論文 - 苅谷 慶喜
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Integrins in Cancer Drug Resistance: Molecular Mechanisms and Clinical Implications
Yoshinobu Kariya, Michiru Nishita
Int. J. Mol. Sci. 26 ( 7 ) 3143 2025年3月
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Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3–Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit
Yoshinobu Kariya, Jianguo Gu, Yukiko Kariya
Biomolecules 13 ( 12 ) 1752 2023年12月
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Osteopontin in Cancer: Mechanisms and Therapeutic Targets
Yoshinobu Kariya, Yukiko Kariya
Int. J. Transl. Med, 2 419 - 447 2022年8月
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Phosphorylated osteopontin secreted from cancer cells induces cancer cell motility.
Yoshinobu Kariya, Midori Oyama, Yukiko Kariya, Yasuhiro Hashimoto
Biomolecules 11 ( 9 ) 1323 2021年9月
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αvβ3 integrin induces partial EMT independent of TGF-β signaling
Yoshinobu Kariya, Midori Oyama, Takato Suzuki, Yukiko Kariya
Comminications Biology 4 ( 1 ) 490 2021年4月
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Yoshinobu Kariya, Midori Oyama, Mikio Ohtsuka, Nobuyuki Kikuchi, Yasuhiro Hashimoto, Toshiyuki Yamamoto
Fukushima journal of medical science 66 ( 3 ) 119 - 123 2020年12月（ ISSN:0016-2590 ）
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Ratio of Alpha 2-Macroglobulin Levels in Cerebrospinal Fluid and Serum: An Expression of Neuroinflammation in Acute Disseminated Encephalomyelitis.
Yuichi Suzuki, Koichi Hashimoto, Kyoka Hoshi, Hiromi Ito, Yoshinobu Kariya, Kyohei Miyazaki, Masatoki Sato, Yukihiko Kawasaki, Mari Yoshida, Takashi Honda, Yasuhiro Hashimoto, Mitsuaki Hosoya
Pediatric neurology 98 61 - 67 2019年9月（ ISSN:0887-8994 ）
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Molecular diagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid.
Roxana Chiorean, Sorina Danescu, Oana Virtic, Mayson B. Mustafa, Adrian Baican, Annette Lischka, Takashi Hasimoto, Kim Yancey, Yoshinobu Kariya, Manuel Koch, Cassian Sitaru
Orphanet journal of rare diseases 13 ( 1 ) 111 2018年7月
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β4-integrin/PI3K Signaling Promotes Tumor Progression through Galectin-3-N-glycan Complex.
Yukiko Kariya, Midori Oyama, Yasuhiro Hashimoto, Jianguo Gu, Yoshinobu Kariya
Molecular Cancer Research 16 ( 6 ) 1024 - 1034 2018年6月（ ISSN:1541-7786 ）
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Biological Role of Site-specific O-glycosylation in Cell Adhesion Activity and Phosphorylation of Osteopontin.
Midori Oyama, Yoshinobu Kariya, Yukiko Kariya, Kana Matsumoto, Mayumi Kanno, Yoshiki Yamaguchi, Yasuhiro Hashimoto
Biochemical Journal 475 ( 9 ) 1583 - 1595 2018年5月（ ISSN:0264-6021 ）
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Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.
Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe
PLoS One 12 ( 10 ) e0186414 2017年10月
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Roles of Integrin α6β4 Glycosylation in Cancer.
Yoshinobu Kariya, Yukiko Kariya, Jianguo Gu
Cancers 9 ( 7 ) 2017年7月
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RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells.
Yukiko Kariya, Takeo Tatsuta, Shigeki Sugawara, Yoshinobu Kariya, Kazuo Nitta, Masahiro Hosono
International Journal of Oncology 49 ( 4 ) 1334 - 42 2016年10月（ ISSN:1019-6439 ）
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Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica.
Yoshinobu Kariya, Yukiko Kariya, Toshie Saito, Shuhei Nishiyama, Takashi Honda, Keiko Tanaka, Mari Yoshida, Kazuo Fujihara, Yasuhiro Hashimoto
BBA Clinical 3 126 - 34 2015年6月
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In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver.
Yuka Matsumoto, Toshie Saito, Kyoka Hoshi, Hiromi Ito, Yoshinobu Kariya, Masamichi Nagae, Yoshiki Yamaguchi, Yoshiaki Hagiwara, Noriaki Kinoshita, Ikuo Wada, Kiyoshi Saito, Takashi Honda, Yasuhiro Hashimoto
Journal of Biochemistry 157 ( 4 ) 211 - 6 2015年4月（ ISSN:0021-924X ）
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A Glycan Marker for Idiopathic Normal Pressure Hydrocephalus
Kyoka Hoshi, Yuka Matsumoto, Toshie Saito, Hiromi Ito, Yoshinobu Kariya, Yoshiki Yamaguchi, Katsutoshi Furukawa, Hiroyuki Arai, Masakazu Miyajima, Hajime Arai, Hisashi Narimatsu, Kiyoshi Saito, Takashi Honda, Yasuhiro Hashimoto
Glycoscience: Biology and Medicine 1 - 7 2014年11月
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Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties.
Yoshinobu Kariya, Mayumi Kanno, Kana Matsumoto-Morita, Midori Konno, Yoshiki Yamaguchi, Yasuhiro Hashimoto
Biochemical Journal 463 ( 1 ) 93 - 102 2014年10月（ ISSN:0264-6021 ）
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Lectin-dependent inhibition of antigen-antibody reaction: application for measuring α2,6-sialylated glycoforms of transferrin.
Kyoka Hoshi, Yoshinobu Kariya, Kiyomitsu Nara, Hiromi Ito, Kana Matsumoto, Masamicihi Nagae, Yoshiki, Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Atsushi Kuno, Hisashi Narimatsu, Keiro Shirotani, and Yasuhiro Hashimoto
Journal of Biochemistry 154 ( 3 ) 229 - 32 2013年9月（ ISSN:0021-924X ）
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Yorinobu Kariya, Yukiko Kariya, Jianguo Gu
Laminins: Structure, Biological Activity and Role in Disease. 29 - 51 2013年
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Potential roles of N-glycosylation in cell adhesion.
Jianguo Gu, Tomoya Isaji, Qingsong Xu, Yoshinobu Kariya, Wei Gu, Tomohiko Fukuda, Yuguang Du
Glycoconjugate Journal 29 ( 8-9 ) 599 - 607 2012年12月（ ISSN:0282-0080 ）
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Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration.
Yoshinobu Kariya, Hiroki Sato, Naoko Katou, Yukiko Kariya, Kaoru Miyazaki
PloS one 7 ( 5 ) e35546 2012年
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Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.
Taizo Mori, Yoshinobu Kariya, Eriko Komiya, Shouichi Higashi, Yohei Miyagi, Kiyotoshi Sekiguchi, Kaoru Miyazaki
Cancer Science 102 ( 5 ) 1095 - 100 2011年5月（ ISSN:1347-9032 ）
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Wnt/ß-catenin signaling down-regulates N-acetylglucosaminyltransferase III expression: the implications of two mutually exclusive pathways for regulation.
Qingsong Xu, Ryota Akama, Tomoya Isaji, Yingying Lu, Hirokazu Hashimoto, Yoshinobu Kariya, Tomohiko Fukuda, Yuguang Du, Jianguo Gu
Journal of Biological Chemistry 286 ( 6 ) 4310 - 8 2011年2月（ ISSN:0021-9258 ）
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N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes.
Yoshinobu Kariya, Jianguo Gu
PloS one 6 ( 11 ) e27084 2011年
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Laminin-3B11, a novel vascular-type laminin capable of inducing prominent lamellipodial protrusions in microvascular endothelial cells.
Taizo Mori, Kota Ono, Yoshinobu Kariya, Takashi Ogawa, Shouichi Higashi, and Kaoru Miyazaki
The Journal of biological chemistry 285 ( 45 ) 35068 - 78 2010年11月（ ISSN:0021-9258 ）
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Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility.
Yoshinobu Kariya, Chihiro Kawamura, Toshiki Tabei and Jianguo Gu
The Journal of biological chemistry 285 ( 5 ) 3330 - 40 2010年1月（ ISSN:0021-9258 ）
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Functional roles of the bisecting GlcNAc in integrin-mediated cell adhesion.
Tomoya Isaji, Yoshinobu Kariya, Qingsong Xu, Tomohiko Fukuda, Naoyuki Taniguchi, Jianguo Gu
Methods in enzymology 480 445 - 59 2010年（ ISSN:0076-6879 ）
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Roles of laminin-332 and alpha6beta4 integrin in tumor progression.
Yoshinobu Kariya, Yukiko Kariya, Jianguo Gu
Mini reviews in medicinal chemistry 9 ( 11 ) 1284 - 91 2009年10月（ ISSN:1389-5575 ）
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Importance of N-glycosylation on alpha5beta1 integrin for its biological functions.
Jianguo Gu, Tomoya Isaji , Yuya Sato, Yoshinobu Kariya, Tomohiko Fukuda
Biological & pharmaceutical bulletin 32 ( 5 ) 780 - 5 2009年5月（ ISSN:0918-6158 ）
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A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions.
Jianguo Gu, Yuya Sato, Yoshinobu Kariya, Tomoya Isaji, Naoyuki Taniguchi and Tomohiko Fukuda
Journal of proteome research 8 ( 2 ) 431 - 5 2009年2月（ ISSN:1535-3893 ）
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N-Glycosylation of laminin-332 regulates its biological functions. A novel function of the bisecting GlcNAc.
Yoshinobu Kariya, Rika Kato, Satsuki Itoh, Tomohiko Fukuda, Yukinao Shibukawa, Noriko Sanzen, Kiyotoshi Sekiguchi, Yoshinao Wada, Nana Kawasaki, Jianguo Gu
The Journal of biological chemistry 283 ( 48 ) 33036 - 45 2008年11月（ ISSN:0021-9258 ）
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N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex.
Ryota Akama, Yuya Sato, Yoshinobu Kariya, Tomoya Isaji, Tomohiko Fukuda, LiangHao Lu, Naoyuki Taniguchi, Masayuki Ozawa and Jianguo Gu
Proteomics 8 ( 16 ) 3221 - 8 2008年8月（ ISSN:1615-9853 ）
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Localization of laminin alpha3B chain in vascular and epithelial basement membranes of normal human tissues and its down-regulation in skin cancers.
Yoshinobu Kariya, Taizo Mori, Chie Yasuda, Naoko Watanabe, Yoshie Kaneko, Yukiko Nakashima, Takashi Ogawa, Kaoru Miyazaki
Journal of molecular histology 39 ( 4 ) 435 - 46 2008年8月（ ISSN:1567-2379 ）
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The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain.
Takashi Ogawa, Yoshiaki Tsubota, Junko Hashimoto, Yoshinobu Kariya and Kaoru Miyazaki
Molecular biology of the cell 18 ( 5 ) 1621 - 33 2007年5月（ ISSN:1059-1524 ）
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The beta3 chain short arm of laminin-332 (laminin-5) induces matrix assembly and cell adhesion activity of laminin-511 (laminin-10).
Yukiko Nakashima, Yoshinobu Kariya and Kaoru Miyazaki
Journal of cellular biochemistry 100 ( 3 ) 545 - 56 2007年2月（ ISSN:0730-2312 ）
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Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions.
Yanyang Zhao, Satsuki Itoh, Xiangehun Wang, Tomoya Isaji, Eiji Miyoshi, Yoshinobu Kariya, Kaoru Miyazaki, Nana Kawasaki, Naoyuki Taniguchi, Jianguo Gu
The Journal of biological chemistry 281 ( 50 ) 38343 - 50 2006年12月（ ISSN:0021-9258 ）
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Regulation of proliferation and chondrogenic differentiation of human mesenchymal stem cells by laminin-5 (laminin-332).
Junko Hashimoto, Yoshinobu Kariya and Kaoru Miyazaki
Stem cells (Dayton, Ohio) 24 ( 11 ) 2346 - 54 2006年11月（ ISSN:1066-5099 ）
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Beta4 Integrin and EGF Coordinately Regulate Electric Field-mediated Directional Migration via Rac1.
Christine E. Pullar, Brian S. Baier, Yoshinobu Kariya, Alan J. Russell, Basil A. J. Horst, M. Peter Marinkovich and R. Rivkah Isseroff
Molecular biology of the cell 17 ( 11 ) 4925 - 35 2006年11月（ ISSN:1059-1524 ）
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N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration.
Yanyang Zhao, Takatoshi Nakagawa, Satsuki Itoh, Kei-ichiro Inamori, Tomoya Isaji, Yoshinobu Kariya, Akihiro Kondo, Eiji Miyoshi, Kaoru Miyazaki, Nana Kawasaki, Naoyuki Taniguchi, Jianguo Gu
The Journal of biological chemistry 281 ( 43 ) 32122 - 30 2006年10月（ ISSN:0021-9258 ）
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Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells.
Hyung Keun Lee, Joon H. Lee, Min Kim, Yoshinobu Kariya, Kaoru Miyazaki, and Eung Kweon Kim
Investigative ophthalmology & visual science 47 ( 3 ) 873 - 82 2006年3月（ ISSN:0146-0404 ）
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Regulation of cell adhesion and type VII collagen binding by the beta3 chain short arm of laminin-5: effect of its proteolytic cleavage.
Yukiko Nakashima, Yoshinobu Kariya, Chie Yasuda, Kaoru Miyazaki
Journal of biochemistry 138 ( 5 ) 539 - 52 2005年11月（ ISSN:0021-924X ）
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Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4-5 domain of alpha3 chain.
Yoshiaki Tsubota, Chie Yasuda, Yoshinobu Kariya, Takashi Ogawa, Tomomi Hirosaki, Hirot Mizushima, and Kaoru Miyazaki
The Journal of biological chemistry 280 ( 15 ) 14370 - 7 2005年4月（ ISSN:0021-9258 ）
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The basement membrane protein laminin-5 acts as a soluble cell motility factor.
Yoshinobu Kariya and Kaoru Miyazaki
Experimental cell research 297 ( 2 ) 508 - 20 2004年7月（ ISSN:0014-4827 ）
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Regulation of biological activity of laminin-5 by proteolytic processing of gamma2 chain.
Takashi Ogawa, Yoshiaki Tsubota, Masato Maeda, Yosinobu Kariya and Kaoru Miyazaki
Journal of cellular biochemistry 92 ( 4 ) 701 - 14 2004年7月（ ISSN:0730-2312 ）
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Characterization of laminin 5B and NH2-terminal proteolytic fragment of its alpha3B chain: promotion of cellular adhesion, migration, and proliferation.
Yoshinobu Kariya, Chie Yasuda, Yukiko Nakashima, Kumiko Ishida, Yoshiaki Tsubota and Kaoru Miyazaki
The Journal of biological chemistry 279 ( 23 ) 24774 - 84 2004年6月（ ISSN:0021-9258 ）
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Differential regulation of cellular adhesion and migration by recombinant laminin-5 forms with partial deletion or mutation within the G3 domain of alpha3 chain.
Yoshinobu Kariya, Yoshiaki Tsubota, Tomomi Hirosaki, Hiroto Mizushima, Wilma Puzon-McLaughlin, Yoshikazu Takada, and Kaoru Miyazaki
Journal of cellular biochemistry 88 ( 3 ) 506 - 20 2003年2月（ ISSN:0730-2312 ）
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癌細胞が分泌する蛋白質の機能に基づいた検索と同定
安光英太郎、苅谷慶喜、宮崎香
生物物理化学 47 127 - 130 2003年
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Laminin-6 is activated by proteolytic processing and regulates cellular adhesion and migration differently from laminin-5.
Tomomi Hirosaki, Yoshiaki Tsubota, Yoshinobu Kariya, Kayano Moriyama, Hiroto Mizushima, Kaoru Miyazaki
The Journal of biological chemistry 277 ( 51 ) 49287 - 95 2002年12月（ ISSN:0021-9258 ）
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Efficient expression system of human recombinant laminin-5.
Yoshinobu Kariya, Kumiko Ishida, Yoshiaki Tsubota, Yukiko Nakashima, Tomomi Hirosaki, Takashi Ogawa and Kaoru Miyazaki
Journal of biochemistry 132 ( 4 ) 607 - 12 2002年10月（ ISSN:0021-924X ）
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Nucleotide sequence of phospholipase A(2) gene expressed in snake pancreas reveals the molecular evolution of toxic phospholipase A(2) genes.
Takahiko J. Fujimi, Yoshinobu Kariya, Takahide Tsuchiya, Toru Tamiya
Gene 292 ( 1-2 ) 225 - 31 2002年6月（ ISSN:0378-1119 ）