医療－産業トランスレーショナルリサーチセンター 平成25年（2013年）
論文
〔原著〕
HIROHAMA, M; KUMAR, A; FUKUDA, I; MATSUOKA, S; IGARASHI, Y; SAITOH, H; TAKAGI, M*; SHIN-YA, K; HONDA, K; KONDOH, Y; SAITO, T; NAKAO, Y; OSADA, H; ZHANG, KY; YOSHIDA, M; ITO, A. Spectomycin B1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E2. ACS Chemical Biology. 2013; 8:2635-2642.
KOMATSU, M; KOMATSU, K; KOIWAI, H; YAMADA, Y; KOZONE, I; IZUMIKAWA, M; HASHIMOTO, J; TAKAGI, M*; OMURA, S; SHIN-YA, K; CANE, DE; IKEDA, H. Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites. ACS Synthetic Biology. 2013; 2:384-396.
BIAN, Z; FURUYA, N; ZHENG, DM; ALEJANDRO, Oliva; TREJO, J; TADA, N; EZAKI, J*; UENO, T. Ferulic acid induces mTor inactivation in cultured mammalian cells. Biological and Pharmaceutical Bulletin. 2013; 36(1):120-124.
IZUMIKAWA, M; KAWAHARA, T; HWANG, JH; TAKAGI, M*; SHIN-YA, K. JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047. Bioscience, Biotechnology and Biochemistry. 2013; 77:663-665.
OISHI, Jun; AOKI, Mikiko; NABESHIMA, Kazuki; SUZUMIYA, Junji; TAKEUCHI, Tamotsu; OGOSE, Akira; HAKOZAKI, Michiyuki*; YAMASHITA, Yuichi; IWASAKI, Hiroshi. Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-beta. BMC Cancer. 2013 05; 13:224.
SHIBATA, K; YOSHIDA, M; TAKAHASHI, T; TAKAGI, M*; SHIN-YA, K; DOI, T. Synthesis of hepta-oxazole macrocyclic analogues of telomestatin and evaluation of their telomerase inhibitory activities. Bulletin of the Chemical Society of Japan. 2013; 86:1453-1465.
PLUQUET, O; DEJEANS, N; BOUCHECAREILH, M; LHOMOND, S; PINEAU, R; HIGA, A*; DELUGIN, M; COMBE, C; LORIOT, S; CUBEL, G; DUGOT-SENANT, N; VITAL, A; LOISEAU, H; GOSLINE, SJ; TAOUJI, S; HALLETT, M; SARKARIA, JN; ANDERSON, K; WU, W; RODRIGUEZ, FJ; ROSENBAUM, J; SALTEL, F; FERNANDEZ-ZAPICO, ME; CHEVET, E. Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα. Cancer Research. 2013 08; 73(15): 4732-4743.
ENDO, Makoto; YAMAMOTO, Hidetaka; SETSU, Nokitaka; KOHASHI, Kenichi; TAKAHASHI, Yusuke; ISHII, Takeaki; IIDA, Keiichiro; MATSUMOTO, Yoshihiro; HAKOZAKI, Michiyuki*; AOKI, Mikiko; IWASAKI, Hiroshi; DOBASHI, Yoh; NISHIYAMA, Kenichi; IWAMOTO, Yukihide; ODA, Yoshinao. Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors. Clinical Cancer Research. 2013 01; 19(2):450-461.
FUSE, S; INABA, K; TAKAGI, M*; TANAKA, M; HIROKAWA, T; JOHMOTO, K; UEKUSA, H; SHIN-YA, K; TAKAHASHI, T; DOI, T. Design and synthesis of 2-phenyl-1, 4-dioxa-spiro[4.5]deca-6, 9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A. European Journal of Medicinal Chemistry. 2013; 66:180-184.
KOIKE, M; SHIBATA, M; EZAKI, J*; PETERS, C; SAFTIG, P; KOMINAMI, E; UCHIYAMA, Y. Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system. European Journal of Neuroscience. 2013 03; 37(5):816-830.
HOSHI, T; TEZUKA, T; YOKOYAMA, K; IEMURA, S*; NATSUME, T; YAMANASHI, Y. Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes. FEBS Letters. 2013 11; 587(23):3749-3754.
HAKOZAKI, Michiyuki*; HOJO, Hiroshi*; TAJINO, Takahiro*; YAMADA, Hitoshi*; KIKUCHI, Shinichi*; KIKUTA, Atsushi*; KONNO, Shinichi*; ABE, Masafumi*. Therapeutic cytodifferentiation in the alveolar rhabdomyosarcoma without genetic change of the PAX3-FKHR chimeric fusion gene: a case study. Human Cell. 2013 12; 26(4):149-154.
HOSOYA, T; TAKAGI, M*; SHIN-YA, K. New pyridone alkaloids JBIR-130, JBIR-131 and JBIR-132 from Isariasp. NBRC 104353. Journal of Antibiotics. 2013; 66:235-238.
TAOUJI, S; HIGA, A*; DELOM, F; PALCY, S; MAHON, FX; PASQUET, JM; BOSSÉ, R; SÉGUI, B; CHEVET, E. Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival. Journal of Biological Chemistry. 2013 06; 288(24): 17190-17201.
KAKIHANA, T; ARAKI, K; VAVASSORI, S; IEMURA, S*; CORTINI, M; FAGIOLI, C; NATSUME, T; SITIA, R; NAGATA, K. Dynamic regulation of ero1α and peroxiredoxin 4 localization in the secretory pathway. Journal of Biological Chemistry. 2013 10; 288(41):29586-29594.
GOTO, T; SATO, A; ADACHI, S; IEMURA, S*; NATSUME, T; SHIBUYA, H. IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. Journal of Biological Chemistry. 2013 12; 288(51):36351-36360.
ARAKI, K; IEMURA, S*; KAMIYA, Y; RON, D; KATO, K; NATSUME, T; NAGATA, K. Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases. Journal of Cell Biology. 2013 09; 202(6):861-874.
ONO, Y; IEMURA, S*; NOVAK, SM; DOI, N; KITAMURA, F; NATSUME, T; GREGORIO, CC; SORIMACHI, H. PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. Journal of Molecular Biology. 2013 08; 425(16):2955-2972.
DOBASHI, Yuu*; YOSHIMURA, Hisashi; ATARASHI, Eriko; TAKAHASHI, Kimimasa; TOHEI, Atsushi; AMAO, Hiromi. Upregulation of superoxide dismutase activity in the intestinal tract mucosa of germ-free mice. Journal of Veterinary Medical Science. 2013; 75(1):49-54.
TSUCHIYA, Y; TANIGUCHI, H; ITO, Y; MORITA, T; KARIM, MR; OHTAKE, N; FUKAGAI, K; ITO, T; OKAMURO, S; IEMURA, S*; NATSUME, T; NISHIDA, E; KOBAYASHI, A. The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression. Molecular and Cellular Biology. 2013 09; 33(17):3461-3472.
MURAKAMI, K; ICHINOHE, Y; KOIKE, M; SASAOKA, N; IEMURA, S*; NATSUME, T; KAKIZUKA, A. VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels. PLoS One. 2013 02; 8(2).
GOTO, T; SATO, A; SHIMIZU, M; ADACHI, S; SATOH, K; IEMURA, S*; NATSUME, T; SHIBUYA, H. IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling. PLoS One. 2013 04; 8(4).
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〔総説等〕
KATAHIRA, K*; SEKIGUCHI, M*. Response to the great east Japan earthquake of 2011 and the Fukushima Nuclear Crisis – The Case of the Laboratory Animal Research Center at Fukushima Medical University–. Experimental Animals. 2013 04; 62(2):79-86.
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〔症例報告〕
HAKOZAKI, Michiyuki*; HOJO, Hiroshi*; TAJINO, Takahiro*; YAMADA, Hitoshi*; KIKUCHI, Shinichi*; KONNO, Shinichi*; ABE, Masafumi*. Poorly differentiated synovial sarcoma showing Homer-Wright rosette structures: a potential diagnostic pitfall. APMIS. 2013 04; 121(4):359-361.
HAKOZAKI, Michiyuki*; FUKUDA, Hironari*; TAJINO, Takahiro*; KIKUCHI, Shinichi*; ABE, Satoshi*; KONNO, Shinichi*. Remitting seronegative symmetrical synovitis with pitting edema syndrome caused by crystal-induced arthritis of the wrist: a case report. Medical Principles and Practice. 2013 03; 22(3):307-310.
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〔その他〕
若井 淳*, 遊佐寿恵*, 片平清昭*, 関口美穂*. デジタルX線TVシステムおよびX線CTを用いた“腰抜け”ウサギの腰部画像診断. 実験動物技術. 2013 06; 48(1):17-20.
箱﨑道之*, 紺野愼一*(翻訳). Ultrasound-guided vs. fluoroscopy-guided caudal epidural steroid injection for the treatment of unilateral lower lumbar radicular pain: a prospective, randomized, single-blind clinical study. ペインクリニック. 2013 11; 34(11): 1580.
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著書・訳書
ISOGAI, Takao*; WAKAMATSU, Ai. Alternative Splicing by Analyzing a Human mRNA Diversity using Data of FLJ Human cDNAs. In: DIMAGGIO, Samuel; BRASCHI, Emma eds. New Developments in Alternative Splicing Research. Hauppauge, NY, USA: Nova Science Publishers, Inc.; 2013. p.127-144.
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研究発表等
〔研究発表〕
HAKOZAKI, Michiyuki*; KLAWITTER, Marina; KOBAYASHI, Hiroshi*; QUERO, Lilian; OSPELT, Caroline; GAY, Steffen; LIEBSCHER, Thomas; SEKIGUCHI, Miho*; BOOS, Norbert; FERGUSON, Stephen, J; WUERTZ, Karin. Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells. Global Spine Congress 2013; 2013 04 04; Hong Kong.
HAKOZAKI, Michiyuki*; TAJINO, Takahiro*; YAMADA, Hitoshi*; KONNO, Shinichi*. Functional reconstruction of knee extension mechanism with pedicle frozen graft with quadriceps femoris tendon, patella and patella tendon: a case report. International Society of Limb Salvage 17th General Meeting; 2013 09 11; Bologna.
HAKOZAKI, Michiyuki*; TAJINO, Takahiro*; YAMADA, Hitoshi*; NUMAZAKI, Hironori*; KIKUCHI, Shinichi*; MURAKAMI, Kazuya; TASAKI, Kazuhiro*; WATANABE, Kazuo; HASEGAWA, Osamu*; KONNO, Shinichi*. Radiological and clinicopathological findings of synovial hemangioma of the knee: report of six cases. International Society of Limb Salvage 17th General Meeting; 2013 09 11; Bologna.
TAJINO, Takahiro*; KONNO, Shinichi*; YAMADA, Hitoshi*; HAKOZAKI, Michiyuki*. The treatment outcome of musculoskeletal tumors in the lower extremity reconstructed with heated (Pasteurized) auto-bone graft. International Society of Limb Salvage 17th General Meeting; 2013 09 11; Bologna.
YAMADA, Hitoshi*; TAJINO, Takahiro*; HAKOZAKI, Michiyuki*; KONNO, Shinichi*. An implantable port method suitable for use by orthopedic surgeons. International Society of Limb Salvage 17th General Meeting; 2013 09 11; Bologna.
権田憲士*, 柴田昌彦*, 大竹 徹*, 安田満彦*, 吉田清香*, 氏家大輔*, 鈴志野聖子*, 志村龍男*, 櫻井健一, 大戸 斉*, 竹之下誠一*. 乳癌患者におけるIL-17の産生動態の検討. 第34回癌免疫外科研究会; 2013 05 16; 岡山.
箱﨑道之*, 田地野崇宏*, 山田 仁*, 藁谷朋子*. 大腿骨骨腫瘍の1例: 再建法の検討. 第15回骨軟部腫瘍サマーセミナー; 2013 08 31; 金沢.
立花和之進*, 大竹 徹*, 安田満彦*, 渡辺久美子*, 吉田清香*, 芦澤 舞*, 鈴志野聖子*, 村上祐子*, 竹之下誠一*. 進行再発乳癌に対するBevacizumab+Paclitaxelの治療成績. 第51回日本癌治療学会; 2013 10 24; 京都.
吉田清香*, 大竹 徹*, 安田満彦*, 渡辺久美子*, 阿部宣子*, 立花和之進*, 村上祐子*, 竹之下誠一*. ホルモン感受性陽性進行再発乳癌に対するフルベストラントの使用経験. 第51回日本癌治療学会; 2013 10 26; 京都.
箱﨑道之*, 田地野崇宏*, 山田 仁*, 田﨑和洋*, 長谷川靖*, 渡邉一男. 左上肢多発性軟部腫瘍. 第49回日本骨軟部腫瘍研究会; 2013 05 24; 佐倉.
土橋 悠*, 阿久津麻奈, 藤平篤志, 天尾弘実. 腸内細菌叢除去に伴うマウス盲腸粘膜内抗酸化酵素スーパーオキシドディスムターゼ活性の変化. 第60回日本実験動物学会総会; 2013; つくば.
田地野崇宏*, 菊地臣一*, 武田 明*, 山田 仁*, 箱﨑道之*, 紺野愼一*. 軟部肉腫に対する生検が治療成績に与える影響の検討. 第46回日本整形外科学会骨・軟部腫瘍学術集会; 2013 07 12; 東京. 日本整形外科学会雑誌. 87(6):S1153.
山田 仁*, 菊地臣一*, 田地野崇宏*, 箱﨑道之*, 渡邉一男, 田﨑和洋*, 長谷川靖*, 紺野愼一*. 当院におけるCancer Board 骨・軟部腫瘍の意義と課題. 第46回日本整形外科学会骨・軟部腫瘍学術集会; 2013 07 12; 東京. 日本整形外科学会雑誌. 87(6):S1204.
箱﨑道之*, 田地野崇宏*, 山田 仁*, 沼崎広法*, 菊地臣一*, 村上和也*, 長谷川靖*, 田﨑和洋*, 渡邉一男, 紺野愼一*. 膝関節に生じた滑膜血管腫の検討. 第46回日本整形外科学会骨・軟部腫瘍学術集会; 2013 07 12; 東京. 日本整形外科学会雑誌. 87(6):S1256.
箱﨑道之*. 急性腎盂腎炎との鑑別が困難であった急性偽痛風性腰椎椎間板炎: 1例報告. 第57回日本リウマチ学会総会・学術集会; 2013 04 20; 京都. Modern Rheumatology. 23(Suppl.):S384.
金内洋一*, 菊地臣一*, 田地野崇宏*, 山田 仁*, 箱﨑道之*, 田﨑和洋*, 長谷川靖*, 渡邉一男, 紺野愼一*. 脛骨に生じた黄色肉芽腫性骨髄炎: 1例報告. 第62回東日本整形災害外科学会; 2013 09 19; 軽井沢. 東日本整形災害外科学会雑誌. 25(3):261.
加藤欽志*, 箱﨑道之*, 田中健一*, 大谷晃司*, 紺野愼一*. 膝窩部軟部腫瘍に伴う腫瘍性骨軟化症の1例. 第34回東北骨代謝・骨粗鬆症研究会; 2013 02 02; 仙台. Clinical Calcium. 23(4):604.
箱﨑道之*, 田地野崇宏*, 山田 仁*, 田﨑和洋*, 長谷川靖*, 渡邉一男. 左下腿軟部（皮下）腫瘍. 第20回東北地区骨軟部腫瘍研究会; 2013 10 12; 仙台.
箱﨑道之*, 土橋 悠*, 加藤弘毅*, 片平清昭*, 和栗 聡*. 医療‐産業トランスレーショナルリサーチセンターにおける担がんマウスの作製. 第441回福島医学会学術研究集会; 2013 10 24; 福島. 福島医学雑誌. 64(1):50.
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〔特別講演〕
大竹 徹*. 新規分子標的治療薬のポジショニング. 平成25年いわき乳腺疾患研究会; 2013 11 11; いわき.
大竹 徹*. 乳房の診断から治療まで. 第26回福島県臨床画像研究会; 2013 06 08; 福島.
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受託・共同研究・補助等実績一覧
| 年度 | 実施形態 | 研究テーマ | 補助金・資金制度名／種別 | 相手機関名 | 代表研究者 | 共同研究者一覧 |
|---|---|---|---|---|---|---|
| 平成25 | 補助・助成 | 骨軟部肉腫に対する選択的cyclooxygenase-2阻害薬の効果 | 科学研究費補助金／若手研究(B) | 日本学術振興会 | 箱﨑道之* |
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