論文 - 小林 和人
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Enhancement of the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene delivery through the point mutation of fusion glycoprotein type E.
Kato, S., Sugawara, M., Kobayashi, K., Kimura, K., Inoue, K., Takada, M., and Kobayashi, K.
J Neurosci Methods 311 147 - 155 2019年1月
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Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways.
Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M.
Neuron 99 ( 6 ) 1302 - 1314 2018年9月
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Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR
Cell Rep. 24 ( 8 ) 2196 - 2210 2018年8月
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Task-dependent function of striatal cholinergic interneurons in behavioural flexibility.
Okada, K., Nishizawa, K, Setogawa, S., Hashimoto, K. and Kobayashi, K.
Eur J Neurosci. 47 ( 10 ) 1174 - 1183 2018年5月
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Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H.
Sci Rep. 8 ( 1 ) 5435 2018年4月
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Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis.
Boku, S., Izumi, T., Abe, S., Takahashi, T., Nishi, A., Nomaru, H., Naka, Y., Kang, G., Nagashima, M., Hishimoto, A., Enomoto, S., Duran-Torres, G., Tanigaki, K., Zhang, J., Ye, K., Kato, S., Männistö, P.T., Kobayashi, K., and Hiroi, N.
Mol Psychiatry 23 ( 4 ) 985 - 992 2018年4月
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In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.
Saiki, A., Sakai, Y., Fukabori, R., Soma, S., Yoshida, J., Yawo, H., Kobayashi, K., Kimura, M., and Isomura, Y.
Cerebral Cortex 28 ( 3 ) 1024 - 1038 2018年3月
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Action Selection and Flexible Switching Controlled by the Intralaminar Thalamic Neurons.
Kato S, Fukabori R, Nishizawa K, Okada K, Yoshioka N, Sugawara M, Maejima Y, Shimomura K, Okamoto M, Eifuku S, Kobayashi K
Cell reports 22 ( 9 ) 2370 - 2382 2018年2月
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Hashimoto M, Yamanaka A, Kato S, Tanifuji M, Kobayashi K, Yaginuma H
Frontiers in neural circuits 12 6 2018年2月（ ISSN:16625110 ）
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In Vivo Observation of Structural Changes in Neocortical Catecholaminergic Projections in Response to Drugs of Abuse.
Morimoto, M., Kobayashi, K., and Okabe, S
eNeuro 5 ( 1 ) 2018年2月
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Segregated Excitatory-Inhibitory Recurrent Subnetworks in Layer 5 of the Rat Frontal Cortex.
Morishima, M., Kobayashi, K., Kato, S., Kobayashi, K., and Yasuo Kawaguchi.
Cereb Cortex 27 ( 12 ) 5846 - 5857 2017年12月
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Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice.
Fujita, M., Hagino, Y., Takeda, T., Kasai, S., Tanaka, M., Takamatsu, Y., Kobayashi, K., and Ikeda, K.
Mol Brain. 10 ( 1 ) 49 2017年10月
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Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome.
Bhattacherjee, A., Mu, Y., Winte, M., Knapp, J.R., Eggiman, A. Gunewardena, S., Kobayashi, K., Kato, S., Krizsan-Agbas, D., and Smith, P.
Proc Natl Acad Sci U S A. 114 ( 33 ) E6952 - E6961 2017年8月
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Optimisation of murine organotypic slice culture preparation for a novel sagittal-frontal co-culture system.
Joost, S., Kobayashi, K., Wree, A., and Haas, S.J.
J Neurosci Methods. 285 49 - 57 2017年7月
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The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain.
Tanabe, S., Inoue, K.-I., Tsuge, H., Uezono, S., Nagaya, K., Fijiwara, M., Kato, S., Kobayashi, K., and Takada, M.
Neurosci Res. 120 45 - 52 2017年7月
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Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.
Oh YM, Karube F, Takahashi S, Kobayashi K, Takada 3, Uchigashima M, Watanabe M, Nishizawa K, Kobayashi K, Fujiyama F
Brain Struct Funct. 222 ( 5 ) 2359 - 2378 2017年7月
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Spatial distribution of synapses on tyrosine hydroxylase-expressing juxtaglomerular cells in the mouse olfactory glomerulus.
Kiyokage, E., Kobayashi, K, and Toida, K
Journal of Comparative Neurology 525 ( 5 ) 1059 - 1074 2017年4月
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Dopamine D1 receptor immunoreactivity on fine processes of GFAP-positive astrocytes in the substantia nigra pars reticulate of adult mouse.
Nagatomo, K., Suga, S., Saitoh, M., Kogawa, M., Kobayashi, K., Yamamoto, Y., and Yamada, K.
Front. Neuroanat 11 ( 3 ) 2017年2月
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Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.
Matsuda, T., Hiyama, T.Y., Nimura, F., Matsusaka, T., Fukamizu, A., Kobayashi, K., Kobayashi, K., and Noda, M.
Nature Neuroscience 20 ( 2 ) 230 - 241 2017年2月
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Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.
Tohyama, T., Kinoshita, M., Kobayashi, K., Isa, K., Watanabe, D., Kobayashi, K., Liu, M., and Isa, T.
Proceedings of the National Academy of Sciences of the United States of America 114 ( 3 ) 604 - 609 2017年1月
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Involvement of mesolimbic dopaminergic network in neuropathic pain relief by Treadmill exercise: A study for specific neural control with Gi-DREADD in mice.
Kenta Wakaizumi, Takashige Kondo, Yusuke Hamada, Michiko Narita, Rui Kawabe, Hiroki Narita, Moe Watanabe, Shigeki Kato, Emiko Senba, Kazuto Kobayashi, Naoko Kuzumaki, Akihiro Yamanaka, Hiroshi Morisaki, and Minoru Narita
Mol. Pain 12 12 pii:1744806916681567 2016年12月
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Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders.
Yamada, K., Takahashi, S., Karube, F., Fujiyama, F., Kobayashi, K., Nishi, A., and Momiyama, T.
The Journal of Physiological Sciences 66 ( 6 ) 435 - 446 2016年11月
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Survival of corticostriatal neurons by small GTPase Rho.
131. Kobayashi, K. Sano, H., Kato, S., Kuroda, K., Nakamuta, S., Isa, T., Nambu, A., Kaibuchi, K., and Kobayashi, K.
Neurosci. Lett. 630 ( 1 ) 45 - 52 2016年9月
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Ionic basis for membrane potential resonance in neurons of the inferior olive.
Matsumoto-Makidono, Y., Nakayama, H., Yamasaki, M., Miyazaki, T., Kobayashi, K., Watanabe, M., Kano, M., Sakimura, K. and Hashimoto, K.
Cell Rep. 16 994 - 1004 2016年7月
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Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures.
Uchigashima, M., Ohtsuka, T., Kobayashi, K., and Watanabe, M.
Proceedings of the National Academy of Sciences of the United States of America 113 ( 15 ) 4206 - 4211 2016年4月
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Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders.
Yamada, K., Takahashi, S., Karube, F., Fujiyama, F., Kobayashi, K., Nishi, A., and Momiyama, T.
J. Physiol.. Sci. 2016年3月
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Phosphoproteomics of the dopamine pathway enables discovery of Rap1 activation as reward signal in vivo.
Nagai, T., Nakamuta, S., Kuroda, K., Nakauchi, S., Nishioka, T., Takano, T., Zhang, X., Tsuboi, D., Funahashi, Y., Nakano, T., Yoshimoto, J., Kobayashi, K., Uchigashima, M., Watanabe, M., Miura, M., Nishi, A., Kobayashi, K., Yamada, K., Amano, M. and Kaibuchi, K.
Neuron 89 ( 3 ) 550 - 565 2016年2月
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Causal link between the cortico-rubral pathway and functional recovery through forced impaired limb use in rats with stroke.
Ishida, A., Isa, K., Umeda, T., Kobayashi, K., Kobayashi, K., Hida, H., and Isa, T.
J. Neurosci. 36 ( 2 ) 455 - 467 2016年1月
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Altering entry site preference of lentiviral vectors into neuronal cells by pseudotyping with envelope glycoproteins.
Kobayashi, K., Kato, S., Inoue, K., Takada, M., and Kobayashi, K.
Methods Mol. Biol. (Gene Therapy of Neurological Disorders; ed. Manfredsson, F.) 1382 175 - 186 2016年
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Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons.
Masi, A., Narducci, R., Resta, F., Carbone, C., Kobayashi, K., and Mannaioni, G.
Eur. J. Neurosci. 42 ( 9 ) 2699 - 2706 2015年11月
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Differential roles of the nucleus accumbens shell neurons containing dopamine D1 and D2 receptors in behavioral sensitization.
Kai, N., Nishizawa, K., Ueda, S., and Kobayashi, K.
J. Neurochem. 135 1232 - 1241 2015年10月
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Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice. Arterioscler.
Ellawindy, A., Satoh, K., Sunamura, S., Kikuchi, N., Suzuki, K., Minami, T., Ikeda, S., Tanaka, S., Shimizu, T., Enkjargal, B., Miyata, S., Taguchi, Y., Handoh, T., Kobayashi, K., Kobayashi, K., Nakayama, K., Miura, M., and Shimokawa, H.
Thromb. Vasc Biol. 35 ( 10 ) 2172 - 2184 2015年10月
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Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory.
Okada, K, Nishizawa, K., Kobayashi, T., Sakata, S., and Kobayashi, K. (2015)
Sci. Rep. 5 13158 2015年8月
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Double virus vector infection to the prefrontal network of the macaque brain.
Oguchi, M., Okajima, M., Tanaka, S., Koizumi, M., Kikusui, T., Ichihara, N., Kato, S., Kobayashi, K., and Sakagami, M.
PLoS One 10 ( 7 ) e0132825 2015年7月
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An avian sarcoma leukosis virus receptor-envelope system for simultaneous dissociation of multiple neural circuits in mammalian brain.
Matsuyama, M., Ohashi, Y., Tsubota, T., Yaguchi, M., Kato, S., Kobayashi, K., and Miyashita, Y.
Proc. Natl. Acad. Sci. USA 112 ( 22 ) E2947-E2956 2015年6月
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Matsuyama M, Ohashi Y, Tsubota T, Yaguchi M, Kato S, Kobayashi K, Miyashita Y
Proceedings of the National Academy of Sciences of the United States of America 112 ( 22 ) E2947 - 56 2015年6月（ ISSN:0027-8424 ）
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Involvement of cholinergic system in hyperactivity in dopamine-deficient mice.
Hagino, Y., Kasai, S., Fujita, M., Setogawa, S., Yamaura, H., Yanagihara, D., Hashimoto, M., Kobayashi, K., Meltzer, H.Y., and Ikeda, K.
Neuropsychopharmacology 40 1141 - 1150 2015年3月
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遺伝子改変技術による脳機能と病態に関する神経ネットワークの解明
小林 和人
福島医学雑誌 65 ( 3 ) 79 - 93 2015年
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大脳基底核による運動制御と病態生理、
佐野裕美、小林和人、南部篤
分子脳科学、化学同人(三品昌美編) pp. 44-55 (total 291 pages) 2015年
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RHOA inactivation enhances Wnt signaling and promotes colorectal cancer.
Rodrigues, P., Macaya, I., Bazzocco, S., Mazzolini, R., Andretta, E., Dopeso, H., Mateo-Lozano, S., Bilic, J., Cartón-García, F., Nieto, R., Suárez-López, L., Afonso, E., Landolfi, S., Hernandez-Losa, J., Kobayashi, K., y Cajal, S.R., Tabernero, J., Tebbutt, N.C., Mariadason, J.M., Schwartz Jr, S., and Arango, D.
Nat. Commun. 5 5458 2014年11月
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Transcriptional and structural plasticity of tyrosine hydroxylase expressing neurons in both striatum and nucleus accumbens following dopaminergic denervation.
Depboylu, C., Klietz, M., Maurer, L., Oertel, W.H., Kobayashi, K., Weihe, E., Höglinger, G.U., and Schäfer, M. K.
J. Chem. Neuroanat. : (Nov) doi 61/62 169 - 175 2014年11月
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Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method.
Watakabe, A., Takaji, M., Kato, S., Kobayashi, K., Mizukami, H., Ozawa, K., Ohsawa, S., Matsui, R., Watanabe, D., and Yamamori, T.
Front. Neural Circuits 8 110 2014年9月
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Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice.
Ikeda, S., Satoh, K., Kikuchi, N., Miyata, S., Suzuki, K., Omura, J., Shimizu, T., Kobayashi, K., Kobayashi, K., Fukumoto, Y., Sakata, Y., and Shimokawa, H.
Arterioscler. Thromb. Vasc Biol. 34 ( 6 ) 1260 - 1271 2014年6月
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Enhanced flexibility of place discrimination learning by targeting of striatal cholinergic interneurons.
Okada, K., Nishizawa, K., Fukabori, R., Kai, N., Shiota, A., Ueda, S., Tsutsui, Y., Sakata, S., Matsushita, N., and Kobayashi, K.
Nat. Commun. 5 3778 2014年5月
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Lesions of the nucleus accumbens core modulate development of matching behavior.
Kai, N., Tsutsui, Y., and Kobayashi, K.
BMC Neurosci. 15 55 2014年4月
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Improved transduction efficiency of a lentiviral vector for neuron-specific retrograde gene transfer by optimizing the junction of fusion envelope glycoprotein.
Kato, S., Kobayashi, K., and Kobayashi, K.
J. Neurosci. Methods 227 151 - 158 2014年3月
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Methylglyoxal (MG) and cerebro-renal interaction: Does long-term orally-administered MG cause cognitive impairment in normal Sprague-Dawley rats?
Watanabe, K., Okada, K., Fukabori, R., Hayashi, Y., Asahi, K., Terawaki, H., Kobayashi, K., Watanabe, T., and Nakayama, M.
Toxins 6 ( 1 ) 254 - 269 2014年1月
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Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area.
Zhang, C., Tonsfeldt, K.J., Qiu, J., Bosch, M.A., Kobayashi, K., Steiner, R.A., Kelly, M.J. and Rønnekleiv, O.K.
Am. J. Physiol. Endocrinol. Metab. 305 ( 11 ) E1384-1397 2013年12月
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Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice.
Sooksawate, T., Isa, K., Matsui, R., Kato, S., Kinoshita, M., Kobayashi, K., Watanabe, D., Kobayashi, K., and Isa, T.
Front. Neural Circuits 7 162 2013年10月
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Highly efficient retrograde gene transfer into motor neurons by lentiviral vector pseudotyped with fusion glycoprotein.
Hirano, M., Kato, S., Kobayashi, K., Okada, T., Yaginuma, H., and Kobayashi, K.
PLoS One 8 ( 9 ) e75896 2013年9月
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Chronic alterations in monoaminergic cells in locus coeruleus in orexin neuron-ablated narcoleptic mice.
Tsujino, N., Tsunematsu, T., Uchigashima, M., Konno, K., Yamanaka, A., Kobayashi, K., Watanabe, M., Koyama, Y., and Sakurai, T.
PLoS One 8 ( 7 ) e70012 2013年7月
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Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence.
Miyazaki, M., Noda, Y., Mouri, A., Kobayashi, K., Mishina, M., Nabeshima, T., Yamada, K.
Int. J. Neuropsychopharmacol. 16 ( 6 ) 1341 - 1350 2013年7月
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Protocadherin 17 regulates presynaptic assembly in topographic cortico-basal ganglia circuits.
Hoshina, N., Tanimura, A., Yamasaki, M., Inoue, T., Fukabori, R., Kuroda, T., Yokoyama, K., Tezuka, T., Sagara, H., Hirano, S., Kiyonari, H., Takada, M., Kobayashi, K., Watanabe, M., Kano, M., Nakazawa, T. and Yamamoto, T.
Neuron 78 ( 5 ) 839 - 854 2013年6月
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Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra.
Sano, H., Chiken, S., Hikida, T., Kobayashi, K., and Nambu, A.
J. Neurosci. 33 ( 17 ) 7583 - 7594 2013年4月
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Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures.
Uchigashima, M., Ohtsuka, T., Kobayashi, K., and Watanabe, M.
Proc. Natl. Acad. Sci. USA 113 ( 15 ) 4206 - 4211 2013年4月
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Transcranial direct-current stimulation increases extracellular dopamine levels in the rat striatum.
Tanaka, T., Takano, Y., Tanaka, S., Hironaka, N., Kobayashi, K., Watanabe, K., Honda, M.
Front. Syst. Neurosci. 7 6 2013年4月
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Dissecting circuit mechanisms by genetic manipulation of specific neural pathways.
Kato, S., Kobayashi, K., and Kobayashi, K
Rev. Neurosci. 24 ( 1 ) 1 - 8 2013年1月
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Striatal indirect pathway contributes to selection accuracy of learned motor actions.
Nishizawa, K., Fukabori, R., Okada, K., Kai, N., Uchigashima, M., Watanabe, M., Shiota, A., Ueda, S., Tsutsui, Y., and Kobayashi, K.
J. Neurosci. 32 ( 39 ) 13421 - 13432 2012年9月
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Functional properties of dopamine neurons and co-expression of vasoactive-intestinal-polypeptide in the dorsal raphe nucleus and ventro-lateral periaqueductal grey.
Dougalis, A.G., Matthews, GAC, Bishop, MW, Brischoux, F., Kobayashi, K., and Ungless, M.A.
Eur. J. Neurosci. 36 ( 10 ) 3322 - 3332 2012年8月
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Genetic dissection of the circuit for hand dexterity in primates.
Kinoshita, M., Matsui, R., Kato, S., Hasegawa, T., Kasahara, H., Isa, K., Watakabe, A., Yamamori, T., Nishimura, Y., Alstermark, B., Watanabe, D., Kobayashi, K., and Isa, T.
Nature 487 ( 7406 ) 235 - 238 2012年7月
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Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic “hyperdirect” pathway.
Inoue, K., Koketsu, D., Kato, S., Kobayashi, K., Nambu, A., and Takada, M.
PLoS One 7 ( 6 ) e39149 2012年6月
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Striatal direct pathway modulates response time in execution of visual discrimination.
Fukabori, R., Nishizawa, K., Okada, K., Kai, N., Kobayashi, K., Uchigashima, M., Watanabe, M., Tsutsui, Y., and Kobayashi, K.
Eur. J. Neurosci. 35 ( 5 ) 784 - 797 2012年3月
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Visualization of the cortical projection neurons by retrograde TET-Off lentiviral vector.
Watakabe, A., Kato, S., Kobayashi, K., Takaji, M., Nakagami, Y., Sadakane, O., Ohtsuka, M., Hioki, H., Kaneko, T., Okuno, H., Kawashima, T., Bito, H., Kitamura Y., and Yamamori, T.
PLoS One 7 e46157 2012年
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Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein.
Kato, S., Kuramochi, M., Takasumi, K., Kobayashi, K., Inoue, K., Takahara, D., Hitoshi, S., Ikekana, K., Shimada, T., Takada, M., and Kobayashi, K.
Hum. Gene Ther. 22 ( 12 ) 1511 - 1523 2011年12月
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Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of visual discrimination.
Kato, S., Kuramochi, M., Kobayashi, K., Fukabori, R., Okada, K., Uchigashima M., Watanabe, M., Tsutsui, Y., and Kobayashi, K.
J. Neurosci. 31 ( 47 ) 17169 - 17179 2011年11月
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Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum.
Masuda, M., Miura, M., Inoue, R., Imanishi, M., Saino-Saito, S., Takada, M., Kobayashi, K., and Aosaki, T. (2011)
Eur. J. Neurosci. 34 ( 9 ) 1355 - 1367 2011年11月
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Dynamic expression of cadherins modulates vocal plasticity in a songbird.
Matsunaga, E., Suzuki, K., Kato, S., Kurotani, T., Kobayashi, K., and Okanoya, K.
PLoS One 6 ( 9 ) e25272 2011年9月
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p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
Sekine, Y., Takagahara, S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H.
J. Cell. Sci. 124 ( 17 ) 3006 - 3016 2011年9月
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Up-regulation of dopamine D1 receptor in the hippocampus after establishment of conditioned place preference by cocaine.
Tanaka, T., Kai, N., Kobayashi, K., Takano, Y., Hironaka, N.
Neuropharmacology 61 ( 4 ) 842 - 848 2011年9月
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Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb.
Sawada, M., Kaneko, N., Wake, H., Inada, H., Kato, Y., Yanagawa, Y., Kobayashi, K., Nemoto, T., Nabekura, J. and Sawamoto, K.
J. Neurosci. 31 ( 32 ) 11587 - 11596 2011年8月
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Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb.
Koshi Murata, Maki Imai, Shigetada Nakanishi, Dai Watanabe, Ira Pastan, Kazuto Kobayashi, Tomoko Nihira, Hideki Mochizuki, Shuichi Yamada, Kensaku Mori and Masahiro Yamaguchi
J. Neurosci. 31 ( 29 ) 10540 - 10557 2011年7月
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Targeting of locus ceruleus noradrenergic neurons expressing human interleukin-2 receptor a-subunit in transgenic mice by a recombinant immunotoxin anti-Tac(Fv)-PE38: A study for exploring noradrenergic influence upon anxiety-like and depression-like behaviors.
Itoi, K., Sugimoto, N., Suzuki, S., Sawada, K., Das, G., Uchida, K., Fuse, T., Ohara, S., and Kobayashi, K.
J. Neurosci. 31 ( 16 ) 6132 - 6139 2011年4月
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Glomerular Sclerosis is prevented during urinary tract obstruction due to podocyte protection.
Matsusaka, T., Kobayashi, K., Kon, V., Qing-cheng, Pastan, I., Fogo, A.B., and Ichikawa, I.
Am. J. Physiol. Renal Physi. 300 ( 3 ) F792-800 2011年3月
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A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein.
Kato, S., Kobayashi, K., Inoue, K., Kuramochi, M., Okada, T., Yaginuma, H., Morimoto, K., Shimada, T., Takada, M., and Kobayashi, K.
Hum. Gene Ther. 22 ( 2 ) 197 - 206 2011年2月
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Rho/Rho-kinase signaling pathway controls axon patterning of a specified subpopulation of cranial motor neurons.
Kobayashi, K., Masuda, T., Takahashi, M., Miyazaki, J., Nakagawa, M., Uchigashima, M., Watanabe, M., Yaginuma, H., Osumi, N., Kaibuchi, K., and Kobayashi, K.
Eur. J. Neurosci. 33 ( 4 ) 612 - 621 2011年2月
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AKT suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy.
Cheng, H.-C., Kim, S.R., Oo, T., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., and Burke, R.
J. Neurosci. 31 ( 6 ) 2125 - 2135 2011年2月
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Lever pressing responses under a fixed-ratio schedule of mice with 6-hydroxydopamine-induced dopamine depletion in the nucleus accumbens.
Tsutsui, Y., Nishizawa, K., Kai, N., and Kobayashi, K.
Behav. Brain Res. 217 ( 1 ) 60 - 66 2011年1月
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Evaluation of Pax6 mutant rat as a model for autism.
Umeda, T., Takashima, N., Nakagawa, R., Maekawa, M., Ikegami, S., Yoshikawa, T., Kobayashi, K., Okanoya, K., Inokuchi, K., and Osumi, N.
PLoS One 5 ( 12 ) e15500 2010年12月
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Synaptic input of ON-bipolar cells onto the dopaminergic neurons of the mouse retina.
Contini, M., Lin, B., Kobayashi, K., Okano, H., Masland, R.H., and Raviola, E.
J. Comp. Neurol. 518 ( 11 ) 2035 - 2050 2010年6月
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Effects of age, presence of neurons and endothelin-3 on the ability of enteric neuron precursors to colonize recipient gut.
Hotta, R., Anderson, R.B., Kobayashi, K., Newgreen, D.F. and Young, H.M.
Neurogastroenterol. Motil. 22 ( 3 ) 331-e86 2010年3月
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道具的学習と行動制御を研究するモデル実験動物
小林和人、深堀良二、甲斐信行、岡田佳奈、小林とも子
生体の科学 61 ( 1 ) 47 - 52 2010年1月
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Molecular identity of periglomerular and short axon cells.
Kiyokage E., Pan Y., Shao, Z., Kobayashi, K., Szabo, Y., Yanagawa, Y., Obata, K., Okano, H., Toida, K., Puche, A.C., and Shipley. M.T.
J. Neurosci. 30 ( 3 ) 1185 - 1196 2010年1月
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ドパミンによるドパミンニューロンの選択的障害
小林憲太、小林和人
Clinical Neuroscience 28 ( 1 ) 8 - 9 2010年1月
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Unexpected expression of α- and β-globin in mesencephalic dopaminergic neurons and glial cells.
Biagioli, M., Pinto, M., Cesselli, D., Zaninello, M., Lazarevic, D., Simone, R., Vlachouli, C., Plessy, C., Bertin, N., Beltrami, A., Kobayashi, K., Gallo, V., Ferrer, I., Santoro, C., Rivella, S., Beltrami, C.A., Carninci, P., Raviola, E., and Gustincich, S.
Proc. Natl. Acad. Sci. USA 106 ( 36 ) 15446 - 15451 2009年9月
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Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.
Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, and Sulzer D.
Neuron 62 ( 2 ) 218 - 229 2009年4月
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イムノトキシン細胞標的法を用いた直接路・間接路の機能解析
深堀良二、小林和人 (2009)
Brain and Nerve 61 ( 4 ) 412 - 418 2009年4月
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Identification of an activator protein-1-like Sequence as the glucocorticoid response element in the rat tyrosine hydroxylase gene.
Sheela Rani, C.S., Elango, N., Wang, S.-S., Kobayashi, K. and Strong, R.
Mol. Pharmacol. 75 ( 3 ) 589 - 598 2009年3月
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Laminin peptide YIGSR and its receptor regulate sensory axonal response to the chemoattractive guidance cue in the chick embryo.
Masuda, T., Sakuma, C., Kobayashi, K., Kikuchi, K., Soda, E., Shiga, T., Kobayashi, K., and Yaginuma, H.
J. Neurosci. Res. 87 ( 2 ) 353 - 359 2009年2月
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The migratory behavior of immature enteric neurons.
Hao, M., Anderson, R.B., Kobayashi, K., Whitington, P.M., and Young, H.M.
Dev. Neurobiol. 69 ( 1 ) 22 - 35 2009年1月
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Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.
Masuda, T., Kai, N., Sakuma, C., Kobayashi, K., Koga, H., Yaginuma, H.
Brain Res. 1249 ( 1 ) 61 - 67 2009年1月
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Ephrin-A5 regulates the formation of the ascending midbrain dopaminergic pathways.
Cooper, M.A., Kobayashi, K., and Zhou, R.
Dev. Neurobiol. 69 ( 1 ) 36 - 46 2009年1月
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Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region.
Kobayashi, T., Kai, N., Kobayashi, K., Fujiwara, T., Akagawa,I., Onda, M., and Kobayashi, K.
J. Neurosci. Methods 175 ( 1 ) 125 - 132 2008年10月
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Effects on NGF, NT-3, and GDNF family members on neurite outgrowth and migration from pelvic ganglia in embryonic and newborn mice.
Stewart, A.L., Anderson, R.B., Kobayashi, K., Young, H.M.
BMC-Dev. Biol. 8 ( 73 ) 2008年7月
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Selective loss of nigral dopamine neurons induced by overexpression of truncated human -synuclein in mice.
Wakamatsu, M., Ishii, A., Iwata, S., Sakagami, J., Ukai, Y., Ono, M., Kanbe, D., Muramatsu, S.I., Kobayashi, K., Iwatsubo, T., and Yoshimoto, M.
Neurobiol. Aging 29 ( 4 ) 574 - 585 2008年4月
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Non cell-autonomous roles for the planar cell polarity gene Vangl2 in development of the coronary circulation.
Phillips, H.M., Hildreth, V., Murdoch, J.N., Kobayashi, K., Chaudhry, B. and Henderson, D.J.
Circ. Res. 102 ( 5 ) 615 - 623 2008年3月
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Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus.
Appleyard, S.M., Marks, D., Kobayashi, K., Okano, H., Low, M.J., and Andresen, M.C.
J. Neurosci. 27 ( 48 ) 13292 - 13302 2007年11月
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Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein.
Kato, S., Inoue, K., Kobayashi, K., Yasoshima, Y., Miyachi, S., Inoue, S., Hanawa, H., Shimada, T., Takada, M., and Kobayashi, K.
Human Gene Ther. 18 ( 11 ) 1141 - 1152 2007年11月
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Guidance cues from the embryonic dorsal spinal cord chemoattract dorsal root ganglion axons.
Masuda, T., Sakuma C., Taniguchi, M., Kobayashi, K., Kobayashi, K., Shiga, T., and Yaginuma, H.
Neuroreport 18 ( 16 ) 1645 - 1649 2007年10月
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Compartment-specific modulation of GABAergic synaptic transmission by -opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands.
Miura, M., Saino-Saito, S., Masuda, M., Kobayashi, K., and Aosaki, T.
J. Neurosci. 27 ( 36 ) 9721 - 9728 2007年9月
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Controlled cell targeting system to study the brain neural circuitry.
Kobayashi, K.
Neurosci. Res. 58 ( 2 ) 118 - 123 2007年7月
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Controlled cell targeting system to study the brain neural circuitry.
Kobayashi, K.
Neurosci. Res. 58 ( 2 ) 118 - 123 2007年6月
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Accumulation of phosphorylated a-synuclein dopaminergic neurons of transgenic mice that express human -synuclein.
Wakamatsu, M., Ishii, A., Ukai, Y., Sakagami, J., Iwata, S., Ono, M., Matsumoto, K., Nakamura, A., Tada, N., Kobayashi, K., Iwatsubo, T., and Yoshimoto, M.
J. Neurosci. Res. 85 1819 - 1825 2007年4月
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ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons.
Saino-Saito, S., Cave, J.W., Akiba, Y., Sasaki, H., Goto, K., Kobayashi, K., Berlin, R.A., and Baker, H.
J. Comp. Neurol. 502 ( 4 ) 485 - 496 2007年3月
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ニューロンネットワーク解析の新技術：組換え体イムノトキシンを利用した細胞標的法
小林 和人
化学と生物 45 ( 1 ) 16 - 20 2007年1月
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ニューロンネットワーク解析の新技術：組換え体イムノトキシンを利用した細胞標的法
小林 和人
化学と生物 45 ( 1 ) 16 - 20 2007年1月
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Selective loss of nigral dopamine neurons induced by overexpression of truncated human a-synuclein in mice.
Wakamatsu, M., Ishii, A., Iwata, S., Sakagami, J., Ukai, Y., Ono, M., Kanbe, D., Muramatsu, S.I., Kobayashi, K., Iwatsubo, T., and Yoshimoto, M.
Neurobiol. Aging 2006年12月
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Bidirectional reguation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons.
Jomphe, C., Lemelin, P.-L., Okano, H., Kobayashi, K., and Trudeau, L.-E.
Eur. J. Neurosci. 24 ( 10 ) 2789 - 2800 2006年11月
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Decline of endogenous dopamine release in parkin-deficient mice revealed by ex vivo autoradiography.
Sato, S., Chiba, T., Nishiyama, S., Kakiuchi, T., Tsukada, H., Hatano, T., Fukuda, T., Yasoshima, Y., Kai, N., Kobayashi, K., Mizuno, Y., Tanaka, K., and Hattori, N.
J. Neurosci. Res. 84 1350 - 1357 2006年8月
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Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain.
Rawal, N., Castelo-Branco, G., Sousa, K. M., Kobayashi, K., Okano, H., and Arenas, E.
Exp. Cell Res. 312 ( 9 ) 1626 - 1636 2006年5月
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Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson’s disease.
Meuer, K., Teismann, P., Peters, K., Göricke, B., Lingor, P., Schlachetzki, J., Kobayashi, K., Dietz, G. P.H., Schulz, J.B., Bähr, M., Schneider, A., and Weishaupt, J. H.
J. Neurochem. 97 ( 3 ) 675 - 686 2006年5月
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Separation of m-opioid receptor desensitization and internalization: endogenous receptors in primary neuronal cultures.
Arttamangkul, S., Torrecilla, M., Kobayashi, K., Okano, H., and Williams, J.T.
J. Neurosci. 26 ( 15 ) 4118 - 4125 2006年4月
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Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis.
Kai, N., Iwase, K., Imai, K., Nakahira, E., Soma, M., Ohtsuka, S., Yagi, T., Kobayashi, K., Koga, H., Takiguchi, M., and Yuasa, S.
Brain Res. 1073/1074 60 - 70 2006年2月
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Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons.
Sawamoto, K., Nakao, N., Kobayashi, K., Matsushita, N., Takahashi, H. et al.
Proc. Natl. Acad. Sci. USA 98 ( 11 ) 6423 - 6428 2001年
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Modest Neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene
Kobayashi, K., Noda, Y., Matsushita, N., Nishii, K., Sawada, H. et al.,
J. Neurosci. 20 ( 6 ) 2418 - 2426 2000年
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Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission
Nishii, K., Matsushita, N., Sawada, H., Sano, H., Noda, Y., et al.
J. Neurosci. Res. 54 ( 4 ) 450 - 464 1998年
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Autonomic neuropathy in transgenic mice cansed by immunotorin targeting of the peripheral neurons system
Sawada, H., Nishii, K., Suzuki, T., Hasegawa, K., Hata, T., et al.
J. Neurosci. Res. 51 ( 2 ) 162 - 173 1998年
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Ablation of cerebellar Golgi cells disrupts synaptic integration involring GABA inhibition and NMDA receptor activation in motor control
Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., et al.
Cell 95 ( 1 ) 17 - 27 1998年
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Targeted disruption of the tyrosire hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice.
Kobayashi, K., Morita, S., Sawada, H., Mizuguchi, T., Yamada, K. et al.
J. Biol. Chem. 270 ( 45 ) 27235 - 27243 1995年
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Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.
Kobayashi, K., Morita, S., Sawada, H., Mizuguchi, T., Yamada, K., et al.
Proc. Natl. Acad. Sci. USA 92 ( 4 ) 1132 - 1136 1995年
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Functional and high lerel expression of human dopamine β-hydroxylase ih transgenic mice
Kobayashi, K., Morita, S., Mizuguchi, T., Sawada, H., Yamada, K., et al.
J. Biol. Chem. 269 ( 47 ) 29725 - 29731 1994年
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Genetic alteration of catecholamine specificity in transgenic mice.
Kobayashi, K., Sasaoka, T., Morita, S., Nagatsu, I., Iguchi, A. et al.
Proc. Natl. Acad. Sci. USA 89 ( 5 ) 1631 - 1635 1992年
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Tissue-specific and high-level expression of the human tyvosine hydroxylase gene in transgenic mice
Kaneda, N., Sasaoka, T., Kobayashi, K., Kiuchi, K., Nagatsu, I. et al.
Neuron 6 583 - 594 1991年