研究者詳細 - 齋藤　元伸

論文 - 齋藤　元伸

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Activation of the tumor cell-intrinsic STING pathway induced by Fusobacterium nucleatum is associated with poor prognosis in esophageal cancer patients.

Nakajima S, Saito K, Fukai S, Sakuma M, Matsuishi A, Kanoda R, Maruyama Y, Suzuki H, Okayama H, Saito M, Mimura K, Nirei A, Kikuchi T, Hanayama H, Saze Z, Momma T, Nishiyama K, Suzutani T, Kono K

Esophagus : official journal of the Japan Esophageal Society 2025年2月（ ISSN:1612-9059 ）

Lenvatinib suppress FGF19-FGFR4 signaling to enhance antitumor immune response in gastric cancer.

Maruyama Y, Saito M, Nakajima S, Saito K, Suzuki H, Kanoda R, Okayama H, Hanayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Goto A, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2025年2月（ ISSN:1436-3291 ）

Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer.

Kitadai R, Yazaki S, Kuchiba A, Yamanaka T, Shiino S, Yamauchi C, Harano K, Saito M, Hirotsu Y, Aiba H, Yoshida T, Hamamoto R, Shimizu C, Shimomura A, Kojima Y, Shimoi T, Momozawa Y, Sudo K, Yoshida M, Sunami K, Hori M, Katanoda K, Shimada Y, Yamashita Y, Kogawa T, Murata T, Fujiwara S, Miyagi Y, Nakagomi H, Tachibana K, Omata M, Ohtake T, Suto A, Onishi T, Naito Y, Yamashita T, Yonemori K, Kohno T, Shiraishi K

Cancer science 2025年2月（ ISSN:1347-9032 ）

Short-term Outcomes of Robotic Lateral Pelvic Lymph Node Dissection for Lower Rectal Cancer.

Sakamoto W, Fukai S, Sato T, Ito M, Matsumoto T, Ashizawa M, Chida S, Onozawa H, Okayama H, Endo H, Saito M, Saze Z, Momma T, Kono K

Fukushima journal of medical science 2025年2月（ ISSN:0016-2590 ）

Prevalence and outcomes of germline pathogenic variants of homologous recombination repair genes in ovarian cancer.

Miwa M, Kitagawa M, Asami Y, Kobayashi-Kato M, Watanabe T, Ogasawara A, Hiranuma K, Kato H, Saito M, Miyagi Y, Kato T, Yoshida H, Momozawa Y, Kohno T, Shiraishi K, Hasegawa K

Cancer science 115 ( 12 ) 3952 - 3962 2024年12月（ ISSN:1347-9032 ）

[A Case of Laparoscopically Assisted Local Resection of Early-Stage Sigmoid Colon Cancer Arising within a Diverticulum].

Chida S, Kiguchi T, Fukai S, Ito M, Ashizawa M, Onozawa H, Okayama H, Sakamoto W, Saito M, Momma T, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 51 ( 13 ) 1312 - 1314 2024年12月（ ISSN:0385-0684 ）

憩室内に発生した早期S状結腸癌を腹腔鏡補助下に局所切除した1例

千田峻, 木口託見, 深井智司, 伊藤美郷, 芦澤舞, 小野澤寿志, 岡山洋和, 坂本渉, 齋藤元伸, 門馬智之, 河野浩二

癌と化学療法 51 ( 13 ) 1312 - 1314 2024年12月

High levels of tumor cell-intrinsic STING signaling are associated with increased infiltration of CD8(+) T cells in dMMR/MSI-H gastric cancer.

Kanoda R, Nakajima S, Fukai S, Saito M, Saito K, Suzuki H, Kikuchi T, Nirei A, Okayama H, Mimura K, Hanayama H, Sakamoto W, Momma T, Saze Z, Kono K

Scientific reports 14 ( 1 ) 20859 2024年9月

Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma.

Fujiwara Y, Takahashi RU, Saito M, Umakoshi M, Shimada Y, Koyama K, Yatabe Y, Watanabe SI, Koyota S, Minamiya Y, Tahara H, Kono K, Shiraishi K, Kohno T, Goto A, Tsuchiya N

Proc Natl Acad Sci U S A 121 ( 36 ) 2024年9月

[Regulation of the Tumor Microenvironment through HER2 Signaling-Insights from Gastric Cancer Cases with Heterogeneous HER2 Overexpression].

Nakajima S, Fukai S, Kaneta A, Tsumuraya H, Matsuishi A, Okayama H, Saito M, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 51 ( 9 ) 903 - 905 2024年9月（ ISSN:0385-0684 ）

胃癌におけるHER2シグナルを介した腫瘍微小環境の制御　HER2過剰発現の腫瘍内不均一性を呈する胃癌症例からの検討

中嶋正太郎, 深井智司, 金田晃尚, 圓谷秀哲, 松石彬, 岡山洋和, 齋藤元伸, 三村耕作, 坂本渉, 佐瀬善一郎, 門馬智之, 河野浩二

癌と化学療法 51 ( 9 ) 903 - 905 2024年9月

The impact of CLDN18.2 expression on effector cells mediating antibody-dependent cellular cytotoxicity in gastric cancer.

Matsuishi A, Nakajima S, Saito M, Saito K, Fukai S, Tsumuraya H, Kanoda R, Kikuchi T, Nirei A, Kaneta A, Okayama H, Mimura K, Hanayama H, Sakamoto W, Momma T, Saze Z, Kono K

Scientific reports 14 ( 1 ) 17916 2024年8月

福島医大のゲノム医療とがん免疫療法(会議録)

齋藤元伸

福島医学雑誌 74 ( 2 ) 47 - 47 2024年8月

Tumor Infiltrating Effector Regulatory T Cells Express VEGF Receptor 2 in Patients With Colorectal Cancer.

Tsumuraya H, Mimura K, Nakajima S, Hanayama H, Matsuishi A, Okayama H, Fukai S, Ito M, Ashizawa M, Chida S, Onozawa H, Sakamoto W, Saito M, Saze Z, Momma T, Kono K

Anticancer research 44 ( 7 ) 2933 - 2941 2024年7月（ ISSN:0250-7005 ）

TIM-3 Expression on Dendritic Cells in Colorectal Cancer.

Sakuma M, Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Fukai S, Tsumuraya H, Onozawa H, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

Cancers 16 ( 10 ) 1888 - 1888 2024年5月（ ISSN:2072-6694 ）

TGFβ-Responsive Stromal Activation Occurs Early in Serrated Colorectal Carcinogenesis.

Tsumuraya H, Okayama H, Katagata M, Matsuishi A, Fukai S, Ito M, Sakamoto W, Saito M, Momma T, Nakajima S, Mimura K, Kono K

International journal of molecular sciences 25 ( 9 ) 4626 - 4626 2024年4月

The tumor cell-intrinsic cGAS-STING pathway is associated with the high density of CD8(+) T cells after chemotherapy in esophageal squamous cell carcinoma.

Matsuishi A, Nakajima S, Kaneta A, Saito K, Fukai S, Sakuma M, Tsumuraya H, Okayama H, Saito M, Mimura K, Nirei A, Kikuchi T, Hanayama H, Saze Z, Sakamoto W, Momma T, Kono K

Esophagus : official journal of the Japan Esophageal Society 21 ( 2 ) 165 - 175 2024年4月（ ISSN:1612-9059 ）

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses.

Shiraishi K, Takahashi A, Momozawa Y, Daigo Y, Kaneko S, Kawaguchi T, Kunitoh H, Matsumoto S, Horinouchi H, Goto A, Honda T, Shimizu K, Torasawa M, Takayanagi D, Saito M, Saito A, Ohe Y, Watanabe SI, Goto K, Tsuboi M, Tsuchihara K, Takata S, Aoi T, Takano A, Kobayashi M, Miyagi Y, Tanaka K, Suzuki H, Maeda D, Yamaura T, Matsuda M, Shimada Y, Mizuno T, Sakamoto H, Yoshida T, Goto Y, Yoshida T, Yamaji T, Sonobe M, Toyooka S, Yoneda K, Masago K, Tanaka F, Hara M, Fuse N, Nishizuka SS, Motoi N, Sawada N, Nishida Y, Kumada K, Takeuchi K, Tanno K, Yatabe Y, Sunami K, Hishida T, Miyazaki Y, Ito H, Amemiya M, Totsuka H, Nakayama H, Yokose T, Ishigaki K, Nagashima T, Ohtaki Y, Imai K, Takasawa K, Minamiya Y, Kobayashi K, Okubo K, Wakai K, Shimizu A, Yamamoto M, Iwasaki M, Matsuda K, Inazawa J, Shiraishi Y, Nishikawa H, Murakami Y, Kubo M, Matsuda F, Kamatani Y, Hamamoto R, Matsuo K, Kohno T

Cancer communications (London, England) 44 ( 2 ) 287 - 293 2024年2月

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses.

Cancer Commun (Lond) 2023年10月

TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer.

Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

Cancers 15 ( 20 ) 2023年10月（ ISSN:2072-6694 ）

放射線治療による腫瘍細胞内cGAS-STING経路を介した食道扁平上皮癌微小環境の変化

中嶋正太郎, 三村耕作, 金田晃尚, 片方雅紀, 岡山洋和, 齋藤元伸, 佐瀬善一郎, 花山寛之, 多田武志, 門馬智之, 河野浩二

癌と化学療法 50 ( 10 ) 1099 - 1101 2023年10月（ ISSN:0385-0684 ）

Down-regulation of stimulator of interferon genes (STING) expression and CD8(+) T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer.

Fukai S, Nakajima S, Saito M, Saito K, Kase K, Nakano H, Sato T, Sakuma M, Kaneta A, Okayama H, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26 ( 6 ) 878 - 890 2023年8月（ ISSN:1436-3291 ）

A Potential Biomarker of Dynamic Change in Peripheral CD45RA(-)CD27(+)CD127(+) Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma.

Sakuma M, Mimura K, Nakajima S, Kaneta A, Kikuchi T, Nirei A, Tada T, Hanayama H, Okayama H, Sakamoto W, Saito M, Momma T, Saze Z, Kono K

Cancers 15 ( 14 ) 3641 2023年7月（ ISSN:2072-6694 ）

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Shi J, Shiraishi K, Choi J, Matsuo K, Chen TY, Dai J, Hung RJ, Chen K, Shu XO, Kim YT, Landi MT, Lin D, Zheng W, Yin Z, Zhou B, Song B, Wang J, Seow WJ, Song L, Chang IS, Hu W, Chien LH, Cai Q, Hong YC, Kim HN, Wu YL, Wong MP, Richardson BD, Funderburk KM, Li S, Zhang T, Breeze C, Wang Z, Blechter B, Bassig BA, Kim JH, Albanes D, Wong JYY, Shin MH, Chung LP, Yang Y, An SJ, Zheng H, Yatabe Y, Zhang XC, Kim YC, Caporaso NE, Chang J, Ho JCM, Kubo M, Daigo Y, Song M, Momozawa Y, Kamatani Y, Kobayashi M, Okubo K, Honda T, Hosgood DH, Kunitoh H, Patel H, Watanabe SI, Miyagi Y, Nakayama H, Matsumoto S, Horinouchi H, Tsuboi M, Hamamoto R, Goto K, Ohe Y, Takahashi A, Goto A, Minamiya Y, Hara M, Nishida Y, Takeuchi K, Wakai K, Matsuda K, Murakami Y, Shimizu K, Suzuki H, Saito M, Ohtaki Y, Tanaka K, Wu T, Wei F, Dai H, Machiela MJ, Su J, Kim YH, Oh IJ, Lee VHF, Chang GC, Tsai YH, Chen KY, Huang MS, Su WC, Chen YM, Seow A, Park JY, Kweon SS, Chen KC, Gao YT, Qian B, Wu C, Lu D, Liu J, Schwartz AG, Houlston R, Spitz MR, Gorlov IP, Wu X, Yang P, Lam S, Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeböller H, Ji BT, Wichmann HE, Christiani DC, Rennert G, Arnold S, Brennan P, McKay J, Field JK, Shete SS, Le Marchand L, Liu G, Andrew A, Kiemeney LA, Zienolddiny-Narui S, Grankvist K, Johansson M, Cox A, Taylor F, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Jeon HS, Jiang SS, Sung JS, Chen CH, Hsiao CF, Jung YJ, Guo H, Hu Z, Burdett L, Yeager M, Hutchinson A, Hicks B, Liu J, Zhu B, Berndt SI, Wu W, Wang J, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Wang WC, Xu J, Guan P, Tan W, Yu CJ, Yang G, Sihoe ADL, Chen Y, Choi YY, Kim JS, Yoon HI, Park IK, Xu P, He Q, Wang CL, Hung HH, Vermeulen RCH, Cheng I, Wu J, Lim WY, Tsai FY, Chan JKC, Li J, Chen H, Lin HC, Jin L, Liu J, Sawada N, Yamaji T, Wyatt K, Li SA, Ma H, Zhu M, Wang Z, Cheng S, Li X, Ren Y, Chao A, Iwasaki M, Zhu J, Jiang G, Fei K, Wu G, Chen CY, Chen CJ, Yang PC, Yu J, Stevens VL, Fraumeni JF Jr, Chatterjee N, Gorlova OY, Hsiung CA, Amos CI, Shen H, Chanock SJ, Rothman N, Kohno T, Lan Q

Nature communications 14 ( 1 ) 3043 2023年5月

The Impact of Tumor Cell-Intrinsic Expression of Cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) on the Infiltration of CD8(+) T Cells and Clinical Outcomes in Mismatch Repair Proficient/Microsatellite Stable Colorectal Cancer.

Nakajima S, Kaneta A, Okayama H, Saito K, Kikuchi T, Endo E, Matsumoto T, Fukai S, Sakuma M, Sato T, Mimura K, Saito M, Saze Z, Sakamoto W, Onozawa H, Momma T, Kono K

Cancers 15 ( 10 ) 2826 2023年5月（ ISSN:2072-6694 ）

Radiation-Induced Remodeling of the Tumor Microenvironment Through Tumor Cell-Intrinsic Expression of cGAS-STING in Esophageal Squamous Cell Carcinoma.

Nakajima S, Mimura K, Kaneta A, Saito K, Katagata M, Okayama H, Saito M, Saze Z, Watanabe Y, Hanayama H, Tada T, Sakamoto W, Momma T, Ohira H, Kono K

International journal of radiation oncology, biology, physics 115 ( 4 ) 957 - 971 2023年3月（ ISSN:0360-3016 ）

M2 tumor-associated macrophages resist to oxidative stress through heme oxygenase-1 in the colorectal cancer tumor microenvironment.

Ito M, Mimura K, Nakajima S, Okayama H, Saito K, Nakajima T, Kikuchi T, Onozawa H, Fujita S, Sakamoto W, Saito M, Momma T, Saze Z, Kono K

Cancer immunology, immunotherapy : CII 72 ( 7 ) 2233 - 2244 2023年3月（ ISSN:0340-7004 ）

Clinical decisions by the molecular tumor board on comprehensive genomic profiling tests in Japan: A retrospective observational study.

Shirota H, Komine K, Takahashi M, Takahashi S, Miyauchi E, Niizuma H, Tada H, Shimada M, Niihori T, Aoki Y, Sugiyama I, Kawamura M, Yasuda J, Suzuki S, Iwaya T, Saito M, Saito T, Shibata H, Furukawa T, Ishioka C

Cancer medicine 12 ( 5 ) 6170 - 6181 2023年3月

ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer.

Sato T, Saito M, Nakajima S, Saito K, Katagata M, Fukai S, Okayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26 ( 3 ) 379 - 392 2023年2月（ ISSN:1436-3291 ）

Clinical decisions by the molecular tumor board on comprehensive genomic profiling tests in Japan: A retrospective observational study.

Cancer medicine 12 ( 5 ) 6170 - 6181 2023年

TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer.

Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

Cancers 15 ( 20 ) 4943 2023年

Short-term outcomes of neoadjuvant chemotherapy with capecitabine plus oxaliplatin for patients with locally advanced rectal cancer followed by total or tumor-specific mesorectal excision with or without lateral pelvic lymph node dissection.

Sakamoto W, Kanke Y, Onozawa H, Okayama H, Endo H, Fujita S, Saito M, Saze Z, Momma T, Kono K

Fukushima journal of medical science 68 ( 2 ) 89 - 95 2022年8月（ ISSN:0016-2590 ）

Laparoscopic total gastrectomy performed for juvenile polyposis of the stomach: A case report.

Ito M, Onozawa H, Saito M, Ami H, Ohki S, Koyama Y, Kono K

International journal of surgery case reports 97 107368 2022年8月

Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR/MSI colorectal cancer.

Kaneta A, Nakajima S, Okayama H, Matsumoto T, Saito K, Kikuchi T, Endo E, Ito M, Mimura K, Kanke Y, Saito M, Saze Z, Fujita S, Sakamoto W, Onozawa H, Momma T, Ohki S, Kono K

Cancer immunology, immunotherapy : CII 71 ( 11 ) 2765 - 2776 2022年4月（ ISSN:0340-7004 ）

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K

British journal of cancer 126 ( 6 ) 917 - 926 2022年4月（ ISSN:0007-0920 ）

A rare case of recurrent ovarian cancer with <i>TPM3-NTRK1</i> gene rearrangement: A case report.

Endo Y, Watanabe T, Saito M, Saito K, Suzuki R, Sano H, Natori Y, Sasaki E, Ueda M, Kamo N, Furukawa S, Soeda S, Kono K, Saji S, Fujimori K

Molecular and clinical oncology 16 ( 4 ) 90 2022年4月（ ISSN:2049-9450 ）

Incidence of upper extremity deep vein thrombosis in the retrosternal reconstruction after esophagectomy.

Yamada L, Saito M, Suzuki H, Mochizuki S, Endo E, Kase K, Ito M, Nakano H, Yamauchi N, Matsumoto T, Kaneta A, Kanke Y, Onozawa H, Hanayama H, Okayama H, Fujita S, Sakamoto W, Watanabe Y, Hayase S, Saze Z, Momma T, Ohki S, Kono K

BMC surgery 22 ( 1 ) 91 2022年3月

Immune escape mechanism behind resistance to anti-PD-1 therapy in gastrointestinal tract metastasis in malignant melanoma patients with multiple metastases.

Ito M, Mimura K, Nakajima S, Saito K, Min AKT, Okayama H, Saito M, Momma T, Saze Z, Ohtsuka M, Yamamoto T, Kono K

Cancer immunology, immunotherapy : CII 71 ( 9 ) 2293 - 2300 2022年1月（ ISSN:0340-7004 ）

High Risk Stage II大腸癌におけるGlasgow Prognostic Scoreの意義と治療戦略

大木進司, 岡山洋和, 千田峻, 坂本渉, 藤田正太郎, 齋藤元伸, 門馬智之, 佐瀬善一郎, 河野浩二

癌と化学療法 48 ( 13 ) 1770 - 1773 2021年12月（ ISSN:0385-0684 ）

Immunotherapy Targeting Tumor-Associated Carbohydrate Antigens in Deficient Mismatch Repair Colorectal Cancer

Matsumoto T, Okayama H, Nakano H, Ito M, Nakajima S, Saito M, Saze Z, Momma T, Mimura K, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 48 ( 10 ) 1275 - 1277 2021年10月（ ISSN:0385-0684 ）

The Expression of Immune Checkpoint Receptors and Ligands in the Colorectal Cancer Tumor Microenvironment.

Neupane P, Mimura K, Nakajima S, Okayama H, Ito M, Thar Min AK, Saito K, Onozawa H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Kono K

Anticancer research 41 ( 10 ) 4895 - 4905 2021年10月（ ISSN:0250-7005 ）

ミスマッチ修復機構欠損大腸癌における糖鎖抗原を標的とした免疫療法の可能性

松本拓朗, 岡山洋和, 仲野宏, 伊藤美郷, 中嶋正太郎, 齋藤元伸, 佐瀬善一郎, 門馬智之, 三村耕作, 河野浩二

癌と化学療法 48 ( 10 ) 1275 - 1277 2021年10月（ ISSN:0385-0684 ）

Validation of Gene Expression-Based Predictive Biomarkers for Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer.

Momma T, Okayama H, Kanke Y, Fukai S, Onozawa H, Fujita S, Sakamoto W, Saito M, Ohki S, Kono K

Cancers 13 ( 18 ) 4642 - 4642 2021年9月（ ISSN:2072-6694 ）

Landscape of EBV-positive gastric cancer.

Saito M, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 24 ( 5 ) 983 - 989 2021年9月（ ISSN:1436-3291 ）

The effects of T-DXd on the expression of HLA class I and chemokines CXCL9/10/11 in HER2-overexpressing gastric cancer cells.

Nakajima S, Mimura K, Matsumoto T, Thar Min AK, Ito M, Nakano H, Neupane P, Kanke Y, Okayama H, Saito M, Momma T, Watanabe Y, Hanayama H, Hayase S, Saze Z, Kono K

Scientific reports 11 ( 1 ) 16891 - 16891 2021年8月

A Case of Laparoscopic Surgery for Preoperatively Diagnosed Gastric Metastasis of Lung Cancer

Mochizuki S, Yamada L, Kase K, Ito M, Nakano H, Yamauchi N, Matsumoto T, Kaneta A, Kanke Y, Nakajima T, Hanayama H, Watanabe Y, Onozawa H, Hayase S, Okayama H, Fujita S, Sakamoto W, Saito M, Momma T, Saze Z, Mimura K, Ohki S, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 48 ( 8 ) 1057 - 1060 2021年8月（ ISSN:03850684 ）

術前確定診断された肺癌胃転移に対して腹腔鏡下切除術を施行した1例

望月翔太朗, 山田玲央, 加瀬晃志, 伊藤美郷, 仲野宏, 山内直人, 松本拓朗, 金田晃尚, 菅家康之, 中島隆宏, 花山寛之, 渡辺洋平, 小野澤寿志, 早瀬傑, 岡山洋和, 藤田正太郎, 坂本渉, 齋藤元伸, 門馬智之, 佐瀬善一郎, 三村耕作, 大木進司, 河野浩二

癌と化学療法 48 ( 8 ) 1057 - 1060 2021年8月（ ISSN:0385-0684 ）

Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma.

Nakajima S, Mimura K, Saito K, Thar Min AK, Endo E, Yamada L, Kase K, Yamauchi N, Matsumoto T, Nakano H, Kanke Y, Okayama H, Saito M, Neupane P, Saze Z, Watanabe Y, Hanayama H, Hayase S, Kaneta A, Momma T, Ohki S, Ohira H, Kono K

Molecular cancer research : MCR 19 ( 6 ) 1085 - 1095 2021年6月（ ISSN:1541-7786 ）

Stromal expression of cancer-associated fibroblast-related molecules, versican and lumican, is strongly associated with worse relapse-free and overall survival times in patients with esophageal squamous cell carcinoma.

Yamauchi N, Kanke Y, Saito K, Okayama H, Yamada S, Nakajima S, Endo E, Kase K, Yamada L, Nakano H, Matsumoto T, Hanayama H, Watanabe Y, Hayase S, Saito M, Saze Z, Mimura K, Momma T, Oki S, Hashimoto Y, Kono K

Oncology letters 21 ( 6 ) 445 - 445 2021年6月（ ISSN:1792-1074 ）

Long-term Outcomes of Lower Rectal Cancer Patients Treated with Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection after Preoperative Radiotherapy or Chemoradiotherapy.

Sakamoto W, Ohki S, Onozawa H, Okayama H, Endo H, Fujita S, Saito M, Saze Z, Momma T, Takenoshita S, Kono K

Journal of the anus, rectum and colon 5 ( 2 ) 129 - 136 2021年4月

Collision of Epstein-Barr virus-positive and -negative gastric cancer, diagnosed by molecular analysis: a case report.

Miyabe K, Saito M, Koyama K, Umakoshi M, Ito Y, Yoshida M, Kudo-Asabe Y, Saito K, Nanjo H, Maeda D, Matsusaka K, Goto A, Kono K

BMC gastroenterology 21 ( 1 ) 97 - 97 2021年3月

Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer.

Kobayashi Y, Kumamoto K, Okayama H, Matsumoto T, Nakano H, Saito K, Matsumoto Y, Endo E, Kanke Y, Watanabe Y, Onozawa H, Fujita S, Sakamoto W, Saito M, Momma T, Takenoshita S, Kono K

PloS one 16 ( 2 ) e0247169 2021年2月

ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation.

Kase K, Saito M, Nakajima S, Takayanagi D, Saito K, Yamada L, Ashizawa M, Nakano H, Hanayama H, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Shiraishi K, Kohno T, Kono K

Carcinogenesis 42 ( 1 ) 21 - 30 2021年2月（ ISSN:0143-3334 ）

PD-L1 overexpression in EBV-positive gastric cancer is caused by unique genomic or epigenomic mechanisms.

Nakano H, Saito M, Nakajima S, Saito K, Nakayama Y, Kase K, Yamada L, Kanke Y, Hanayama H, Onozawa H, Okayama H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Goto A, Kono K

Scientific reports 11 ( 1 ) 1982 - 1982 2021年1月

Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer.

Yamada L, Saito M, Thar Min AK, Saito K, Ashizawa M, Kase K, Nakajima S, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 24 ( 1 ) 60 - 71 2021年1月（ ISSN:1436-3291 ）

ハイブリッドアプローチで切除し得た骨盤内脂肪肉腫の1例

藤田正太郎, 門馬智之, 仲野宏, 山内直人, 山田玲央, 松本拓朗, 菅家康之, 花山寛之, 渡辺洋平, 小野澤寿志, 岡山洋和, 坂本渉, 齋藤元伸, 佐瀬善一郎, 河野浩二

癌と化学療法 47 ( 13 ) 1869 - 1871 2020年12月

[A Case of Pelvic Liposarcoma Resected by Hybrid Approach].

Fujita S, Momma T, Nakano H, Yamauchi N, Yamada L, Matsumoto T, Kanke Y, Hanayama H, Watanabe Y, Onozawa H, Okayama H, Sakamoto W, Saito M, Saze Z, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 47 ( 13 ) 1869 - 1871 2020年12月（ ISSN:0385-0684 ）

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer.

Matsumoto T, Okayama H, Nakajima S, Saito K, Nakano H, Endo E, Kase K, Ito M, Yamauchi N, Yamada L, Kanke Y, Onozawa H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

International journal of molecular sciences 21 ( 23 ) 9081 - 9081 2020年11月

胃癌における免疫チェックポイント阻害剤の効果予測因子と臨床病理学的因子の比較検討

齋藤元伸

第120回日本外科学会定期学術集会記録集 7 2020年10月

A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Colorectal Cancer.

Endo E, Okayama H, Saito K, Nakajima S, Yamada L, Ujiie D, Kase K, Fujita S, Endo H, Sakamoto W, Saito M, Saze Z, Momma T, Ohki S, Mimura K, Kono K

Molecular cancer research : MCR 18 ( 9 ) 1402 - 1413 2020年9月（ ISSN:1541-7786 ）

Diagnosis and treatment of gastric hamartomatous inverted polyp (GHIP) using a modified combination of laparoscopic and endoscopic approaches to neoplasia with a non-exposure technique (modified CLEAN-NET): a case report.

Hayase S, Sakuma M, Chida S, Saito M, Ami H, Koyama Y, Ohki S, Kono K

Surgical case reports 6 ( 1 ) 200 - 200 2020年8月

Therapeutic potential of anti-VEGF receptor 2 therapy targeting for M2-tumor-associated macrophages in colorectal cancer.

Min AKT, Mimura K, Nakajima S, Okayama H, Saito K, Sakamoto W, Fujita S, Endo H, Saito M, Saze Z, Momma T, Ohki S, Kono K

Cancer immunology, immunotherapy : CII 70 ( 2 ) 289 - 298 2020年7月（ ISSN:0340-7004 ）

KRT17 as a prognostic biomarker for stage II colorectal cancer.

Ujiie D, Okayama H, Saito K, Ashizawa M, Thar Min AK, Endo E, Kase K, Yamada L, Kikuchi T, Hanayama H, Fujita S, Sakamoto W, Endo H, Saito M, Mimura K, Saze Z, Momma T, Ohki S, Kono K

Carcinogenesis 41 ( 5 ) 591 - 599 2020年7月（ ISSN:0143-3334 ）

Heterogeneity of ARID1A expression in gastric cancer may affect patient survival and therapeutic efficacy.

Saito M, Kohno T, Kono K

Human pathology 101 80 - 81 2020年5月（ ISSN:0046-8177 ）

Immune suppression caused by PD-L2 expression on tumor cells in gastric cancer.

Nakayama Y, Mimura K, Kua LF, Okayama H, Min AKT, Saito K, Hanayama H, Watanabe Y, Saito M, Momma T, Saze Z, Ohki S, Suzuki Y, Ichikawa D, Yong WP, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 23 ( 6 ) 961 - 973 2020年5月（ ISSN:1436-3291 ）

Higher modified Glasgow Prognostic Score and multiple stapler firings for rectal transection are risk factors for anastomotic leakage after low anterior resection in rectal cancer.

Sakamoto W, Ohki S, Kikuchi T, Okayama H, Fujita S, Endo H, Saito M, Saze Z, Momma T, Kono K

Fukushima journal of medical science 66 ( 1 ) 10 - 16 2020年4月（ ISSN:0016-2590 ）

Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers.

Kikuchi T, Mimura K, Ashizawa M, Okayama H, Endo E, Saito K, Sakamoto W, Fujita S, Endo H, Saito M, Momma T, Saze Z, Ohki S, Shimada K, Yoshimura K, Tsunoda T, Kono K

Cancer immunology, immunotherapy : CII 69 ( 1 ) 23 - 32 2020年1月（ ISSN:0340-7004 ）

Tuberculous peritonitis; The effectiveness of diagnostic laparoscopy and the perioperative infectious prevention: A case report.

Yamada L, Saito M, Aita T, Min A, Endo E, Kase K, Ujiie D, Hanayama H, Okayama H, Sakamoto W, Endo H, Fujita S, Saze Z, Momma T, Ohki S, Hamaguchi S, Kono K

International journal of surgery case reports 72 326 - 329 2020年（ ISSN:2210-2612 ）

Tuberculous peritonitis; The effectiveness of diagnostic laparoscopy and the perioperative infectious prevention: A case report.

Yamada L, Saito M, Aita T, Thar Min AK, Endo E, Kase K, Ujiie D, Hanayama H, Okayama H, Sakamoto W, Endo H, Fujita S, Saze Z, Momma T, Ohki S, Hamaguchi S, Kono K

International journal of surgery case reports 72 326 - 329 2020年

A subset of patients with MSS/MSI-low-colorectal cancer showed increased CD8(+) TILs together with up-regulated IFN-γ.

Kikuchi T, Mimura K, Okayama H, Nakayama Y, Saito K, Yamada L, Endo E, Sakamoto W, Fujita S, Endo H, Saito M, Momma T, Saze Z, Ohki S, Kono K

Oncology letters 18 ( 6 ) 5977 - 5985 2019年12月（ ISSN:1792-1074 ）

直腸癌術後の直腸膣瘻に対し、エストリオール膣錠と膣洗浄にて治癒した1例

藤田正太郎, 門馬智之, 佐藤孝洋, 遠藤英成, 加瀬晃志, 氏家大輔, 菊池智宏, 楡井東, 花山寛之, 渡辺洋平, 岡山洋和, 坂本渉, 遠藤久仁, 齋藤元伸, 佐瀬善一郎, 大木進司, 河野浩二.

癌と化学療法 46 ( 13 ) 2078 - 2080 2019年12月

Intestinal Behçet disease associated with myelodysplastic syndrome accompanying trisomy 8 successfully treated with abdominal surgery followed by hematopoietic stem cell transplantation: A case report.

Asano T, Sato S, Furuya MY, Takahashi H, Shichishima-Nakamura A, Ohkawara H, Fujiwara T, Gunji N, Hashimoto C, Momma T, Saito M, Nakano H, Watanabe G, Temmoku J, Fujita Y, Matsuoka N, Kobayashi H, Watanabe H, Mouri M, Mashiyama F, Sakuma H, Ohira H, Mori M, Ikezoe T, Migita K

Medicine 98 ( 46 ) e17979 2019年11月（ ISSN:0025-7974 ）

Prognostic role of ARID1A negative expression in gastric cancer.

Ashizawa M, Saito M, Min AKT, Ujiie D, Saito K, Sato T, Kikuchi T, Okayama H, Fujita S, Endo H, Sakamoto W, Momma T, Ohki S, Goto A, Kono K

Scientific reports 9 ( 1 ) 6769 2019年5月

Molecular Genetics of Thymic Carcinoma.

Saito M, Kono K, Kohno T.

eLS 2019年5月

miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1.

Ashizawa M, Okayama H, Ishigame T, Thar Min AK, Saito K, Ujiie D, Murakami Y, Kikuchi T, Nakayama Y, Noda M, Tada T, Endo H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Ohki S, Mimura K, Kono K

Molecular cancer research : MCR 17 ( 6 ) 1403 - 1413 2019年3月（ ISSN:1541-7786 ）

Explore the correlation between ARID1A and ANXA1 expressions in gastric cancer.

Yamada L, Saito M, Min A, Saito K, Kase K, Onozawa H, Okayama H, Fujita S, Endo H, Sakamoto W, Saze Z, Momma T, Ohki S, Mimura K, Kono K

Annals of Cancer Research and Therapy 27 ( 2 ) 46 - 51 2019年1月（ ISSN:13446835 ）

Expression profile of CADM1 and CADM4 in triple negative breast cancer with primary systemic therapy.

Kanke Y, Saito M, Abe N, Saito K, Goto A, Ohtake T, Murakami Y, Kono K

Oncology letters 17 ( 1 ) 921 - 926 2019年1月（ ISSN:1792-1074 ）

Microanatomy of inferior mesenteric artery sheath in colorectal cancer surgery.

Sakamoto W, Yamada L, Suzuki O, Kikuchi T, Okayama H, Endo H, Fujita S, Saito M, Momma T, Saze Z, Ohki S, Kono K

Journal of the anus, rectum and colon 3 ( 4 ) 167 - 174 2019年

A Case of Esophageal Cancer with Cervical Lymph Node Recurrence Six Years after Complete Response to Definitive Chemoradiotherapy

Fujita S, Ohki S, Hayase S, Ujiie D, Kikuchi T, Tada T, Hanayama H, Okayama H, Sakamoto W, Endo H, Saito M, Gonda K, Saze Z, Momma T, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy 45 ( 13 ) 1821 - 1823 2018年12月（ ISSN:0385-0684 ）

根治的化学放射線療法で完全寛解した6年後に頸部リンパ節再発した食道癌の1例

藤田正太郎, 大木進司, 早瀬傑, 氏家大輔, 菊池智弘, 多田武志, 花山寛之, 岡山洋和, 坂本渉, 遠藤久仁, 斎藤元伸, 権田憲士, 佐瀬善一郎, 門馬智之, 河野浩二

癌と化学療法 45 ( 13 ) 1821 - 1823 2018年12月（ ISSN:0385-0684 ）

Identification of a novel therapeutic target in driver-negative non-small cell lung cancer.

Saito M, Kono K, Kohno T

Translational lung cancer research 7 ( Suppl 3 ) S218 - S220 2018年9月（ ISSN:2218-6751 ）

Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells.

Shimura T, Shibata M, Gonda K, Hayase S, Sakamoto W, Okayama H, Fujita S, Saito M, Momma T, Ohki S, Kono K

Fukushima journal of medical science 64 ( 2 ) 64 - 72 2018年8月（ ISSN:0016-2590 ）

Serum transthyretin level is associated with prognosis of patients with gastric cancer.

Shimura T, Shibata M, Gonda K, Okayama H, Saito M, Momma T, Ohki S, Kono K

Journal of Surgical Research 227 145 - 150 2018年7月（ ISSN:00224804 ）

小細胞肺癌の治療における標的療法と免疫療法の開発(Development of targeted therapy and immunotherapy for treatment of small cell lung cancer)

48 ( 7 ) 603 - 608 2018年7月（ ISSN:0368-2811 ）

Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma.

Thar Min AK, Okayama H, Saito M, Ashizawa M, Aoto K, Nakajima T, Saito K, Hayase S, Sakamoto W, Tada T, Hanayama H, Saze Z, Momma T, Ohki S, Sato Y, Motoyama S, Mimura K, Kono K

Cancer medicine 7 ( 7 ) 3321 - 3330 2018年5月

Development of targeted therapy and immunotherapy for treatment of small cell lung cancer.

Saito M, Shiraishi K, Goto A, Suzuki H, Kohno T, Kono K

Japanese journal of clinical oncology 2018年5月（ ISSN:0368-2811 ）

Targeted therapy according to next generation sequencing-based panel sequencing.

Saito M, Momma T, Kono K

Fukushima journal of medical science 64 ( 1 ) 9 - 14 2018年4月（ ISSN:0016-2590 ）

Targeted therapy according to next generation sequencing-based panel sequencing.

Saito M, Momma T, Kono K

Fukushima journal of medical science 2018年4月（ ISSN:0016-2590 ）

Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer.

Watanabe Y, Saito M, Saito K, Matsumoto Y, Kanke Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Ohki S, Takenoshita S

Oncology letters 15 ( 3 ) 2756 - 2762 2018年3月（ ISSN:1792-1074 ）

Annexin A1 is upregulated in p53-positive gastric cancer

Saito M, Saito K, Nakano H, Kikuchi T, Okayama H, Fujita S, Endo H, Sakamoto W, Momma T, Ohki S, Kono K

Annals of Cancer Research and Therapy 26 ( 1 ) 26 - 30 2018年3月

Augmentation of antibody-dependent cellular cytotoxicity with defucosylated monoclonal antibodies in patients with GI-tract cancer.

Nakajima T, Okayama H, Ashizawa M, Noda M, Aoto K, Saito M, Monma T, Ohki S, Shibata M, Takenoshita S, Kono K

Oncology letters 15 ( 2 ) 2604 - 2610 2018年2月（ ISSN:1792-1074 ）

Upregulated solute carrier family 37 member 1 in colorectal cancer is associated with poor patient outcome and metastasis.

Kikuchi D, Saito M, Saito K, Watanabe Y, Matsumoto Y, Kanke Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Ohki S, Takenoshita S

Oncology letters 15 ( 2 ) 2065 - 2072 2018年2月（ ISSN:1792-1074 ）

Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer.

Saito M, Saito K, Shiraishi K, Maeda D, Suzuki H, Minamiya Y, Kono K, Kohno T, Goto A

Molecular and clinical oncology 8 ( 2 ) 310 - 314 2018年2月（ ISSN:2049-9450 ）

Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.

Matsumoto Y, Saito M, Saito K, Kanke Y, Watanabe Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Kumamoto K, Ohki S, Takenoshita S

Oncology letters 15 ( 2 ) 2188 - 2194 2018年2月（ ISSN:1792-1074 ）

Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer.

Saito M, Goto A, Abe N, Saito K, Maeda D, Ohtake T, Murakami Y, Takenoshita S

Oncology letters 15 ( 2 ) 2401 - 2406 2018年2月（ ISSN:1792-1074 ）

Gene aberration profile of tumors of adolescent and young adult females.

Kanke Y, Shimomura A, Saito M, Honda T, Shiraishi K, Shimada Y, Watanabe R, Yoshida H, Yoshida M, Shimizu C, Takahashi K, Totsuka H, Ogiwara H, Hirose S, Kono K, Tamura K, Okamoto A, Kinoshita T, Kato T, Kohno T

Oncotarget 9 ( 5 ) 6228 - 6237 2018年1月

Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma.

Aoto K, Mimura K, Okayama H, Saito M, Chida S, Noda M, Nakajima T, Saito K, Abe N, Ohki S, Ohtake T, Takenoshita S, Kono K

Oncology reports 39 ( 1 ) 151 - 159 2018年1月（ ISSN:1021-335X ）

分子標的療法および免疫療法による肺腺癌治療(Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy)

48 ( 1 ) 1 - 8 2018年1月（ ISSN:0941-1291 ）

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer.

Noda M, Okayama H, Kofunato Y, Chida S, Saito K, Tada T, Ashizawa M, Nakajima T, Aoto K, Kikuchi T, Sakamoto W, Endo H, Fujita S, Saito M, Momma T, Ohki S, Kono K

PloS one 13 ( 7 ) e0200315 2018年

A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network.

Fujiwara Y, Saito M, Robles AI, Nishida M, Takeshita F, Watanabe M, Ochiya T, Yokota J, Kohno T, Harris CC, Tsuchiya N.

EBioMedicine 33 33 - 48 2018年

The intratumoral distribution influences the prognostic impact of CD68- and CD204-positive macrophages in non-small cell lung cancer

Li Z, Maeda D, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Konno H, Saito H, Minamiya Y, Goto A

Lung Cancer 123 127 - 135 2018年

TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis.

Ando J, Saito M, Imai JI, Ito E, Yanagisawa Y, Honma R, Saito K, Tachibana K, Momma T, Ohki S, Ohtake T, Watanabe S, Waguri S, Kono K, Takenoshita S

Fukushima journal of medical science 63 ( 3 ) 141 - 151 2017年12月（ ISSN:0016-2590 ）

CDX2 is involved in microRNA-associated inflammatory carcinogenesis in gastric cancer.

Saito M, Okayama H, Saito K, Ando J, Kumamoto K, Nakamura I, Ohki S, Ishi Y, Takenoshita S

Oncology letters 14 ( 5 ) 6184 - 6190 2017年11月（ ISSN:1792-1074 ）

The genomic and epigenomic landscape in thymic carcinoma.

Saito M, Fujiwara Y, Asao T, Honda T, Shimada Y, Kanai Y, Tsuta K, Kono K, Watanabe S, Ohe Y, Kohno T

Carcinogenesis 38 ( 11 ) 1084 - 1091 2017年10月（ ISSN:0143-3334 ）

ING2, a tumor associated gene, enhances PAI‑1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C‑terminal.

Ohkouchi C, Kumamoto K, Saito M, Ishigame T, Suzuki SI, Takenoshita S, Harris CC.

Mol Med Rep 16 ( 5 ) 7367 - 7374 2017年9月

The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.

Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Kuriyama S, Konno H, Imai K, Saito H, Minamiya Y, Maeda D

PloS one 12 ( 7 ) e0181270 2017年7月

Clinicopathological examination of dipeptidase 1 expression in colorectal cancer.

Tachibana K, Saito M, Imai JI, Ito E, Yanagisawa Y, Honma R, Saito K, Ando J, Momma T, Ohki S, Ohtake T, Watanabe S, Waguri S, Takenoshita S

Biomedical reports 6 ( 4 ) 423 - 428 2017年4月（ ISSN:2049-9434 ）

Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy.

Saito M, Suzuki H, Kono K, Takenoshita S, Kohno T

Surgery today 2017年3月（ ISSN:0941-1291 ）

Genomic Amplification of <i>CD274</i> (PD-L1) in Small-Cell Lung Cancer.

George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Büttner R, Harris CC, Yokota J, Thomas RK, Kohno T

Clinical cancer research : an official journal of the American Association for Cancer Research 23 ( 5 ) 1220 - 1226 2017年3月（ ISSN:1078-0432 ）

Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer.

Hayashi H, Kohno T, Ueno H, Hiraoka N, Kondo S, Saito M, Shimada Y, Ichikawa H, Kato M, Shibata T, Morizane C, Sakamoto Y, Shimada K, Komatsu Y, Sakamoto N, Okusaka T

Pancreas 46 ( 3 ) 335 - 340 2017年3月（ ISSN:0885-3177 ）

Annexin A1 is involved in resistance to 5-FU in colon cancer cells.

Onozawa H, Saito M, Saito K, Kanke Y, Watanabe Y, Hayase S, Sakamoto W, Ishigame T, Momma T, Ohki S, Takenoshita S

Oncology reports 37 ( 1 ) 235 - 240 2017年1月（ ISSN:1021-335X ）

IL-17 and VEGF are significantly associated with disease progression involving systemic inflammation in patients with gastric and colorectal cancers

Minamikawa Kazuo, Shibata Masahiko, Gonda Kenji, Ujiie Daisuke, Ashizawa Mai, Nakajima Takahiro, Okayama Hirokazu, Sakamoto Wataru, Saito Motonobu, Momma Tomoyuki, Mimura Kousaku, Ohki Shinji, Shimura Tatsuo, Ohto Hitoshi, Takenoshita Seiichi, Kono Koji

Ａｎｎａｌｓ　ｏｆ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ　ａｎｄ　Ｔｈｅｒａｐｙ 25 ( 2 ) 67 - 76 2017年

遺伝子異常に基づく肺腺がんのprecision medicine

齋藤元伸, 河野隆志

血液内科 74 ( 1 ) 109 - 115 2017年

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.

Shiraishi K, Okada Y, Takahashi A, Kamatani Y, Momozawa Y, Ashikawa K, Kunitoh H, Matsumoto S, Takano A, Shimizu K, Goto A, Tsuta K, Watanabe S, Ohe Y, Watanabe Y, Goto Y, Nokihara H, Furuta K, Yoshida A, Goto K, Hishida T, Tsuboi M, Tsuchihara K, Miyagi Y, Nakayama H, Yokose T, Tanaka K, Nagashima T, Ohtaki Y, Maeda D, Imai K, Minamiya Y, Sakamoto H, Saito A, Shimada Y, Sunami K, Saito M, Inazawa J, Nakamura Y, Yoshida T, Yokota J, Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T

Nature communications 7 12451 2016年8月

Driver Gene Aberrations for Precision Medicine of Lung Adenocarcinoma

Saito M, Shiraishi K, Kunitoh H, Takenoshita S, Kohno T

Cancer Sci 107 ( 6 ) 713 - 20 2016年6月

Multiplex Diagnosis of Oncogenic Fusion and MET Exon Skipping by Molecular Counting Using Formalin-Fixed Paraffin Embedded Lung Adenocarcinoma Tissues.

Sunami K, Furuta K, Tsuta K, Sasada S, Izumo T, Nakaoku T, Shimada Y, Saito M, Nokihara H, Watanabe S, Ohe Y, Kohno T

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 11 ( 2 ) 203 - 12 2016年2月（ ISSN:1556-0864 ）

Advances in targeted therapy and immunotherapy for treatment of lung cancer

Saito Motonobu, Takenoshita Seiichi, Kohno Takashi

Annals of Cancer Research and Therapy 24 ( 1 ) 1 - 6 2016年1月（ ISSN:1344-6835 ）

A case of familial breast cancer with double heterozygosity for BRCA1 and BRCA2 genes

Nomizu T, Matsuzaki M, Katagata N, Kobayashi Y, Sakuma T, Monma T, Saito M, Watanabe F, Midorikawa S, Yamaguchi Y

Breast Cancer. 22 ( 5 ) 557 - 61 2015年9月

Development of lung adenocarcinomas with exclusive dependence on oncogene fusions.

Saito M, Shimada Y, Shiraishi K, Sakamoto H, Tsuta K, Totsuka H, Chiku S, Ichikawa H, Kato M, Watanabe S, Yoshida T, Yokota J, Kohno T

Cancer research 75 ( 11 ) 2264 - 71 2015年6月（ ISSN:0008-5472 ）

Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.

Takenaka M, Saito M, Iwakawa R, Yanaihara N, Saito M, Kato M, Ichikawa H, Shibata T, Yokota J, Okamoto A, Kohno T

International journal of oncology 46 ( 6 ) 2389 - 98 2015年6月（ ISSN:1019-6439 ）

Comparisons between Mouse and Human Studies Will Help the Prevention, Diagnosis, and Treatment of the Deadliest Type of Lung Cancer

Kohno T, Saito M

J Thorac Oncol 10 ( 4 ) 551 - 2 2015年4月

Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer.

Okano M, Kumamoto K, Saito M, Onozawa H, Saito K, Abe N, Ohtake T, Takenoshita S

Oncology reports 33 ( 3 ) 1064 - 70 2015年3月（ ISSN:1021-335X ）

A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis

Saito M, Ishigame T, Tsuta K, Kumamoto K, Imai T, Kohno T.

Carcinogenesis 35 ( 11 ) 2452 - 6 2014年11月

A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma.

Saito M, Shiraishi K, Matsumoto K, Schetter AJ, Ogata-Kawata H, Tsuchiya N, Kunitoh H, Nokihara H, Watanabe S, Tsuta K, Kumamoto K, Takenoshita S, Yokota J, Harris CC, Kohno T

Clinical cancer research : an official journal of the American Association for Cancer Research 20 ( 18 ) 4784 - 93 2014年9月（ ISSN:1078-0432 ）

Multiple metastatic malignant melanoma presenting intraluminal gallbladder bleeding

10. Onozawa H, Saito M, Yoshida S, Sakuma T, Matsuzaki M, Katagata N, Watanabe F, Yamaguchi Y, Takenoshita S, Nomizu T

Int surg 99 ( 5 ) 600 - 5 2014年9月

Clinicopathological study of non-palpable familial breast cancer detected by screening mammography and diagnosed as DCIS

Saito M, Matsuzaki M, Sakuma T, Katagata N, Watanabe F, Yamaguchi Y, Schetter AJ, Takenoshita S, Nomizu T

Breast Cancer 21 ( 2 ) 140 - 5 2014年3月

IgG4-related intrahepatic sclerosing cholangitis resulting in sepsis caused by secondary suppurative inflammation: report of a case.

Saito M, Shimura T, Hashimoto Y, Ishigame T, Yashima R, Koyama Y, Takenoshita S

Surgery today 43 ( 10 ) 1175 - 9 2013年10月（ ISSN:0941-1291 ）

Combination of protein coding and noncoding gene expression as a robust prognostic classifier in stage I lung adenocarcinoma

Akagi I, Okayama H, Schetter AJ, Robles AI, Kohno T, Bowman ED, Kazandjian D, Welsh JA, Oue N, Saito M, Miyashita M, Uchida E, Takizawa T, Takenoshita S, Skaug V, Mollerup S, Haugen A, Yokota J, Harris CC

Cancer Res 73 ( 13 ) 3821 - 32 2013年7月

NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression

Okayama H, Saito M, Oue N, Weiss JM, Stauffer J, Takenoshita S, Wiltrout RH, Hussain SP, Harris CC

Int J Cancer 132 ( 1 ) 9 - 18 2013年1月

Hemorrhagic cytomegalovirus colitis in a postoperative colon cancer patient.

Saito M, Ishino A, Ito T, Sakuma T, Matsuzaki M, Katagata N, Watanabe F, Takenoshita S, Nomizu T

Case reports in oncology 6 ( 1 ) 109 - 13 2013年1月

Cathepsin L is highly expressed in gastrointestinal stromal tumors

16. Miyamoto K, Iwadate M, Yanagisawa Y, Ito E, Imai J, Yamamoto M, Sawada N, Saito M, Suzuki S, Nakamura I, Ohki S, Saze Z, Kogure M, Gotoh M, Omicronbara K, Ohira H, Tasaki K, Abe M, Goshima N, Watanabe S, Waguri S, Takenoshita S

Int J Oncol 39 ( 5 ) 1109 - 15 2011年11月

The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts

Saito M, Schetter AJ, Mollerup S, Kohno T, Skaug V, Bowman ED, Mathé EA, Takenoshita S, Yokota J, Haugen A, Harris CC

Clin Cancer Res 17 ( 7 ) 1875 - 82 2011年4月

MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma

Voortman J, Goto A, Mendiboure J, Sohn JJ, Schetter AJ, Saito M, Dunant A, Pham TC, Petrini I, Lee A, Khan MA, Hainaut P, Pignon JP, Brambilla E, Popper HH, Filipits M, Harris CC, Giaccone G

Cancer Res 70 ( 21 ) 8288 - 98 2010年11月

Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas

Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC

PLoS One 5 ( 11 ) e15541 2010年11月

ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression

Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC

Int J Cancer 125 ( 6 ) 1306 - 15 2009年9月

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