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2014
  1. Watanabe, K., Okada, K., Fukabori, R., Hayashi, Y., Asahi, K., Terawaki, H., Kobayashi, K., Watanabe, T., and Nakayama, M. (2014) Methylglyoxal (MG) and cerebro-renal interaction: Does long-term orally-administered MG cause cognitive impairment in normal Sprague-Dawley rats? Toxins 6(1): 254-269 (January) doi:10.3390/toxins6010254 PMID: 24402234.
  2. Kato, S., Kobayashi, K., and Kobayashi, K. (2014) Improved transduction efficiency of a lentiviral vector for neuron-specific retrograde gene transfer by optimizing the junction of fusion envelope glycoprotein. J. Neurosci. Methods 227: 151-158 (March 5). PMID: 24613797.
  3. Okada, K., Nishizawa, K., Fukabori, R., Kai, N., Shiota, A., Ueda, S., Tsutsui, Y., Sakata, S., Matsushita, N., and Kobayashi, K. (2014) Enhanced flexibility of place discrimination learning by targeting of striatal cholinergic interneurons. Nat. Commun. 5: 3778 (6 May) DOI: 10.1038/ncomms4778. PMID: 24797209.
  4. Ikeda, S., Satoh, K., Kikuchi, N., Miyata, S., Suzuki, K., Omura, J., Shimizu, T., Kobayashi, K., Kobayashi, K., Fukumoto, Y., Sakata, Y., and Shimokawa, H. (2014) Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice. Arterioscler. Thromb. Vasc Biol. 34 (6): 1260-1271 (Jun) doi: 10.1161/ATVBAHA.114.303320. PMID: 24675663.
  5. Kai, N., Tsutsui, Y., and Kobayashi, K. (2014) Lesions of the nucleus accumbens core modulate development of matching behavior. BMC Neurosci. 15:55 (30 April) doi: 10.1186/1471-2202-15-55. PMID: 24886021.
  6. Hagino, Y., Kasai, S., Fujita, M., Setogawa, S., Yamaura, H., Yanagihara, D., Hashimoto, M., Kobayashi, K., Meltzer, H.Y., and Ikeda, K. (2014) Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice. Neuropsychopharmacology. [in press] (Nov 4) DOI: 10.1038/npp.2014.295. PMID: 25367503.
  7. Rodrigues, P., Macaya, I., Bazzocco, S., Mazzolini, R., Andretta, E., Dopeso, H., Mateo-Lozano, S., Bilić, J., Cartón-García, F., Nieto, R., Suárez-López, L., Afonso, E., Landolfi, S., Hernandez-Losa, J., Kobayashi, K., Cajal, S.R., Tabernero, J., Tebbutt, N.C., Mariadason, J.M., Schwartz, S. Jr., and Arango, D. (2014) RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Nat Commun. 5:5458 (Nov 21) DOI: 10.1038/ncomms6458. PMID: 25413277.
2013
  1. Kato, S., Kobayashi, K., and Kobayashi, K. (2013) Dissecting circuit mechanisms by genetic manipulation of specific neural pathways. Rev. Neurosci. 24 (1) 1-8 (January) PMID: 23152400. doi: 10.1515/revneuro-2012-0043.
  2. Sano, H., Chiken, S., Hikida, T., Kobayashi, K., and Nambu, A. (2013) Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. J. Neurosci. 33 (17) 7583-7594 (April 24) PMID: 23616563.
  3. Tanaka, T., Takano, Y., Tanaka, S., Hironaka, N., Kobayashi, K., Watanabe, K., Honda, M. (2013) Transcranial direct-current stimulation increases extracellular dopamine levels in the rat striatum. Front. Syst. Neurosci. 7: 6 (April 11) PMID: 23596399.
  4. Hoshina, N., Tanimura, A., Yamasaki, M., Inoue, T., Fukabori, R., Kuroda, T., Yokoyama, K., Tezuka, T., Sagara, H., Hirano, S., Kiyonari, H., Takada, M., Kobayashi, K., Watanabe, M., Kano, M., Nakazawa, T. and Yamamoto, T. (2013) Protocadherin 17 regulates presynaptic assembly in topographic cortico-basal ganglia circuits. Neuron 78 (5) 839-854 (June 5) PMID: 23684785.
  5. Miyazaki, M., Noda, Y., Mouri, A., Kobayashi, K., Mishina, M., Nabeshima, T., Yamada, K. (2013) Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence. Int. J. Neuropsychopharmacol. 16 (6) 1341-1350 (July) PMID: 23195702.
  6. Tsujino, N., Tsunematsu, T., Uchigashima, M., Konno, K., Yamanaka, A., Kobayashi, K., Watanabe, M., Koyama, Y., and Sakurai, T. (2013) Chronic alterations in monoaminergic cells in locus coeruleus in orexin neuron-ablated narcoleptic mice. PLoS One 8(7): e70012. (July 29) PMID: 23922890.
  7. Hirano, M., Kato, S., Kobayashi, K., Okada, T., Yaginuma, H., and Kobayashi, K. (2013) Highly efficient retrograde gene transfer into motor neurons by lentiviral vector pseudotyped with fusion glycoprotein. PLoS One 8(9): e75896. (September 24) PMID: 24086660. doi: 10.1371/journal.pone.0075896
  8. Takada, M., Inoue, K., Koketsu, K., Kato, S., Kobayashi, K., Nambu, A. (2013) Elucidating information processing in primate basal ganglia circuitry: a novel technique for pathway-selective ablation mediated by immunotoxin. Front. Neural Circuits 7: 140 (September 3) PMID:24027499; doi:10.3389/fncir.2013.00140
  9. Sooksawate, T., Isa, K., Matsui, R., Kato, S., Kinoshita, M., Kobayashi, K., Watanabe, D., Kobayashi, K., and Isa, T. (2013) Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice. Front. Neural Circuits. 7: 162 (October 11) PMID: 24130520; doi: 10.3389/fncir.2013.00162
  10. Zhang, C., Tonsfeldt, K.J., Qiu, J., Bosch, M.A., Kobayashi, K., Steiner, R.A., Kelly, M.J. and Rønnekleiv, O.K. (2013) Rostral periventricular kisspeptin neurons express HCN1 and Cav3.1 channels and exhibit postinhibitory rebound burst firing driven by circulating 17β-estradiol. Am. J. Physiol. Endocrinol. Metab. 305(11): E1384-1397 (Dec) PMID: 24105416.
2012
  1. Fukabori, R., Nishizawa, K., Okada, K., Kai, N., Kobayashi, K., Uchigashima, M., Watanabe, M., Tsutsui, Y., and Kobayashi, K. (2012) Striatal direct pathway modulates response time in execution of visual discrimination. Eur. J. Neurosci. 35 (5) 784-797 (March) PMID: 22356538; DOI: 10.1111/j.1460-9568.2012.08005.x
  2. Kinoshita, M., Matsui, R., Kato, S., Hasegawa, T., Kasahara, H., Isa, K., Watakabe, A., Yamamori, T., Nishimura, Y., Alstermark, B., Watanabe, D., Kobayashi, K., and Isa, T. (2012) Genetic dissection of the circuit for hand dexterity in primates. Nature 487 (7406) 235-238 (July 12) PMID: 22722837 doi: 10.1038/nature11206
  3. Inoue, K., Koketsu, D., Kato, S., Kobayashi, K., Nambu, A., and Takada, M. (2012) Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic “hyperdirect” pathway. PLoS One 7 (6) e39149 (June 25) PMID: 22761729 doi: 10.1371/journal.pone.0039149. Epub 2012 Jun 25
  4. Nishizawa, K., Fukabori, R., Okada, K., Kai, N., Uchigashima, M., Watanabe, M., Shiota, A., Ueda, S., Tsutsui, Y., and Kobayashi, K. (2012) Striatal indirect pathway contributes to selection accuracy of learned motor actions. J. Neurosci. 32 (39) 13421-13432 (September 26) PMID: 23015433 DOI: 10.1523/JNEUROSCI.1969-12.2012
  5. Watakabe, A., Kato, S., Kobayashi, K., Takaji, M., Nakagami, Y., Sadakane, O., Ohtsuka, M., Hioki, H., Kaneko, T., Okuno, H., Kawashima, T., Bito, H., Kitamura Y., and Yamamori, T. (2012) Visualization of the cortical projection neurons by retrograde TET-Off lentiviral vector. PLoS One 7 (10): e46157. (October 5) PMID: 23071541. doi: 10.1371/journal.pone.0046157. Epub 2012 Oct 5.
  6. Dougalis, A.G., Matthews, GAC, Bishop, MW, Brischoux, F., Kobayashi, K., and Ungless, M.A. (2012) Functional properties of dopamine neurons and co-expression of vasoactive-intestinal-polypeptide in the dorsal raphe nucleus and ventro-lateral periaqueductal grey. Eur. J. Neurosci. 36 (10) 3322-3332 (Nov) PMID: 229225150.
    doi: 10.1111/j.1460-9568.2012.08255.x. Epub 2012 Aug 26.
2011
  1. Kato, S., Kobayashi, K., Inoue, K., Kuramochi, M., Okada, T., Yaginuma, H., Morimoto, K., Shimada, T., Takada, M., and Kobayashi, K. (2011) A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein. Hum. Gene Ther. 22 (2) 197-206 (February) PMID:20954846
  2. Kobayashi, K., Masuda, T., Takahashi, M., Miyazaki, J., Nakagawa, M., Uchigashima, M., Watanabe, M., Yaginuma, H., Osumi, N., Kaibuchi, K., and Kobayashi, K. (2011) Rho/Rho-kinase signaling controls axon patterning of a specified subpopulation of cranial motor neurons. Eur. J. Neurosci. 33 (4) 612-621 (February) PMID:21219475
  3. Cheng, H.-C., Kim, S.R., Oo, T., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., and Burke, R. (2011) AKT suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J. Neurosci. 31 (6) 2125-2135 (February 9) PMID: 21307249.
  4. Matsusaka, T., Kobayashi, K., Kon, V., Qing-cheng, Pastan, I., Fogo, A.B., and Ichikawa, I. (2011) Glomerular Sclerosis is prevented during urinary tract obstruction due to podocyte protection. Am. J. Physiol. Renal Physiol. 300 (3) F792-800 (March) PMID: 21177778.
  5. Itoi, K., Sugimoto, N., Suzuki, S., Sawada, K., Das, G., Uchida, K., Fuse, T., Ohara, S., and Kobayashi, K. (2011) Targeting of locus ceruleus noradrenergic neurons expressing human interleukin-2 receptor -subunit in transgenic mice by a recombinant immunotoxin anti-Tac(Fv)-PE38: A study for exploring noradrenergic influence upon anxiety-like and depression-like behaviors. J. Neurosci. 31(16) 6132-6139. (April 20) PMID: 21508238; DOI:10.1523/JNEUROSCI.5188-10.2011
  6. Murata, K., Imai, M., Nakanishi, S., Watanabe, D., Pastan, I., Kobayashi, K., Nihira, T., Mochizuki, H., Yamada, S., Mori, K., and Yamaguchi, M. (2011) Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb. J. Neurosci. 31(29) 10540-10557. (July 20) PMID: 21775599; DOI: 10.1523/JNEUROSCI.1285-11.2011
  7. Tanaka, T., Kai, N., Kobayashi, K., Takano, Y., Hironaka, N. (2011) Up-regulation of dopamine D1 receptor in the hippocampus after establishment of conditioned place preference by cocaine. Neuropharmacology 61 (4) 842-848. (Sep) PMID: 21669213
  8. Sekine, Y., Takagahara, S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H. (2011) p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. J. Cell. Sci. 124 (17) 3006-3016. (Sep 1) PMID: 21878507
  9. Sawada, M., Kaneko, N., Wake, H., Inada, H., Kato, Y., Yanagawa, Y., Kobayashi, K., Nemoto, T., Nabekura, J. and Sawamoto, K. (2011) Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb. J. Neurosci. 31 (32) 11587-11596 (Aug 10) PMID: 21832189; DOI: 10.1523/JNEUROSCI.0614-11.2011
  10. Matsunaga, E., Suzuki, K., Kato, S., Kurotani, T., Kobayashi, K., and Okanoya, K. (2011) Dynamic expression of cadherins modulates vocal plasticity in a songbird. PLoS One 6 (9) e25272 (Sep 20) PMID: 21949888
  11. Masuda, M., Miura, M., Inoue, R., Imanishi, M., Saino-Saito, S., Takada, M., Kobayashi, K., and Aosaki, T. (2011) Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum. Eur. J. Neurosci. 34 (9) 1355-1367 (Nov) PMID: 22004548; DOI: 10.1111/j.1460-9568.2011.07873.x
  12. Kato, S., Kuramochi, M., Kobayashi, K., Fukabori, R., Okada, K., Uchigashima M., Watanabe, M., Tsutsui, Y., and Kobayashi, K. (2011) Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of visual discrimination. J. Neurosci. 31 (47) 17169-17179 (Nov 23) PMID: 22114284; DOI: 10.1523/JNEUROSCI.4005-11.2011
  13. Kato, S., Kuramochi, M., Takasumi, K., Kobayashi, K., Inoue, K., Takahara, D., Hitoshi, S., Ikekana, K., Shimada, T., Takada, M., and Kobayashi, K. (2011) Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein. Hum. Gene Ther. 22 (12) 1511-1523 (December) PMID: 21806473; DOI: 10.1089/hum.2011.111
2010
  1. Kiyokage E., Pan Y., Shao, Z., Kobayashi, K., Szabo, Y., Yanagawa, Y., Obata, K., Okano, H., Toida, K., Puche, A.C., and Shipley. M.T. (2010) Molecular identity of periglomerular and short axon cells. J. Neurosci. 30 (3) 1185-1196 (20 January) PMID: 20089927
  2. Hotta, R., Anderson, R.B., Kobayashi, K., Newgreen, D.F. and Young, H.M. (2010) Effects of age, presence of neurons and endothelin-3 on the ability of enteric neuron precursors to colonize recipient gut. Neurogastroenterol. Motil. 22 (3) 331-e86 PMID: 19775251
  3. Contini, M., Lin, B., Kobayashi, K., Okano, H., Masland, R.H., and Raviola, E. (2010) Synaptic input of ON-bipolar cells onto the dopaminergic neurons of the mouse retina. J. Comp. Neurol. 518 (11) 2035-2050 (1 June) PMID: 20394057; DOI: 10.1002/cne.22320
  4. Tsutsui, Y., Nishizawa, K., Kai, N., and Kobayashi, K. (2010) Lever pressing responses under a fixed-ratio schedule of mice with 6-hydroxydopamine-induced dopamine depletion in the nucleus accumbens. Behav. Brain Res. 217 (2011) 60-66 (5 Nov) PMID:20943202
  5. Umeda, T., Takashima, N., Nakagawa, R., Maekawa, M., Ikegami, S., Yoshikawa, T., Kobayashi, K., Okanoya, K., Inokuchi, K., and Osumi, N. (2010) Evaluation of Pax6 mutant rat as a model for autism. PLoS One 5 (12) e15500 (Dec 21) PMID: 21203536
2009
  1. Hao, M., Anderson, R.B., Kobayashi, K., Whitington, P.M., and Young, H.M. (2009)　The migratory behavior of immature enteric neurons. Dev. Neurobiol. 69 (1) 22-35 (Jan) PMID: 18985707.
  2. Cooper, M.A., Kobayashi, K., and Zhou, R. (2009) Ephrin-A5 regulates the formation of the ascending midbrain dopaminergic pathways. Dev. Neurobiol. 69 (1) 36-46 (Jan) PMID: 19003794.
  3. Masuda, T., Kai, N., Sakuma, C., Kobayashi, K., Koga, H., Yaginuma, H. (2009) Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Brain Res. 1249 61-67 (January) PMID: 19026994
  4. Masuda, T., Sakuma, C., Kobayashi, K., Kikuchi, K., Soda, E., Shiga, T., Kobayashi, K., and Yaginuma, H. (2009) Laminin peptide YIGSR and its receptor regulate sensory axonal response to the chemoattractive guidance cue in the chick embryo. J. Neurosci. Res. 87 (2) 353-359 (February) PMID: 18798276.
  5. Sheela Rani, C.S., Elango, N., Wang, S.-S., Kobayashi, K. and Strong, R. (2009) Identification of an activator protein-1-like Sequence as the glucocorticoid response element in the rat tyrosine hydroxylase gene. Mol. Pharmacol. 75 (3) 589-598. (March) PMID: 19060113.
  6. Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, and Sulzer D. (2009) Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron 62 (2) 218-229 (April 30) PMID: 19409267.
  7. Biagioli, M., Pinto, M., Cesselli, D., Zaninello, M., Lazarevic, D., Roncaglia, P., Simone, R., Vlachouli, C., Plessy, C., Bertin, N., Beltrami, A., Kobayashi, K., Gallo, V., Santoro, C., Ferrer, I., Rivella, S., Beltrami, C.A., Carninci, P., Raviola, E., and Gustincich, S. (2009) Unexpected expression of α- and β-globin in mesencephalic dopaminergic neurons and glial cells. Proc. Natl. Acad. Sci. USA 106: 15454-15459. (8 September) PMID: 19717439
2008
  1. Wakamatsu, M., Ishii, A., Iwata, S., Sakagami, J., Ukai, Y., Ono, M., Kanbe, D., Muramatsu, S.I., Kobayashi, K., Iwatsubo, T., and Yoshimoto, M. (2008) Selective loss of nigral dopamine neurons induced by overexpression of truncated human -synuclein in mice. Neurobiol. Aging 29 (4) 574-585 (April) PMID: 17174013
  2. Phillips, H.M., Hildreth, V., Murdoch, J.N., Kobayashi, K., Chaudhry, B. and Henderson, D.J. (2008) Non cell-autonomous roles for the planar cell polarity gene Vangl2 in development of the coronary circulation. Circ. Res. 102 (5) 615-623 (March 14) PMID: 18174466
  3. Stewart, A.L., Anderson, R.B., Kobayashi, K., Young, H.M. (2008) Effects on NGF, NT-3, and GDNF family members on cell migration and neurite outgrowth from pelvic ganglia in embryonic and newborn mice. BMC-Dev. Biol. 8:73 (July 25) PMID: 18657279.
  4. Kobayashi, T., Kai, N., Kobayashi, K., Fujiwara, T., Akagawa,I., Onda, M., and Kobayashi, K. (2008) Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region. J. Neurosci. Methods 175 (1) 125-132 (October 30) PMID: 18775748.
2007
  1. Saino-Saito, S., Cave, J.W., Akiba, Y., Sasaki, H., Goto, K., Kobayashi, K., Berlin, R.A., and Baker, H. (2007) ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons. J. Comp. Neurol. 502 (4) 485-496 (March 29) PMID: 17394138.
  2. Wakamatsu, M., Ishii, A., Ukai, Y., Sakagami, J., Iwata, S., Ono, M., Matsumoto, K., Nakamura, A., Tada, N., Kobayashi, K., Iwatsubo, T., and Yoshimoto, M. (2007) Accumulation of phosphorylated -synuclein dopaminergic neurons of transgenic mice that express human -synuclein. J. Neurosci. Res. 85, 1819-1825 (April 26) PMID: 17465029.
  3. Kobayashi, K. (2007) Controlled cell targeting system to study the brain neural circuitry. Neurosci. Res. 58 (2) 118-123 (June) PMID: 17313983.
  4. Miura, M., Saino-Saito, S., Masuda, M., Kobayashi, K., and Aosaki, T. (2007) Compartment-specific modulation of GABAergic synaptic transmission by -opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands. J. Neurosci. 27 (36) 9721-9728 (September 5) PMID: 17804632.
  5. Masuda, T., Sakuma C., Taniguchi, M., Kobayashi, K., Kobayashi, K., Shiga, T., and Yaginuma, H. (2007) Guidance cues from the embryonic dorsal spinal cord chemoattract dorsal root ganglion axons. Neuroreport 18 (16) 1645-1649 (October 29) PMID: 17921861
  6. Kato, S., Inoue, K., Kobayashi, K., Yasoshima, Y., Miyachi, S., Inoue, S., Hanawa, H., Shimada, T., Takada, M., and Kobayashi, K. (2007) Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein. Human Gene Ther. 18 (11) 1141-1152 (November 11) PMID: 17944573
  7. Appleyard, S.M., Marks, D., Kobayashi, K., Okano, H., Low, M.J., and Andresen, M.C. (2007) Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus. J. Neurosci. 27 (48) 13292-13302 (November 28) PMID: 18045923
2006
  1. Kai, N., Iwase, K., Imai, K., Nakahira, E., Soma, M., Ohtsuka, S., Yagi, T., Kobayashi, K., Koga, H., Takiguchi, M., and Yuasa, S. (2006) Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis. Brain Res. 1073/1074, 60-70 (February 16) PMID: 16427614
  2. Arttamangkul, S., Torrecilla, M., Kobayashi, K., Okano, H., and Williams, J.T. (2006) Separation of opioid receptor desensitization and internalization: endogenous receptors in primary neuronal cultures. J. Neurosci. 26 (15) 4118-4125 (April 12) PMID: 16611829
  3. Rawal, N., Castelo-Branco, G., Sousa, K. M., Kobayashi, K., Okano, H., and Arenas, E. (2006) Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain. Exp. Cell Res. 312 (9) 1626-1636. (May 15) PMID: 16510140
  4. Meuer, K., Teismann, P., Peters, K., Göricke, B., Lingor, P., Schlachetzki, J., Kobayashi, K., Dietz, G. P.H., Schulz, J.B., Bähr, M., Schneider, A., and Weishaupt, J. H. (2006) Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson’s disease. J. Neurochem. 97 (3) 675-686 (May) PMID: 16573658
  5. Sato, S., Chiba, T., Nishiyama, S., Kakiuchi, T., Tsukada, H., Hatano, T., Fukuda, T., Yasoshima, Y., Kai, N., Kobayashi, K., Mizuno, Y., Tanaka, K., and Hattori, N. (2006) Decline of endogenous dopamine release in parkin-deficient mice revealed by ex vivo autoradiography. J. Neurosci. Res. 84: 1350-1357 (August 29) PMID: 16941649
  6. Jomphe, C., Lemelin, P.-L., Okano, H., Kobayashi, K., and Trudeau, L.-E. (2006) Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons. Eur. J. Neurosci. 24 (10) 2789-2800 (November 20) PMID: 17116165
2005
  1. Pignatelli, A., Kobayashi, K., Okano, H., and Belluzzi, O. (2005) Functional properties of dopaminergic neurones in the mouse olfactory bulb. J. Physiol. 564 (2) 501-514 (Apr 15) PMID: 15731185
  2. Matsusaka, T., Xin, J., Niwa, S., Kobayashi, K., Akatsuka, A., Hashizume, H., Wang, Q., Pastan, I., Fogo, B.A., and Ichikawa, I. (2005) Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J. Am. Soc. Nephrol. 16 (4) 1013-1023 (Apr) PMID: 15758046
  3. Jomphe, C., Bourque, M.-J., Fortin, G., St-Gelais, F., Okano, H., Kobayashi, K., and Trudeau, L.-E. (2005) Use of TH-GFP transgenic mice as a source of identified dopaminergic neurons for physiological studies in postnatal cell culture. J. Neurosci. Methods 146 (1) 1-12 (July 15) PMID: 15935217
  4. Yasoshima, Y., Kai, N., Yoshida S., Shiosaka, S., Koyama, Y., Kayama, Y., and Kobayashi, K. (2005) Subthalamic neurons coordinate basal ganglia function through differential neural pathways. J. Neurosci. 25 (34) 7743-7753 (August 24) PMID: 16120775
  5. Kobayashi, K. and Nagatsu, T. (2005) Molecular genetics of tyrosine 3-mono- oxygenase and inherited diseases. Biochem. Biophy. Res. Commun. 338 (1) 267-270 (December 9) PMID: 16105653
2004
  1. Kobayashi, K., Takahashi, M., Matsushita, N., Miyazaki, J.-I., Yaginuma, H., Osumi, N., Kaibuchi, K., and Kobayashi, K. (2004) Survival of developing motor neurons by Rho GTPase signaling pathway through Rho-kinase. J. Neurosci. 24 (14) 3480-3488. (April 7) (This week of Journal of Neuroscience)
  2. Okada, H., Matsushita, N., Kobayashi, K., and Kobayashi, K. (2004) Identification of GABAA receptor subunit variants in midbrain dopaminergic neurons. J. Neurochem. 89 (1) 7-14. (April)
  3. Yoshizaki, T., Inaji, M., Kouike, H., Shimazaki, T., Sawamoto, K., Ando, K., Date, I., Kobayashi, K., Suhara, T., Uchiyama, Y., and Okano, H. (2004) Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells. Neurosci. Lett. 363 (1) 33-37 (June 3)
  4. Matsushita, N., Kobayashi, K., Miyazaki, J., and Kobayashi, K. (2004) Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice. J. Neurosci. Res. 78 (1) 7-15 (October 1).
  5. Saino-Saito, S., Sasaki, H., Volpe, B. T., Kobayashi, K., Berlin, R., and Baker, H. (2004) Differentiation of the dopaminergic phenotype in the olfactory system of neonatal and adult mice. J. Comp. Neurol. 479 (4) 389-398 (Oct 27).
2003
  1. Baker, H., Kobayashi, K., Okano, H., and Saino-Saito, S. (2003) Cortical and striatal expression of tyrosine hydroxylase mRNA in neonatal and adult mice. Cell. Mol. Neurobiol. 23 (4/5) 507-518 (October).
  2. Sano, H., Yasoshima, Y., Matsushita, N., Kaneko, T., Kohno, K., Pastan, I., and Kobayashi, K. (2003) Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function. J. Neurosci. 23 (27) 9078-9088. (October 8) PMID: 14534241
  3. Shin, R.-M., Masuda, M, Miura, M., Sano, H., Shirasawa, T., Song, W.-J., Kobayashi, K. and Aosaki, T. (2003) Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J. Neurosci. 23 (37) 11662-11672. (December 17)
2002
  1. Matsushita, N., Okada, H., Yasoshima, Y., Takahashi, K., Kiuchi, K., and Kobayashi, K. (2002) Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development. J. Neurochem. 82 (2) 295-304. (July 15)
2001
  1. Sawamoto, K., Nakao, N., Kobayashi, K., Matsushita, N., Takahashi, H., Kakishita, K., Yamamoto, A., Yoshizaki, T., Terashima, T., Murakami, F., Itakura, T., Okano, H. (2001) Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons. Proc. Natl. Acad. Sci. USA, 98 (11) 6423-6428. (May 22)
  2. Kobayashi, T., Kida, Y., Kaneko, T., Pastan, I., and Kobayashi, K. (2001) Efficient ablation by immunotoxin-mediated cell targeting of the cell types that express human interleukin-2 receptor depending on the internal ribosome entry site. J. Gene Med. 3 (5) 505-510. (September/October)
  3. Kobayashi, K. (2001) Role of catecholamine signaling in brain and nervous system functions: new insights from mouse molecular genetic study. J. Invest. Dermatol. 6　(1), 117-121.
  4. Kobayashi, K. and Yasoshima, Y. (2001) The central noradrenaline system and memory consolidation. Neuroscientist, 7 (5) 371-376.
  5. Kobayashi, K. and Kobayashi, T. (2001) Genetic evidence for noradrenergic control of long-term memory consolidation. Bain Dev., 23, S16-23.
  6. Ishiguro, H., Yamada, K., Sawada, H., Nishii, K., Ichino, N., Sawada, M., Kurosawa, Y., Matsushita, N., Kobayashi, K., Goto, J., Hashida, H., Masuda, N., Kanazawa, I., and Nagatsu, T. (2001) Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington’s Disease gene. J. Neurosci. Res., 65 (4), 289-297. (August 15)
2000
  1. Kobayashi, K., and Sano, H. (2000) Dopamine deficiency in mice. Brain Dev., 22, S54-S60.
  2. Kobayashi, K., Noda, Y., Matsushita, N., Nishii, K., Sawada, H., Nagatsu, T., Nakahara, D., Fukabori, R., Yasoshima, Y., Yamamoto, T., Miura, M., Kano, M., Mamiya, T., Miyamoto, Y., and Nabeshima, T. (2000) Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene. J. Neurosci., 20 (6), 2418-2426. (March 15)
  3. Iwawaki, T., Kohno, K., and Kobayashi, K. (2000) Identification of a potential Nurr1response element that activates the tyrosine hydroxylase gene promoter in cultured cells. Biochem. Biophy. Res. Commun., 274 (3), 590-595.
  4. Usukura, J., Nishizawa, Y., Shimomura, A., Kobayashi, K., Nagatsu, T., and Hagiwara, M. (2000) Direct imaging of phosphorylation-dependent conformational change and DNA biding of CREB by electron microscopy. Genes to Cells, 5, 515-522.
1999
  1. Kobayashi, K., and Nagatsu, T. (1999) Mutant mice lacking the tyrosine hydroxylase gene and transcomplementation with the human genome: Ongoing prospects for human genetherapy. Biogenic Amines, 15, 1-20.
1998
  1. Sawada, H., Nishii, K., Suzuki, T., Hasegawa, K., Hata, T., Nagatsu, I., Kreitman, R. J., Pastan, I., Nagatsu, T., and Kobayashi, K. (1998) Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system. J. Neurosci. Res., 51, 162-173. (January 15)
  2. Cubells, J. F., van Kammen, D. P., Kelley, M. E., Anderson, G. M., O’Connor, D. T., Price, L. H., Malison, R., Rao, P. A., Kobayashi, K., Nagatsu, T., and Gelernter, J. (1998) Dopamine -hydrozxlase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation. Hum. Genet., 102, 533-540.
  3. Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R.,Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki, M., Kobayashi, K., Nagatsu, T., Pastan, I., and Nakanishi, S. (1998) Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell, 95 (1), 17-27. (October 2)
  4. Nishii, K., Matsushita, N., Sawada, H., Sano, H., Noda, Y., Mamiya, T., Nabeshima, T., Nagatsu, I., Hata, T., Kiuchi, K., Yoshizato, H., Nakashima, K., Nagatsu, T., Kobayashi, K. (1998) Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission. J. Neurosci. Res., 54, 450-464. (November 15)
1997
  1. Cubells, J. F., Kobayashi, K., Nagatsu, T., Kidd, K. K., Kidd, J. R., Calafell, F., Kranzler, H. R., Ichinose, H., and Gelerner, J. (1997) Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH). Am. J. Med. Genet., 74, 374-379.
1996
  1. Kobayashi, K., Ohye, T., Pastan, I., and Nagatsu, T. (1996) A novel strategy for negative selection in mouse embryonic stem cells operated with immunotoxin- mediated cell targeting. Nucl. Acids Res., 24, 3653-3655.
1995
  1. Suzuki, T., Kobayashi, K., and Nagatsu, T. (1995) Genomic structure and tissue distribution of the mouse dopamine D4 receptor. Neurosci. Lett., 199, 69-72.
  2. Sumi-Ichinose, C., Hasegawa, S., Ichinose, H., Sawada, H., Kobayashi, K., Sakai, M., Fujii, T., Nomura, H., Nomura, T., Nagatsu, I., Hagino, Y., Fujita, K., and Nagatsu, T. (1995) Analysis of the alternative promoters that regulate tissue-specific expression of human aromatic L-amino acid decarboxylase. J. Neurochem., 64, 514-524.
  3. Kobayashi, K., Ota, A., Togari, A., Morita, S., Mizuguchi, T., Sawada, H., Yamada, K.,Nagatsu, I., Matsumoto, S., Fujita, K., and Nagatsu, T. (1995) Alteration of catecholamine phenotype in transgenic mice influences expression of adrenergic receptor subtypes. J. Neurochem., 65, 492-501.
  4. Kobayashi, K., Morita, S., Sawada, H., Mizuguchi, T., Yamada, K., Nagatsu, I., Fujita, K., Kreitman, R.J., Pastan, I., and Nagatsu, T. (1995) Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice. Proc. Natl. Acad. Sci. USA, 92 (4), 1132-1136. (February 14)
  5. Kobayashi, K., Morita, S., Sawada, H., Mizuguchi, T., Yamada, K., Nagatsu, I., Hata, T., Watanabe, I., Fujita, K., and Nagatsu, T. (1995) Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice. J. Biol. Chem., 270 (45), 27235-27243. (November 10)
1994
  1. Kobayashi, K., Morita, S., Mizuguchi, T., Sawada, H., Yamada, K., Nagatsu, I., Fujita, K., and Nagatsu, T. (1994) Functional and high level expression of human dopamine -hydroxylase in transgenic mice. J. Biol. Chem., 269, 29725-29731.(November 25)
  2. Nabeshima, T., Ito, A., Kobayashi, K., Morita, S., Mizuguchi, T., Sawada, H., Nitta, A.,Hasegawa, T., Hayashi, K., and Nagatsu, T. (1994) Effects of subacute administration of methamphetamine and nicotine on locomoter activity in transgenic mice expressing the human tyrosine hydroxylase gene. J. Neural. Transm., 97, 41-49.
1993
  1. Morita, S., Kobayashi, K., Mizuguchi, T., Sawada, H., Yamada, K., Nagatsu, I., Titani, K., Fujita, K., Hidaka, H., and Nagatsu, T. (1993) The 5′-flanking region of human dopamine -hydroxylase gene promotes the neuron subtype-specific gene expression in the central nervous system of transgenic mice. Mol. Brain Res., 17, 239-244.
1992

  1. Morita, S., Kobayashi, K., Hidaka, H., and Nagatsu, T. (1992) Organization and complete nucleotide sequence of the gene encoding mouse phenylethanolamine N-methyltransferase. Mol. Brain Res., 13, 313-319.
  2. Nakano, T., Kobayashi, K., Saito, S., Fujita, K., and Nagatsu, T. (1992) Mouse dopamine -hydroxylase: primary structure deduced from the cDNA sequence and exon/intron organization of the gene. Biochem. Biophys. Res. Commun., 189, 590-599.
  3. Iwata, N., Kobayashi, K., Sasaoka, T., Hidaka, H., and Nagatsu, T. (1992) Structure of the mouse tyrosine hydroxylase gene. Biochem. Biophys. Res. Commun., 182, 348-354.
  4. Sasaoka, T., Kobayashi, K., Nagatsu, I., Takahashi, R., Kimura, M., Yokoyama, M., Nomura, T., Katsuki, M., and Nagatsu, T. (1992) Analysis of the human tyrosinehydroxylase promoter-chloramphenicol acetyltransferase chimeric gene expression in transgenic mice. Mol. Brain Res., 16, 274-286.
  5. Kobayashi, K., Sasaoka, T., Morita, S., Nagatsu, I., Iguchi, A., Kurosawa, Y., Fujita,K., Nomura, T., Kimura, M., Katsuki, M., and Nagatsu, T. (1992) Genetic alteration of catecholamine specificity in transgenic mice. Proc. Natl. Acad. Sci. USA, 89 (5), 1631-1635. (March 1)
1991
  1. Kaneda, N., Sasaoka, T., Kobayashi, K., Kiuchi, K., Nagatsu, I., Kurosawa, Y., Fujita, K., Yokoyama, M., Nomura, T., Katsuki, M., and Nagatsu, T. (1991) Tissue-specific and high-level expression of the human tyrosine hydroxylase gene in transgenic mice. Neuron, 6, 583-594.
  2. Ishii, A., Kobayashi, K., Kiuchi, K., and Nagatsu, T. (1991) Expression of two forms of human dopamine b-hydroxylase in COS cells. Neurosci. Lett., 125, 25-28.
1990

  1. Sasaki, T., Kohara, A., Shimizu, T., and Kobayashi, K. (1990) Single site proteolysis in silkwarm antitrypsin causes structural changes in behavior against denaturing reagents. Agric. Biol. Chem., 34, 139-145
  2. Nagatsu, I., Kobayashi, K., Fujii, T., Komori, K., Sekiguchi, K., Titani, T., Fujita, K., and Nagatsu, T. (1990) Antibodies raised against different oligopeptide segments of human dopamine -hydroxylase. Neurosci. Lett., 120, 141-145
1989
  1. Kobayashi, K., Kurosawa, Y., Fujita, K., and Nagatsu, T. (1989) Human dopamine　-hydroxylase gene: two mRNA types having different 3′-terminal regions are produced through alternative polyadenylation. Nucl. Acids Res., 17, 1089-1102.
1988
  1. Kobayashi, K., Kiuchi, K., Ishii, A., Kaneda, N., Kurosawa, Y., Fujita, K., and Nagatsu, T. (1988) Expression of four types of human tyrosine hydroxylase in COS cells. FEBS Lett., 238, 431-434.
  2. Kobayashi, K., Kaneda, N., Ichinose, H., Kishi, F., Nakazawa, A., Kurosawa, Y., Fujita, K., and Nagatsu, T. (1988) Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. J. Biochem., 103, 907-912.
1987
  1. Sasaki, T., Kobayashi, K., and Ozeki, T. (1987) Interaction of silkwarm larval hemolymph antitrypsin and bovine trypsin. J. Biochem., 102, 433-441
  2. Kobayashi, K., Nakamura, K., and Asahi, T. (1987) CF1ATPase - and -subunit genes are separated in the sweet potato chloroplast genome. Nucl. Acids Res., 15, 7177.
  3. Kobayashi, K., Kaneda, N., Ichinose, H., Kishi, F., Nakazawa, A., Kurosawa, Y., Fujita, K., and Nagatsu, T. (1987) Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3. Nucl. Acids Res., 15, 6733.
  4. Kaneda, N., Kobayashi, K., Ichinose, H., Kishi, F., Nakazawa, A., Kurosawa, Y., Fujita, K., and Nagatsu, T. (1987) Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene. Biochem. Biophys. Res. Commun., 146, 971-975
1986
  1. Kobayashi, K., Iwasaki, Y., Sasaki, T., Nakamura, K., and Asahi, T. (1986) Putativeamino-terminal sequence for -subunit of plant mitochondrial F1ATPase deduced from the amino terminal sequence of the mature subunit. FEBS Lett., 203, 144-148
1984
  1. 1. Sasaki, T., and Kobayashi, K. (1984) Isolation of two novel proteinase inhibitorsfrom hemolymph of silkwarm, Bombyx mori.: comparison with human serum inhibitors. J. Biochem., 95, 1009-1017.
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