Internal Medicine 2
||Hiromasa OHIRA, MD. PhD.
||Atsushi IRISAWA, MD. PhD.
|The department is nationally well known for
it's patient care, clinical investigations and
basic research. The distinguished faculties have
a major commitment to teaching and research in
addition to their clinical activities.
The Department of Internal Medicine 2 was established
in 1949. Until 2001, Prof. Shunichi Wakabayashi,
MD.PhD., Prof. Takeo Yoshida, MD. PhD., and Reiji
Kasukawa, MD., PhD., had directed our department.
Prof. Yukio Sato, MD. PhD, has been directing
our department since January 1st, 2001. Our research
fields are rheumatology, immunology, allergies,
molecular biology, gastroenterology, and hepatology.
About 40 medical staffs that have own specialty
are working at both the clinical and the research
There is a 50-bed inpatient rheumatic disease,
digestive and liver disease, allergic disease,
and general internal disease service at general
hospital attached Fukushima Medical University
that cares for patients with rheumatic disease,
liver diseases, and general internal disease,
gastrointestinal and pancreatic diseases.
Our department have many correlated hospitals
in Fukushima prefecture as following,
1) northern prefecture area: Ohara General hp,
Fukushima Red-Cross hp, Fujita General Public
hp, Saiseikai Fukushima hp, Saiseikai Kawamata
hp, Rehabilitation Iizaka-Onsen hp, Masu Memorial
2) southern prefecture area: Ohta Memorial hp,
Ohta Nishinouchi hp, Onomachi Public hp, Miharu
Prefectural hp, Motomiya Prefectural hp, Hoshi
hp, Sanatorium Fukushima hp, Hanawa Kousei hp,
Iwase Public hp,
3) sea-side area: Fukushima Rosai hp, Joban Municipal
hp, Soma Public hp,
4) Aizu area: Aizu General Prefectural hp.
Moreover, our department has several related institutions
in abroad. Our staff has been studying in these
institutions; Department of medicine and the Sam
and Rose Stein Institute for Aging at Univ. of
California San Diego, Division of Rheumatology
and Immunology at Medical Univ. of South Carolina,
and Division of Gastroenterology at Univ. of Florida.
|The research fields of our department are rheumatology,
immunology, allergy, molecular biology, gastroenterology
and hepatology. We actively attend and present
at many international meeting, ACR, DDW, etc.
Many faculties who have own specialty study every
|Faculty members of our department teach rheumatology,
allergy, gastroenterology and hepatology to medical
students in regular class and bedside.
Concerning the Fellowship Training, our department
offers fellowship position each year for highly
qualified physicians dedicated to obtaining the
highest quality training in all aspects of rheumatology,
allergy, gastroenterology, hepatology, and general
internal medicine. The program is distinctive
because of its commitment to providing fellows:
1. The opportunity to learn all diagnostic and
therapeutic procedures to qualified individuals;
2. The ability to obtain additional formal education
as well as exposure to clinical, bench, and transitional
Divisional education activities include a weekly
research conference, a weekly problems conference
in which the fellows present interesting cases
to be discussed by the faculty, and a biweekly
journal club. In addition, there is a biweekly
lecture series for fellows and medical students
by faculty. This series focuses on major advances
in the diagnosis and treatment of rheumatic, digestive,
liver, and allergic diseases, and is provided
by the faculty and fellows. Finally, a rheumatic
disease conference, a digestive disease conference,
and a liver conference are also held each week
to decide on therapeutic policy.
allergy and Molecular biology
|Injection of plasmid DNA into
the gastric mucosa induces mucosal and systemic
immunity. Cell Immunol 199, 58-63, 2000.
|Anti-tumor immunity against
CT26 colon tumor in mice immunized with
plasmid DNA encoding beta-galactosidase
fused to an envelope protein of endogenous
retrovirus. Cell Immunol 204, 11-18, 2000.
|Adjuvant effect of a 14-member
macrolide antibiotic on DNA vaccine. Cell
Immunol 197, 145-150, 1999.
of IgM rheumatoid factors reacting with
IgG subclasses. Clin. Rheumatol 14, 425-497,
|Gold sodium thiomalete selectively
inhibits interleukin-5-mediated eosinophil
survival. J. Allergy Clin. Immunol 96, 251-256,
of patients with primary biliary cirrhosis
associated with CREST symptoms. Hepatology
Research 2001 (in press).
|Autoimmune hepatitis accompanied
with systemic lupus erythematosus. Hepatology
Research 2001 (in press).
|Lipo prostaglandin E1 reduces
the production of CXC chemokines in endotoxin-induced
rat liver injury. Hepatology Research 19,
|Endoscopic recurrence of esophageal
varices is associated with the specific
EUS abnormalities; severe peri-esophageal
collateral veins and large perforating veins.
Gastrointest Endosc 53: 77-84: 2001.
|Adherence of cyanoacrylate,
which leaked from gastric varices to the
left renal vein during endoscopic injection
sclerotherapy: a histpathological study.
Endoscopy 32, 804-806, 2000.
(20MHz) analysis of collateral veins inside
and outside the esophageal walls related
to the esophageal varices in patients with
portal hypertension. Gastrointest Endosc
50: 374-380: 1999.
|Enhanced interleukin-8 production
by cultured Chang liver cells subjected
to ethanol exposure and subsequent stimulation
with tumor necrosis factor-Alfa. Digestion
58, 72-77, 1997.
|Interleukin-6 induces proliferation
of hepatocytes in vivo. J Hepatol 25, 941-947,
prostaglandin I2 production by cultured
rat hepatic sinusoidal endothelial cells.
Int Hepatol Commun 6, 71-78, 1996.
|Leukocyto adhesion molecules
in the liver and plasma cytokine level in
endotoxin-induced rat liver injury. Scand.
J. Gastroenterol, 30, 1027-1035, 1995.
|Clinical effectiveness of
Lansoprazole on patients with gastric ulcers:
Evaluation of quality of ulcer healing based
on endoscopic ultrasonographic findings.
J Clin Gastroenterol 20, 36-39,1995.
institutions with our faculties
|Modulation of renal disease
in MRL/lpr mice genetically deficient in
the alternative complement pathway factor
B. Journal of Immunology, 164, 786-794,2000.
|Thrombin upregulates interleukin-8
in lung fibroblasts via cleavage of proteolytically
activated receptor-1 and protein kinase
c-gamma activation. American Journal of
Respiratory cell and molecular biology 22,
|Pre-priming: a novel approach
to DNA based vaccination and immunomodulation.
Springer Semin Immunopathol 22: 85-96, 2000.
|Immunostimulatory DNA Prepriming:
A Novel Approach for Prolonged Th1-Biased
Immunity. Cell Immunol 198: 69-75, 1999.
|A contaminant of L-Tryptophan
enhances expression of dermal collagen in
a murine model of eosinophilia myalgia syndrome.
Proceedings of the association of American
physicians 108, 315-322, 1996.
|Immunostimulatory DNA sequences
necessary for effective intradermal gene
immunization. Science 273, 352-354, 1996.
|Immunostimulatory DNA sequences
function as T helper-I-promoting adjuvants.
Nat Med 3, 849-854-1997
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