Faculty Profiles - MISAKA Shingen

Papers - MISAKA Shingen

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Role of (―)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers.

Abe Osamu, Ono Tomoyuki, Sato Hideyuki, Müller Fabian, Ogata Hiroshi, Miura Itaru, Shikama Yayoi, Yabe Hirooki, Onoue Satomi, Fromm Martin F, Kimura Junko, Misaka Shingen

European Journal of Clinical Pharmacology 2018.2

Update of green tea interactions with cardiovascular drugs and putative mechanisms

José P. Werba, Shingen Misaka, Monica Gianna Giroli, Kenju Shimomura, Manuela Amatoa, Niccolò Simonelli, Lorenzo Vigoa, Elena Tremoli

Journal of Food and Drug Analysis 2018.2

Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers.

Shingen Misaka, Osamu Abe, Hideyuki Sato, Tomoyuki Ono, Yayoi Shikama, Satomi Onoue, Hirooki Yabe, Junko Kimura

European Journal of Clinical Pharmacology 74 ( 5 ) 601 - 609 2018

The non-metabolized β-blocker nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein, but not of OATP1B1 and OATP1B3

Shingen Misaka, Jana Knop, Katrin Singer, Eva Hoier, Markus Keiser, Fabian Müller, Hartmut Glaeser, Jörg König, Martin F. Fromm

Molecular Pharmaceutics 13 512 - 519 2016

Inhibitory effects of green tea and (-)-epigallocatechin gallate on transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein.

Jana Knop, Shingen Misaka, Katrin Singer, Eva Hoier, Fabian Müller, Hartmut Glaeser, Jörg König, Martin F. Fromm

Plos One 10 ( 10 ) e0139370 2015.10

Overview of green tea interaction with cardiovascular drugs.

Werba JP, Misaka S, Giroli MG, Yamada S, Cavalca V, Kawabe K, Squellerio I, Laguzzi F, Onoue S, Veglia F, Myasoedova V, Takeuchi K, Adachi E, Inui N, Tremoli E, Watanabe H.

Current Pharmaceutical Design 21 1213 - 1219 2015

Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.

Shingen Misaka, Junichi Yatabe, Fabian Müller, Kozue Takano, Keisuke Kawabe, Hartmut Glaeser, Midori S. Yatabe, Satomi Onoue, José P. Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F. Fromm, Junko Kimura

Clinical Pharmacology & Therapeutics 95 ( 4 ) 432 - 438 2014

Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats.

Shingen Misaka, Nozomu Miyazaki, Tetsuhito Fukushima, Shizuo Yamada, Junko Kimura

Phytomedicine 20 ( 14 ) 1247 - 1250 2013

Clinical relevance of drug efflux pumps in the gut.

Shingen Misaka, Fabian Müller, Martin F. Fromm

Current Opinion in Pharmacology 13 847 - 852 2013

Pharmacokinetic and pharmacodynamic interactions of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers.

Shingen Misaka, Nozomu Miyazaki, Midori S. Yatabe, Tomoyuki Ono, Yayoi Shikama, Tetsuhito Fukushima, Junko Kimura

Journal of Clinical Pharmacology 53 ( 7 ) 738 - 745 2013

Effects of itraconazole, dexamethasone and naringin on pharmacokinetics of nadolol in rats.

Nozomu Miyazaki, Shingen Misaka, Hiroshi Ogata, Tetsuhito Fukushima, Junko Kimura

Drug Metabolism and Pharmacokinetics 28 ( 4 ) 356 - 361 2013

Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes.

Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José P. Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada

Drug Metabolism and Pharmacokinetics 28 ( 3 ) 244 - 249 2013

Green tea extract affects cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats.

Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Monica Giroli, José P. Werba, Hiroshi Watanabe, Shizuo Yamada

Drug Metabolism and Pharmacokinetics 28 ( 6 ) 514 - 518 2013

Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis

Shingen Misaka, Hideyuki Sato, Yosuke Aoki, Takahiro Mizumoto, Satomi Onoue, Shizuo Yamada

Peptides 32 401 - 407 2011

Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R^{15, 20, 21}, L¹⁷, A^24,25, des-N²⁸]-VIP-GRR) in experimental asthma/COPD model rats

Satomi Onoue, Yosuke Aoki, Takuya Matsui, Yoshiki Kojo, Shingen Misaka, Takahiro Mizumoto, Shizuo Yamada

International Journal of Pharmaceutics 410 54 - 60 2011

Evaluation of pharmacodynamic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy

Shingen Misaka, Souhei Kurosawa, Shinya Uchida, Akira Yoshida, Yoshihisa Kato, Yoshiyuki Kagawa, Shizuo Yamada

Journal of Pharmacy and Pharmacology 63 58 - 64 2011

Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes

Shinya Uchida, Kayoko Shimada, Shingen Misaka, Hiromitsu Imai, Naoki Inui, Kazuhiko Takeuchi, Noriyuki Namiki, Takashi Ishizaki, Kyoichi Ohashi, Shizuo Yamada, Hiroshi Watanabe

Drug Metabolism and Pharmacokinetics 25 605 - 610 2010

Effects of a stabilized vasoactive intestinal peptide derivative, [R^{15, 20, 21}, L¹⁷]-VIP-GRR (IK312532), on cigarette smoke-induced lung inflammation in rats

Satomi Onoue, Shingen Misaka, Yosuke Aoki, Shin-ichiro Karaki, Atsukazu Kuwahara, Takahiro Mizumoto, Shizuo Yamada

European Journal of Pharmaceutical Sciences 41 508 - 514 2010

Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: Anti-inflammatory effect in experimental asthmatic rats

Shingen Misaka, Yosuke Aoki, Shin-ichiro Karaki, Atsukazu Kuwahara, Takahiro Mizumoto, Satomi Onoue, Shizuo Yamada

Peptides 31 72 - 78 2010

Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets.

Hattori K, Shimizu M, Yamachi M, Tezuka K, Fukushima T, Yokota S, Okano T, Misaka S, Hidema S, Kanai K, Shimomura K, Maejima Y

Aging 17 ( 5 ) 1139 - 1147 2025.5

Limited Sampling Strategy for Predicting the Area under Plasma Concentration-Time Curve of Nadolol in Healthy Subjects.

Misaka S, Maejima Y, Shimomura K

Journal of clinical pharmacology 65 ( 5 ) 621 - 627 2025.5（ ISSN:0091-2700 ）

Canagliflozin-induced renal glutathione distribution mapping in non-diabetic male rat kidneys.

Watanabe G, Horita S, Moriya RF, Masuishi Y, Misaka S, Taira S, Shimomura K, Shimabukuro M, Kazama JJ

Physiological reports 13 ( 7 ) e70320 2025.4

Peripheral Dopamine Suppression and Elevated Cystatin C in Early Diabetic Nephropathy in Spontaneously Diabetic Rats.

Horita S, Watanabe G, Misaka S, Taira S, Satoh M, Maejima Y, Shimomura K, Shimabukuro M, Kazama JJ, Shigetomi S

American journal of physiology. Renal physiology 327 ( 4 ) F581 - F590 2024.8（ ISSN:1931857X ）

Comparative analysis of functional components in Sakekasu (Sake lees)

Nishidono Y., Misaka S., Maejima Y., Shimomura K., Tanaka K.

Functional Foods in Health and Disease 14 ( 1 ) 74 - 86 2024.1（ ISSN:23787007 ）

Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice.

Maejima Y, Yokota S, Yamachi M, Misaka S, Ono T, Oizumi H, Mizuno K, Hidema S, Nishimori K, Aoyama M, de Wet H, Shimomura K

Frontiers in endocrinology 15 1387964 2024（ ISSN:1664-2392 ）

Sex differences in the effects of aromatherapy on anxiety and salivary oxytocin levels.

Nakajima D, Yamachi M, Misaka S, Shimomura K, Maejima Y

Frontiers in endocrinology 15 1380779 2024（ ISSN:1664-2392 ）

Stabilized Astaxanthin Nanoparticles Developed Using Flash Nanoprecipitation to Improve Oral Bioavailability and Hepatoprotective Effects.

Ghosh A, Banik S, Yamada K, Misaka S, Prud'homme RK, Sato H, Onoue S

Pharmaceutics 15 ( 11 ) 2023.10（ ISSN:1999-4923 ）

Effect of lemborexant on pharmacokinetics of clozapine: A potential drug-drug interaction mediated by time-dependent inhibition of CYP3A4.

Watanabe K, Misaka S, Kanno-Nozaki K, Chiyoda T, Suzuki Y, Sato A, Suto T, Kuroda J, Shimomura K, Miura I, Yabe H

British journal of clinical pharmacology 90 ( 1 ) 354 - 359 2023.8（ ISSN:0306-5251 ）

Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers.

Misaka S, Ono Y, Taudte RV, Hoier E, Ogata H, Ono T, König J, Watanabe H, Fromm MF, Shimomura K

Clinical pharmacology and therapeutics 112 ( 3 ) 627 - 634 2022.9（ ISSN:0009-9236 ）

C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice.

Ono Y, Saito M, Sakamoto K, Maejima Y, Misaka S, Shimomura K, Nakanishi N, Inoue S, Kotani J

Frontiers in pharmacology 13 1031906 2022（ ISSN:1663-9812 ）

Identification of oxytocin receptor activating chemical components from traditional Japanese medicines.

Maejima Y, Horita S, Yokota S, Ono T, Proks P, Yoshida-Komiya H, Ueta Y, Nishimori K, Misaka S, Shimomura K

Journal of food and drug analysis 29 ( 4 ) 653 - 675 2021.12（ ISSN:1021-9498 ）

Urinary Excretion of Nadolol as a Possible In Vivo Probe for Drug Interactions Involving P-Glycoprotein.

Shimazaki S, Kuroda J, Shimomura K, Misaka S

Journal of clinical pharmacology 61 ( 6 ) 799 - 805 2021.6（ ISSN:0091-2700 ）

Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers.

Misaka S, Ono Y, Uchida A, Ono T, Abe O, Ogata H, Sato H, Suzuki M, Onoue S, Shikama Y, Shimomura K

Clinical and translational science 14 ( 2 ) 476 - 480 2021.3（ ISSN:1752-8054 ）

Atorvastatin-Green Tea Interaction: Possible Mechanisms are Complicated, But Clinical Relevance is Not?

Misaka S, Shimomura K

European journal of drug metabolism and pharmacokinetics 45 ( 3 ) 423 - 425 2020.6（ ISSN:0378-7966 ）

Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers.

Misaka S, Abe O, Ono T, Ono Y, Ogata H, Miura I, Shikama Y, Fromm MF, Yabe H, Shimomura K

British journal of clinical pharmacology 2020.4（ ISSN:0306-5251 ）

【緑茶の機能性と薬理】緑茶と薬物の相互作用

三坂眞元

機能性食品と薬理栄養 13 ( 1 ) 35 - 43 2019.8（ ISSN:1348-2564 ）

【緑茶の機能性と薬理】緑茶と薬物の相互作用

三坂眞元

機能性食品と薬理栄養 13 ( 1 ) 35 - 43 2019.8（ ISSN:1348-2564 ）

Memantine has no effect on K<sub>ATP</sub> channels in pancreatic β cells.

Imai R, Misaka S, Horita S, Yokota S, O'hashi R, Maejima Y, Shimomura K

BMC research notes 11 ( 1 ) 614 2018.8

Misaka S, Shimomura K

European journal of clinical pharmacology 1 - 2 2018.5（ ISSN:0031-6970 ）

Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury.

Shimizu T, Suzuki S, Sato A, Nakamura Y, Ikeda K, Saitoh S, Misaka S, Shishido T, Kubota I, Takeishi Y

Journal of molecular and cellular cardiology 89 ( Pt B ) 306 - 13 2015.12（ ISSN:0022-2828 ）

Effects of natural products on pharmacokinetics and pharmacodynamics of drugs

Yamada S., Misaka S., Ito Y., Watanabe H., Umegaki K.

AAPS Advances in the Pharmaceutical Sciences Series 12 189 - 211 2014.1（ ISSN:22107371 ）

Effect of oral L-arginine administration on exhaled nitric oxide (NO) concentration in healthy volunteers.

Ogata H., Yatabe M., Misaka S., Shikama Y., Sato S., Munakata M., Kimura J.

Fukushima journal of medical science 59 ( 1 ) 43 - 48 2013.1

Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS.

Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José P. Werba, Monica Giroli, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada

Biomedical Chromatography 27 ( 1 ) 1 - 6 2013

Effect of two weeks consumption of pomegranate juice on the pharmacokinetics of single dose of midazolam: an open-label, randomized, single-center, two-period crossover study in healthy Japanese volunteers.

Shingen Misaka, Reiko Nakamura, Shinya Uchida, Kazuhiko Takeuchi, Norio Takahashi, Naoki Inui, Kazuhiro Kosuge, Shizuo Yamada, Hiroshi Watanabe

Clinical Therapeutics 33 246 - 252 2011

Pharmacokinetics and pharmacodynamics of midazolam administered intravenously and orally at low doses to healthy volunteers

Shingen Misaka, Shinya Uchida, Hiromitsu Imai, Naoki Inui, Shinichiro Nishio, Kyoichi Ohashi, Hiroshi Watanabe, Shizuo Yamada

Clinical and Experimental Pharmacology and Physiology 37 290 - 295 2010

Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability

Satomi Onoue, Shingen Misaka, Yuki Ohmori, Hideyuki Sato, Takahiro Mizumoto, Mariko Hirose, Sumiko Iwasa, Takehiko Yajima, Shizuo Yamada

European Journal of Pharmaceutics and Biopharmaceutics 73 95 - 101 2009

Novel dry powder formulation of ovalbumin for development of COPD-like animal model: physicochemical characterization and biomarker profiling in rats

Shingen Misaka, Hideyuki Sato, Yukinori Yamauchi, Satomi Onoue, Shizuo Yamada

European Journal of Pharmaceutical Sciences 37 469 - 476 2009

New treatments for COPD and viable formulation/device options for inhalation therapy

Satomi Onoue, Shingen Misaka, Yohei Kawabata, Shizuo Yamada

Expert Opinion on Drug Delivery 6 ( 8 ) 793 - 811 2009

Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications

Satomi Onoue, Shingen Misaka, Shizuo Yamada

Naunyn-Schmiedeberg's Archives of Pharmacology 377 579 - 590 2008

Effects of ursodeoxycholic acid on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam in healthy volunteers

Dongmei Yan, Yingbao Yang, Shinya Uchida, Shingen Misaka, Jinghui Luo, Kazuhiko Takeuchi, Naoki Inui, Shizuo Yamada, Kyoichi Ohashi, Hiroshi Watanabe

Naunyn-Schmiedeberg's Archives of Pharmacology 377 629 - 636 2008

Maintenance time of sedative effects after an intravenous infusion of diazepam: a guide for endoscopy using diazepam

Mitsushige Sugimoto, Takahisa Furuta, Akiko Nakamura, Naohito Shirai, Mutsuhiro Ikuma, Shingen Misaka, Shinya Uchida, Hiroshi Watanabe, Kyoichi Ohashi, Takashi Ishizaki, Akira Hishida

World Journal of Gastroenterology 14 5197 - 5203 2008

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Papers - MISAKA Shingen