sjogren’s syndrome ¨ prompts revisiting role of aquaporins in CNS demyelinating diseases: A literature review.

Sandhya P, Akaishi T, Fujihara K, Aoki M.

Mult Scler Relat Disord. 69 104466 2023年1月

Long-term efficacy of satralizumab in AQP4-IgG-seropositive neuromyelitis optica spectrum disorder (NMOSD) from SAkuraSky and SAkuraStar.

Kleiter I, Traboulsee A, Palace J, Yamamura T, Fujihara K, Saiz A, Javed A, Mayes D, von Büdingen HC, Klingelschmitt G, Stokmaier D, Bennett JL.

Neurol Neuroimmunol Neuroinflamm. 10 ( 1 ) e200071 2022年12月

Diagnosis and classification of optic neuritis.

Petzold A, Fraser C, Abegg M, Alroughani R, Alshowaeir D, Alvarenga R, Andris C, Asgari N, Barnett Y, Battistella R, Behbehani R, Berger T, Bikbov M, Biotti D, Biousse V, Boschi A, Brazdil M, Brezhnev A, Calabresi P, Cordonnier M, Costello F, Cruz FM, Cunha LP, Daoudi S, Deschamps R, DeSeze J, Diem R, Etemadifar M, Flores-Rivera J, Fonseca P, Frederiksen J, Frohman E, Frohman T, Froment Tilikete C, Fujihara K, Gálvez A, Gouider R, Gracia F, Grigoriadis N, Guajardo JM, Habek M, Hawlina M, Hernández Martínez de Lapiscina E, Hooker J, Hor JY, Howlett W, Huang-Link Y, Idrissova Z, Illes Z, Jancic J, Jindahra P, Karussis D, Kerty E, Kim HJ, Lagrèze W, Leocani L, Levin N, Liskova P, Liu Y, Maiga Y, Marignier R, McGuigan C, Meira D, Merle H, Monteiro MLR, Moodley A, Moura F, Muñoz S, Mustafa S, Nakashima I, Noval S, Oehninger C, Ogun O, Omoti A, Pandit L, Paul F, Rebolleda G, Reddel S, Rejdak K, Rejdak R, Rodriguez-Morales A, Rougier MB, Sa MJ, Sanchez-Dalmau B, Saylor D, Shatriah I, Siva A, Stiebel-Kalish H, Szatmary G, Ta L, Tenembaum S, Tran H, Trufanov Y, Van Pesch V, Wang AG, Wattjes M, Willoughby E, Zakaria M, Zvornicanin J, Balcer L, Plant GT.

Lancet Neurol. 21 ( 12 ) 1120 - 1134 2022年12月

Association between B-cell depletion and attack risk in neuromyelitis optica spectrum disorder: An exploratory analysis from N-MOmentum, a double-blind, randomised, placebo-controlled, multicentre phase 2/3 trial.

Bennett JL, Aktas O, Rees WA, Smith MA, Gunsior M, Yan L, She D, Cimbora D, Pittock SJ, Weinshenker BG, Paul F, Marignier R, Wingerchuk D, Cutter G, Green A, Hartung HP, Kim HJ, Fujihara K, Levy M, Katz E, Cree BAC on behalf of the N-MOmentum study investigators.

EBioMedicine. 86 104321 2022年12月

Neuromyelitis Optica Spectrum Disorders in Africa (A Narrative Review of 622 Cases).

Kissani N, Ouadika1 RJB, Kishk NA, Chaymae O, Ibrahim EAA, Maiga Y, Paul R, Daniel GM, Hamid A, Assogba K, Gaye NM, Hor JY, Tegueu CK, Marignier R, Palace J, Weinshenker BG, Ragab AH, Fujiharaa K. Neuromyelitis Optica Spectrum Disorders in Africa (A Narrative Review of 622 Cases).

Open Access Library J. e9649 2022年9月

Relapse activity in the chronic phase of anti-myelin-oligodendrocyte glycoprotein antibody-associated disease.

Akaishi T, Misu T, Fujihara K, Takahashi T, Takai Y, Nishiyama S, Kaneko K, Fujimori J, Ishii T, aoki M, Nakashima I.

J Neurol. 269 ( 6 ) 3136 - 3146 2022年6月

Network Meta-analysis of Food and Drug Administration-approved Treatment Options for Adults with Aquaporin-4 Immunoglobulin G-positive Neuromyelitis Optica Spectrum Disorder.

Wingerchuk DM, Zhang I, Kielhorn A, Royston M, Levy M, Fujihara K, Nakashima I, Tanvir I, Paul F, Pittock SJ.

Neurol Ther. 11 ( 1 ) 123 - 135 2022年5月

Exploring steroid tapering in patients with neuromyelitis optica spectrum disorder treated with satralizumab in SAkuraSky: a case series.

Yamamura T, Araki M, Fujihara K, Okuno T, Misu T, Guo YC, Hemingway C, Matsushima J, Sugaya N, Yamashita M, von Büdingen HC, Miyamoto K.

Mult Scler Relat Disord. 61 103772 2022年5月

RGMa signal in macrophages induces neutrophil-related astrocytopathy in NMO.

4. Iwamoto S, Itokazu T, Sasaki A, Kataoka H, Tanaka S, Hirata T, Miwa K, Suenaga T, Takai Y, Misu T, Fujihara K, Yamashita T.

Ann Neurol. 91 ( 4 ) 532 - 547 2022年4月

Eculizumab monotherapy for NMOSD: Data from PREVENT and its open-label extension.

Pittock SJ, Fujihara K, Palace J, Berthele A, Kim HJ, Oreja-Guevara C, Nakashima I, Levy M, Shang S, Yountz M, Miller L, Róisín Armstrong R, Wingerchuk DM, and the PREVENT Study Group.

Mult Scler. 28 ( 3 ) 480 - 486 2022年3月

Network Meta-analysis of Food and Drug Administration-approved Treatment Options for Adults with Aquaporin-4 Immunoglobulin G-positive Neuromyelitis Optica Spectrum Disorder.

Wingerchuk DM, Zhang I, Kielhorn A, Royston M, Levy M, Fujihara K, Nakashima I, Tanvir I, Paul F, Pittock SJ.

Neurol Ther. 11 ( 1 ) 123 - 135 2022年3月

Eculizumab monotherapy for NMOSD: Data from PREVENT and its open-label extension.

Pittock SJ, Fujihara K, Palace J, Berthele A, Kim HJ, Oreja-Guevara C, Nakashima I, Levy M, Shang S, Yountz M, Miller L, Róisín Armstrong R, Wingerchuk DM, and the PREVENT Study Group.

Mult Scler. 28 ( 3 ) 480 - 486 2022年3月

AQP4-IgG seronegative patient outcomes in the N-MOmentum trial of inebilizumab in neuromyelitis optica spectrum disorder.

1. Marignier R, Pittock SJ, Paul F, Kim HJ, Bennett JL, Weinshenker BG, Wingerchuk D, Green AJ, Fujihara K, Cutterj G, Aktas O, Hartung HP, Drappa J, Ratchford JN, She D, Smith M, Rees W, Cimbora D, Katz E, Cree BAC, on behalf of the N-MOmentum study investigators.

Mult Scler Relat Disord 57 103356 2022年1月

Difference of anti-viral immunity induced by two mRNA vaccines: Implications in MS patients treated with anti-CD20-depleting therapy.

Tanaka M, Fujihara K.

Clin Exp Neuroimmunol ( 13 ) 5 - 6 2022年

Autoantibodies in central nervous system and neuromuscular autoimmune disorders A narrative review.

Joen MY, Seok JM, Fujihara K, Kim BJ.

Precis Future Med. 6 ( 2 ) 105 - 116 2022年

Relapse activity in the chronic phase of anti-myelin-oligodendrocyte glycoprotein antibody-associated disease.

Akaishi T, Misu T, Fujihara K, Takahashi T, Takai Y, Nishiyama S, Kaneko K, Fujimori J, Ishii T, aoki M, Nakashima I.

J Neurol. 2021年11月

White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments.

Akaishi T. Misu T, Fujihara K. Nakaya N, Nakamura T, Kogure M, Hatanaka R, Itabashi F, Kanno I, Takahashi T, Kuroda H, Fujimori J, Takai Y, Nishiayama S, Kaneko K, Ishii T, Aoki M, Nakashima I, Hozawa A.

Sci Rep. 11 ( 1 ) 22357 2021年11月

GRP78 antibodies are associated with blood-brain barrier-breakdown in anti-myelin oligodendrocyte glycoprotein antibody-associated disorder.

Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T.

Neurol Neuroimmunol Neuroinflamm. 9 ( 1 ) e1038 2021年11月

Patient-reported burden of symptoms in neuromyelitis optica: a secondary analysis on pain and quality of life.

Fujihara K, Hattori S, Kleiter I, Levy M, Matsuda Y, Mitsutake A, Haramura M, Palace J, Yamamura T. on behalf of The Guthy-Jackson Charitable Foundation NMOSD Quality of Life Working Group.

J Neurol Sci. 428 117546 2021年9月

MOG-antibody associated disease.

Marignier R, Hacohen Y, Cobo-Calvo A, Pröbstel AK, Aktas O, Dphil HA, Amato MP, Asgari N, Banwell B, Bennett J, Brilot F, Capobianco M, Chitnis T, Ciccarelli O, Deiva K, De Sèze J, Fujihara K, Jacob A, Kim HJ, Kleiter I, Lassmann H, Leite MI, Linington C, Meinl E, Palace J, Paul F, Petzold A, Pittock S, Reindl M, Sato DK, Selmaj K, Siva A, Stankoff B, Tintore M, Traboulsee A, Waters P, Waubant E, Weinshenker B, Derfuss T, Vukusic S, Hemmer B.

Lancet Neurol. 20 ( 9 ) 762 - 772 2021年9月

Five-year visual outcome after optic neuritis in anti-MOG antibody-associated disease.

Akaishi T, Himori N, Takeshita T, Misu T, Takahashi T, Takai Y, Nishiyama S, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakazawa T, Nakashima I.

Mult Scler Relat Disord Mult Scler Relat Disord. 56 103222 2021年8月

Disability outcomes in the N-MOmentum trial of inebilizumab in neuromyelitis optica spectrum disorder.

Marignier R, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk D, Fujihara K, Paul F, Cutter GR, Green AJ, Aktas O, Hartung HP, Lublin FD, Williams IM, Drappa J, She D, Cimbora D, Rees W, Smith M, Ratchford JN, EKatz E, Cree BAC.

Neurol Neuroimmunol Neuroinflamm. 8 ( 3 ) e978 2021年5月

Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders.

Takai Y, Misu T, Suzuki H, Takahashi T, Okada H, Tanaka S, Okita K, Sasou S, Watanabe M, Namatame C, Matsumoto Y, Ono H, Kaneko K, Nishiyama S, Kuroda H, Nakashima I, Lassmann H, Fujihara K, Itoyama Y, Aoki M.

Brain. 144 ( 8 ) 2401 - 2415 2021年5月

Difference in the source of anti-AQP4-IgG and anti-MOG-IgG antibodies in CSF in patients with neuromyelitis optica spectrum disorder.

Akaishi T, Takahashi T, Misu T, Kaneko K, Takai Y, Nishiyama S, Ogawa R, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakashima I.

Neurology. 97 ( 1 ) e1 - e12 2021年5月

Acute retrobulbar optic neuritis with anti-myelin oligodendrocyte glycoprotein antibody-associated disease complicated with microscopic polyangiitis: a case report.

Asano T, Saito Y, Matsuoka N, Temmoku J, Fujita Y, Hattori K, Kobayashi S, Ojima A, Takahashi T, Matsumoto H, Yashiro-Furuya M, Sato S, Kobayashi H, Watanabe H, Yano K, Sasajima T, Fujihara K, Migita K.

Medicine (Baltimore). 100 ( 15 ) e24889 2021年4月

Eculizumab in Asian patients with anti-aquaporin-IgG-positive neuromyelitis optica spectrum disorder: A subgroup analysis from the randomized phase 3 PREVENT trial and its open-label extension.

Kim HJ, Nakashima I, Viswanathan S, Wang KC, Shang S, Miller L, Yountz M, Wingerchuk DM, Pittock SJ, Levy M, Berthele A, Totolyan N, Palace J, Barnett MH, Fujihara K; PREVENT Study Group.

Mult Scler Relat Disord. 50 ( 102849 ) 2021年2月

Optic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.

Akaishi T, Himori N, Takeshita T, Fujihara K, Misu T, Takahashi T, Fujimori J, Ishii T, Aoki M, Nakazawa T, Nakashima I.

Brain Behav. 11 ( 5 ) e02083 2021年2月

Long-term Safety and Efficacy of Eculizumab in Aquaporin-4 IgG-Positive NMOSD.

Wingerchuk DM, Fujihara K, Palace J, Berthele A, Levy M, Kim HJ, Nakashima I, Oreja-Guevara C, Wang KC, Miller L, Shang S, Sabatella G, Yountz M, MD, Pittock, SJ, for the PREVENT Study Group.

Ann Neurol. 89 ( 6 ) 1088 - 1098 2021年2月

Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD.

Cree BA, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk D, Fujihara K, Paul F, Cutter GR, Marignier R, Green AJ, Aktas O, Hartung HP, Williams IM, Drappa J, She D, Cimbora D, Rees W, Ratchford JN, Katz E.

Mult Scler. 27 ( 13 ) 2052 - 2061 2021年2月

Progression pattern of neurological disability in reference to clinical attacks in anti-MOG antibody-associated disorders.

Akaish T, Misu T, Takahashi T, Takai Y, Nishiyama S, Fujimori J, Ishi T, Aoki M, Fujihara K, Nakashima I.

J Neuroimmunol 31 ( 351 ) 577467 2021年2月

Early Treatment Initiation with Oral Prednisolone for Relapse Prevention Alleviates Depression and Fatigue in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder.

Akaishi T, Takahashi T, Fujihara K, Misu T, Fujimori J, Takai Y, Nishiyama S, Abe M, Ishii T, Aoki M, Nakashima I.

Front Neurol 22 ( 12 ) 608149 2021年2月

Impact of comorbid Sjögren syndrome in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders.

Akaishi T, Takahashi T, Fujihara K, Misu T, Fujimori J, Takai Y, Nishiyama S, Kaneko K, Ogawa R, Abe M, Ishii T, Aoki M, Nakashima I.

J Neurol 2021年1月

CH50 as a putative biomarker of eculizumab treatment in neuromyelitis optica spectrum disorder.

Namatame C, Misu T, Takai Y, Nishiyama S, Nakashima I, Fujihara K, Aoki M.

Heliyon 7 ( 1 ) e05899 - e05899 2021年1月

Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: subgroup analyses of the randomized controlled phase 3 PREVENT trial.

Palace J, Wingerchuk DM, Fujihara K, Berthele A, Oreja-Guevara C, Kim HJ, Nakashima I, Levy M, Terzi M, Totolyan N, Viswanathan S, Wang KC, Pace A, Yountz M, Miller L, Armstrong R, Pittock S, on behalf of the PREVENT Study Group.

Mult Scler Relat Disord ( 47 ) 102641 2021年1月

Optimal management of neuromyelitis optica spectrum disorder with aquaporin-4 antibody by oral prednisolone maintenance therapy.

Takai Y, Kuroda H, Misu T, Akaishi T, Nakashima I, Takahashi T, Nishiyama S, Fujihara K, Aoki M.

Mult Scler Relat Disord 22 ( 49 ) 102750 2021年1月

New therapies for neuromyelitis optica spectrum disorders.

Levy M, Fujihara K. Place J.

Lancet Neurol. 20 ( 1 ) 60 - 67 2021年1月

Patterns of cortical grey matter thickness reduction in multiple sclerosis.

Fujimori, Fujihara K, Wattjes M, Nakashima I.

Brain Behav 27 e02050 2021年1月

Treatment of MOG Antibody Associated Disorders: Results of an International Survey.

Whittam DH, Karthikeayan V, Gibbons E, Kneen R, Chandratre S, Ciccarelli O, Hacohen Y, de Seze J, Deiva K, Hintz en RQ, Wildemann B, Jarius S, Kleiter I, Rostasy K, Huppke P, Hemmer B, Paul F, Aktas O, Pröbstel AK, Arrambide G, Tintore M, Amato MP, Nosadini M, Mancardi MM, Capobianco M, Illes Z, Siva A, Altintas A, Akman-Demir G, Pandit L, Apiwattankul M, Hor JY, Viswanathan S, Qiu W, Kim HJ, Nakashima I, Fujihara K, Ramanathan S, Dale RC, Boggild M, Broadley S, Lana-Peixoto MA, Sato DK, Tenembaum S, Cabre P, Wingerchuk DM, Weinshenker BG, Greenberg B, Matiello M, Klawiter EC, Bennett JL, Wallach AI, Kister I, Banwell BL, Traboulsee A, Pohl D, Palace J, Leite MI, Levy M, Marignier R, Solomon T, Lim M, Huda S, Jacob A.

J Neurol 267 ( 12 ) 3565 - 3577 2020年12月

Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody.

Akaishi T, Fujimori J, Takahashi T, Misu T, Takai Y, Nishiyama S, Kaneko K, Ogawa R, Abe M, Ishii T, Aoki M, Fujihara K, Nakashima I.

J Neuroimmunol 15 ( 349 ) 577431 2020年12月

Distinctive lesions of bran MRI between MOG-antibody-associated and AQP4-antibody-associated diseases.

Matsumoto Y, Misu T, Mugikura S, Takai Y, Nishiyama S, Kuroda H, Takahashi T, Fujimori J, Nakashima I, Fujihara K, Aoki M.

J Neurol Neurosurg Psychiatry 92 ( 6 ) 2020年12月

Rapid administration of high-dose intravenous methylprednisolone improves visual outcomes after optic neuritis in patients with AQP4-IgG-positive NMOSD.

Akaishi T, Takshita T, Himori N, Takahashi T, Misu T, Ogawa R, Kaneko K, Fujimori J, Abe M, Ishii T, Fujihara K, Aoki M, Nakazawa T, Nakashima I.

Front Neurol 2 ( 11 ) 932 2020年9月

Progressive patterns of neurological disability in multiple sclerosis and neuromyelitis optica spectrum disorders.

Akaishi T、Takahashi T, Misu T, Abe M, Ishii T, Fujimori J, Aoki M, Fujihara K, Nakashima I.

Sci Rep 17 ( 10(1) ) 13890 2020年8月

Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology.

Fujihara K, Bennett JL, de Seze J, Haramura M, Kleiter I, Weinshenker BG, Kang D; Mughal T, Yamamura T.

Neurol Neuroimmunol Neuroinflamm 20 ( 7(5) ) e841 2020年8月

Measurements of corpus callosum index and fractional anisotropy of the corpus callosum with their cutoffs are useful to comprehend global brain volume loss in multiple sclerosis.

Fujimori J, MD, Uryu K, Fujihara K, Wattjes MP, Suzuki C, Nakashima I.

Mult Scler Relat Disord 8 ( 45 ) 102388 2020年7月

Impact of intrathecal IgG synthesis on neurological disability in patients with multiple sclerosis.

Akaishi T, Takahashi T, Fujihara K, Misu T, Nishiyama S, Takai Y, Fujimori J, Abe M, Ishii T, Aoki M, Nakashima I.

Mult Scler Relat Disord 7 ( 45 ) 102382 2020年7月

Risk factors of attacks in neuromyelitis optica spectrum disorders.

Akaishi T, Takahashi T, Fujihara K, Misu T, Abe M, Ishii T, Aoki M, Nakashima I.

J Neuroimmunol 15 ( 343 ) 577236 2020年6月

Treatment of MOG-IgG-associated disorder with rituximab: an international study of 121 patients.

Whittam DH, Cobo-Calvo A, Chiriboga ASL, Pardo S, Gornall M, Cicconi S, Brandt A, Berek K, Berger T, Jelcic I, Gombolay G, Oliveira LM, Callegaro D, Kaneko K, Misu T, Capobianco M, Gibbons E, Karthikeayan V, Brochet B, Audoin R, Mathey G, Laplaud D, Thouvenot F, Cohen M, Tourbah A, Maillart E, Ciron J, Deschamps R, Biotti D, Rostasy K, Neuteboom R, Hemingway C, Forsyth R, Matiello M, Webb S, Hunt D, Murray K, Hacohen Y, Lim M, Leite MI, Palace J, Solomon T, Lutterotti A, Fujihara K, Nakashima I, Bennett J, Pandit L, Chitnis T, Weinshenker BG, Wildemann B, Sato DK, Kim SH, Huda S, Kim HJ, Reindl M, Levy M, Jarius S, Tenembaum S, Paul F, Pittock S, Marignier R, Anu Jacob A.

Mult Scler Relat Disord 2 ( 44 ) 102251 2020年6月

Neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease: current topics.

Fujihara K. Cook L.

Curr Opin Neurol 33 ( 3 ) 300 - 308 2020年6月

Epidemiology of neuromyelitis optica spectrum disorder and its prevalence and incidence worldwide.

Hor JY, Asgari N, Nakashima I, Broadley SA, Leite MI, Kissani N, Jacob A, Marignier R, Weinshenker BG, Paul F, Pittock SJ, Palace J, Wingerchuk DM, Behne JM, Yeaman MR, Fujihara K, with the Guthy-Jackson Charitable Foundation International Clinical Consortium for NMOSD.

Front Neurol 26 ( 11 ) 501 2020年6月

Number of MRI T1-hypointensity corrected by T2/FLAIR lesion volume indicates clinical severity in patients with multiple sclerosis.

Akaishi T, Takahashi T, Fujihara K, Abe M, Ishii T, Aoki M, Nakashima I, Misu T, Mugikura S.

PLoS One 3 ( 15(4) ) e0231225 2020年4月

Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes.

Tsymala I, Nigritinou M, Zeka B, Schulz R, Niederschick F, Matković M, Bauer IJ, Szalay M, Schanda K, Lerch M, Misu T, Fujihara K, Bennett JL, Dahle C, Pache F, Rommer P, Leutmezer F, Illes Z, Leite MI, Palace J, Scholze P, Reindl M, Lassmann H, Bradl M.

Acta Neuropathol Commun 15 ( 8(1) ) 49 2020年4月

Perivenous demyelination:association with anti-myelin oligodendrocyte glycoprotein.

Misu T, Takai Y, Takahashi T, Nakashima I, Fujihara K, Aoki M.

Clin Exp Neuroimmunol 11 ( Suppl. 1 ) 22 - 27 2020年

MOG-IgG-associated disease.

Kaneko K, Takahahi T, Misu T, Nakashima I, Fujihara K.

Clin Exp Neuroimmunol 11 ( Suppl. 1 ) 28 - 33 2020年

Trila of satralizumab in neuromyelitis optica spectrum disorder

Yamamura T, Kleiter I, Fujihara K, Palace J, Greenberg B, Zakrzewska-Pniewska B, Patti F, Tsai CP, Saiz A, Yamazaki H, Kawata Y, Wright P, De Seze J

N Engl J 2019年11月

Long-term outcome of a group of Japanese children with myelin-oligodendrocyte glycoprotein encephalomyelitis without preventive immunosuppressive therapy

Hino-Fukuyo N, Haginoya K, Takahashi T, Nakashima I, Fujihara K, Takai Y, Akasaka M, Kure S

Brain Dev 2019年10月

Neuromyelitis optica spectrum disorders: still evolving and broadening

Fujihara K

Curr Opin Neurol 2019年6月

Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet’s disease.

Fujimori J, Takahashi T, Matsumoto Y, Fujihara K, Takai Y, Misu T, Nakashima I

J Neuroimmunol 2019年6月

【補体標的治療の現状と展望】視神経脊髄炎

黒田　宙、藤原　一男

BRAIN and NERVE:　神経研究の進歩 71 ( 6 ) 573 - 580 2019年6月

治療法の再整理とアップデートのために　専門家による私の治療　急性散在脳脊髄炎（ADEM）

松本勇貴, 藤原一男

日本医事新報 ( 4964 ) 42 - 42 2019年6月

Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders: tools for clinical practice and drug trial design

Palace J, Lin DY, Zeng D, Majed M, Elsone L, Hamid S, Messina S, Misu T, Sagen J, Whittam D, Takai Y, Leite MI, Weinshenker B, Cabre P, Jacob A, Nakashima I, Fujihara K, Pittock SJ

Brain 2019年5月

Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat.

Hillebrand S, Schanda K, Nigritinou M, Tsymala I, Böhm D, PeschL P, Bauer J, Takai T, Fujihara K, Nakashima I, Misu T, Reindl M, Lassmann H, Bradl M.

Acta Neuropathol 137 ( 3 ) 467 - 485 2019年3月

Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat

Hillebrand S, Schanda K, Nigritinou M, Tsymala I, Böhm D, PeschL P, Bauer J, Takai T, Fujihara K, Nakashima I, Misu T, Reindl M, Lassmann H, Bradl M

Acta Neuropathol 2019年3月

【視神経脊髄炎スペクトル障害（NMO-SD）】NMO-SDの疾患概念

三須　建郎、藤原　一男

脳神経内科 90 ( 1 ) 1 - 6 2019年1月

NMO spectrum and MOG-antibody-related disseminated encephalomyelitis

Misu T, Fujihara K

Clin Exp Neuroimmunol 2019年

Debate on the treatment of multiple sclerosis: Experience from an intractable multiple sclerosis case with rebound syndrome after fingolimod cessation

Kuroda　H, Nishiyama　S, Matsumoto Y, Misu T, Fujihara K, Aoki M

Clin Exp Nuroimmunol 10 2019年

Trial of eculizumab in aquaporin-4 positive neuromyelitis optica spectrum disorder

Pittock SJ, Berthele A, Fujihara K, Kim HJ, Levy M, Palace J, Nakashima I, Terzi M, Totolyan N, Viswanathan S, Wang KC, Pace A, Fujita KP, Armstrong R, Wingerchuk DM

N Engl J Med 2019年

A randomised, placebo-controlled, double-blind trial of inebilizumab for the treatment of neuromyelitis optica spectrum disorder: results of the N-MOmentum study

Cree B, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Fujihara K, Paul F, Cutter GR, Marignier R, Green AJ, Aktas O, Hartung HP, Lublin FD, Drappa J, Barron G, Madani S, Ratchford JN, She D, Cimbora D, Katz E

Lancet 2019年

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: practical considerations.

Jurynczyk M, Jacob A, Fujihara K, Palace J.

Pract Neurol 2018年12月

脱髄性疾患

北山通朗, 藤原一男

研修医が知っておきたい神経疾患の診断と治療 11 ( 10 ) 56 - 67 2018年12月

視神経脊髄炎関連疾患と抗AQP4抗体　NMOSDの診断基準

松本勇貴, 藤原一男

Clinical Neuroscience,中枢神経系脱髄疾患-最前線抗MOG抗体の関与を考える 36 ( 11 ) 1306 - 1309 2018年11月

MOG-Enzephalomyelitis: Internationale Empfehlungen zu Diagnose und Antikörpertestung.

Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J, Franciotta D, Fujihara K, Jacob A, Kim HJ, Kleiter I, Kümpfel T, Levy M, Palace J, Ruprecht K, Saiz A, Trebst C, Weinshenker BG, Wildemann B.

Nervenarzt 2018年9月

虚血性心疾患によって発症した若年発症の両眼非動脈炎型虚血性視神経症の1例

小林奈美江, 小野田貴嗣, 小林健太郎, 永沼和香子, 藤原一男

臨床眼科 72 ( 9 ) 1241 - 1247 2018年9月

多発性硬化症の創薬の展望

越智博文, 藤原一男

医薬ジャーナル, 神経難病と創薬 54 ( 7 ) 1661 - 1667 2018年7月

神経脊髄炎　多発性硬化症との相違点

藤原一男

東京都医師会雑誌 71 ( 5 ) 384 - 388 2018年6月

MOG encephalomyelitis: international recommendations on diagnosis and antibody testing.

Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J, Franciotta D, Fujihara K, Jacob A, Kim HJ, Kleiter I, Kümpfel T, Levy M, Palace J, Ruprecht K, Saiz A, Trebst C, Weinshenker BG, Wildemann B.

J Neuroinflammation 3 ( 15(1) ) 134 2018年5月

MOG-IgG-associated optic neuritis, encephalitis, and myelitis (MONEM): lessons learned from neuromyelitis optica spectrum disorder.

dos Passos GR, Oliveira LM, da Costa BK, Apostolos-Pereira SL, Callegaro D, Fujihara K, Sato DK.

Front Neurol 2018年4月

Severe aquaporin 4-IgG-positive neuromyelitis optica with disseminated herpes zoster in a pregnant woman successfully treated with intravenous immunoglobulins.

Matsumoto Y. Norshalena S, Tsuchiya M, Kaneko C, Kubo J, Yamamoto T, Takahashi T, Fujihara K.

Mult Scler J Exp Transl Clin. 9 ( 4(1) ) 2018年3月

Myelin oligodendrocyte glycoprotein immunoglobulin G‐associated disease: An overview

Fujihara K, Sato DK, Nakashima I, Takahashi T, Kaneko K, Ogawa R, Akaishi T, Matsumoto Y, Takai Y, Nishiyama S, Kuroda H, Misu T, Aoki M.

Clin Exp Neuroimmunol 9 ( Suppl.1 ) 48 - 55 2018年

Area Postrema Syndrome: Frequency, Criteria and Severity in AQP4-IgG positive NMOSD.

Shosha E, Dubey D, Palace J, Nakashima I, MD, Jacob A, Fujihara K, Takahashi T, Whittam D, Leite MI, Misu T, Takai Y, Messina S, Elsone L, Majed M, Flanagan E, Gadoth A, Huebert C, Sagen J, Greenberg BM, Levy M, Banerjee A, Weinshenker B, Pittock SJ.

Neurology 91 ( 17 ) e1642 - e1651 2018年

CSF cytokine profile in MOG-IgG+neurologic disease is similar to AQP4-IgG+NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications.

Kaneko K, Sato DK, Nakashima I, Ogawa R, Akaishi T, Takai Y, Nishiyama S, Takahashi T, Misu T, Kuroda H, Tanaka S, Nomura K, Yuji Hashimoto Y, Callegaro D, Steinman L, Fujihara K, Aoki M.

J Neurol Neurosurg Psychiatry 89 927 - 936 2018年

A Case of Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder.

Asato Y, Kamitani T, Ootsuka K, Kuramochi M, Nakanishi K, Shimada T, Takahashi T, Misu T, Aoki M, FujiharaK, Kawabata Y.

Intern Med 7 ( 20 ) 2981 - 2986 2018年

A nationwide epidemiological study of neuromyelitis optica in Japan.

Miyamoto K, Fujihara K, Kira J, Kuriyama N, Matsui M, Tamakoshi A, Kusunoki S.

J Neurol Neurosurg Psychiatry 89 667 - 668 2018年

Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria.

Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA.

Lancet Neurol 17 162 - 173 2018年

Fingolimod-associated PML with mild IRIS in multiple sclerosis: a clinicopathological study.

Nishiyama S, Misu T, Shishido-Hara Y, Nakamichi K, Saijo M, Takai Y, Takei K, Yamamoto N, Kuroda H, Saito R5, Watanabe M, Tominaga T, Nakashima I, Fujihara K, Aoki M.

Neurol Neuroimmunol Neuroinflamm 5 e415 2018年

小児臨床検査のポイント2017】自己抗体検査　臓器特異的自己抗体　神経疾患関連抗体　抗aquaporin-4(AQP4)抗体(解説/特集)

高橋利幸、藤原一男

小児内科 49 408 - 410 2017年11月

Cognitive Impairment in Neuromyelitis Optica Spectrum Disorders: A comparison of the Wechsler Adult Intelligence Scale-III and the Wechsler Memory Scale Revised with the Rao Brief Repeatable Neuropsychological Battery.

Fujimori J, Nakashima I, Baba T, Meguro Y, Ogawa R, Fujihara K.

eNeurologicalSci 21 ( 9 ) 3 - 7 2017年9月

【NMOとMSの最新情報】 NMO(neuromyelitis optica)の最新の診断基準(解説/特集)

松本勇貴, 藤原一男

脊椎脊髄ジャーナル 30 ( 8 ) 736 - 741 2017年8月

Differential diagnosis of neuromyelitis optica spectrum disorders.

Kim SM, Kim SJ, Lee HJ, Kuroda H, Palace J, Fujihara K.

Ther Adv Neurol Disord 10 ( 7 ) 265 - 289 2017年7月

Bilateral frontal cortex encephalitis and paraparesis in a patient with anti-MOG antibodies.

Fujimori J, Takai Y, Nakashima I, Sato DK, Takahashi T, Kaneko K, Nishiyama S, Watanabe M, Tanji H, Kobayashi M, Misu T, Aoki M, Fujihara K

J Neurol Neurosurg Psychiatry 88 ( 6 ) 534 - 536 2017年6月

第1章　左眼の奥が痛くて、物が見えづらいんです(左眼痛、左視力低下)

黒田宙, 藤原一男

内科「症候から考える画像診断アトラス」 119 578 - 581 2017年4月

MOG-antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy.

Ogawa R, Nakashima I, Takahashi T, Kaneko K, Akaishi T, Takai Y, Sato DK, Nishiyama S, Misu T, Kuroda H, Aoki M, Fujihara K

Neurol Neuroimmunol Neuroinflamm 4 ( 2 ) 322 - 322 2017年1月

Impact of the Great East Japan Earthquake in 2011 on MS and NMOSD: a study in Sendai, Japan.

Kanamori Y, Nakashima I, Takai Y, Misu T, Kuroda H, Nishiyama S, Takahashi T, Sato S, Fujimori J, Higuchi J, Itoyama Y, Aoki M, Fujihara K

J Neurol Neurosurg Psychiatry 88 362 - 364 2017年

Practical issues and new horizons in MS, NMOSD and related disorders.

Fujihara K.

Clin Exp Neuroimmunol 8 1 - 2 2017年

Neuromyelitis optica spectrum disorders.

Akaishi T, Nakashima I, Sato DK, Takahashi T, Fujihara K.

Neuroimaging Clin N Am 27 251 - 265 2017年

Whole brain and grey matter volume of Japanese patients with multiple sclerosis.

Akaishi T, Nakashima I, Mugikura S, Aoki M, Fujihara K.

J Neuroimmunol 306 68 - 75 2017年

Disruption of the leptomeningeal blood barrier in neuromyelitis optica spectrum disorder.

Asgari N, Flanagan EP, Fujihara K, Kim HJ, Skejoe HPB, Wuerfel J, Kuroda H, Kim SH, Maillart E, Marignier R, Pittock SJ, Paul F, Weinshenker BG.

Neuro Neuroimmunol Neuroiflamm 4 e343 2017年

Hypoxia-like tissue injury and glial response contribute to Balo’s concentric lesion development.

Takai Y, Misu T, Nishiyama S, Ono H, Kuroda H, Nakashima I, Saito R, Kanamori M, Sonoda Y, Kumabe T, Mugikura S, Watanabe M, Aoki M, Fujihara K

Neurology 87 ( 19 ) 2000 - 2005 2016年11月

Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD.

Zeka B, Hastermann M, Kaufmann N, Schanda K, Pende M, Misu T, Rommer P, Fujihara K, Nakashima I, Dahle C, Leutmezer F, Reindl M, Lassmann H, Bradl M

Acta Neuropathol Commun 4 ( 1 ) 82 - 82 2016年8月

Pseudo-perifascicular atrophy in the healing phase of Jo-1 antisynthetase syndrome.

Tateyama M, Shibuya S, Sato H, Fujihara K, Aoki M

Neuromuscul Disord 26 ( 8 ) 521 - 522 2016年8月

Lack of KIR4.1 autoantibodies in Japanese patients with MS and NMO.

Higuchi O, Nakane S, Sakai W, Maeda Y, Niino M, Takahashi T, Fukazawa T, Kikuchi S, Fujihara K,Matuo H

Neurol Neuroimmunol Neuroinflamm 3 ( 5 ) 263 - 263 2016年7月

Demyelinating diseases in Asia.

Ochi H, Fujihara K

Curr Opin Neurol 29 ( 3 ) 222 - 228 2016年6月

Anti-myelin Oligodendrocyte Glycoprotein Antibodies in a Patient with Recurrent Optic Neuritis Involving the Cerebral White Matter and Brainstem.

Adachi T, Yasui K, Takahashi T, Fujihara K, Watanabe Y, Nakashima K

Intern Med 55 ( 10 ) 1351 - 1354 2016年5月

Genetic analysis of the aquaporin-4 gene for anti-AQP4 antibody-positive neuromyelitis optica in a Japanese population.

Ogasawara M, Meguro A, Sakai T, Mizuki N, Takahashi T, Fujihara K, Tsuneoka H, Shikishima K

Jpn J Ophthalmol 60 ( 3 ) 198 - 205 2016年5月

Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal Cord.

Oji S, Nicolussi EM, Kaufmann N, Zeka B, Schanda K, Fujihara K, Illes Z, Dahle C, Reindl M, Lassmann H, Bradl M

PLoS One 2016年3月

Pregnancy outcomes in aquaporin-4-positive neuromyelitis optica spectrum disorder.

Nour MM, Nakashima I, Coutinho E, Woodhall M, Sousa F, Revis J, Takai Y, George J, Kitley J, Santos ME, Nour JM, Cheng F, Kuroda H, Misu T, Martins-da-Silva A, DeLuca GC, Vincent A, Palace J, Waters P, Fujihara K, Leite MI

Neurology 86 ( 1 ) 79 - 87 2016年1月

Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies.

Kaneko K, Sato DK, Nakashima I, Nishiyama S, Tanaka S, Marignier R, Hyun JW, Oliveira LM, Reindl M, Seifert-Held T, Sepulveda M, Siritho S, Waters PJ, Kurosawa K, Akaishi T, Kuroda H, Misu T, Prayoonwiwat N, Berger T, Saiz A, Kim HJ, Nomura K, Callegaro D, Fujihara K, Aoki M

J Neurol Neurosurg Psychiatry 2016年1月

Placebo-controlled study in neuromyelitis optica-Ethical and design considerations

Cree BA, Bennett JL, Sheehan M, Cohen J, Hartung HP, Aktas O, Kim HJ, Paul F, Pittock S, Weinshenker B, Wingerchuk D, Fujihara K, Cutter G, Patra K, Flor A, Barron G, Madani S, Ratchford JN, Katz E

Mult Scledr 2016年

MRI and retinal abnormalities in isolated optic neuritis with myelin-oligodendrocyte glycoprotein and aquaporin-4 antibodies

Akaishi T, Sato DK, Nakashima I, Takeshita T, Takahashi T, Doi H, Kurosawa K, Kaneko K, Kuroda H, Nishiyama S, Misu T, Nakazawa T, Fujihara K, Aoki M

Journal of neurology, neurosurgery, and psychiatry 2016年

The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients

Siritho S, Sato DK, Kaneko K, Fujihara K, Prayoonwiwat N

Mult Scler 2016年

Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica

Yamasaki R, Matsushita T, Fukazawa T, Yokoyama K, Fujihara K, Ogino M, Yokota T, Miyamoto K, Niino M, Nomura K, Tomioka R, Tanaka M, Kawachi I, Ohashi T, Kaida KI, Matsui M, Nakatsuji Y, Ochi H, Fukaura H, Kanda T, Nagaishi A, Togo K, Mizusawa H, Murai H, Kira JI

Mult Scler 2016年

Quotient of cerebrospinal fluid/serum immunoglobulin G as a predictive factor for non-responders to intravenous methylprednisolone therapy in patients with relapsing neuromyelitis optica spectrum disorder: implication for early institution of plasmapheresis.

Oji S, Tanaka S, Kojima M, Fukaura H, Mori M, Takahashi T, Fujihara K, Nomura K

Clin Exp Neuroimmunol 7 272 - 280 2016年

The Binding Property of a Monoclonal Antibody Against the Extracellular Domains of Aquaporin-4 Directs Aquaporin-4 Toward Endocytosis.

Huang P, Takai Y, Kusano-Arai O, Ramadhanti J, Iwanari H, Miyauchi T, Sakihama T, Han JY, Aoki M, Hamakubo T, Fujihara K, Yasui M, Abe Y

Biochem Biophys Rep 7 77 - 83 2016年

Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity in human astrocytes: pathogenetic implications in neuromyelitis optica.

Nishiyama S, Misu T, Nuriya M, Takano R, Takahashi T, Nakashima I, Yasui M, Itoyama Y, Aoki M, Fujihara K

Biochem Biophys Rep 7 45 - 51 2016年

Experimental neuromyelitis optica induces a type I interferon signature in the spinal cord.

Oji S, Nicolussi E, Kaufmann N, Schanda K, Fujihara K, Illes Z, Reindl M, Lassmann H, Bradl M

PLoS ONE 11 ( 3 ) 2016年

Lesion length of optic neuritis impacts visual prognosi in neuromyelitis optica.

Akaishi T, Ichiro Nakashima, Takeshita T, Mugikura S, Sato DK, Takahashi T, Nishiyama S, Kurosawa K, Misu T, Nakazawa T, Aoki M, Fujihara K

J Neuroimmunol 293 28 - 33 2016年

Different etiologies and prognoses of optic neuritis in demyelinating diseases.

Akaishi T, Nakashima I, Takeshita T, Kaneko K, Mugikura S, Sato DK, Takahashi T, Nakazawa T, Aoki M, Fujihara K

J Neuroimmnol 299 152 - 157 2016年

Serological markers associated with neuromyelitis optica spectrum disorders in South India.

Pandit L, Sato DK, Mustafa S, Takahashi T, D'Cunha A, Malli C, Sudhir A, Fujihara K

Ann Indian Acad Neurol 19 ( 4 ) 505 - 509 2016年

Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications".

Passos G, Sato D, Becker J, Fujihara K

Mediators Inflamm Mediators Inflamm 2016年

High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG.

Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M, Abe Y

Br J Pharmacol. 173 103 - 114 2016年

The Binding Property of a Monoclonal Antibody Against the Extracellular Domains of Aquaporin-4 Directs Aquaporin-4 Toward Endocytosis.

Huang P, Takai Y, Kusano-Arai O, Ramadhanti J, Iwanari H, Miyauchi T, Sakihama T, Han JY, Aoki M, Hamakubo T, Fujihara K, Yasui M, Abe Y

Biochem Biophys Rep 7 77 - 83 2016年

免疫性神経疾患-病態解明と治療の最前線:NMOの発症機序

小川諒, 藤原一男

医学のあゆみ 2015年

Clinical values of FDG PET in polymyositis and dermatomyositis syndromes: imaging of skeletal muscle inflammation

Tateyama M, Fujihara K, Misu T, Arai A, Kaneta T, Aoki M+L16L13:L17L13:L15

BMJ Open 2015年

Importance of QAlb, QIgG, and Reibergram in inflammatory neurological disorders with disease-specific patterns of blood-brain barrier-permeability

Akaishi T, Narikawa K, Suzuki Y, Mitsuzawa S, Tsukita K, Kuroda H, Nakashima I, Fujihara K, Aoki M

Neurology and Clinical Neuroscience 2015年

Spinal cord ring enhancement in patients with neuromyelitis optica

Yokote H, Nose Y, Ishibashi S, Kamata T, Tanaka K, Takahashi T, Fujihara K, Yokota T, Mizusawa H

Acta Neurol Scand 2015年

Influenza-associated MOG antibody-positive longitudinally extensive transverse myelitis: a case report

Amano H, Miyamoto N, Shimura H, Sato D, Fujihara K, Ueno S, Nakamura R, Ueno Y, Watanabe M, Hattori N, Urabe T

BMC Neurol 2015年

Acute callosal disconnection syndrome as an initial manifestation of neuromyelitis optica spectrum disorders

Kobayashi J, Kuroda H, Ezura M, Sugeno N, Shibui A, Takahashi T, Misu T, Fujihara K, Mori E, Aoki M

Neurology and Clinical Neuroscience 2015年

The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model

Geis C, Ritter C, Ruschil C, Weishaupt A, Gr?newald B, Stoll G, Holmoy T, Misu T, Fujihara K, Hemmer B, Stadelmann C, Bennett JL, Sommer C, Toyka KV

Experimental Neurology 2015年

Multiple Sclerosis in Japan appears to be a milder disease compared to the UK

Piccolo L, Kumar G, Nakashima I, Misu T, Kong Y, Wakerley B, Ryan S, Cavey A, Fujihara K, Palace J

Journal of Neurology 2015年

Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica

Kariya Y, Kariya Y, Saito T, Nishiyama S, Honda T, Tanaka K, Yoshida M, Fujihara K, Hashimoto Y

Biochimica et Biophysica Acta (BBA) Clinical 2015年

Novel clinical grading of delayed neurologic sequelae after carbon monoxide poisoning and factors associated with outcome

Kuroda H, Fujihara K, Kushimoto S, Aoki M

Neurotoxicology 2015年

Clinical features and long-term outcome of a group of Japanese children with inflammatory central nervous system disorders and seropositivity to myelin-oligodendrocyte glycoprotein antibodies.

Hino-Fukuyo N, Kazuhiro Haginoya K, Nakashima I, Sato DK, Takahashi T, Misu T, Fujihara K, Hirose M, Kakisaka Y, Uematsu M, Kobayashi T, Shigeo Kure S

Brain Dev 2015年

Comparison of the Rao Brief Repeatable Neuropsychological Battery with Wechsler Adult Intelligence Scale-III and Wechsler Memory Scale-Revised in Japanese patients with Multiple Sclerosis

Fujimori J, Baba T, Meguro Y, Nakashima I, Mori E, Fujihara K, Aoki M

Clinical and Experimental Neuroimmunology 2015年

Depressive state and chronic fatigue in multiple sclerosis

Akaishi T, Nakashima I, Misu T, Fujihara K, Aoki M

Journal of Neurology 2015年

MRI characteristics of neuromyelitis optica spectrum disorder

Kim, HJ, Paul F, Lana-Peixoto MA, Tenembaum S, Asgari N, Palace J, Klawiter EC, Sato DK, de Seze J, Jens Wuerfel J, Banwell BL, Villoslada P, Saiz A, Fujihara K, Kim SH

Neurology 2015年

Neuromyelitis optica and multiple sclerosis: Seeing differences through Optical Coherence Tomography

Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S, Tenembaum S, Banwell B, Greenberg B, Levy M, Fujihara K, Chan KH, Kim HJ, Asgari N, Sato DK, Klawiter EC, Saiz A, Wuerfel J, Zimmermann H, Green A, Villoslada P, Paul1 F

Mult Scledr 2015年

Challenges and opportunities in designing clinical trials for neuromyelitis optica

Weinshenker BG, Barron G, Behne JM, Bennett JL, Chin PS, Cree B, de Seze J, Armando Flor, Fujihara K, Greenberg BM, Higashi S, Holt W, Khan OA, Knappertz V, Levy M, Melia AT, Palace J, Smith TJ, Sormani MP, Van Herle K, VanMeter SA, Villoslada P, Walton MK, Wasiewski W, Wingerchuk D, Yeaman M

Neurology 2015年

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

Kremer S, Renard F, Achard S, Lana-Peixoto MA, Palace J, Asgari N, Klawiter EC, Tenembaum SN, Banwell B, Greenberg BM, Bennett JL, Levy M, (GJCF) Neuromyelitis Optica (NMO) International Clinical Consortium and Biorepository, Cabre P, Marignier R, Tedder T, van Pelt D, Broadley S, Chitnis T, Wingerchuk D, Pandit L, Leite MI, Apiwattanakul M, Kleiter I, Prayoonwiwat N, Han M, Hellwig K, van Herle K, John G, Hooper DC, Nakashima I, Sato D, Yeaman MR, Waubant E, Zamvil S, St?ve O, Aktas O, Smith TJ, Jacob A, O'Connor KVilloslada P, Saiz A, Fujihara K, Chan KH, Schippling S, Paul F, Kim HJ, de Seze J, Wuerfel JT; and the Guthy-Jackson Charitable Foundation

JAMA Neurology 2015年

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG

Neurology 2015年

視神経脊髄炎

金子仁彦、藤原一男

臨床雑誌内科　内科疾患の診断基準・病型分類・重症度 2015年

神経・筋　多発性硬化症

金子仁彦、藤原一男

臨床雑誌内科　内科疾患の診断基準・病型分類・重症度 2015年

AQP4 in biopsied demyelinating lesions as a diagnostic clue to NMOSD and MS:Final answer ?

Fujihara K, Misu T

Neurology 2015年

Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS

Zeka B, Hastermann M, Hochmeister S, Kögl N, Kaufmann N, Schanda K, Mader S, Misu T, Rommer P, Fujihara K, Illes Z, Leutmezer F, Sato DK, Nakashima I, Reindl M, Lassmann H, Bradl M

Acta Neuropathologica 2015年

Fulminant demyelinating encephalomyelitis: Insights from antibody studies and neuropathology

Di Pauli F, Höftberger R, Reindl M, Beer R, Rhomberg P, Schanda K, Sato D, Fujihara K, Lassmann H, Schmutzhard E, Berger T

Neurol Neuroimmunol Neuroinflamm 2015年

Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

Kurosawa K, Misu T, Takai Y, Sato DK, Takahashi T, Abe Y, Iwanari H, Ogawa R, Nakashima I, Fujihara K, Hamakubo T, Yasui M, Aoki M

Acta Neuropathologica Commun 2015年

Anti-MOG (Myelin Oligodendrocyte Glycoprotein)-positive optic neuritis with optic disc ischemia and macular star

Moura FC, Sato DK, Rimkus CM, Apostolos-Pereira SL, de Oliveira LM, Leite CC, Fujihara K, Monteiro MLR, Callegaro D

Neuro-Ophthalmology 2015年

免疫症候群(第2版)-その他の免疫疾患を含めて-】臓器特異的自己免疫疾患　免疫性神経・筋疾患　免疫性中枢神経疾患　視神経脊髄炎

黒澤和大, 藤原一男

日本臨床:別冊免疫症候群I 2015年

多発性硬化症(解説/特集)

藤盛寿一, 藤原一男

精神科:特集Ⅰ　免疫と精神神経疾患 2015年

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