多発性硬化症治療学講座 平成27年（2015年）
論文
〔原著〕
YOKOTE, H; NOSE, Y; ISHIBASHI, S; KAMATA, T; TANAKA, K; TAKAHASHI, T; FUJIHARA, K*; YOKOTA, T; MIZUSAWA, H. Spinal cord ring enhancement in patients with neuromyelitis optica. Acta Neurologica Scandinavica. 2015 07; 132(1):37-41.
ZEKA, B; HASTERMANN, M; HOCHMEISTER, S; KÖGL, N; KAUFMANN, N; SCHANDA, K; MADER, S; MISU, T; ROMMER, P; FUJIHARA, K*; ILLES, Z; LEUTMEZER, F; SATO, DK; NAKASHIMA, I; REINDL, M; LASSMANN, H; BRADL, M. Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS. Acta Neuropathologica. 2015 12; 130(6):783-798.
KUROSAWA, K; MISU, T; TAKAI, Y; SATO, DK; TAKAHASHI, T; ABE, Y; IWANARI, H; OGAWA, R; NAKASHIMA, I; FUJIHARA, K*; HAMAKUBO, T; YASUI, M; AOKI, M. Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody. Acta Neuropathologica Communications. 2015 12; 3:82.
KARIYA, Y*; KARIYA*, Y; SAITO, T*; NISHIYAMA, S; HONDA, T*; TANAKA, K; YOSHIDA, M; FUJIHARA, K*; HASHIMOTO, Y*. Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica. Biochimica et Biophysica Acta (BBA) Clinical. 2015 01; 3:126-134.
TATEYAMA, M; FUJIHARA, K*; MISU, T; ARAI, A; KANETA, T; AOKI, M. Clinical values of FDG PET in polymyositis and dermatomyositis syndromes: imaging of skeletal muscle inflammation. BMJ Open. 2015 01; 5(1):e006763.
HINO-FUKUYO, N; KAZUHIRO, HAGINOYA, K; NAKASHIMA, I; SATO, DK; TAKAHASHI, T; MISU, T; FUJIHARA, K*; HIROSE, M; KAKISAKA, Y; UEMATSU, M; KOBAYASHI, T; KURE, S. Clinical features and long-term outcome of a group of Japanese children with inflammatory central nervous system disorders and seropositivity to myelin-oligodendrocyte glycoprotein antibodies. Brain and Development. 2015 10; 37(9):849-852.
FUJIMORI, J; BABA, T; MEGURO, Y; NAKASHIMA, I; MORI, E; FUJIHARA, K*; AOKI, M. Comparison of the Rao Brief Repeatable Neuropsychological Battery with Wechsler Adult Intelligence Scale-III and Wechsler Memory Scale-Revised in Japanese patients with Multiple Sclerosis. Clinical and Experimental Neuroimmunology. 2015 08; 6(3):306-308.
GEIS, C; RITTER, C; RUSCHIL, C; WEISHAUPT, A; GRÜNEWALD, B; STOLL, G; HOLMOY, T; MISU, T; FUJIHARA, K*; HEMMER, B; STADELMANN, C; BENNETT, JL; SOMMER, C; TOYKA, KV. The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. Experimental Neurology. 2015 03; 265:8-21.
PICCOLO, L; KUMAR, G; NAKASHIMA, I; MISU, T; KONG, Y; WAKERLEY, B; RYAN, S; CAVEY, A; FUJIHARA, K*; PALACE, J. Multiple Sclerosis in Japan appears to be a milder disease compared to the UK. Journal of Neurology. 2015; 262(4):831-836.
AKAISHI, T; NAKASHIMA, I; MISU, T; FUJIHARA, K*; AOKI, M. Depressive state and chronic fatigue in multiple sclerosis. Journal of Neuroimmunology. 2015 06; 283:70-73.
AKAISHI, T; NARIKAWA, K; SUZUKI, Y; MITSUZAWA, S; TSUKITA, K; KURODA, H; NAKASHIMA, I; FUJIHARA, K*; AOKI, M. Importance of the quotient of albumin, quotient of immunoglobulin G and Reibergram in inflammatory neurological disorders with disease-specific patterns of blood–brain barrier permeability. Neurology and Clinical Neuroscience. 2015 05; 3(3):94-100.
KURODA, H; FUJIHARA, K*; KUSHIMOTO, S; AOKI, M. Novel clinical grading of delayed neurologic sequelae after carbon monoxide poisoning and factors associated with outcome. Neurotoxicology. 2015 05; 48:35-43.
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〔総説等〕
KREMER, S; RENARD, F; ACHARD, S; LANA-PEIXOTO, MA; PALACE, J; ASGARI, N; KLAWITER, EC; TENEMBAUM, SN; BANWELL, B; GREENBERG, BM; BENNETT, JL; LEVY, M; VILLOSLADA, P; SAIZ, A; FUJIHARA, K*; CHAN, KH; SCHIPPLING, S; PAUL, F; KIM, HJ; DE SEZE, J; WUERFEL, JT, The Guthy-Jackson Charitable Foundation. Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder. JAMA Neurology. 2015 07; 72(7):815-822.
BENNETT, JL; DE SEZE, J; LANA-PEIXOTO, M; PALACE, J; WALDMAN, A; SCHIPPLING, S; TENEMBAUM, S; BANWELL, B; GREENBERG, B; LEVY, M; FUJIHARA, K*; CHAN, KH; KIM, HJ; ASGARI, N; SATO, DK; KLAWITER, EC; SAIZ, A; WUERFEL, J; ZIMMERMANN, H; GREEN, A; VILLOSLADA, P; PAUL, F. Neuromyelitis optica and multiple sclerosis: Seeing differences through Optical Coherence Tomography. Multiple Sclerosis Journal. 2015 05; 21(6):678-688.
WEINSHENKER, BG; BARRON, G; BEHNE, JM; BENNETT, JL; CHIN, PS; CREE, B; DE, SEZE, J; ARMANDO, FLOR; FUJIHARA, K*; GREENBERG, BM; HIGASHI, S; HOLT, W; KHAN, OA; KNAPPERTZ, V; LEVY, M; MELIA, AT; PALACE, J; SMITH, TJ; SORMANI, MP; VAN, HERLE, K; VANMETER, SA; VILLOSLADA, P; WALTON, MK; WASIEWSKI, W; WINGERCHUK, D; YEAMAN, M. Challenges and opportunities in designing clinical trials for neuromyelitis optica. Neurology. 2015 04; 84(17):1805-1815.
KIM, HJ; PAUL, F; LANA-PEIXOTO, MA; TENEMBAUM, S; ASGARI, N; PALACE, J; KLAWITER, EC; SATO, DK; DE, SEZE, J; JENS, WUERFEL, J; BANWELL, BL; VILLOSLADA, P; SAIZ, A; FUJIHARA, K*; KIM, SH. MRI characteristics of neuromyelitis optica spectrum: an international update. Neurology. 2015 03; 84(11):1165-1173.
小川 諒, 藤原一男*. 免疫性神経疾患-病態解明と治療の最前線 Neuromyelitis optica(NMO) NMOの発症機序. 医学のあゆみ. 2015 10; 255(5):385-389.
藤盛寿一, 藤原一男*. 特集Ⅰ 免疫と精神神経疾患 多発性硬化症. 精神科. 2015 10; 27(4):258-261.
金子仁彦, 藤原一男*. 内科疾患の診断基準・病型分類・重症度 (第7章)神経・筋 多発性硬化症. 内科. 2015 06; 115(6):1221-1224.
金子仁彦, 藤原一男*. 内科疾患の診断基準・病型分類・重症度 (第7章)神経・筋 診断メモ 視神経脊髄炎. 内科. 2015 06; 115(6):1256.
黒澤和大, 藤原一男*. 【免疫症候群(第2版)－その他の免疫疾患を含めて－】 臓器特異的自己免疫疾患 免疫性神経・筋疾患 免疫性中枢神経疾患 視神経脊髄炎. 日本臨床 別冊 免疫症候群I. 2015 11; 16-19.
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〔症例報告〕
DI, PAULI, F; HÖFTBERGER, R; REINDL, M; BEER, R; RHOMBERG, P; SCHANDA, K; SATO, D; FUJIHARA, K*; LASSMANN, H; SCHMUTZHARD, E; BERGER, T. Fulminant demyelinating encephalomyelitis: Insights from antibody studies and neuropathology. Neurology: Neuroimmunology & Neuroinflammation. 2015 11; 2(6):e275.
KOBAYASHI, J; KURODA, H; EZURA, M; SUGENO, N; SHIBUI, A; TAKAHASHI, T; MISU, T; FUJIHARA, K*; MORI, E; AOKI, M. Acute callosal disconnection syndrome as an initial manifestation of neuromyelitis optica spectrum disorders. Neurology and Clinical Neuroscience. 2015 07; 3(4):137-139.
MOURA, FC; SATO, DK; RIMKUS, CM; APOSTOLOS-PEREIRA, SL; DE, OLIVEIRA, LM; LEITE, CC; FUJIHARA, K*; MONTEIRO, MLR; CALLEGARO, D. Anti-MOG (Myelin Oligodendrocyte Glycoprotein)-positive optic neuritis with optic disc ischemia and macular star. Neuro-Ophthalmology. 2015; 39(6):285-288.
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〔その他〕
FUJIHARA, K*; MISU, T. AQP4 in biopsied demyelinating lesions as a diagnostic clue to NMOSD and MS: Final answer? Neurology. 2015 01; 84(2):110-111.
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著書・訳書
藤原一男*. 多発性硬化症(MS)、視神経脊髄炎(NMO、デビック病). In: 尾崎承一 責任編集. 難病辞典. 東京: 学研メディカル秀潤社; 2015 12. p.47-52.
藤原一男*. 多発性硬化症治療薬. In: 福井次矢 監修, 小松康宏, 渡邉裕司 編集. Pocket Drugs 2015. 東京: 医学書院; 2015 01. p.82-86.
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研究発表等
〔シンポジウム〕
FUJIHARA, K*. New insights into the Molecular Pathogenesis of NMO Spectrum Disorders. European Charcot Foundation Symposium in the 8th Annual Meeting of Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS); 2015 11 19; Seoul, Korea.
FUJIHARA, K*. Prevalence and Phenotypes of Demyelinating Diseases Outside Europe and NA: Asia. The 31st Congress of European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); 2015 10; Barcelona, Spain.
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〔特別講演〕
FUJIHARA, K*. The Concept of Neuromyelitis Optica Spectrum Disorders: Its Evolution and Lessons. The 16th Annual Conference of Indian Academy of Neurology; 2015 10; Agra, India.
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〔招待講演〕
FUJIHARA, K*. Is there an “Eatern Type of MS”? Istanbul MS Days 2015; 2015 11; Istanbul, Turkey.
FUJIHARA, K*. A young lady with severe myasthenia and emaciation. The 16th Annual Conference of Indian Academy of Neurology; 2015 10; Agra, India.
FUJIHARA, K*. Evolving concept of NMO Spectrum Disorders: what can we learn? The 1st Chinese International Summit Meeting of Neuroimmunology and Neuroinfections; 2015 05; Beijing, China.
FUJIHARA, K*. Multiple Sclerosis and Other Demyelinating Diseases, Our Current Understanding of NMO and its Spectrum Disorders. The 22nd World Congress of Neurology; 2015 11; Santiago, Chile.
FUJIHARA, K*. Neuroimmunology and Multiple Sclerosis, Update in NMO. The 22nd World Congress of Neurology; 2015 11; Santiago, Chile.
FUJIHARA, K*. Neuromyelitis Optica Spectrum Disorders: Pathophysiology of NMOSD. The 31st Congress of European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); 2015 10; Barcelona, Spain.
FUJIHARA, K*. How to diagnose and treat indistinguishable early cases of inflammatory CNS diseases in Asians, New Diagnostic Criteria of NMOSD. The 8th Annual Meeting of Pan-Asian Committee for Treatmetn and Research in Multiple Sclerosis (PACTRIMS); 2015 11; Seoul, Korea.
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受託・共同研究・補助等実績一覧
| 年度 | 実施形態 | 研究テーマ | 補助金・資金制度名／種別 | 相手機関名 | 代表研究者 | 共同研究者一覧 |
|---|---|---|---|---|---|---|
| 平成27 | 補助・助成 | エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 | 厚生労働科学研究費（難治性疾患等政策研究事業） | 国立保健医療科学院 | 松井 真 | 池田修一, 荻野美恵子, 梶 龍兒, 神田 隆, 吉良潤一, 楠 進, 久保田龍二, 桑原 聡, 清水 潤, 清水優子, 鈴木則宏, 園生雅弘, 祖父江元, 竹内英之, 田中正美, 中辻裕司, 新野正明, 河内 泉, 野村恭一, 酒井康成, 藤原一男*, 松尾秀徳, 横田隆徳, 木村政勝, 山村 隆, 吉川弘明, 渡邊 修 |
| 平成27 | 補助・助成 | 非典型的多発性硬化症の臨床・病態解析 | 科学研究費補助金／基盤研究(B) (一般) | 独立行政法人日本学術振興会 | 藤原一男* | |
| 平成27 | 国内共同研究 | HAMの革新的な医薬品等の開発促進に関する研究 | 難治性疾患実用化研究事業 | 日本医療研究開発機構(AMED) | 山野嘉久 | 長谷川泰弘, 新野正明, 藤原一男*, 中川正法, 竹之内徳博, 永井将弘, 吉良潤一, 中村龍文, 髙嶋 博, 渡嘉敷崇, 米澤久司, 坪井義夫, 髙田礼子, 齊藤峰輝, 外丸詩野, 植田幸嗣, 松田文彦, 井上永介* |
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