Basic technology for dynamics and control of neural circuit

Kazuto Kobayashi (Fukushima Medical University) (Representative)

“Technology for pathway-specific manipulation and control of neural circuit”

Our research group will develop the novel technology for genetic manipulation and control of neural circuit functions in the central nervous system. In particular, the highly efficient/neuron-specific retrograde gene transfer vector systems are useful for pathway-specific manipulation of the circuit functions in a wide range of brain science fields. In this project, our genetic technology will be extended further to control the activity of selective neuronal types in the circuit and applied for the study of neural mechanisms underlying the functional shift of the cortico-basal ganglia circuit during processes of operant learning.

 
Recent Publications
1. Kato, S., Kobayashi, K., and Kobayashi, K. (2013) Dissecting circuit mechanisms by genetic manipulation of specific neural pathways. Rev. Neurosci. 24: 1-8.
2. Okada, K., Nishizawa, K., Fukabori, R., Kai, N., Shiota, A., Ueda, S., Tsutsui, Y., Sakata, S., Matsushita, N., and Kobayashi, K. (2014) Enhanced flexibility of place discrimination learning by targeting of striatal cholinergic interneurons. Nat. Commun. 5: 3778.
3. Kobayashi, K., Kato, S., Inoue, K., Takada, M., and Kobayashi, K. (2016) Altering entry site preference of lentiviral vectors into neuronal cells by pseudotyping with envelope glycoproteins. Methods Mol. Biol. 1382: 175-186.

Posted:2016/02/17