論文 - 井上 直和
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Different temporal dynamics of primary cilia formation and elongation during adipocyte differentiation in umbilical cord- and bone marrow-derived mesenchymal stem cells
Masako Hirai, Naokazu Inoue, Tomoaki Nagai, Michiru Nishita
Biochem Biophys Res Commun 768 ( 151918 ) 2025年4月
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Noncanonical phagocytosis-like SEAL establishes mammalian fertilization
Naokazu Inoue, Takako Saito, Ikuo Wada
Cell Reports 2025年4月
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Molecular mechanisms leading to gamete fusion
Naokazu Inoue
Fukushima J Med Sci 2025年3月
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Involvement of cellular protrusions in gamete interactions
Yuhkoh Satouh, Naokazu Inoue
Seminars in Cell & Developmental Biology 129 93 - 102 2022年9月
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Deletion of the initial methionine codon of the Tmem95 gene causes subfertility, but not complete infertility, in male mice
Naokazu Inoue, Ikuo Wada
Biology of Reproduction 106 ( 3 ) 378 - 381 2022年3月
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Gamete Fusion Assay in Mice
Naokazu Inoue
Bio-protocol 11 ( 22 ) e4233. 2021年11月
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IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation.
Naokazu Inoue1, Yuhkoh Satouh, Ikuo Wada
Molecular Reproduction and Development 88 ( 7 ) 479 - 481 2021年7月
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進化の過程で10億年間保存されてきた配偶子融合因子
井上直和
実験医学 39 ( 13 ) 2126 - 2129 2021年7月（ ISSN:978-4-7581-2546-8 ）
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Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion
Naokazu Inoue, Yoshihisa Hagihara, Ikuo Wada
eLife 10 ( e66313 ) 2021年4月
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Tet1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models
Ryoichi Ono, Masahiro Masuya, Naokazu Inoue, Makoto Shinmei, Satomi Ishii, Yuri Maegawa , Bishnu Devi Maharjan, Naoyuki Katayama, Tetsuya Nosaka
PLoS One 16 ( 3 ) e0248425. 2021年3月
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Unveiling a novel function of CD9 in surface compartmentalization of oocytes
Naokazu Inoue, Takako Saito, Ikuo Wada
Development 2020年7月
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Sperm IZUMO1-Dependent Gamete Fusion Influences Male Fertility in Mice
Takako Saito, Ikuo Wada, Naokazu Inoue
Int J Mol Sci 20 ( 19 ) E4809 2019年9月
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Alternative splicing of the Izumo1 gene ensures triggering gamete fusion in mice.
Saito T, Wada I, Inoue N
Scientific reports 9 ( 1 ) 3151 2019年2月
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Monitoring dimeric status of IZUMO1 during the acrosome reaction in living spermatozoon.
Naokazu Inoue, Ikuo Wada
Cell Cycle 2018年6月
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Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung.
Ikezawa M, Tajika Y, Ueno H, Murakami T, Inoue N, Yorifuji H
Developmental Dynamics 247 ( 5 ) 754 - 762 2018年1月
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Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.
Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y
Scientific reports 7 39825 2017年1月（ ISSN:2045-2322 ）
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Novel insights into the molecular mechanism of sperm-egg fusion via IZUMO1.
Naokazu Inoue
Journal of Plant Research 2016年12月
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Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.
Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T.
Nature 2016年6月
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受精の膜融合活性化メカニズムの解明
井上 直和
上原記念生命科学財団研究報告集 29 1 - 7 2015年12月
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Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice.
Inoue N, Hagihara Y, Wright D, Suzuki T, Wada I
Nat Commun 6 8858 2015年11月
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Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing.
Miyazaki H, Kiyose N, Akazawa Y, Takashima M, Hagihara Y, Inoue N, MAtsuda T, Ogawa R, Inoue S, Ito Y
J Biochem 158 ( 3 ) 205 - 215 2015年9月
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ハイスループットシークエンシングを併用したバイオパンニングによる抗原特異的アルパカVHH抗体の単離と性状解析(Isolation and characterization of antigen-specific alpaca(Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing)
Miyazaki Nobuo, Kiyose Norihiko, Akazawa Yoko, Takashima Mizuki, Hagihara Yosihisa, Inoue Naokazu, Matsuda Tomonari, Ogawa Ryu, Inoue Seiya, Ito Yuji
The Journal of Biochemistry 158 ( 3 ) 205 - 215 2015年9月（ ISSN:0021-924X ）
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Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice
Matsuo, T., Hattori, T., Asaba, A., Inoue, N., Kanomata, N., Kikusui, T., Kobayakawa, R., Kobayakawa, K.
Proc Natl Acad Sci U S A 112 ( 3 ) 311 - 320 2015年1月
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哺乳類の受精の膜融合メカニズム
井上 直和
福島医学雑誌 64 ( 3 ) 119 - 125 2014年9月（ ISSN:0016-2582 ）
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精子と卵子の膜融合
井上直和、宮戸健二
細胞工学 33 ( 4 ) 386 - 392 2014年3月
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精子と卵子の膜融合
井上直和、宮戸健二
細胞工学 33 ( 4 ) 386 - 392 2014年3月
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【受精メカニズム新論争〜ドグマの再構築〜】 精子と卵子の膜融合
井上 直和, 宮戸 健二
細胞工学 33 ( 4 ) 386 - 392 2014年3月（ ISSN:0287-3796 ）
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Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion
Inoue N., Hamada D., Kamikubo H., Hirata K., Kataoka M., Yamamoto M., Ikawa M., Okabe M., Hagihara Y.
Development (Cambridge) 140 ( 15 ) 3221 - 3229 2013年8月（ ISSN:09501991 ）
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Functional and structural study of mouse sperm protein, IZUMO1, by using molecular dissection
Naokazu Inoue, Daizo Hamada, Hironari Kamikubo, Kunio Hirata, Mikio Kataoka, Masaki Yamamoto, Masahito Ikawa, Masaru Okabe and Yoshihisa Hagihara
Development 140 ( 15 ) 3221 - 3229 2013年
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Production of mouse pups from germline transmission-failed knockout chimeras
Yoshitaka Fujihara, Kazuhiro Kaseda, Naokazu Inoue, Masahito Ikawa, Masaru Okabe
Transgenic Res 22 ( 1 ) 195 - 200 2013年
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Genetic basis of cell-cell fusion mechanisms
Pablo S. Aguilar*, Mary K. Baylies*, Andre Fleissner*, Laura Helming*, Naokazu Inoue*, Benjamin Podbilewicz, Hongmei Wang*, Melissa Wong* *These authors were equally contributed
Trends Genet 29 ( 7 ) 427 - 437 2013年
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Functional and structural study of mouse sperm protein, IZUMO1, by using molecular dissection
Naokazu Inoue, Daizo Hamada, Hironari Kamikubo, Kunio Hirata, Mikio Kataoka, Masaki Yamamoto, Masahito Ikawa, Masaru Okabe and Yoshihisa Hagihara
Development 140 ( 15 ) 3221 - 3229 2013年
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Production of mouse pups from germline transmission-failed knockout chimeras
Yoshitaka Fujihara, Kazuhiro Kaseda, Naokazu Inoue, Masahito Ikawa, Masaru Okabe
Transgenic Res 22 ( 1 ) 195 - 200 2013年
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Genetic basis of cell-cell fusion mechanisms
Pablo S. Aguilar*, Mary K. Baylies*, Andre Fleissner*, Laura Helming*, Naokazu Inoue*, Benjamin Podbilewicz, Hongmei Wang*, Melissa Wong* *These authors were equally contributed
Trends Genet 29 ( 7 ) 427 - 437 2013年
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Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1
Yuhkoh Satouh*, Naokazu Inoue*, Masahito Ikawa, Masaru Okabe *The first two authors were equally contributed
J Cell Sci 125 4985 - 4990 2012年
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Tetraspanin-interacting protein IGSF8 is dispensable for mouse fertility
Naokazu Inoue, Takao Nishikawa, Masahito Ikawa, Masaru Okabe
Fertil Steril 98 ( 2 ) 465 - 470 2012年
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SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia
Yoshitaka Fujihara, Yuhkoh Satouh, Naokazu Inoue, Ayako Isotani, Masahito Ikawa, Masaru Okabe
Development 139 ( 19 ) 3583 - 3589 2012年
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The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion
Naokazu Inoue, Masahito Ikawa, Masaru Okabe
Asian J Androl 13 81 - 87 2011年
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Calsperin is a testis-specific chaperone required for sperm fertility
Masahito Ikawa, Keizo Tokuhiro, Ryo Yamaguchi, Adam M. Benham, Taku Tamura, Ikuo Wada, Yuhkoh Satouh, Naokazu Inoue, Masaru Okabe
J Biol Chem 286 5639 - 5646 2011年
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Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs
Naokazu Inoue, Yuhkoh Satouh, Masahito Ikawa, Masaru Okabe, Ryuzo Yanagimachi
Proc Natl Acad Sci USA 108 20008 - 20011 2011年
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精子・卵子膜融合とIZUMO1
井上直和, 岡部勝
J. Mamm. Ova Res 27 183 - 190 2010年
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Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse
Yoshitaka Fujihara, Masao Murakami, Naokazu Inoue, Yuhkoh Satouh, Kazuhiro Kaseda, Masahito Ikawa, Masaru Okabe
J Cell Sci 123 1531 - 1536 2010年
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Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse
Naokazu Inoue, Tatsuya Kasahara, Masahito Ikawa, Masaru Okabe
PLoS One 5 e10301 2010年
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The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection
Hiroyuki Oshiumi, Moeko Miyashita, Naokazu Inoue, Masaru Okabe, Misako Matsumoto, Tsukasa Seya
Cell Host Microbe 8 496 - 509 2010年
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Fertilization: a sperm's journey to and interaction with the oocyte
Masahito Ikawa, Naokazu Inoue, Adam M Benham, Masaru Okabe
J Clin Invest 120 984 - 994 2010年
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目で見るリプロダクションの基礎
伊川正人, 井上直和, 岡部勝
HORMONE FRONTIER IN GYNECOLOGY 9 182 - 185 2008年
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Putative sperm fusion protein IZUMO and the role of N-glycosylation
Naokazu Inoue, Masahito Ikawa, Masaru Okabe
Biochem Biophys Res Commun 377 910 - 914 2008年
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Mechanisms of sperm-egg interactions emerging from gene-manipulated animals
Masahito Ikawa, Naokazu Inoue, Masaru Okabe
Int J Dev Biol 52 657 - 664 2008年
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Sperm-egg interaction and gene manipulated animals
Naokazu Inoue, Ryo Yamaguchi, Masahito Ikawa, Masaru Okabe
Soc Reprod Fertil Suppl 65 363 - 371 2007年
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Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients
Shinichi Hayasaka, Yukihiro Terada, Naokazu Inoue, Masaru Okabe, Nobuo Yaegashi, Kunihiro Okamura
Fertil Steril 88 214 - 216 2007年
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受精の膜融合における必須分子Izumoの同定
井上直和, 岡部勝
Medical Science Digest 32 ( 10 ) 416 - 417 2006年
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Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice
Fuminori Sakurai, Kenji Kawabata, Naoya Koizumi, Naokauz Inoue, Masaru Okabe, Teruhide Yamaguchi, Takao Hayakawa, Hiroyuki Mizuguchi
Gene Ther 13 1118 - 1126 2006年
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受精のメカニズム -イズモを中心に卵子と精子の結合に必要な因子とその異常に関連した受精異常について-
井上直和, 伊川正人, 岡部勝
産科と婦人科 73 ( 6 ) 735 - 742 2006年
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生殖と細胞接着
伊川正人, 井上直和, 岡部勝
Molecular Medicine 42 ( 12 ) 1358 - 1367 2005年
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The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs
Naokazu Inoue, Masahito Ikawa, Ayako Isotani, Masaru Okabe
Nature 434 234 - 238 2005年
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Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection
Masashi Shingai#, Naokazu Inoue#, Tsuyoshi Okuno, Masaru Okabe, Takashi Akazawa, Yasuhide Miyamoto, Minoru Ayata, Kenya Honda, Mitsue Kurita-Taniguchi, Misako Matsumoto, Hisashi Ogura, Tadatsugu Taniguchi, Tsuakasa Seya #The first two authors were equally contributed
J Immunol 175 3252 - 3261 2005年
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受精の膜融合必須分子Izumoの発見
井上直和, 岡部勝
細胞工学 24 ( 5 ) 490 - 491 2005年
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受精の膜融合における必須分子Izumoの発見
井上直和, 岡部勝
ブレインテクノニュース 110 251 - 256 2005年
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受精はどこまでわかったか？
井上直和, 山口亮, 伊川正人
蛋白質 核酸 酵素 50 ( 11 ) 1405 - 1412 2005年
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精子と卵子の相互作用
井上直和, 岡部勝
HORMONE FRONTIER IN GYNECOLOGY 11 251 - 256 2004年
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A short consensus repeat-containing complement regulatory protein of lamprey that participates in cleavage of lamprey complement 3
Yuko Kimura#, Naokazu Inoue#, Aya Fukui, Hiroyuki Oshiumi, Misako Matsumoto, Mayumi Nonaka, Shigeru Kuratani, Teizo Fujita, Masaru Nonaka, Tsukasa Seya #The first two authors were equally contributed
J Immunol 173 1118 - 1128 2004年
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Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain
Hiroyuki Matsumura, Hidetoshi Hasuwa, Naokazu Inoue, Masahito Ikawa, Masaru Okabe
Biochem Biophys Res Commun 321 275 - 279 2004年
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Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm
Naokazu Inoue, Masahito Ikawa, Tomoko Nakanishi, Misako Matsumoto, Midori Nomura, Tsukasa Seya, Masaru Okabe
Mol Cell Biol 23 2614 - 2622 2003年
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Inhibition of murine osteosarcoma cell proliferation by glucocorticoid
Takashi Yamamoto, Miyuki Nishiguchi, Naokazu Inoue, Hiroe G Goto, Ikuo Kudawara, Takafumi Ueda, Hideki Yoshikawa, Yumiko Tanigaki, Yasuko Nishizawa
Anticancer Res 22 4151 - 4156 2002年
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Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: identification of a CMV-responsive element in the CD46 promoter region
Midori Nomura, Mitsue Kurita-Taniguchi, Kazuhiro Kondo, Naokazu Inoue, Misako Matsumoto, Koichi Yamanishi, Masaru Okabe, Tsukasa Seya
Eur J Immunol 32 2954 - 2964 2002年
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Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP)
Hisako Sakiyama, Takashi Nonaka, Riako Masuda, Naokazu Inoue, Yoshinori Kuboki, Mayumi Iijima, Yoshio Hirabayasi, Masahiko Takahagi, Kazuko Yoshida, Kazuko Kuriiwa, Michiteru Yoshida, Shinobu Imajoh-Ohmi
Cell Tissue Res 309 269 - 279 2002年
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Cloning of hamster type XVII collagen cDNA, and pathogenesis of anti-type XVII collagen antibody and complement in hamster bullous pemphigoid
Katsushi Yamamoto, Naokazu Inoue, Riako Masuda, Akira Fujimori, Toshiyuki Saito, Shinonbu Imajoh-Ohmi, Hiroshi Shinkai, Hisako Sakiyama
J Invest Dermatol 118 485 - 492 2002年
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Three soluble form messages of murine CD46 are produced through alternative mRNA splicing
Akira Tsujimura, Kou Nunoue, Naokazu Inoue, Kyoko Shida, Mitsue Kurita-Taniguchi, Misako Matsumoto, Midori Nomura, Tatsuo Takeya, Tsukasa Seya
J Biochem (Tokyo) 130 841 - 848 2001年
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Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns
Aya Fukui, Naokazu Inoue, Misako Matsumoto, Midori Nomura, Kazuhiko Yamada, Yoichi Matsuda, Kumao Toyoshima, Tsukasa Seya
J Biol Chem 276 47143 - 47149 2001年
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A novel chicken membrane-associated complement regulatory protein: molecular cloning and functional characterization
Naokazu Inoue, Aya Fukui, Midori Nomura, Misako Matsumoto, Yasuko Nishizawa, Kumao Toyoshima, Tsukasa Seya
J Immunol 166 424 - 431 2001年
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Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers
Hisako Sakiyama, Riako Masuda, Naokazu Inoue, Katusi Yamamoto, Kazuko Kuriiwa, Koichi Nakagawa, Kazuko Yoshida
J Bone Miner Metab 19 220 - 227 2001年
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Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases
Yuki Takada, Hisako Sakiyama, Kazuko Kuriiwa, Riako Masuda, Naokazu Inoue, Koichi Nakagawa, Naoki Itano, Toshiyuki Saito, Takeshi Yamada, Koji Kimata
Cell Tissue Res 298 317 - 325 1999年
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Selective complement C1s deficiency caused by homozygous four-base deletion in the C1s gene
Naokazu Inoue, Toshiyuki Saito, Riako Masuda, Yoshio Suzuki, Michiko Ohtomi, Hisako Sakiyama
Hum Genet 103 415 - 418 1998年