Adaptive Circuit Shift in the Central Olfactory System

For terminally differentiated neurons, the “birthdate” when they become post-mitotic has a special meaning; it can determine the neuronal fates and influence their connection patterns. We have been developing the “birthdate tagging system”, which consists of several transgenic mouse lines in which loxP recombination can be induced in a neuronal birthdate-dependent manner. This system enables manipulation of neurons based on the new classification “birthdate”. Using this system, I am now investigating potential adaptive circuit shift in the central olfactory system.

 
Recent Publications
1. Mita S, Monasterio-Schrader P, Fünfschilling U, Kawasaki T, Mizuno H, Iwasato T, Nave K-A, Werner HB, Hirata T (2015) Transcallosal projections require glycoprotein M6-dependent neurite growth and guidance. Cereb Cortex 25: 4111-4125.
2. Suzuki IK, Hirata T (2014) A common developmental plan for neocortical gene-expressing neurons in the pallium of the domestic chicken Gallus gallus domesticus and the Chinese softshell turtle Pelodiscus sinensis. Front Neuroanat April 8:1-17.
3. Suzuki IK, Kawasaki T, Gojobori T, Hirata T (2012) The temporal sequence of the mammalian neocortical neurogenmporal sequence of the mammalian neocortical neurogenetic program drives mediolateral pattern in the chick pallium. Dev Cell 22: 863-870.

Posted:2016/03/10